T and B lymphocyte antigen-positive null cell leukemias.

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:To understand the regulatory mechanism of erythropoietin (EPO) receptor (EPOR) gene expression, the effect of EPO on the steady-state level of EPOR mRNA was examined using the human EPO-dependent cell line UT-7 as a model system. We found that the treatment of UT-7 cells with EPO resulted in a transient decrease of th...

journal_title：Blood

authors： Komatsu N,Kirito K,Kashii Y,Furukawa Y,Kikuchi J,Suwabe N,Yamamoto M,Miura Y

更新日期：1997-02-15 00:00:00

abstract：:Toxicity-reduced conditioning is being used for allogeneic stem cell transplantation in older and/or comorbid patients. We report on the treatment of 133 patients (median age: 55.6 years [23-73 years]) with acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS; n = 81), myeloproliferative syndromes (MPS; n = 20),...

journal_title：Blood

authors： Marks R,Potthoff K,Hahn J,Ihorst G,Bertz H,Spyridonidis A,Holler E,Finke JM

更新日期：2008-07-15 00:00:00

abstract：:Gastrointestinal (GI) bleeding is distinctive of severe von Willebrand disease (VWD), generally arising in older patients; in most cases, blood transfusion and hospitalization are required. The presence of arteriovenous malformations is often described when endoscopic examinations are performed. Patients with congenit...

journal_title：Blood

authors： Biguzzi E,Siboni SM,Peyvandi F

更新日期：2020-09-03 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), where...

journal_title：Blood

authors： Dowdell KC,Niemela JE,Price S,Davis J,Hornung RL,Oliveira JB,Puck JM,Jaffe ES,Pittaluga S,Cohen JI,Fleisher TA,Rao VK

更新日期：2010-06-24 00:00:00

abstract：:An electroimmunoassay was applied to the quantitation of platelet-associated IgG (PAIgG). Protein solubilized by Triton X100 from washed platelets was electrophoresed at pH 5.0 in agarose gels containing carbamoylated rabbit anti-human IgG (pI approximately equal to 5.0). Because the rabbit antibody is immobilized und...

journal_title：Blood

authors： Kunicki TJ,Koenig MB,Kristopeit SM,Aster RH

更新日期：1982-07-01 00:00:00

abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

journal_title：Blood

authors： Valent P,Akin C,Metcalfe DD

更新日期：2017-03-16 00:00:00

abstract：:In this issue of Blood, Bagnara et al describe the development of a reliable and convincing xenograft model of CLL that recapitulates aspects of the leukemic microenvironment and gives intriguing insights into disease biology. ...

journal_title：Blood

authors： Devereux S

更新日期：2011-05-19 00:00:00

abstract：:The present studies were undertaken to determine whether factor VIII/von Willebrand factor (vWF) present in the vessel wall (in addition to that in plasma) may mediate the attachment of platelets to subendothelium. Subendothelium from everted rabbit aorta was exposed to human citrated blood flowing through an annular ...

journal_title：Blood

authors： Turitto VT,Weiss HJ,Zimmerman TS,Sussman II

更新日期：1985-04-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin's lymphoma (NHL) that is highly heterogeneous from both clinical and histopathologic viewpoints. The immunoglobulin (Ig) heavy (H) chain variable region genes were examined in 71 patients with untreated primary DLBCL. Fifty-eight potentially functio...

journal_title：Blood

authors： Lossos IS,Okada CY,Tibshirani R,Warnke R,Vose JM,Greiner TC,Levy R

更新日期：2000-03-01 00:00:00

abstract：:Endothelial progenitor cells are critically involved in essential biologic processes, such as vascular homeostasis, regeneration, and tumor angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with robust proliferative potential. Their profound vessel-forming capacity makes them a pr...

journal_title：Blood

authors： Reinisch A,Hofmann NA,Obenauf AC,Kashofer K,Rohde E,Schallmoser K,Flicker K,Lanzer G,Linkesch W,Speicher MR,Strunk D

更新日期：2009-06-25 00:00:00

abstract：:WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is an immune deficiency linked in many cases to heterozygous mutations causing truncations in the cytoplasmic tail of CXC chemokine receptor 4 (CXCR4). Leukocytes expressing truncated CXCR4 display enhanced responses to the receptor ligand CXC...

journal_title：Blood

authors： Lagane B,Chow KY,Balabanian K,Levoye A,Harriague J,Planchenault T,Baleux F,Gunera-Saad N,Arenzana-Seisdedos F,Bachelerie F

更新日期：2008-07-01 00:00:00

abstract：:Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification proc...

journal_title：Blood

authors： Löffler A,Kufer P,Lutterbüse R,Zettl F,Daniel PT,Schwenkenbecher JM,Riethmüller G,Dörken B,Bargou RC

更新日期：2000-03-15 00:00:00

abstract：:To characterize and clarify the function of CD34 antigen experimentally, we isolated two types of CD34 mRNA from a cDNA library of murine stromal cell line, PA-6 stimulated with lipopolysaccharide (LPS) and 12-o-tetra-decanoylphorbol 13-acetate (TPA) using a human CD34 probe. In addition to the clone (open reading fra...

