Nocturnal oxygen saturation and painful sickle cell crises in children.

abstract：:We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of...

journal_title：Blood

authors： Zappasodi R,Ruggiero G,Guarnotta C,Tortoreto M,Tringali C,Cavanè A,Cabras AD,Castagnoli L,Venerando B,Zaffaroni N,Gianni AM,De Braud F,Tripodo C,Pupa SM,Di Nicola M

更新日期：2015-03-12 00:00:00

abstract：:The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cel...

journal_title：Blood

authors： Berger C,Berger M,Hackman RC,Gough M,Elliott C,Jensen MC,Riddell SR

更新日期：2009-09-17 00:00:00

abstract：:In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...

journal_title：Blood

authors： Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

更新日期：2004-06-15 00:00:00

abstract：:The extended use of brentuximab-vedotin was reported for CD30(+) nonanaplastic peripheral T-cell lymphomas (PTCLs) with promising efficacy. CD30 status assessment is thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. Th...

journal_title：Blood

authors： Bossard C,Dobay MP,Parrens M,Lamant L,Missiaglia E,Haioun C,Martin A,Fabiani B,Delarue R,Tournilhac O,Delorenzi M,Gaulard P,de Leval L

更新日期：2014-11-06 00:00:00

abstract：:Immune function has been restored in 9 of 10 children with X-linked severe combined immunodeficiency by gamma c gene transfer in CD34+ cells. The distribution of both T-cell receptor (TCR) V beta family usage and TCR V beta complementarity-determining region 3 (CDR3) length revealed a broadly diversified T-cell repert...

journal_title：Blood

authors： Schmidt M,Hacein-Bey-Abina S,Wissler M,Carlier F,Lim A,Prinz C,Glimm H,Andre-Schmutz I,Hue C,Garrigue A,Le Deist F,Lagresle C,Fischer A,Cavazzana-Calvo M,von Kalle C

更新日期：2005-04-01 00:00:00

abstract：:Oxygen-induced retinopathy (OIR) is a well-characterized model for retinopathy of prematurity, a disorder that results from rapid microvascular proliferation after exposure of the retina to high oxygen levels. Here, we report that the proliferative phase of OIR requires transcriptional induction of the annexin A2 (A2)...

journal_title：Blood

authors： Huang B,Deora AB,He KL,Chen K,Sui G,Jacovina AT,Almeida D,Hong P,Burgman P,Hajjar KA

更新日期：2011-09-08 00:00:00

abstract：:In this issue of Blood, Smith and colleagues report on the functional role of the interaction between these 2 proteins by studying the involved binding sites responsible for clot stabilization.(1) ...

journal_title：Blood

authors： Kohler HP

更新日期：2013-03-14 00:00:00

abstract：:The endogenous presentation of the majority of viral epitopes through MHC class I pathway is strictly dependent on the transporter associated with antigen processing (TAP) complex, which transfers the peptide products of proteasomal degradation into the endoplasmic reticulum. A small number of epitopes can be presente...

journal_title：Blood

authors： Tey SK,Khanna R

更新日期：2012-08-02 00:00:00

abstract：:Two new myeloid cell lines (K051 and K052) were established from a patient with multilineage CD7-positive acute leukemia. The K051 and K052 were established from the patient's bone marrow cells at diagnosis and at relapse, respectively. The K051 cell expressed myeloid-associated antigens (CD13 and CD33), a platelet-as...

journal_title：Blood

authors： Abo J,Inokuchi K,Dan K,Nomura T

更新日期：1993-11-01 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:The t(11;14)(q13;q32) translocation, which juxtaposes the BCL1 oncogene with the Ig heavy chain locus, has been associated with an uncommon subtype of non-Hodgkin's lymphoma (NHL) termed mantle cell lymphoma (MCL). To date, no molecular marker that serves as an indicator of tumor progression or clinical prognosis has ...

