Abstract:
:Since the initial observations by Kaiser and Edelman, interest in the role of calcium in ACS-induced apoptosis has wavered, in part because of the fact that extracellular calcium is only necessary for induction of apoptosis in thymocytes, but not in peripheral lymphocytes or lymphoma cells. Now, as result of molecular evidence implicating two separate ligand-gated calcium channels in ACS-induced apoptosis, interest in the role of calcium is sure to be renewed. The major challenge lies in determining the signal transduction pathway through which ACS-induced calcium fluxes mediate apoptosis.
journal_name
Bloodjournal_title
Bloodauthors
Distelhorst CW,Dubyak Gsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
731-4issue
3eissn
0006-4971issn
1528-0020journal_volume
91pub_type
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