Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

journal_title：Blood

authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

更新日期：2009-06-04 00:00:00

abstract：:Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification proc...

journal_title：Blood

authors： Löffler A,Kufer P,Lutterbüse R,Zettl F,Daniel PT,Schwenkenbecher JM,Riethmüller G,Dörken B,Bargou RC

更新日期：2000-03-15 00:00:00

abstract：:X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 tim...

journal_title：Blood

authors： Jain A,Kovacs JA,Nelson DL,Migueles SA,Pittaluga S,Fanslow W,Fan X,Wong DW,Massey J,Hornung R,Brown MR,Spinner JJ,Liu S,Davey V,Hill HA,Ochs H,Fleisher TA

更新日期：2011-10-06 00:00:00

abstract：:The Strecker degradation reaction was evaluated as a means of modifying hemoglobin in vitro, utilizing ninhydrin as a model compound. Ninhydrin led to modification of hemoglobin (when incubated with hemoglobin or red cells) at physiologic temperature and pH. Isoelectric focusing documented the formation of new hemoglo...

journal_title：Blood

authors： Kokkini G,Stevens VJ,Peterson CM,Cerami A

更新日期：1980-10-01 00:00:00

abstract：:The balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8(+) T-cell response. Accumulating data pinpoint CD4(+) CD25(high) regulatory T (Treg) cells as a key factor for the inefficiency of CD8(+) T-cell responses in viral persistence. Little is known...

journal_title：Blood

authors： Nikolova M,Lelievre JD,Carriere M,Bensussan A,Lévy Y

更新日期：2009-05-07 00:00:00

abstract：:Conventional assays evaluating antitumor activity of immune effector cells have limitations that preclude their high-throughput application. We adapted the recently developed Compartment-Specific Bioluminescence Imaging (CS-BLI) technique to perform high-throughput quantification of innate antitumor activity and to sh...

journal_title：Blood

authors： McMillin DW,Delmore J,Negri JM,Vanneman M,Koyama S,Schlossman RL,Munshi NC,Laubach J,Richardson PG,Dranoff G,Anderson KC,Mitsiades CS

更新日期：2012-04-12 00:00:00

abstract：:The c-kit proto-oncogene encodes a receptor tyrosine kinase that is thought to play an important role in hematopoiesis. In a series of human acute myeloblastic leukemia (AML), the expression of the c-kit proto-oncogene and its product was studied by means of Northern blot and immunoblot analyses. The c-kit mRNA was ex...

journal_title：Blood

authors： Ikeda H,Kanakura Y,Tamaki T,Kuriu A,Kitayama H,Ishikawa J,Kanayama Y,Yonezawa T,Tarui S,Griffin JD

更新日期：1991-12-01 00:00:00

abstract：:Over the years, methods of cytogenetic analysis evolved and became part of routine laboratory testing, providing valuable diagnostic and prognostic information in hematologic disorders. Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease and thereby to rational application o...

journal_title：Blood

authors： Maciejewski JP,Mufti GJ

更新日期：2008-08-15 00:00:00

abstract：:The relative requirements of colonies derived from erythroid (BFU-E) and myeloid (CFU-c) progenitors for transferrin were examined using monoclonal antibodies directed against the transferrin molecule (TF-6) or its cell surface receptor (TFR-A12, TFR1-2B). Growth of erythroid bursts was profoundly reduced at concentra...

journal_title：Blood

authors： Shannon KM,Larrick JW,Fulcher SA,Burck KB,Pacely J,Davis JC,Ring DB

更新日期：1986-06-01 00:00:00

abstract：:Recently, the interleukin-2 receptor (IL-2R) was shown to be present on human neutrophils, and IL-2-neutrophil interactions are believed to be important in both tumor rejection and increased susceptibility to bacterial infections. Furthermore, neutrophils have been shown to synthesize host defense proteins, such as cy...

journal_title：Blood

authors： Girard D,Gosselin J,Heitz D,Paquin R,Beaulieu AD

更新日期：1995-08-01 00:00:00

abstract：:Although the graft-versus-leukemia effect of allogeneic bone marrow transplantation (BMT) is of paramount importance in the maintenance of disease remission, the role played by the autologous T-cell response in antitumor immune surveillance is less defined. We evaluated the emergence of antileukemia cytotoxic T-lympho...

