Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.

abstract：:Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens. Thirty of these patients also received an infusion of HLA-haploidentical marrow cells. Only those patients having evidence of hematologic recovery within 3 mo after ATG therapy were considered res...

journal_title：Blood

authors： Doney K,Dahlberg SJ,Monroe D,Storb R,Buckner CD,Thomas ED

更新日期：1984-02-01 00:00:00

abstract：:The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

journal_title：Blood

authors： Bourgeade MF,Défachelles AS,Cayre YE

更新日期：1998-05-01 00:00:00

abstract：:Varying doses of 5-azacytidine (5-aza) were given to four sickle cell individuals for 500, 200, 100, and 30 days. The percentage of fetal hemoglobin (HbF) containing reticulocytes (F reticulocytes) increased two- to five-fold within five days of 5-aza therapy in all patients, with a two- to three-fold rapid response (...

journal_title：Blood

authors： Dover GJ,Charache S,Boyer SH,Vogelsang G,Moyer M

更新日期：1985-09-01 00:00:00

abstract：:The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13. It is unclear how ADAMTS13 activity is regulated within the vascular system. In the absence of a regulatory mechanism, ADAMTS13 activity might compromise plate...

journal_title：Blood

authors： Crawley JT,Lam JK,Rance JB,Mollica LR,O'Donnell JS,Lane DA

更新日期：2005-02-01 00:00:00

abstract：:Inherited type 1 antithrombin (AT) deficiency is characterized by a reduction in both immunologically and functionally detectable protein. The disorder is associated with a high risk of thromboembolic disease. We have investigated the molecular basis of type 1 AT deficiency in three unrelated families. We have used th...

journal_title：Blood

authors： Jochmans K,Lissens W,Yin T,Michiels JJ,van der Luit L,Peerlinck K,De Waele M,Liebaers I

更新日期：1994-12-01 00:00:00

abstract：:Tumor-infiltrating T lymphocytes (TIL-T) are always present in B-cell-derived non-Hodgkin's lymphoma (NHL). In this investigation, we explored the possibility that collaboration might exist between these cells. TIL-T were isolated from 39 lymph nodes of patients with NHL. In most of the cases, few of them (less than 1...

journal_title：Blood

authors： Jacob MC,Piccinni MP,Bonnefoix T,Sotto MF,Couderc P,Bensa JC,Sotto JJ

更新日期：1990-03-01 00:00:00

abstract：:Numerous studies have reported the presence of oxidatively modified high-density lipoprotein (OxHDL) within the intima of atheromatous plaques as well as in plasma; however, its role in the pathogenesis of thrombotic disease is not established. We now report that OxHDL, but not native HDL, is a potent inhibitor of pla...

journal_title：Blood

authors： Valiyaveettil M,Kar N,Ashraf MZ,Byzova TV,Febbraio M,Podrez EA

更新日期：2008-02-15 00:00:00

abstract：:T cell-based therapies have much promise in cancer treatment. This approach may be enhanced if used in combination with radiotherapy provided that tumor-specific T cells can be protected against the effects of radiotherapy. Previously, we demonstrated that administration of TLR9 ligand into mice decreased activation- ...

journal_title：Blood

authors： Zheng L,Asprodites N,Keene AH,Rodriguez P,Brown KD,Davila E

更新日期：2008-03-01 00:00:00

abstract：:A variant subline (KG-1a) of the human acute myelogenous leukemia (AML) cell line (KG-1) has been isolated. The cells retain the same constitutive markers as the parent line, including HLA antigens, isoenzymes, and karyotype. The cells from the subline are morphologically and histochemically undifferentiated blast cel...

journal_title：Blood

authors： Koeffler HP,Billing R,Lusis AJ,Sparkes R,Golde DW

更新日期：1980-08-01 00:00:00

abstract：:The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue mac...

journal_title：Blood

authors： Dale DC,Boxer L,Liles WC

更新日期：2008-08-15 00:00:00

abstract：:Vinblastine was administered to anemic baboons to test whether stimulation of Hb F takes place following distortion of erythropoiesis by an M-stage-specific compound. The treatments elicited erythroid cell cytoreduction followed by regeneration. During the phase of reticulocyte reduction, gamma/gamma + beta biosynthet...

journal_title：Blood

authors： Veith R,Papayannopoulou T,Kurachi S,Stamatoyannopoulos G

更新日期：1985-08-01 00:00:00

abstract：:We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during ...

journal_title：Blood

authors： Fratelli M,Gagliardini V,Galli G,Gnocchi P,Ghiara P,Ghezzi P

更新日期：1995-06-15 00:00:00

abstract：:Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expression compared wit...

journal_title：Blood

authors： Liyanage SU,Hurren R,Voisin V,Bridon G,Wang X,Xu C,MacLean N,Siriwardena TP,Gronda M,Yehudai D,Sriskanthadevan S,Avizonis D,Shamas-Din A,Minden MD,Bader GD,Laposa R,Schimmer AD

