Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients.

abstract：:Varying doses of 5-azacytidine (5-aza) were given to four sickle cell individuals for 500, 200, 100, and 30 days. The percentage of fetal hemoglobin (HbF) containing reticulocytes (F reticulocytes) increased two- to five-fold within five days of 5-aza therapy in all patients, with a two- to three-fold rapid response (...

journal_title：Blood

authors： Dover GJ,Charache S,Boyer SH,Vogelsang G,Moyer M

更新日期：1985-09-01 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:Plasma fibronectin enhances platelet thrombus formation on surfaces coated with collagen. We investigated the role of fibronectin assembly in this process. Platelets adherent to fibrillar type I collagen, but not platelets adherent to von Willebrand factor (VWF), supported assembly of plasma fibronectin under static c...

journal_title：Blood

authors： Cho J,Mosher DF

更新日期：2006-10-01 00:00:00

abstract：:Advances in immune assessment, including the development of T-cell receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and higher-order phenotyping of T-cell maturation subsets have improved our understanding of T-cell homeostasis. Limited data exist using these m...

journal_title：Blood

authors： Komanduri KV,St John LS,de Lima M,McMannis J,Rosinski S,McNiece I,Bryan SG,Kaur I,Martin S,Wieder ED,Worth L,Cooper LJ,Petropoulos D,Molldrem JJ,Champlin RE,Shpall EJ

更新日期：2007-12-15 00:00:00

abstract：:CTLA-4 is a critical inhibitory "checkpoint" molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly cause CTLA-4 deficiency. Numerous articles have also been publishe...

journal_title：Blood

authors： Lo B,Fritz JM,Su HC,Uzel G,Jordan MB,Lenardo MJ

更新日期：2016-08-25 00:00:00

abstract：:Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...

journal_title：Blood

authors： Krow-Lucal ER,Kim CC,Burt TD,McCune JM

更新日期：2014-03-20 00:00:00

abstract：:In this issue of Blood, Willems et al describe the dependence of acute myeloid leukemia (AML) cells on glutamine for maintaining protein synthesis downstream of mammalian target of rapamycin (mTOR) and show that the enzyme asparaginase can be used to target this dependence. Using various AML cell lines, primary sample...

journal_title：Blood

authors： Samudio I,Konopleva M

更新日期：2013-11-14 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:IL-12 exerts several regulatory effects on natural killer (NK) cells by activating IL-12 signaling. IL-12 signaling is tightly auto-regulated to control its onset and termination, with prolonged IL-12 treatment resulting in IL-12 hyporesponsiveness. However, the mechanisms underlying IL-12 auto-regulation are still un...

journal_title：Blood

authors： Huang Y,Lei Y,Zhang H,Hou L,Zhang M,Dayton AI

更新日期：2011-12-22 00:00:00

abstract：:One obstacle to retrovirus-mediated gene therapy for human hematopoietic disorders is the low efficiency of gene transfer into pluripotent hematopoietic stem cells (HSC). We have previously shown a direct correlation between retrovirus receptor mRNA levels in mouse HSC and the efficiency with which they are transduced...

journal_title：Blood

authors： Orlic D,Girard LJ,Anderson SM,Pyle LC,Yoder MC,Broxmeyer HE,Bodine DM

更新日期：1998-05-01 00:00:00

abstract：:Crystallographic structures indicate that gamma-chain residue Asn308 participates in D:D interactions and indeed substitutions of gammaAsn308 with lysine or isoleucine have been identified in dysfibrinogens with impaired polymerization. To probe the role of Asn308 in polymerization, we synthesized 3 variant fibrinogen...

journal_title：Blood

authors： Okumura N,Gorkun OV,Terasawa F,Lord ST

更新日期：2004-06-01 00:00:00

abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...

journal_title：Blood

authors： Costa JM,Vidaud D,Laurendeau I,Vidaud M,Fressinaud E,Moisan JP,David A,Meyer D,Lavergne JM

更新日期：2000-08-15 00:00:00

abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...

journal_title：Blood

authors： van Dam GJ,Claas FH,Yazdanbakhsh M,Kruize YC,van Keulen AC,Ferreira ST,Rotmans JP,Deelder AM

更新日期：1996-12-01 00:00:00

abstract：:The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution...

journal_title：Blood

authors： Zhong JF,Zhan Y,Anderson WF,Zhao Y

更新日期：2002-11-15 00:00:00

abstract：:Prediagnostic serum concentration of soluble CD30 (sCD30), a marker for chronic B-cell stimulation, has been associated with increased risk of developing AIDS-related non-Hodgkin lymphoma (NHL) in a recent study of HIV(+) patients. To investigate among healthy persons whether serum sCD30 is associated with NHL risk, w...

journal_title：Blood

authors： Purdue MP,Lan Q,Martinez-Maza O,Oken MM,Hocking W,Huang WY,Baris D,Conde B,Rothman N

更新日期：2009-09-24 00:00:00

abstract：:Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFNgamma has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild-type (wt), IFNgamma(-/-), and IFNgammaR(-/-) mice as donors or recipients in we...

journal_title：Blood

authors： Burman AC,Banovic T,Kuns RD,Clouston AD,Stanley AC,Morris ES,Rowe V,Bofinger H,Skoczylas R,Raffelt N,Fahy O,McColl SR,Engwerda CR,McDonald KP,Hill GR

更新日期：2007-08-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both human...

