Abstract:
:CTLA-4 is a critical inhibitory "checkpoint" molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly cause CTLA-4 deficiency. Numerous articles have also been published describing CTLA-4 blockade in cancer immunotherapy and its side effects, which are ultimately the consequence of treatment-induced CTLA-4 deficiency. Here, we review these 2 diseases and CTLA-4 blockade therapy, emphasizing the crucial role of CTLA-4 in immune checkpoint regulation.
journal_name
Bloodjournal_title
Bloodauthors
Lo B,Fritz JM,Su HC,Uzel G,Jordan MB,Lenardo MJdoi
10.1182/blood-2016-04-712612subject
Has Abstractpub_date
2016-08-25 00:00:00pages
1037-42issue
8eissn
0006-4971issn
1528-0020pii
blood-2016-04-712612journal_volume
128pub_type
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