journal_title：Blood

authors： Louie DC,Offit K,Jaslow R,Parsa NZ,Murty VV,Schluger A,Chaganti RS

更新日期：1995-10-15 00:00:00

abstract：:The healthy mother of a child with transient immune neutropenia was found to be "NA-null." The mother's neutrophils did not react with anti-NA1 and anti-NA2 antibodies (polyclonal human alloantibodies and mouse monoclonal antibodies). A healthy donor was discovered during routine neutrophil antigen typing whose neutro...

journal_title：Blood

authors： Huizinga TW,Kuijpers RW,Kleijer M,Schulpen TW,Cuypers HT,Roos D,von dem Borne AE

更新日期：1990-11-15 00:00:00

abstract：:We report a novel, reproducible methodology which enabled 10 human myeloma cell lines (HMCL) to be obtained from each of 10 tumor samples harvested from 9 patients with extramedullary proliferation. Fresh samples were cultured with interleukin 6 (IL-6) and granulocyte macrophage-colony stimulating factor (GM-CSF) at a...

journal_title：Blood

authors： Zhang XG,Gaillard JP,Robillard N,Lu ZY,Gu ZJ,Jourdan M,Boiron JM,Bataille R,Klein B

更新日期：1994-06-15 00:00:00

abstract：:We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SCF increases the absolute number of PHSC per mouse threefold. The incr...

journal_title：Blood

authors： Bodine DM,Seidel NE,Zsebo KM,Orlic D

更新日期：1993-07-15 00:00:00

abstract：:To determine whether the erythropoietin receptor (Epo-R) plays a role in the course of malignant erythropoietic disorders, this gene was studied in murine and human erythroleukemia cells. An altered Epo-R gene was found in a murine Friend erythroleukemia cell line, FCL1, due to a spleen focus-forming virus (SFFV) long...

journal_title：Blood

authors： Chretien S,Moreau-Gachelin F,Apiou F,Courtois G,Mayeux P,Dutrillaux B,Cartron JP,Gisselbrecht S,Lacombe C

更新日期：1994-04-01 00:00:00

abstract：:Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several groups studied the biological effects of MPs generated ex vivo. Here, we analyzed for the first time the impact of circulating MPs o...

journal_title：Blood

authors： Garnier Y,Ferdinand S,Garnier M,Cita KC,Hierso R,Claes A,Connes P,Hardy-Dessources MD,Lapouméroulie C,Lemonne N,Etienne-Julan M,El Nemer W,Romana M

更新日期：2020-07-09 00:00:00

abstract：:T-cell alloreactivity directed against non-self-HLA molecules has been assumed to be less peptide specific than conventional T-cell reactivity. A large variation in degree of peptide specificity has previously been reported, including single peptide specificity, polyspecificity, and peptide degeneracy. Peptide polyspe...

journal_title：Blood

authors： Amir AL,van der Steen DM,Hagedoorn RS,Kester MG,van Bergen CA,Drijfhout JW,de Ru AH,Falkenburg JH,van Veelen PA,Heemskerk MH

更新日期：2011-12-22 00:00:00

abstract：:Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. Up to one-third of c...

journal_title：Blood

authors： Camus SM,De Moraes JA,Bonnin P,Abbyad P,Le Jeune S,Lionnet F,Loufrani L,Grimaud L,Lambry JC,Charue D,Kiger L,Renard JM,Larroque C,Le Clésiau H,Tedgui A,Bruneval P,Barja-Fidalgo C,Alexandrou A,Tharaux PL,Boulanger CM

更新日期：2015-06-11 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders in which recurrent mutations define clonal hematopoiesis. The origin of the phenotypic diversity of non-del(5q) MDS remains unclear. Here, we investigated the clonal architecture of the CD34+CD38- hematopoietic stem/progenitor cell (HSPC) compartme...

journal_title：Blood

authors： Chesnais V,Arcangeli ML,Delette C,Rousseau A,Guermouche H,Lefevre C,Bondu S,Diop M,Cheok M,Chapuis N,Legros L,Raynaud S,Willems L,Bouscary D,Lauret E,Bernard OA,Kosmider O,Pflumio F,Fontenay M

更新日期：2017-01-26 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:IL-15 is an important cytokine for the function of the immune system, but the form(s) of IL-15 produced in the human body are not fully characterized. Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Rα) in the same cell allows for efficient production, surface display, and eventual cleavage a...