journal_title：Blood

authors： Montagna D,Maccario R,Locatelli F,Montini E,Pagani S,Bonetti F,Daudt L,Turin I,Lisini D,Garavaglia C,Dellabona P,Casorati G

更新日期：2006-12-01 00:00:00

abstract：:Hypersensitivity to cross-linking agents and predisposition to malignancy are characteristic of the genetically heterogeneous inherited bone marrow failure syndrome, Fanconi anemia (FA). The protein encoded by the recently cloned FA complementation group A gene, FAA, has been expected to localize in the nucleus as bas...

journal_title：Blood

authors： Kruyt FA,Waisfisz Q,Dijkmans LM,Hermsen MA,Youssoufian H,Arwert F,Joenje H

更新日期：1997-11-01 00:00:00

abstract：:The survival of patients with aggressive non-Hodgkin lymphoma (NHL) is increasing, but the incidence of secondary cancer and late toxicity is poorly defined for those treated with cyclophosphamide-hydroxydaunomycin/doxorubicin-Oncovin-prednisone (CHOP)-like chemotherapy. From February 1984 to January 1998, 2837 patien...

journal_title：Blood

authors： André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

更新日期：2004-02-15 00:00:00

abstract：:The factor VIII/von Willebrand factor protein was radiolabeled after modification by galactose oxidase and reduction with tritiated potassium borohydride. This mild efficient method for labeling resulted in retention of over 90% of the biologic activities of the factor VIII/von Willebrand factor protein. Binding of th...

journal_title：Blood

authors： Morisato DK,Gralnick HR

更新日期：1980-01-01 00:00:00

abstract：:We previously showed the presence of receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) on tumor tissues and tumor cell lines that are derived from the neural crest. To determine whether normal neural cells express functional GM-CSF receptors, we isolated and analyzed primary rat brain cells, incl...

journal_title：Blood

authors： Baldwin GC,Benveniste EN,Chung GY,Gasson JC,Golde DW

更新日期：1993-12-01 00:00:00

abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

journal_title：Blood

authors： Valent P,Akin C,Metcalfe DD

更新日期：2017-03-16 00:00:00

abstract：:By stimulating the expression of murine IP-10 and Mig, CXC chemokines that inhibit neovascularization and cause damage to established tumor vasculature, human B cells immortalized with Epstein-Barr virus (EBV) can promote an effective antitumor response in athymic mice. In the present study, we examined the potential ...

journal_title：Blood

authors： Cherney BW,Sgadari C,Kanegane C,Wang F,Tosato G

更新日期：1998-04-01 00:00:00

abstract：:The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML...

journal_title：Blood

authors： Metzeler KH,Herold T,Rothenberg-Thurley M,Amler S,Sauerland MC,Görlich D,Schneider S,Konstandin NP,Dufour A,Bräundl K,Ksienzyk B,Zellmeier E,Hartmann L,Greif PA,Fiegl M,Subklewe M,Bohlander SK,Krug U,Faldum A,Berdel

更新日期：2016-08-04 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Posttransplantation CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pretransplantation CMV serology (P ...

journal_title：Blood

authors： Albano MS,Taylor P,Pass RF,Scaradavou A,Ciubotariu R,Carrier C,Dobrila L,Rubinstein P,Stevens CE

更新日期：2006-12-15 00:00:00

abstract：:Cure of hematologic malignancies after allogeneic hematopoietic stem cell transplantation is partially attributable to immunocellular antitumor reactions termed graft-versus-tumor (GvT) effect. GvT effects are heterogeneous with respect to effector cell populations, target antigens, and their interrelation with graft-...

journal_title：Blood

authors： Stelljes M,Strothotte R,Pauels HG,Poremba C,Milse M,Specht C,Albring J,Bisping G,Scheffold C,Kammertoens T,Oelmann E,Silling G,Berdel WE,Kienast J

