Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress.

abstract：:Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is initiated and driven by the oncogenic fusion protein BCR-ABL, a constitutively active tyrosine kinase. Despite major advances in the treatment of this highly aggressive disease with potent inhibitors of the BCR-ABL kinase such as dasatinib, pat...

journal_title：Blood

authors： Appelmann I,Rillahan CD,de Stanchina E,Carbonetti G,Chen C,Lowe SW,Sherr CJ

更新日期：2015-02-26 00:00:00

abstract：:We investigated the effects of interleukin-4 (IL-4) on the survival of leukemic and normal B-cell progenitors cultured on bone marrow stroma. IL-4 (at 100 U/mL) was cytotoxic in 16 of 21 cases of B-lineage acute lymphoblastic leukemia, causing reductions in CD19+ cell numbers that ranged from 50% to greater than 99% (...

journal_title：Blood

authors： Manabe A,Coustan-Smith E,Kumagai M,Behm FG,Raimondi SC,Pui CH,Campana D

更新日期：1994-04-01 00:00:00

abstract：:The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor (SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo. Transforming growth factor-beta (TGF-beta) has been shown to be a potent inhibitor of SLF-mediated synergistic growth of murine Lin-Sca-1+ pr...

journal_title：Blood

authors： Dubois CM,Ruscetti FW,Stankova J,Keller JR

更新日期：1994-06-01 00:00:00

abstract：:Reduced oxygenation of a variety of cells results in transcriptional upregulation of several genes, including the hematopoietic hormone erythropoietin, the angiogenic vascular endothelial growth factor (VEGF), and glycolytic enzymes such as aldolase. Recently, the heme protein cytochrome b558 of the nicotinamide adeni...

journal_title：Blood

authors： Wenger RH,Marti HH,Schuerer-Maly CC,Kvietikova I,Bauer C,Gassmann M,Maly FE

更新日期：1996-01-15 00:00:00

abstract：:One hundred thirty-eight patients with hairy cell leukemia were randomized to receive either a dose of 2.0 megaunits (MU)/m2 or a 10-fold lower dose of 0.2 MU/m2 of a highly purified natural alpha-interferon, administered daily for 28 days followed by a three times a week schedule. Ninety-seven of these patients had p...

journal_title：Blood

authors： Smalley RV,Anderson SA,Tuttle RL,Connors J,Thurmond LM,Huang A,Castle K,Magers C,Whisnant JK

更新日期：1991-12-15 00:00:00

abstract：:NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased marked...

journal_title：Blood

authors： Natsuka S,Akira S,Nishio Y,Hashimoto S,Sugita T,Isshiki H,Kishimoto T

更新日期：1992-01-15 00:00:00

abstract：:The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO(+) patient samples, differing classes of activating c-KIT receptor tyrosine kinase mutations have been observed. The most common (12%-48%) involves mutations, such as D816V, which occ...

journal_title：Blood

authors： Nick HJ,Kim HG,Chang CW,Harris KW,Reddy V,Klug CA

更新日期：2012-02-09 00:00:00

abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

journal_title：Blood

authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

更新日期：2010-12-16 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:The cellular immune defect in untreated Hodgkin's disease (HD) has long been recognized. This defect appears to be responsible for at least some of the morbidity and ultimately the mortality associated with the disease. In recent years, many studies have shown that the T cell component of the immune response is the ap...

journal_title：Blood

authors： Ford RJ,Tsao J,Kouttab NM,Sahasrabuddhe CG,Mehta SR

更新日期：1984-08-01 00:00:00

abstract：:In the present study, Epstein-Barr virus (EBV) isolates from 18 malignant tumors (angioimmunoblastic lymphadenopathy [AILD], n = 4; Hodgkin's disease [HD], n = 3; pleomorphic T-cell non-Hodgkin's lymphoma [T-NHL], n = 1; B-cell non-Hodgkin's lymphoma [B-NHL], n = 8; gastric carcinoma, n = 2) as well as from 10 tonsils...

journal_title：Blood

authors： Schuster V,Ott G,Seidenspinner S,Kreth HW

更新日期：1996-02-15 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced pr...

journal_title：Blood

authors： Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA

更新日期：2014-07-17 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels...

journal_title：Blood

authors： Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

更新日期：2011-08-18 00:00:00

abstract：:Fanconi anemia (FA) is a genetic disorder associated with bone marrow (BM) failure and leukemia. Recent studies demonstrate variable immune defects in FA. However, the cause for FA immunodeficiency is unknown. Here we report that deletion of Fanca or Fancd2 dysregulates the suppressive activity of regulatory T cells (...

journal_title：Blood

authors： Du W,Erden O,Wilson A,Sipple JM,Schick J,Mehta P,Myers KC,Steinbrecher KA,Davies SM,Pang Q

更新日期：2014-03-20 00:00:00

abstract：:Current monoclonal antibody therapies for multiple myeloma have had limited success, perhaps due to narrow target specificity. We have previously described the ability of polyclonal rabbit antithymocyte globulin (rATG) to induce caspase- and cathepsin-mediated apoptosis in human B and plasma cells. We now extend this ...

journal_title：Blood

authors： Zand MS,Vo T,Pellegrin T,Felgar R,Liesveld JL,Ifthikharuddin JJ,Abboud CN,Sanz I,Huggins J

更新日期：2006-04-01 00:00:00

abstract：:Studies with the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin-3 (IL-3) fusion protein, PIXY321, demonstrated enhanced biological activity of this molecule in comparison with GM-CSF or IL-3 alone or in combination. Experiments were performed to study the mechanisms resulting in PIXY321-induced ...

