Abstract:
:Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope specificity-determining affinity and a high titer, the ability of antibodies to promote formation of their own target antigens seems to be a key factor for pathogenicity.
journal_name
Bloodjournal_title
Bloodauthors
Greinacher A,Krauel K,Jensch Idoi
10.1182/blood-2012-06-430694subject
Has Abstractpub_date
2012-08-02 00:00:00pages
930-1issue
5eissn
0006-4971issn
1528-0020pii
120/5/930journal_volume
120pub_type
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