Measurement of free, one-chain tissue-type plasminogen activator in human plasma with an enzyme-linked immunosorbent assay based on an active site-specific murine monoclonal antibody.

abstract：:DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at di...

journal_title：Blood

authors： Bocker MT,Hellwig I,Breiling A,Eckstein V,Ho AD,Lyko F

更新日期：2011-05-12 00:00:00

abstract：:The study of chemoattractant receptors on human monocytes had been limited by the lack of a radioligand suitable for use with the small numbers of cells routinely available from human donors. A new synthetic oligopeptide radioligand f[35S]met-leu-phe, with a higher specific radioactivity than was available with the tr...

journal_title：Blood

authors： Benyunes MC,Snyderman R

更新日期：1984-03-01 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00

abstract：:Type I interferon (IFNalpha/beta) plays a complex role in HIV-1 infection and has been proposed alternately to have roles in either disease protection or progression. Although IFNalpha/beta plays crucial roles in regulating monocytes and dendritic cells, responsiveness of these cells to IFNalpha/beta in HIV-1 infectio...

journal_title：Blood

authors： Hardy GA,Sieg SF,Rodriguez B,Jiang W,Asaad R,Lederman MM,Harding CV

更新日期：2009-05-28 00:00:00

abstract：:The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...

journal_title：Blood

authors： Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

更新日期：2007-01-15 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation through a complex signaling network. To elucidate the ALK pathways s...

journal_title：Blood

authors： Boccalatte FE,Voena C,Riganti C,Bosia A,D'Amico L,Riera L,Cheng M,Ruggeri B,Jensen ON,Goss VL,Lee K,Nardone J,Rush J,Polakiewicz RD,Comb MJ,Chiarle R,Inghirami G

更新日期：2009-03-19 00:00:00

abstract：:The 8p11 myeloproliferative syndrome (EMS) is associated with translocations that disrupt the FGFR1 gene. To date, 8 fusion partners of FGFR1 have been identified. However, no primary leukemia cell lines were identified that contain any of these fusions. Here, we screened more than 40 acute myeloid leukemia cell lines...

journal_title：Blood

authors： Gu TL,Goss VL,Reeves C,Popova L,Nardone J,Macneill J,Walters DK,Wang Y,Rush J,Comb MJ,Druker BJ,Polakiewicz RD

更新日期：2006-12-15 00:00:00

abstract：:Lymphomatoid granulomatosis (LyG) is an angiodestructive lymphoproliferative disorder (LPD) often involving the lungs. Its etiology is uncertain, but a number of previous studies had suggested it is a T-cell LPD associated with Epstein-Barr virus (EBV). Because of the similarity between LYG and nasal angiocentric lymp...

journal_title：Blood

authors： Wilson WH,Kingma DW,Raffeld M,Wittes RE,Jaffe ES

更新日期：1996-06-01 00:00:00

abstract：:Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in the pathology of heme...

journal_title：Blood

authors： James J,Srivastava A,Varghese MV,Eccles CA,Zemskova M,Rafikova O,Rafikov R

更新日期：2020-08-06 00:00:00

abstract：:Monocytes are thought to play a role in host resistance to tumor cell growth in animals and humans. In addition, platelets are known to be involved in tumor metastases. To investigate the interaction of these two cell types and their effect on tumor cells, human monocytes and platelets were examined using an in vitro ...

journal_title：Blood

authors： Ibele GM,Kay NE,Johnson GJ,Jacob HS

更新日期：1985-05-01 00:00:00

abstract：:In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). The epitope is available for binding in aggressive lymphomas b...

journal_title：Blood

authors： Esserman L,Takahashi S,Rojas V,Warnke R,Levy R

更新日期：1989-12-01 00:00:00

abstract：:Inhibition of complement-mediated granulocyte aggregation has recently been proposed as a mechanism of action of high-dose corticosteroids in shock states. Such inhibition may be effected through alteration of receptor function. Methylprednisolone inhibits binding of the synthetic chemotaxin f-methionine-leucine-pheny...

journal_title：Blood

authors： Skubitz KM,Hammerschmidt DE

更新日期：1986-10-01 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00

abstract：:We have performed a retrospective analysis of the development of T- and B-cell functions after HLA-nonidentical T-cell-depleted bone marrow transplantation (BMT) performed in 193 patients with severe combined immunodeficiency (SCID) at 18 European centers between December 1982 and December 31, 1993. One hundred sixtee...

journal_title：Blood

authors： Haddad E,Landais P,Friedrich W,Gerritsen B,Cavazzana-Calvo M,Morgan G,Bertrand Y,Fasth A,Porta F,Cant A,Espanol T,Müller S,Veys P,Vossen J,Fischer A

更新日期：1998-05-15 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...

journal_title：Blood

authors： Crombie JL,LaCasce AS

更新日期：2020-11-10 00:00:00

abstract：:Congenital dyserythropoietic anemia type II (CDA-II) is an autosomal recessive disease characterized by anemia, jaundice, splenomegaly, and erythroblast multinuclearity. The natural history of the disease is unknown. The frequency, the relevance of complications, and the use of splenectomy are poorly defined. This stu...