journal_title：Blood

authors： Mignacca RC,Lee HJ,Kwon EM,Sakamoto KM

更新日期：1996-08-01 00:00:00

abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...

journal_title：Blood

authors： Colman RW,Jameson BA,Lin Y,Johnson D,Mousa SA

更新日期：2000-01-15 00:00:00

abstract：:This article reports a Glanzmann thrombasthenia (GT) patient, N.M., with a point mutation in the third cysteine-rich repeat of beta3-integrin or platelet glycoprotein (GP) IIIa, leading to the expression of a constitutively activated fibrinogen receptor. The diagnosis of GT was based on a severely reduced platelet-agg...

journal_title：Blood

authors： Ruiz C,Liu CY,Sun QH,Sigaud-Fiks M,Fressinaud E,Muller JY,Nurden P,Nurden AT,Newman PJ,Valentin N

更新日期：2001-10-15 00:00:00

abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

journal_title：Blood

authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

更新日期：1994-12-15 00:00:00

abstract：:Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by cytotoxic immune effector cells. Although GzmH is most closely related to the caspase-activating granzyme B (GzmB), neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme. ...

journal_title：Blood

authors： Fellows E,Gil-Parrado S,Jenne DE,Kurschus FC

更新日期：2007-07-15 00:00:00

abstract：:Although plasmacytoid dendritic cells (pDCs) are involved in HIV-1 pathogenesis, the precise mechanism of interaction between pDCs and HIV-1 in vivo is not clear. The conflicting reports in HIV-1-infected patients highlight the importance of studying the interaction between HIV-1 and pDCs in relevant in vivo models. T...

journal_title：Blood

authors： Zhang L,Jiang Q,Li G,Jeffrey J,Kovalev GI,Su L

更新日期：2011-06-09 00:00:00

abstract：:Although double umbilical cord blood transplantation (dUCBT) in adult patients may be associated with less graft failure compared with single UCBT, hematopoietic recovery generally originates from a single cord blood unit (CBU). CBU predominance is still incompletely understood. We recently showed that blood CD4+ T-ce...

journal_title：Blood

authors： Lamers CH,Wijers R,van Bergen CA,Somers JA,Braakman E,Gratama JW,Debets R,Falkenburg JH,Cornelissen JJ

更新日期：2016-10-27 00:00:00

abstract：:Three populations of erythrocytes have been shown by flow cytometric analysis on complement regulatory proteins: CD59 and decay-accelerating factor (DAF) on erythrocytes in paroxysmal nocturnal hemoglobinuria (PNH). CD59 and DAF in PNH may be completely deficient in CD59- and DAF-negative erythrocytes, they may be dec...

journal_title：Blood

authors： Fujioka S,Yamada T

更新日期：1992-04-01 00:00:00

abstract：:BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate-resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutants emerging in the p...

journal_title：Blood

authors： Bradeen HA,Eide CA,O'Hare T,Johnson KJ,Willis SG,Lee FY,Druker BJ,Deininger MW

更新日期：2006-10-01 00:00:00

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:Cylindromatosis (CYLD) is a deubiquitinase that was initially identified as a tumor suppressor and has recently been implicated in diverse normal physiologic processes. In this study, we have investigated the involvement of CYLD in angiogenesis, the formation of new blood vessels from preexisting ones. We find that kn...

journal_title：Blood

authors： Gao J,Sun L,Huo L,Liu M,Li D,Zhou J

更新日期：2010-05-20 00:00:00

abstract：:Fifty patients with Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML) in early chronic phase received imatinib mesylate, 400 mg orally daily. After a median follow-up of 9 months, 49 patients (98%) achieved a complete hematologic response and 45 patients (90%) achieved a major cytogenetic res...

journal_title：Blood

authors： Kantarjian HM,Cortes JE,O'Brien S,Giles F,Garcia-Manero G,Faderl S,Thomas D,Jeha S,Rios MB,Letvak L,Bochinski K,Arlinghaus R,Talpaz M

更新日期：2003-01-01 00:00:00

abstract：:We have previously described the development of oncoretrovirus vectors for human gamma-globin using a truncated beta-globin promoter, modified gamma-globin cassette, and alpha-globin enhancer. However, one of these vectors is genetically unstable, and both vectors exhibit variable expression patterns in cultured cells...

journal_title：Blood

authors： Emery DW,Yannaki E,Tubb J,Nishino T,Li Q,Stamatoyannopoulos G

更新日期：2002-09-15 00:00:00

abstract：:A retrospective study compared posttransplant engraftment parameters in 203 patients with myelofibrosis (MF) with those in a population of 203 matched controls without MF. There were no significant differences between these groups in the proportions of patients who died without achieving engraftment and in the disease...

journal_title：Blood

authors： Soll E,Massumoto C,Clift RA,Buckner CD,Appelbaum FR,Storb R,Sale G,Hackman R,Martin P

更新日期：1995-12-15 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and acts through binding to its specific receptor (G-CSF-R) on neutrophilic granulocytes. Previous studies of signaling from the 4 G-CSF-R cytoplasmic tyrosine residues used model cell lines that may have idiosyncratic, nonphysiolog...

journal_title：Blood

authors： Akbarzadeh S,Ward AC,McPhee DO,Alexander WS,Lieschke GJ,Layton JE

更新日期：2002-02-01 00:00:00