Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens.

abstract：:Since the initial observations by Kaiser and Edelman, interest in the role of calcium in ACS-induced apoptosis has wavered, in part because of the fact that extracellular calcium is only necessary for induction of apoptosis in thymocytes, but not in peripheral lymphocytes or lymphoma cells. Now, as result of molecular...

journal_title：Blood

authors： Distelhorst CW,Dubyak G

更新日期：1998-02-01 00:00:00

abstract：:Mechanisms involving the in vitro effect of rituximab in cells from 55 patients with B-cell lymphoproliferative disorders were investigated. No cytotoxic effect was observed when cells were incubated with rituximab alone, but in the presence of human AB serum rituximab induced complement-dependent cell death (R-CDC). ...

journal_title：Blood

authors： Bellosillo B,Villamor N,López-Guillermo A,Marcé S,Esteve J,Campo E,Colomer D,Montserrat E

更新日期：2001-11-01 00:00:00

abstract：:Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla protein (MGP) is important in inhibiting calcification. Because MGP activation is vitamin K dependent, we performed a cross-sectional study investigating the relationship between the use of vitamin K antagonists and ext...

journal_title：Blood

authors： Rennenberg RJ,van Varik BJ,Schurgers LJ,Hamulyak K,Ten Cate H,Leiner T,Vermeer C,de Leeuw PW,Kroon AA

更新日期：2010-06-17 00:00:00

abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...

journal_title：Blood

authors： White JG,Krumwiede M

更新日期：1985-04-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group (ECOG) conducted a randomized trial in patients less than or equal to 65 years old (median, 44 years) to determine whether increasing the intensity of postremission therapy in acute myeloid leukemia (AML) would improve the outcome. After uniform induction therapy, patients in com...

journal_title：Blood

authors： Cassileth PA,Lynch E,Hines JD,Oken MM,Mazza JJ,Bennett JM,McGlave PB,Edelstein M,Harrington DP,O'Connell MJ

更新日期：1992-04-15 00:00:00

abstract：:The pathophysiology of iron-induced compromised fertility in women with thalassemia major (TM) was evaluated in 26 adult TM females. Low gonadotropin secretion resulted in reduced ovarian antral follicle count and ovarian volume, but levels of anti-müllerian hormone (AMH), a sensitive marker for ovarian reserve indepe...

journal_title：Blood

authors： Singer ST,Vichinsky EP,Gildengorin G,van Disseldorp J,Rosen M,Cedars MI

更新日期：2011-09-08 00:00:00

abstract：:We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of this agent, PTL also induces cellular protective responses that likely function to reduce its overall ...

journal_title：Blood

authors： Hassane DC,Sen S,Minhajuddin M,Rossi RM,Corbett CA,Balys M,Wei L,Crooks PA,Guzman ML,Jordan CT

更新日期：2010-12-23 00:00:00

abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...

journal_title：Blood

authors： Burger JA,Quiroga MP,Hartmann E,Bürkle A,Wierda WG,Keating MJ,Rosenwald A

更新日期：2009-03-26 00:00:00

abstract：:The ability to determine the functional capacity of putative human hematopoietic stem cell (HSC) populations requires in vivo assays in which long-term multilineage differentiation can be assessed. We hypothesized that if human fetal bone was transplanted adjacent to a fetal thymus fragment in severe combined immunode...

journal_title：Blood

authors： Fraser CC,Kaneshima H,Hansteen G,Kilpatrick M,Hoffman R,Chen BP

更新日期：1995-09-01 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:The extracellular presence of endotoxin-free heat shock protein 70 (HSP70) enhances the rate and capacity of macrophage-mediated phagocytosis at 6 times the basal rate. It is protein-specific, dose- and time-dependent and involves the internalization of inert microspheres, Gram-positive and -negative bacteria and fung...

journal_title：Blood

authors： Wang R,Kovalchin JT,Muhlenkamp P,Chandawarkar RY

更新日期：2006-02-15 00:00:00

abstract：:Both SDF-1 and CXCR4 disruption are lethal to mice at the embryonic stage and cause abnormalities in B lymphopoiesis, myelopoiesis, cardiogenesis, vasculogenesis, and cerebellar development. To investigate the role of SDF-1 and CXCR4 in hematopoiesis during the adult stage, mice reconstituted with bone marrow-derived ...

journal_title：Blood

authors： Onai N,Zhang Yy,Yoneyama H,Kitamura T,Ishikawa S,Matsushima K

更新日期：2000-09-15 00:00:00

abstract：:Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony form...

journal_title：Blood

authors： Niho Y,Till JE,McCulloch EA

更新日期：1975-06-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 is essential for unrestrained growth of cancers. However, only 11% of hematological malignancies have mutant p53. Mechanisms that cause wild-type p53 dysfunction and promote leukemia are inadequately deciphered. The stem cell protein Asrij/OCIAD1 is misexpressed in several huma...

journal_title：Blood

authors： Sinha S,Dwivedi TR,Yengkhom R,Bheemsetty VA,Abe T,Kiyonari H,VijayRaghavan K,Inamdar MS

更新日期：2019-05-30 00:00:00

abstract：:Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Int...

journal_title：Blood

authors： Do JS,Min B

更新日期：2009-06-18 00:00:00

abstract：:Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to ionizing radiation (IR) has not been firmly established. Based on the role of the sphingomyelin (SM) cycle apoptotic pathway in IR-induced apoptosis, we hypothes...