journal_title：Blood

authors： Bergamaschi C,Bear J,Rosati M,Beach RK,Alicea C,Sowder R,Chertova E,Rosenberg SA,Felber BK,Pavlakis GN

更新日期：2012-07-05 00:00:00

abstract：:Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modification with lentiviral vectors (LVs), thus requiring high doses or repe...

journal_title：Blood

authors： Ozog S,Timberlake ND,Hermann K,Garijo O,Haworth KG,Shi G,Glinkerman CM,Schefter LE,D'Souza S,Simpson E,Sghia-Hughes G,Carillo RR,Boger DL,Kiem HP,Slukvin I,Ryu BY,Sorrentino BP,Adair JE,Snyder SA,Compton AA,Torbet

更新日期：2019-10-17 00:00:00

abstract：:Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells. The disease is driven by somatic mutations in exon 9 of CALR or exon 10 of MPL or JAK2-V617F in >90% of the cases, whereas the rem...

journal_title：Blood

authors： Milosevic Feenstra JD,Nivarthi H,Gisslinger H,Leroy E,Rumi E,Chachoua I,Bagienski K,Kubesova B,Pietra D,Gisslinger B,Milanesi C,Jäger R,Chen D,Berg T,Schalling M,Schuster M,Bock C,Constantinescu SN,Cazzola M,Kralovi

更新日期：2016-01-21 00:00:00

abstract：:Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope speci...

journal_title：Blood

authors： Greinacher A,Krauel K,Jensch I

更新日期：2012-08-02 00:00:00

abstract：:Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic m...

journal_title：Blood

authors： Huang Y,de Reyniès A,de Leval L,Ghazi B,Martin-Garcia N,Travert M,Bosq J,Brière J,Petit B,Thomas E,Coppo P,Marafioti T,Emile JF,Delfau-Larue MH,Schmitt C,Gaulard P

更新日期：2010-02-11 00:00:00

abstract：:Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. Conditioning regimens consisted of high-dose melphalan (MEL) with or without total body irradiation (TX1 = 35) and MEL as the first preparative regim...

journal_title：Blood

authors： Lemoli RM,Martinelli G,Zamagni E,Motta MR,Rizzi S,Terragna C,Rondelli R,Ronconi S,Curti A,Bonifazi F,Tura S,Cavo M

更新日期：2000-04-01 00:00:00

abstract：:Folate receptor (FR) type beta is a promising target for therapeutic intervention in acute myelogenous leukemia (AML) owing particularly to its specific up-regulation in AML cells by all-trans retinoic acid (ATRA). Here we identify functional elements in the FR-beta gene and examine the molecular mechanism of transcri...

journal_title：Blood

authors： Hao H,Qi H,Ratnam M

更新日期：2003-06-01 00:00:00

abstract：:Cellular oxygen partial pressure is sensed by a family of prolyl-4-hydroxylase domain (PHD) enzymes that modify hypoxia-inducible factor (HIF)alpha subunits. Upon hydroxylation under normoxic conditions, HIFalpha is bound by the von Hippel-Lindau tumor suppressor protein and targeted for proteasomal destruction. Since...

journal_title：Blood

authors： Martin F,Linden T,Katschinski DM,Oehme F,Flamme I,Mukhopadhyay CK,Eckhardt K,Tröger J,Barth S,Camenisch G,Wenger RH

更新日期：2005-06-15 00:00:00

abstract：:Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114,548 lymphoid neoplasms diagnosed during 1992-2001 in 12 Surveillance, Epidemiology, ...

journal_title：Blood

authors： Morton LM,Wang SS,Devesa SS,Hartge P,Weisenburger DD,Linet MS

更新日期：2006-01-01 00:00:00

abstract：:The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are rep...

journal_title：Blood

authors： Nowicki MO,Falinski R,Koptyra M,Slupianek A,Stoklosa T,Gloc E,Nieborowska-Skorska M,Blasiak J,Skorski T

更新日期：2004-12-01 00:00:00