journal_title：Blood

authors： Schneidawind D,Baker J,Pierini A,Buechele C,Luong RH,Meyer EH,Negrin RS

更新日期：2015-05-28 00:00:00

abstract：:Sardinian beta-thalassemia patients all are homozygotes for the same null allele in the beta-globin gene, but the clinical manifestations are extremely variable in severity. Previous studies have shown that the coinheritance of alpha-thalassemia or the presence of genetic variants that sustain fetal hemoglobin product...

journal_title：Blood

authors： Galanello R,Sanna S,Perseu L,Sollaino MC,Satta S,Lai ME,Barella S,Uda M,Usala G,Abecasis GR,Cao A

更新日期：2009-10-29 00:00:00

abstract：:Leukocyte adhesion deficiency type II (LADII) is a rare inherited disorder of fucose metabolism. Patients with LADII lack fucosylated glycoconjugates, including the carbohydrate ligands of the selectins, leading to an immunodeficiency caused by the lack of selectin-mediated leukocyte-endothelial interactions. A simple...

journal_title：Blood

authors： Lühn K,Marquardt T,Harms E,Vestweber D

更新日期：2001-01-01 00:00:00

abstract：:Fibrin forms the cohesive network of hemostatic plugs and thrombi, and it also provides the temporary matrix for initial support of healing and revascularization. Because cell proliferation is needed for revascularization after vessel injury, we have characterized structural requirements of fibrin needed to support ce...

journal_title：Blood

authors： Sporn LA,Bunce LA,Francis CW

更新日期：1995-09-01 00:00:00

abstract：:Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further define the role of rIFN-α, we investigated the outcomes of pegylated-rIFN-α2a (PEG) therapy in ET and PV patients previously treated with...

journal_title：Blood

authors： Yacoub A,Mascarenhas J,Kosiorek H,Prchal JT,Berenzon D,Baer MR,Ritchie E,Silver RT,Kessler C,Winton E,Finazzi MC,Rambaldi A,Vannucchi AM,Leibowitz D,Rondelli D,Arcasoy MO,Catchatourian R,Vadakara J,Rosti V,Hexner E

更新日期：2019-10-31 00:00:00

abstract：:NF-kappaB is a transcription factor that controls the expression of a number of genes important for mediating immune and inflammatory responses. In this study, we examined whether bortezomib and PS-1145, each of which inhibits NF-kappaB, could protect mice from lethal graft-versus-host disease (GVHD), which is charact...

journal_title：Blood

authors： Vodanovic-Jankovic S,Hari P,Jacobs P,Komorowski R,Drobyski WR

更新日期：2006-01-15 00:00:00

abstract：:Posttranslational protein modifications (PTMs) are necessary for cells to function properly. The role of PTMs in regulating immune responses, specifically those mediated by dendritic cells (DCs), which are critical for both innate and adaptive immunity, is not well understood. Utilizing multiple but complementary appr...

journal_title：Blood

authors： Mathewson N,Toubai T,Kapeles S,Sun Y,Oravecz-Wilson K,Tamaki H,Wang Y,Hou G,Sun Y,Reddy P

更新日期：2013-09-19 00:00:00

abstract：:Although a large body of data on mobilization have yielded valuable clues, the mechanism(s) dictating egress of stem/progenitor cells during baseline hematopoiesis and after their mobilization are poorly understood. We have previously provided functional in vivo evidence that cytoadhesion molecules, specifically the b...

journal_title：Blood

authors： Papayannopoulou T,Priestley GV,Nakamoto B

更新日期：1998-04-01 00:00:00

abstract：:Chemoresistance is a major problem in the treatment of patients with multiple myeloma (MM). Because of the central role of the nuclear transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) in chemoresistance, cell survival, and proliferation, we investig...

journal_title：Blood

authors： Bharti AC,Shishodia S,Reuben JM,Weber D,Alexanian R,Raj-Vadhan S,Estrov Z,Talpaz M,Aggarwal BB

更新日期：2004-04-15 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes (LGLs) that contain distinct lysosomal granules. The present study was undertaken to determine if these lysosomes contain glycosaminoglycans (GAGs) similar to those previously described in myeloid cells. Mononuclear cells from human blood were stained with HNK-1...

journal_title：Blood

authors： Parmley RT,Rahemtulla F,Cooper MD,Rodén L

更新日期：1985-07-01 00:00:00

abstract：:The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in v...

journal_title：Blood

authors： van de Kar NC,Monnens LA,Karmali MA,van Hinsbergh VW

更新日期：1992-12-01 00:00:00

abstract：:Targeting mechanisms of neutrophil elastase (NE) and other luminal proteins stored in myeloperoxidase (MPO)-positive secretory lysosomes/primary granules of neutrophils are unknown. These granules contain an integral membrane protein, CD63, with an adaptor protein-3-dependent granule delivery system. Therefore, we hyp...

journal_title：Blood

authors： Källquist L,Hansson M,Persson AM,Janssen H,Calafat J,Tapper H,Olsson I

更新日期：2008-10-15 00:00:00

abstract：:Tissue factor-induced blood coagulation was studied in 20 individuals, for varying periods of time during 54 months, in contact pathway-inhibited whole blood at 37 degrees C and evaluated in terms of the activation of various substrates. After quenching over time with inhibitors, the soluble phases were analyzed for t...

journal_title：Blood

authors： Brummel KE,Paradis SG,Butenas S,Mann KG

更新日期：2002-07-01 00:00:00

abstract：:The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differentiation. Little is known of possible variations in the levels of Pax5 expression and their influences on hematopoietic development. We have developed a retroviral transduction system that allows for the study of possible inte...

journal_title：Blood

authors： Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F

更新日期：2012-11-01 00:00:00