Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin.

abstract：:Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor constitute the IL-6 family of cytokines and play important roles in hematopoiesis, immune response, and nervous system. The receptors for the IL-6 family of cytokines share gp130 through which signals are generated, ...

journal_title：Blood

authors： Matsuda T,Takahashi-Tezuka M,Fukada T,Okuyama Y,Fujitani Y,Tsukada S,Mano H,Hirai H,Witte ON,Hirano T

更新日期：1995-02-01 00:00:00

abstract：:The oxygen transport function of hemoglobin (HB) is thought to have arisen ∼500 million years ago, roughly coinciding with the divergence between jawless (Agnatha) and jawed (Gnathostomata) vertebrates. Intriguingly, extant HBs of jawless and jawed vertebrates were shown to have evolved twice, and independently, from ...

journal_title：Blood

authors： Miyata M,Gillemans N,Hockman D,Demmers JAA,Cheng JF,Hou J,Salminen M,Fisher CA,Taylor S,Gibbons RJ,Ganis JJ,Zon LI,Grosveld F,Mulugeta E,Sauka-Spengler T,Higgs DR,Philipsen S

更新日期：2020-07-16 00:00:00

abstract：:Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in...

journal_title：Blood

authors： Ofer S,Fibach E,Kessel M,Bauminger ER,Cohen SG,Eikelboom J,Rachmilewitz EA

更新日期：1981-08-01 00:00:00

abstract：:CD4(+) T helper 1 (Th1) cells and Th2 cells are distinguished based on the pattern of cytokines they are able to produce. Selectin ligands and chemokine receptors are differentially expressed in Th1 and Th2 cells, providing a basis for tissue-specific recruitment of helper T-cell subsets. However, the modes and mechan...

journal_title：Blood

authors： Colantonio L,Iellem A,Clissi B,Pardi R,Rogge L,Sinigaglia F,D'Ambrosio D

更新日期：1999-11-01 00:00:00

abstract：:The primary objective was to describe the prevalence and characteristics of microbiologically defined infections and infection-related mortality (IRM) in 492 children with acute myeloid leukemia enrolled on CCG 2961. Secondary objectives were to determine the relationship between demographic, disease-related, and ther...

journal_title：Blood

authors： Sung L,Lange BJ,Gerbing RB,Alonzo TA,Feusner J

更新日期：2007-11-15 00:00:00

abstract：:Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with constitutive depletion of DCs, as well as in patients with congenital...

journal_title：Blood

authors： Humblet-Baron S,Barber JS,Roca CP,Lenaerts A,Koni PA,Liston A

更新日期：2019-01-24 00:00:00

abstract：:An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth through numerous stimulators and inhibitors of angiogenesis by several pathways, including differential exocytosis of angiogenesis regulators....

journal_title：Blood

authors： Battinelli EM,Markens BA,Italiano JE Jr

更新日期：2011-08-04 00:00:00

abstract：:Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 b...

journal_title：Blood

authors： Greisman HA,Lu Z,Tsai AG,Greiner TC,Yi HS,Lieber MR

更新日期：2012-10-04 00:00:00

abstract：:The nuclear factor-kappa B (NF-kappaB) gene transactivator serves in the formation of immune, inflammatory, and stress responses. In quiescent cells, NF-kappaB principally resides within the cytoplasm in association with inhibitory kappa (IkappaB) proteins. The status of IkappaB and NF-kappaB proteins was evaluated fo...

journal_title：Blood

authors： Granville DJ,Carthy CM,Jiang H,Levy JG,McManus BM,Matroule JY,Piette J,Hunt DW

更新日期：2000-01-01 00:00:00

abstract：:The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects of most therapies use...

journal_title：Blood

authors： Hamon Y,Luciani MF,Becq F,Verrier B,Rubartelli A,Chimini G

更新日期：1997-10-15 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:The effects of immunoglobulin G (IgG) from patients with the antiphospholipid syndrome (APS) upon monocyte activation have not been fully characterized. We carried out a comprehensive proteomic analysis of human monocytes treated with IgG from patients with different manifestations of the APS. Using 2-dimensional diff...

journal_title：Blood

authors： Ripoll VM,Lambrianides A,Pierangeli SS,Poulton K,Ioannou Y,Heywood WE,Mills K,Latchman DS,Isenberg DA,Rahman A,Giles IP

更新日期：2014-12-11 00:00:00

abstract：:Families with 3 different syndromes characterized by autosomal dominant inheritance of low platelet count and giant platelets were studied. Fechtner syndrome is an autosomal-dominant variant of Alport syndrome manifested by nephritis, sensorineural hearing loss, and cataract formation in addition to macrothrombocytope...

journal_title：Blood

authors： Toren A,Rozenfeld-Granot G,Rocca B,Epstein CJ,Amariglio N,Laghi F,Landolfi R,Brok-Simoni F,Carlsson LE,Rechavi G,Greinacher A