更新日期：2004-08-15 00:00:00

abstract：:Human transferrin receptor-2 (TFR-2) is a protein highly homologous to TFR-1/CD71 and is endowed with the ability to bind transferrin (TF) with low affinity. High levels of TFR-2 mRNA were found in the liver and in erythroid precursors. Mutations affecting the TFR-2 gene led to hemochromatosis type 3, a form of inheri...

journal_title：Blood

authors： Deaglio S,Capobianco A,Calì A,Bellora F,Alberti F,Righi L,Sapino A,Camaschella C,Malavasi F

更新日期：2002-11-15 00:00:00

abstract：:Reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells is essential to the control of CMV infection in CMV-positive recipients (R(+)) after allogeneic hematopoietic stem cell transplantation (HCT). Six-color flow cytometry was used to assess the functional profile of CMV-specific CD8(+) T cells in 62 of 178 R...

journal_title：Blood

authors： Zhou W,Longmate J,Lacey SF,Palmer JM,Gallez-Hawkins G,Thao L,Spielberger R,Nakamura R,Forman SJ,Zaia JA,Diamond DJ

更新日期：2009-06-18 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

journal_title：Blood

authors： Chang TY,Dvorak CC,Loh ML

更新日期：2014-10-16 00:00:00

abstract：:People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency viru...

journal_title：Blood

authors： Zhang M,Rosenberg PS,Brown DL,Preiss L,Konkle BA,Eyster ME,Goedert JJ,Second Multicenter Hemophilia Cohort Study.

更新日期：2006-02-01 00:00:00

abstract：:The pathophysiology of microthrombocytopenia in the Wiskott-Aldrich syndrome (WAS) and its milder form, X-linked thrombocytopenia (XLT), is unclear. Although quantitative defects are correctable by splenectomy, residual platelet abnormalities are suggestive of intrinsic disturbances of production. In contrast to human...

journal_title：Blood

authors： Sabri S,Foudi A,Boukour S,Franc B,Charrier S,Jandrot-Perrus M,Farndale RW,Jalil A,Blundell MP,Cramer EM,Louache F,Debili N,Thrasher AJ,Vainchenker W

更新日期：2006-07-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signal...

journal_title：Blood

authors： Liu G,Place AT,Chen Z,Brovkovych VM,Vogel SM,Muller WA,Skidgel RA,Malik AB,Minshall RD

更新日期：2012-08-30 00:00:00

abstract：:Patients with the B-cell malignancy hairy cell leukemia (HCL) exhibit a skewed T-cell repertoire with oligoclonal expression or absence of many members of the T-cell receptor (TCR) BV gene families. To evaluate whether interferon-alpha (IFN-alpha) therapy would not only restore normal hematopoiesis, but also the abnor...

journal_title：Blood

authors： Kluin-Nelemans HC,Kester MG,van deCorput L,Boor PP,Landegent JE,van Dongen JJ,Willemze R,Falkenburg JH

更新日期：1998-06-01 00:00:00

abstract：:We have investigated the role of plasminogen activator inhibitor 1 (PAI-1) in the regulation of fibrinolysis using a model thrombus composed of thrombin-stimulated platelets, fibrin(ogen), plasminogen, and recombinant tissue-type plasminogen activator. Laser light scattering kinetic measurements showed that clot lysis...

journal_title：Blood

authors： Braaten JV,Handt S,Jerome WG,Kirkpatrick J,Lewis JC,Hantgan RR

更新日期：1993-03-01 00:00:00

abstract：:We used restriction endonuclease analysis to determine the incidence of alpha-thalassemia in two Mediterranean islands. In a random population sample, the gene frequency of deletion-type alpha-thalassemia-2 (-alpha) was 0.18 in Sardinians and 0.07 in Greek Cypriots. All cases were the rightward crossover type. From th...

journal_title：Blood

authors： Pirastu M,Lee KY,Dozy AM,Kan YW,Stamatoyannopoulos G,Hadjiminas MG,Zachariades Z,Angius A,Furbetta M,Rosatelli C,Cao A

更新日期：1982-08-01 00:00:00