journal_title：Blood

authors： Maddens S,Charruyer A,Plo I,Dubreuil P,Berger S,Salles B,Laurent G,Jaffrézou JP

更新日期：2002-08-15 00:00:00

abstract：:Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that Δ(12)-PGJ(3), a n...

journal_title：Blood

authors： Hegde S,Kaushal N,Ravindra KC,Chiaro C,Hafer KT,Gandhi UH,Thompson JT,van den Heuvel JP,Kennett MJ,Hankey P,Paulson RF,Prabhu KS

更新日期：2011-12-22 00:00:00

abstract：:The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits. Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxa...

journal_title：Blood

authors： Sandau KB,Fandrey J,Brüne B

更新日期：2001-02-15 00:00:00

abstract：:Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of nove...

journal_title：Blood

authors： Kress AK,Kalmer M,Rowan AG,Grassmann R,Fleckenstein B

更新日期：2011-03-31 00:00:00

abstract：:The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Acc...

journal_title：Blood

authors： Eash KJ,Means JM,White DW,Link DC

更新日期：2009-05-07 00:00:00

abstract：:Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulatory cells (Tregs) in...

journal_title：Blood

authors： Goodyear OC,Dennis M,Jilani NY,Loke J,Siddique S,Ryan G,Nunnick J,Khanum R,Raghavan M,Cook M,Snowden JA,Griffiths M,Russell N,Yin J,Crawley C,Cook G,Vyas P,Moss P,Malladi R,Craddock CF

更新日期：2012-04-05 00:00:00

abstract：:Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse by neo-insertion that partially disrupts mTOR transcription and creates a potential physiologic model of mTORC1/TORC2 inhibition. Homozygous knock-in mice exhi...

journal_title：Blood

authors： Zhang S,Readinger JA,DuBois W,Janka-Junttila M,Robinson R,Pruitt M,Bliskovsky V,Wu JZ,Sakakibara K,Patel J,Parent CA,Tessarollo L,Schwartzberg PL,Mock BA

更新日期：2011-01-27 00:00:00

abstract：:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be imp...

journal_title：Blood

authors： Meek B,Cloosen S,Borsotti C,Van Elssen CH,Vanderlocht J,Schnijderberg MC,van der Poel MW,Leewis B,Hesselink R,Manz MG,Katsura Y,Kawamoto H,Germeraad WT,Bos GM

更新日期：2010-01-14 00:00:00

abstract：:Mice carrying a conditional prothrombin knockout allele (fII(lox)) were established to develop an experimental setting for exploring the importance of thrombin in the maintenance of vascular integrity, the inflammatory response, and disease processes in adult animals. In the absence of Cre-mediated recombination, homo...

journal_title：Blood

authors： Mullins ES,Kombrinck KW,Talmage KE,Shaw MA,Witte DP,Ullman JM,Degen SJ,Sun W,Flick MJ,Degen JL

更新日期：2009-01-15 00:00:00

abstract：:The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that HSC quiescence and function are aberrant in mice lacking Irgm1. To investigate the molecular basis for these defects, we conducted microarray expression profil...

journal_title：Blood

authors： King KY,Baldridge MT,Weksberg DC,Chambers SM,Lukov GL,Wu S,Boles NC,Jung SY,Qin J,Liu D,Songyang Z,Eissa NT,Taylor GA,Goodell MA

更新日期：2011-08-11 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disease. Inherited forms of HLH are caused by biallelic mutations in several effectors of granule-dependent lymphocyte-mediated cytotoxicity. A small proportion of patients with a so-called "secondary" form of HLH, which develops in the a...

journal_title：Blood

authors： Sepulveda FE,Garrigue A,Maschalidi S,Garfa-Traore M,Ménasché G,Fischer A,de Saint Basile G

更新日期：2016-04-28 00:00:00

abstract：:The response to intravenous challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity, or a surgically created omental pouch. There was a marked rise in heterophil antibody titer following intravenous challeng...

journal_title：Blood

authors： Schwartz AD,Dadash-Zadeh M,Goldstein R,Luck S,Conway JJ

更新日期：1977-05-01 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Using data from ARISTOTLE, we describe the periprocedural management of anticoagulation and rates of subsequent clinical outcomes among patients chronically anticoagulated with warfarin or apixaban. We recorded whether (and for how long) anticoagulant therapy was interrupted preprocedure, whether bridging therapy was ...

journal_title：Blood

authors： Garcia D,Alexander JH,Wallentin L,Wojdyla DM,Thomas L,Hanna M,Al-Khatib SM,Dorian P,Ansell J,Commerford P,Flaker G,Lanas F,Vinereanu D,Xavier D,Hylek EM,Held C,Verheugt FW,Granger CB,Lopes RD

更新日期：2014-12-11 00:00:00

abstract：:Pulmonary complication in severe Plasmodium falciparum malaria is manifested as a prolonged impairment of gas transfer or the more severe acute respiratory distress syndrome (ARDS). In either clinical presentation, vascular permeability is a major component of the pathologic process. In this report, we examined the ef...

journal_title：Blood

authors： Gillrie MR,Krishnegowda G,Lee K,Buret AG,Robbins SM,Looareesuwan S,Gowda DC,Ho M

更新日期：2007-11-01 00:00:00