Abstract：
:Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic myelocytic leukemia (JCML) at the onset of his illness and 6 mo later during the accelerated phase. The activities of the age-dependent red cell enzymes, hexokinase, aldolase, pyruvate kinase, and glucose-6-phosphate dehydrogenase, were elevated, as were the concentrations of red cell 2,3-DPG and ATP, consistent with a young red cell population metabolizing at an increased glycolytic rate. The activities of the non-age-dependent enzymes, glyceraldehyde-3-phosphate dehydrogenase (G3PD), phosphoglycerate kinase, and enolase, were also increased to levels similar to or greater than those observed in term infants. As the illness progressed, the activity of red cell G3PD increased further, and phosphoglucose isomerase activity increased markedly. These results are consistent with the prior suggestion that JCML represents a reversion to "fetal" erythropoiesis.
journal_name
Bloodjournal_title
Bloodauthors
Travis SFsubject
Has Abstractpub_date
1983-09-01 00:00:00pages
602-5issue
3eissn
0006-4971issn
1528-0020journal_volume
62pub_type
杂志文章相关文献
BLOOD文献大全abstract：:Cultured mononuclear phagocytes produce soluble factors that stimulate endothelial cells to release GM-colony-stimulating activity (GM-CSA). One such factor was recently identified as interleukin 1 (IL 1). Studies were designed to determine which types of granulopoietic factors are released by IL 1-stimulated endothel...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular injury. Unexpectedly, we observed platelets translocating over A1A2A3 domains protein slower than on A1 domain at high shear stress. This observ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-10-530428
更新日期：2014-04-24 00:00:00
abstract：:Kaposi's sarcoma-associated herpes virus (KSHV)/human herpes virus 8 (HHV8) DNA sequences have been demonstrated in Kaposi's sarcoma (KS), as well as in some acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphomas (NHL) and in multicentric Castleman's disease. Although KSHV DNA generally is abundant ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-05-15 00:00:00
abstract：:The current study presents evidence that all human serum contains a class of high-affinity folate binders (KA=2.8 X10(10 liters/mole), which migrate as a single peak on gel filtration. Failure of previous studies to detect this characteristic in all but a minority of subjects is attributable to its variable, often tot...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
abstract：:We have shown previously that the cause of anemia in healthy elderly subjects can usually not be identified. In this study, hematopoiesis was examined in 18 healthy elderly subjects with unexplained anemia and in 15 young and 15 healthy elderly individuals without anemia. No reduction in circulating testosterone was n...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Radioimmunotherapy (RIT) has emerged as an effective treatment for lymphoma, however the underlying mechanisms are poorly understood. We therefore investigated the relative contributions of antibody and targeted radiation to the clearance of tumor in vivo, using 2 different syngeneic murine B-cell lymphoma models. Alt...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2003-06-2037
更新日期：2004-02-15 00:00:00
abstract：:The FAS receptor-FAS ligand system is a key apoptotic pathway for cells of the immune system. Ligation of the FAS-receptor (CD95) induces apoptosis by activation of pro-caspase-8 followed by downstream events, including an increase in reactive oxygen species (ROS) and the release of proapoptotic factors from the mitoc...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-11-3559
更新日期：2003-07-01 00:00:00
abstract：:The diagnosis of heparin-induced thrombocytopenia (HIT) requires detection of antibodies to the heparin/platelet factor 4 (PF4) complexes via enzyme-linked immunosorbent assay. Addition of excess heparin to the sample decreases the optical density by 50% or more and confirms the presence of these antibodies. One hundr...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-01-262659
更新日期：2010-09-09 00:00:00
abstract：:Factor IXAlabama is a variant factor IX molecule responsible for a clinically moderate form of hemophilia B. Twenty-five kilobases (kb) of the variant gene, including seven exons coding for the structural protein, were cloned and characterized. The restriction map and the arrangement of coding regions are identical to...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The high frequency of allogeneic reactive CD8(+) T cells in human and their resistance to immunosuppression might be one of the reasons why successful tolerance-inducing strategies in rodents have failed in primates. Studies on the requirement for T-helper cells in priming CD8(+) T-cell responses have led to disparate...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-02-268623
更新日期：2010-10-21 00:00:00
abstract：:Foxp3(+) regulatory T cells (Tregs) maintain self-tolerance and adoptive therapy, and using Foxp3(+) Tregs has been proposed as treatment for autoimmune diseases. The clinical use of Tregs will require large numbers of cells and methods for in vitro expansion of Tregs are being developed. Foxp3(+) Tregs can be divided...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-09-377895
更新日期：2012-03-22 00:00:00