更新日期：2000-11-15 00:00:00

abstract：:In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malign...

journal_title：Blood

authors： Smith SD,Morgan R,Gemmell R,Amylon MD,Link MP,Linker C,Hecht BK,Warnke R,Glader BE,Hecht F

更新日期：1988-02-01 00:00:00

abstract：:Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer develo...

journal_title：Blood

authors： Healy J,Bélanger H,Beaulieu P,Larivière M,Labuda D,Sinnett D

更新日期：2007-01-15 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the ...

journal_title：Blood

authors： Petzer V,Tymoszuk P,Asshoff M,Carvalho J,Papworth J,Deantonio C,Bayliss L,Wake MS,Seifert M,Brigo N,Valente de Souza L,Hilbe R,Grubwieser P,Demetz E,Dichtl S,Volani C,Berger S,Böhm F,Hoffmann A,Pfeifhofer-Obermair C

更新日期：2020-08-27 00:00:00

abstract：:CXCR4 chemokine receptors retain hematopoietic progenitors and leukemia cells within the marrow microenvironment. We prospectively evaluated the prognostic implication of CXCR4 in 90 consecutive patients with acute myelogenous leukemia (AML) by flow cytometry. Patients were divided into groups with low (n=32), interme...

journal_title：Blood

authors： Spoo AC,Lübbert M,Wierda WG,Burger JA

更新日期：2007-01-15 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is poorly understood. We demonstrated herein that hematopoietic CD34+ cells constitutively produced endogenous secreted IL-15 (ES-IL-15) that activated different transcriptio...

journal_title：Blood

authors： Giron-Michel J,Caignard A,Fogli M,Brouty-Boyé D,Briard D,van Dijk M,Meazza R,Ferrini S,Lebousse-Kerdilès C,Clay D,Bompais H,Chouaib S,Péault B,Azzarone B

更新日期：2003-07-01 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-deriv...

journal_title：Blood

authors： Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:Cyclopentenone prostaglandins are potent inhibitors of nuclear factor-kappa B (NF-kappa B), a transcription factor with a critical role in promoting inflammation and connected with multiple aspects of oncogenesis and cancer cell survival. In the present report, we investigated the role of NF-kappa B in the antineoplas...

journal_title：Blood

authors： Piva R,Gianferretti P,Ciucci A,Taulli R,Belardo G,Santoro MG

更新日期：2005-02-15 00:00:00

abstract：:Mammals express thousands of long noncoding (lnc) RNAs, a few of which are known to function in tissue development. However, the entire repertoire of lncRNAs in most tissues and species is not defined. Indeed, most lncRNAs are not conserved, raising questions about function. We used RNA sequencing to identify 1109 pol...

journal_title：Blood

authors： Paralkar VR,Mishra T,Luan J,Yao Y,Kossenkov AV,Anderson SM,Dunagin M,Pimkin M,Gore M,Sun D,Konuthula N,Raj A,An X,Mohandas N,Bodine DM,Hardison RC,Weiss MJ

更新日期：2014-03-20 00:00:00

abstract：:We administered gemtuzumab ozogamycin ("mylotarg"; 9 mg/m(2) day 1 or 5) and all-trans retinoic acid (ATRA) to 19 patients with untreated acute promyelocytic leukemia (APL). There were 3 patients who also received idarubicin because of a white blood cell (WBC) count of more than 30 000/microL. In complete remission (C...

journal_title：Blood

authors： Estey EH,Giles FJ,Beran M,O'Brien S,Pierce SA,Faderl SH,Cortes JE,Kantarjian HM

更新日期：2002-06-01 00:00:00

abstract：:About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Nor...

journal_title：Blood

authors： Abu-Issa R,Eichele G,Youssoufian H

更新日期：1999-07-15 00:00:00

abstract：:Nonrandom chromosomal translocations are considered to be causal events leading to leukemic transformation. However, the mechanism(s) that cause these translocations are poorly understood. Libura and colleagues report exciting new findings on the mechanism(s) that lead to chromosomal translocation. ...

journal_title：Blood

authors： Aplan PD

更新日期：2005-03-01 00:00:00

abstract：:We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in which the transplantation of defined populations of human hematopoietic stem cells resulted in the establishment of human hematopoiesis and led to the formation of ...

journal_title：Blood

authors： Almeida-Porada G,Porada CD,Chamberlain J,Torabi A,Zanjani ED

更新日期：2004-10-15 00:00:00

abstract：:Some multilineage hemopoietic colonies contain, in addition to myeloid cells, T lymphocytes. These proliferate extensively in liquid suspension culture under the influence of a T cell growth factor provided by phytohemagglutinin-T cell-conditioned medium (PHA-TCM). The clonal origin of these myeloid and lymphoid compo...

journal_title：Blood

authors： Lim B,Jamal N,Tritchler D,Messner HA

更新日期：1984-06-01 00:00:00