更新日期：2017-05-11 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:Peripheral blood stem cells (PBSCs) are widely used in autologous transplantation because of ease of collection and rapid hematopoietic reconstitution. However, PBSCs have rarely been used for allogeneic transplantation because of concerns about donor toxicities from cytokine administration and the theoretical increas...

journal_title：Blood

authors： Bensinger WI,Weaver CH,Appelbaum FR,Rowley S,Demirer T,Sanders J,Storb R,Buckner CD

更新日期：1995-03-15 00:00:00

abstract：:Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-dependent and Toll/interleukin (IL)-1R domain-containing adapter, inducing interferon (IFN)-beta-dependent signaling, leading to production of proinflammatory mediators and type I interferon (IFN) to eliminate pathogens. However, unco...

journal_title：Blood

authors： Wang Y,Chen T,Han C,He D,Liu H,An H,Cai Z,Cao X

更新日期：2007-08-01 00:00:00

abstract：:It has been suggested that autotransplantation of splenic tissue following trauma may result in splenic implanta that protect the human host from severe infection with encapsulated bacteria. To test this hypothesis, Sprague-Dawley rats underwent sham operation, splenectomy, or splenectomy followed by autotransplantati...

journal_title：Blood

authors： Moxon ER,Schwartz AD

更新日期：1980-11-01 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying MK-restricted expr...

journal_title：Blood

authors： Macaulay IC,Thon JN,Tijssen MR,Steele BM,MacDonald BT,Meade G,Burns P,Rendon A,Salunkhe V,Murphy RP,Bennett C,Watkins NA,He X,Fitzgerald DJ,Italiano JE Jr,Maguire PB

更新日期：2013-01-03 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:A case of acute lymphoblastic leukemia (ALL) was encountered in which the two clonal gamma T-cell receptor gene (TCR gamma) rearrangements found in bone marrow (BM) samples at relapse both differed from the single clonal TCR gamma rearrangement present in BM obtained at diagnosis 5 years previously. In contrast, two c...

journal_title：Blood

authors： Tycko B,Ritz J,Sallan S,Sklar J

更新日期：1992-01-15 00:00:00

abstract：:The expression of early and mature B cell markers, surface beta 2-microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the...

journal_title：Blood

authors： Epstein J,Barlogie B,Katzmann J,Alexanian R

更新日期：1988-04-01 00:00:00

abstract：:We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received...

journal_title：Blood

authors： Atsuta Y,Suzuki R,Nagamura-Inoue T,Taniguchi S,Takahashi S,Kai S,Sakamaki H,Kouzai Y,Kasai M,Fukuda T,Azuma H,Takanashi M,Okamoto S,Tsuchida M,Kawa K,Morishima Y,Kodera Y,Kato S,Japan Cord Blood Bank Network.

更新日期：2009-02-19 00:00:00

abstract：:The transmembrane 4 superfamily (TM4SF) has come into prominence for its association with a wide range of cell surface molecules, especially integrins. We report that TM4SF molecules CD9, CD63, and CD81 are physically associated with c-kit receptor tyrosine kinase in the human factor-dependent myeloid cell line, MO7e....

journal_title：Blood

authors： Anzai N,Lee Y,Youn BS,Fukuda S,Kim YJ,Mantel C,Akashi M,Broxmeyer HE

更新日期：2002-06-15 00:00:00

abstract：:The effects of recombinant human erythropoietin (rEp) on murine hematopoietic progenitors were studied using a serum-free culture. A high concentration of rEp stimulated the formation of mixed erythroid-megakaryocyte colonies (EM colonies) and blast cell colonies, as well as erythroid colonies, erythroid bursts, and m...

journal_title：Blood

authors： Nishi N,Nakahata T,Koike K,Takagi M,Naganuma K,Akabane T

更新日期：1990-10-01 00:00:00

abstract：:Essential thrombocythemia (ET) and polycythemia vera (PV) are characterized by persistent platelet activation. The mechanisms involved in their clearance are poorly characterized. In the present study, we report that leukocytes were actively involved in platelet disposal in 51 patients with ET and 30 with PV, but not ...

journal_title：Blood

authors： Maugeri N,Malato S,Femia EA,Pugliano M,Campana L,Lunghi F,Rovere-Querini P,Lussana F,Podda G,Cattaneo M,Ciceri F,Manfredi AA

更新日期：2011-09-22 00:00:00

abstract：:Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide ...

journal_title：Blood

authors： Ma YP,van Leeuwen FE,Cooke R,Broeks A,Enciso-Mora V,Olver B,Lloyd A,Broderick P,Russell NS,Janus C,Ashworth A,Houlston RS,Swerdlow AJ

更新日期：2012-01-26 00:00:00

abstract：:Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs)...

journal_title：Blood

authors： Jalkanen ST,Butcher EC

更新日期：1985-09-01 00:00:00