abstract：:JMH is a high-frequency human erythrocyte blood group antigen. Previous work has shown that JMH is absent from complement-sensitive erythrocytes of patients with paroxysmal nocturnal hemoglobinuria (PNH); such cells have a broad defect in expression of phosphatidylinositol (PI)-linked proteins. Using both human JMH an...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-03-15 00:00:00
abstract：:Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin-1 (matrix metalloproteinase-3 [MMP-3]) induced in endothelial cells was critical for ICB induced b...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2009-02-203919
更新日期：2009-10-08 00:00:00
abstract：:Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-07-15 00:00:00
abstract：:We describe two assays to detect the action of colony-inhibiting cells. In the first assay, we used a simple density separation technique to remove dense neutrophils (PMN) from suspensions of blood and of bone marrow cells prior to culture in semisolid agar. Conditions were arranged to ensure that control suspensions ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1976-03-01 00:00:00
abstract：:The presence of minimal amounts of fibrinogen-fibrin intermediates in human plasma was visualized by an agglutination reaction of glutaraldehyde-treated human erythrocytes coated with purified fibrin monomers. A degree of monomer coating was established which produced erythrocytes not agglutinated by normal plasma but...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1976-06-01 00:00:00
abstract：:Selective use of recombinant human cytokines has enabled the culture of large numbers of eosinophils from human cord blood mononuclear cells, raising the possibility of their use as a model of eosinophil function. Cultured eosinophils (CE) were compared with normal-density peripheral blood eosinophils (PBE) in terms o...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Epithin/PRSS14, a type II transmembrane serine protease, is involved in normal epithelial development and tumor progression. Here we report, as an interacting substrate of epithin, a receptor tyrosine kinase Tie2 that is well known for important roles in the vessel stability. Epithin interacts with and degrades the Ti...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-03-275289
更新日期：2011-01-27 00:00:00
abstract：:To directly determine whether the mechanism of activation of human plasminogen (HPg) by staphylokinase (Sak) required formation of an active complex of Sak and HPg, recombinant (r) variants of HPg were examined that allowed dissection of the steps involved in this activation. The rate of activation of wild-type (wt) r...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-11-316794
更新日期：2011-04-14 00:00:00
abstract：:Leukocyte adhesion deficiency type II (LADII) is a rare inherited disorder of fucose metabolism. Patients with LADII lack fucosylated glycoconjugates, including the carbohydrate ligands of the selectins, leading to an immunodeficiency caused by the lack of selectin-mediated leukocyte-endothelial interactions. A simple...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v97.1.330
更新日期：2001-01-01 00:00:00
abstract：:Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein synthesis. We cultured endothelium from VWD and normal dogs to study intracel...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-02-0464
更新日期：2005-01-01 00:00:00
abstract：:Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single in vivo treatment of se...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-12-15 00:00:00
abstract：:The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role in the regulation ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-02-270322
更新日期：2010-10-21 00:00:00
abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v97.12.3960
更新日期：2001-06-15 00:00:00
abstract：:Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leuk...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Monocytes from patients with sickle cell disease (SCD) are in an activated state. However, the mechanism of activation of monocytes in SCD is not known. Our studies showed that placenta growth factor (PlGF) activated monocytes and increased mRNA levels of cytokines (tumor necrosis factor-alpha [TNF-alpha] and interleu...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-11-3423
更新日期：2003-08-15 00:00:00
abstract：:The report of the so-called Berlin patient cured of HIV with hematopoietic stem cell transplantation and a few other studies raised tremendous hope, excitement, and curiosity in the field. The National Heart, Lung and Blood Institute of the National Institutes of Health convened a Working Group to address emerging hea...
journal_title：Blood
pub_type：
doi：10.1182/blood-2013-07-518316
更新日期：2013-10-31 00:00:00
abstract：:In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusions of lentiviral vector–modified autologous CD4T lymphocytes in 17 HIV-infected patients aviremic on antiretroviral therapy (ART). ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2013-01-475921
更新日期：2013-02-28 00:00:00
abstract：:Transformation to aggressive lymphoma is a critical event in the clinical course of follicular lymphoma (FL) patients. Yet, it is a challenge to reliably predict transformation at the time of diagnosis. Understanding the risk of transformation would be useful for guiding and monitoring patients, as well as for evaluat...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2017-03-691345
更新日期：2017-07-20 00:00:00