journal_title：Blood

authors： Iolascon A,Delaunay J,Wickramasinghe SN,Perrotta S,Gigante M,Camaschella C

更新日期：2001-08-15 00:00:00

abstract：:An unusual mouse line (max 41) that carries an inserted transgene encoding the nuclear transcription factor, Max, exhibits a 50- to 60-fold elevation of blood neutrophils and a 10-fold elevation of blood monocytes. Analysis showed that these elevated levels of blood cells were sustained incrementally by a sevenfold in...

journal_title：Blood

authors： Metcalf D,Lindeman GJ,Nicola NA

更新日期：1995-05-01 00:00:00

abstract：:Identification of receptor activator of nuclear factor-kappaB (RANK) and RANK-ligand (RANKL) has provided new insights into the osteoclast differentiation pathway. Osteoclast precursor cells were isolated using monoclonal antibodies against c-Fms and RANK, and the effect of adherence on the in vitro differentiation an...

journal_title：Blood

authors： Miyamoto T,Arai F,Ohneda O,Takagi K,Anderson DM,Suda T

更新日期：2000-12-15 00:00:00

abstract：:We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of this agent, PTL also induces cellular protective responses that likely function to reduce its overall ...

journal_title：Blood

authors： Hassane DC,Sen S,Minhajuddin M,Rossi RM,Corbett CA,Balys M,Wei L,Crooks PA,Guzman ML,Jordan CT

更新日期：2010-12-23 00:00:00

abstract：:Interleukin-8 (IL-8) belongs to a family of chemoattractant cytokines involved in chemotaxis and activation of neutrophils. As in vivo administration of IL-8 induces granulocytosis and the release of immature white blood cells into the circulation, we assessed a possible mobilizing effect of IL-8 on myeloid progenitor...

journal_title：Blood

authors： Laterveer L,Lindley IJ,Hamilton MS,Willemze R,Fibbe WE

更新日期：1995-04-15 00:00:00

abstract：:Although well characterized in the mouse, the role of Notch signaling in the human T-cell receptor alphabeta (TCR-alphabeta) versus TCR-gammadelta lineage decision is still unclear. Although it is clear in the mouse that TCR-gammadelta development is less Notch dependent compared with TCR-alphabeta differentiation, re...

journal_title：Blood

authors： Van de Walle I,De Smet G,De Smedt M,Vandekerckhove B,Leclercq G,Plum J,Taghon T

更新日期：2009-03-26 00:00:00

abstract：:We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...

journal_title：Blood

authors： Vischer UM,Wagner DD

更新日期：1994-06-15 00:00:00

abstract：:A broad range of hematopoietic stem cells and progenitors reside within a fraction of umbilical cord blood (UCB) that exhibits low light scatter properties (SSC(lo)) and high expression of aldehyde dehydrogenase (ALDH(br)). Many SSC(lo) ALDH(br) cells coexpress CD34; however, other cells express either ALDH or CD34. T...

journal_title：Blood

authors： Storms RW,Green PD,Safford KM,Niedzwiecki D,Cogle CR,Colvin OM,Chao NJ,Rice HE,Smith CA

更新日期：2005-07-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is composed of large, frequently bizarre, cells of T- or null-cell phenotype that show a preferential sinusoidal growth pattern and consistent CD30 positivity. Whether these tumors represent a single entity or several, and what the exact cell origin, is controversial. Recently, gr...

journal_title：Blood

authors： Krenacs L,Wellmann A,Sorbara L,Himmelmann AW,Bagdi E,Jaffe ES,Raffeld M

更新日期：1997-02-01 00:00:00

abstract：:In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable an...

journal_title：Blood

authors： Carobbio A,Thiele J,Passamonti F,Rumi E,Ruggeri M,Rodeghiero F,Randi ML,Bertozzi I,Vannucchi AM,Antonioli E,Gisslinger H,Buxhofer-Ausch V,Finazzi G,Gangat N,Tefferi A,Barbui T

更新日期：2011-06-02 00:00:00

abstract：:Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated...

journal_title：Blood

authors： Lu ZY,Zhang XG,Rodriguez C,Wijdenes J,Gu ZJ,Morel-Fournier B,Harousseau JL,Bataille R,Rossi JF,Klein B

更新日期：1995-05-01 00:00:00

abstract：:T-cell production depends on the recruitment of hematopoietic progenitors into the thymus. T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT), but the reasons for this delay are not well understood. Under normal physiologic conditions, thymic settling is selecti...

journal_title：Blood

authors： Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A

更新日期：2011-08-18 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00

abstract：:Although the mechanisms by which all-trans-retinoic acid (RA) regulates gene transcription are well understood, very little is known on the signaling events regulating RA-dependent initiation of mRNA translation. We examined whether the mammalian target of rapamycin (mTOR)/p70 S6 kinase pathway is activated by RA. RA ...

journal_title：Blood

authors： Lal L,Li Y,Smith J,Sassano A,Uddin S,Parmar S,Tallman MS,Minucci S,Hay N,Platanias LC

更新日期：2005-02-15 00:00:00