K-Ras is essential for normal fetal liver erythropoiesis.

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the differentiation of human monocytes into two phenotypically distinct types of macrophages. However, in vivo, not only CSF but also many other cytokines are produced under va...

journal_title：Blood

authors： Akagawa KS,Takasuka N,Nozaki Y,Komuro I,Azuma M,Ueda M,Naito M,Takahashi K

更新日期：1996-11-15 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in ...

journal_title：Blood

authors： Lindemann A,Ludwig WD,Oster W,Mertelsmann R,Herrmann F

更新日期：1989-03-01 00:00:00

abstract：:Secondary acute myeloid leukemias (AMLs) evolving from an antecedent myeloproliferative neoplasm (MPN) are characterized by a unique set of cytogenetic and molecular features distinct from de novo AML. Given the high frequency of poor-risk cytogenetic and molecular features, malignant clones are frequently insensitive...

journal_title：Blood

authors： Dunbar AJ,Rampal RK,Levine R

更新日期：2020-07-02 00:00:00

abstract：:Techniques for the quantitation of virus-specific and alloantigen-reactive T cells vary in their measurement of clinically relevant T-cell effector populations, their sensitivity and quantitative accuracy, and the time required to obtain measurable results. We compared frequencies of Epstein-Barr virus (EBV)-specific ...

journal_title：Blood

authors： Koehne G,Smith KM,Ferguson TL,Williams RY,Heller G,Pamer EG,Dupont B,O'Reilly RJ

更新日期：2002-03-01 00:00:00

abstract：:Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment markedly decreased th...

journal_title：Blood

authors： Zhou W,Tsai HM

更新日期：2009-01-22 00:00:00

abstract：:Obinutuzumab is a type 2, glycoengineered, anti-CD20 antibody recently approved with chlorambucil for the initial therapy of chronic lymphocytic leukemia (CLL). In this nonrandomized, parallel-cohort, phase 1b, multicenter study, we explored the safety and preliminary efficacy of obinutuzumab-bendamustine (G-B) or obi...

journal_title：Blood

authors： Brown JR,O'Brien S,Kingsley CD,Eradat H,Pagel JM,Lymp J,Hirata J,Kipps TJ

更新日期：2015-04-30 00:00:00

abstract：:Human band 3 Walton is an AE1 mutation that results in the deletion of the 11 COOH-terminal amino acids of the protein and is associated with dominant distal renal tubular acidosis. The properties of band 3 Walton expressed with normal band 3 in the heterozygous mutant erythrocytes and the kidney isoform expressed in ...

journal_title：Blood

authors： Toye AM,Bruce LJ,Unwin RJ,Wrong O,Tanner MJ

更新日期：2002-01-01 00:00:00

abstract：:The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE...

journal_title：Blood

authors： Sangerman J,Lee MS,Yao X,Oteng E,Hsiao CH,Li W,Zein S,Ofori-Acquah SF,Pace BS

更新日期：2006-11-15 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels control mitochondri...

journal_title：Blood

authors： Jacque N,Ronchetti AM,Larrue C,Meunier G,Birsen R,Willems L,Saland E,Decroocq J,Maciel TT,Lambert M,Poulain L,Hospital MA,Sujobert P,Joseph L,Chapuis N,Lacombe C,Moura IC,Demo S,Sarry JE,Recher C,Mayeux P,Tambur

更新日期：2015-09-10 00:00:00

abstract：:The expression and function of a glycoprotein Ib (GPIb) complex on human umbilical vein endothelial cells (HUVECs) is still a matter of controversy. We characterized HUVEC GPIb using viper venom proteins: alboaggregins A and B, echicetin, botrocetin, and echistatin. Echicetin is an antagonist, and alboaggregins act as...

journal_title：Blood

authors： Tan L,Kowalska MA,Romo GM,Lopez JA,Darzynkiewicz Z,Niewiarowski S

更新日期：1999-04-15 00:00:00

abstract：:A cytotoxic common ALL antiserum (CALLA) specific for leukemic cells of most patients with non-T-cel- acute lymphoblastic leukemia (ALL) and of some patients with chronic myelogenous leukemia (CML) in blast crisis has been reproducibly prepared using cell lines for absorption. CALLA reacts with leukemic cells of 110 o...

journal_title：Blood

authors： Pesando JM,Ritz J,Lazarus H,Costello SB,Sallan S,Schlossman SF

更新日期：1979-12-01 00:00:00

abstract：:Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)--restricted hypervariable but not conserved idiotype peptides. We hypothesized that idiotype-directed T-cell immunity occurs naturally an...

journal_title：Blood

authors： Strothmeyer AM,Papaioannou D,Dühren-von Minden M,Navarrete M,Zirlik K,Heining-Mikesch K,Veelken H

更新日期：2010-09-09 00:00:00

abstract：:Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. Up to one-third of c...

journal_title：Blood

authors： Camus SM,De Moraes JA,Bonnin P,Abbyad P,Le Jeune S,Lionnet F,Loufrani L,Grimaud L,Lambry JC,Charue D,Kiger L,Renard JM,Larroque C,Le Clésiau H,Tedgui A,Bruneval P,Barja-Fidalgo C,Alexandrou A,Tharaux PL,Boulanger CM