journal_title：Blood

authors： Suda J,Sudo T,Ito M,Ohno N,Yamaguchi Y,Suda T

更新日期：1992-05-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) transplanted in utero are in competition with endogenous HSC; thus, ultimately the graft constitutes a relatively small fraction of total HSC pool. To enhance the engraftment of donor cells in sheep fetuses, we preincubated these cells, ex vivo, for 16 hours at 37 degrees C with the cond...

journal_title：Blood

authors： Zanjani ED,Ascensao JL,Harrison MR,Tavassoli M

更新日期：1992-06-01 00:00:00

abstract：:To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-id...

journal_title：Blood

authors： Sullivan KM,Weiden PL,Storb R,Witherspoon RP,Fefer A,Fisher L,Buckner CD,Anasetti C,Appelbaum FR,Badger C

更新日期：1989-05-01 00:00:00

abstract：:Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

journal_title：Blood

authors： Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

更新日期：2004-01-15 00:00:00

abstract：:Over the years, methods of cytogenetic analysis evolved and became part of routine laboratory testing, providing valuable diagnostic and prognostic information in hematologic disorders. Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease and thereby to rational application o...

journal_title：Blood

authors： Maciejewski JP,Mufti GJ

更新日期：2008-08-15 00:00:00

abstract：:As our technological capacities improve, genomic testing is increasingly integrating into patient care. The field of clinical hematology is no exception. Genomic testing carries great promise, but several ethical issues must be considered whenever such testing is performed. This review addresses these ethical consider...

journal_title：Blood

authors： Marron JM,Joffe S

更新日期：2017-07-27 00:00:00

abstract：:In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two pati...

journal_title：Blood

authors： Streeter RR,Presant CA,Reinhard E

更新日期：1977-09-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell-derived malignancies by targeting CD19. The success has not yet expanded to treat acute myeloid leukemia (AML). We developed a Sequentially Tumor-Selected Antibody and Antigen Retrieval (STAR) system to rapidly isolate multiple nan...

journal_title：Blood

authors： He X,Feng Z,Ma J,Ling S,Cao Y,Gurung B,Wu Y,Katona BW,O'Dwyer KP,Siegel DL,June CH,Hua X

更新日期：2020-03-05 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:Approximately 60% of patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) are curable with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemoimmunotherapy. Epratuzumab (E) is an unlabeled anti-CD22 monoclonal antibody with efficacy in relapsed DLBCL. This phase 2 trial te...

journal_title：Blood

authors： Micallef IN,Maurer MJ,Wiseman GA,Nikcevich DA,Kurtin PJ,Cannon MW,Perez DG,Soori GS,Link BK,Habermann TM,Witzig TE

更新日期：2011-10-13 00:00:00

abstract：:Using quantitative fluorescence in situ hybridization and flow cytometry, the telomere length of telomere repeat sequences after stem cell transplantation (SCT) were measured. The study included the telomeres of peripheral blood monocytes that should reflect the length of telomeres in stem cells and the telomeres of T...

journal_title：Blood

authors： Rufer N,Brümmendorf TH,Chapuis B,Helg C,Lansdorp PM,Roosnek E

更新日期：2001-01-15 00:00:00

abstract：:Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and heterozygous state, suggesting that meizothrombin has dominant anticoagulant effects in vivo. The enzymatic characterization of recombinant mouse meizothrombin, meizot...

journal_title：Blood

authors： Shim K,Zhu H,Westfield LA,Sadler JE

更新日期：2004-07-15 00:00:00

abstract：:Protein C is activated by thrombin with a value of k(cat)/K(m) = 0.11mM(-1)s(-1) that increases 1700-fold in the presence of the cofactor thrombomodulin. The molecular origin of this effect triggering an important feedback loop in the coagulation cascade remains elusive. Acidic residues in the activation domain of pro...

journal_title：Blood

authors： Pozzi N,Barranco-Medina S,Chen Z,Di Cera E

更新日期：2012-07-19 00:00:00

abstract：:In an effort to discover specific markers to isolate human hematopoietic stem cells, Jokubaitis and colleagues report that the monoclonal antibody BB9 reacts with hematopoietic cells displaying morphologic, phenotypic, and/or functional properties of stem and progenitor cells throughout human ontogeny. ...

journal_title：Blood

authors： Yoder MC

更新日期：2008-04-15 00:00:00

abstract：:Umbilical cord blood (UCB) is used for HSCT. It is known that UCB can comprise Ag-specific T cells. Here we question whether solely transmaternal cell flow may immunize UCB. Twenty-three female UCB samples were collected from healthy mothers and analyzed for minor histocompatibility Ag HY-specific responses. Forty-two...

journal_title：Blood

authors： Dierselhuis MP,Blokland EC,Pool J,Schrama E,Scherjon SA,Goulmy E

更新日期：2012-07-19 00:00:00

abstract：:It has been shown previously that multilineage human hematopoiesis is maintained within human fetal bone marrow (BM) fragments implanted into severe combined immunodeficient (SCID) mice. We describe here an application of this animal model, the SCID-hu mouse, to the study of human myeloid leukemias. BM cells from 8 pa...

journal_title：Blood

authors： Namikawa R,Ueda R,Kyoizumi S

更新日期：1993-10-15 00:00:00