更新日期：2015-06-11 00:00:00

abstract：:Fluid shear stress in arteries and arterioles partially obstructed by atherosclerosis or spasm may exceed the normal time-average level of 20 dyne/cm2. In vitro, at fluid shear stresses of 30 to 60 dyne/cm2 applied for 30 seconds, platelet aggregation occurs. At these shear stresses, either large or unusually large vo...

journal_title：Blood

authors： Moake JL,Turner NA,Stathopoulos NA,Nolasco L,Hellums JD

更新日期：1988-05-01 00:00:00

abstract：:Autologous stem-cell transplantation has become a widely used therapy in Hodgkin's disease (HD). To appreciate the early and late risks associated with this procedure, its lethal toxicity and effects on the incidence of secondary cancers were studied. Data related to 467 French patients grafted from 1982 to 1995 for p...

journal_title：Blood

authors： André M,Henry-Amar M,Blaise D,Colombat P,Fleury J,Milpied N,Cahn JY,Pico JL,Bastion Y,Kuentz M,Nedellec G,Attal M,Fermé C,Gisselbrecht C

更新日期：1998-09-15 00:00:00

abstract：:Recurrence of the underlying malignancy remains a major cause of treatment failure after autologous bone marrow transplantation (BMT) for patients with lymphoma. In this regard, we have developed an immunotherapeutic approach designed to induce resistance against residual tumor cells persisting after BMT. Previous stu...

journal_title：Blood

authors： Kwak LW,Campbell MJ,Zelenetz AD,Levy R

更新日期：1990-12-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin's lymphoma (NHL) that is highly heterogeneous from both clinical and histopathologic viewpoints. The immunoglobulin (Ig) heavy (H) chain variable region genes were examined in 71 patients with untreated primary DLBCL. Fifty-eight potentially functio...

journal_title：Blood

authors： Lossos IS,Okada CY,Tibshirani R,Warnke R,Vose JM,Greiner TC,Levy R

更新日期：2000-03-01 00:00:00

abstract：:The variability of laboratory findings in von Willebrand's disease (vWd) was evaluated by performing serial studies of bleeding time (BT), factor VIII coagulant activity (VIII:C), factor-VIII-related antigen (VIIIR:Ag) and ristocetin cofactor (VIIIR:Rcof) in 50 individuals from 25 families with this disorder. The type...

journal_title：Blood

authors： Abildgaard CF,Suzuki Z,Harrison J,Jefcoat K,Zimmerman TS

更新日期：1980-10-01 00:00:00

abstract：:The importance of the second messengers calcium (Ca(2+)) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca(2+) sensor(s). We he...

journal_title：Blood

authors： Stefanini L,Roden RC,Bergmeier W

更新日期：2009-09-17 00:00:00

abstract：:An unusual mouse line (max 41) that carries an inserted transgene encoding the nuclear transcription factor, Max, exhibits a 50- to 60-fold elevation of blood neutrophils and a 10-fold elevation of blood monocytes. Analysis showed that these elevated levels of blood cells were sustained incrementally by a sevenfold in...

journal_title：Blood

authors： Metcalf D,Lindeman GJ,Nicola NA

更新日期：1995-05-01 00:00:00

abstract：:Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation-induced cytidine deaminase (AID). Resulting uracil-guanine mismatches are processed by uracil DNA glycosylase (UNG)-media...

journal_title：Blood

authors： Gu X,Booth CJ,Liu Z,Strout MP

更新日期：2016-01-07 00:00:00

abstract：:To determine whether the erythropoietin receptor (Epo-R) plays a role in the course of malignant erythropoietic disorders, this gene was studied in murine and human erythroleukemia cells. An altered Epo-R gene was found in a murine Friend erythroleukemia cell line, FCL1, due to a spleen focus-forming virus (SFFV) long...

journal_title：Blood

authors： Chretien S,Moreau-Gachelin F,Apiou F,Courtois G,Mayeux P,Dutrillaux B,Cartron JP,Gisselbrecht S,Lacombe C

更新日期：1994-04-01 00:00:00

abstract：:Glutathione-S-transferase (GST)-Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA. Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of...

journal_title：Blood

authors： Robinson A,Gibbins J,Rodríguez-Liñares B,Finan PM,Wilson L,Kellie S,Findell P,Watson SP

更新日期：1996-07-15 00:00:00

abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

journal_title：Blood

authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

更新日期：1996-09-15 00:00:00

abstract：:In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). The epitope is available for binding in aggressive lymphomas b...

journal_title：Blood

authors： Esserman L,Takahashi S,Rojas V,Warnke R,Levy R

更新日期：1989-12-01 00:00:00

abstract：:We have previously shown that circulating progenitor cells in patients with polycythemia vera (PV) are hypersensitive to insulin-like growth factor I (IGF-I) with respect to erythroid burst formation in serum-free medium, and that this effect occurs through the IGF-I receptor. To investigate the molecular basis of thi...

journal_title：Blood

authors： Mirza AM,Correa PN,Axelrad AA

更新日期：1995-08-01 00:00:00