Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience.

abstract：:We have shown that cytosol samples from human leukemia cells frequently contain glucocorticoid receptor fragments that have a mol wt (Mr) of approximately 52,000. In the present study we demonstrate that the Mr approximately 52,000-receptor fragments are derived from intact glucocorticoid receptors (Mr approximately 9...

journal_title：Blood

authors： Distelhorst CW,Miesfeld R

更新日期：1987-03-01 00:00:00

abstract：:Long-term survival is now an expected outcome after hematopoietic cell transplantation (HCT). However, the burden of morbidity long-term after HCT remains unknown. We examined the magnitude of risk of chronic health conditions reported by 1022 HCT survivors and their siblings (n = 309). A severity score (grades 1 [mil...

journal_title：Blood

authors： Sun CL,Francisco L,Kawashima T,Leisenring W,Robison LL,Baker KS,Weisdorf DJ,Forman SJ,Bhatia S

更新日期：2010-10-28 00:00:00

abstract：:Adeno-associated virus (AAV)-based gene therapies can restore endogenous factor VIII (FVIII) expression in hemophilia A (HA). AAV vectors typically use a B-domain-deleted FVIII transgene, such as human FVIII-SQ in valoctocogene roxaparvovec (AAV5-FVIII-SQ). Surprisingly, the activity of transgene-produced FVIII-SQ was...

journal_title：Blood

authors： Rosen S,Tiefenbacher S,Robinson M,Huang M,Srimani J,Mackenzie D,Christianson T,Pasi KJ,Rangarajan S,Symington E,Giermasz A,Pierce GF,Kim B,Zoog SJ,Vettermann C

更新日期：2020-11-26 00:00:00

abstract：:Patients with classic hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) typically have high levels of Epstein-Barr virus (EBV) DNA in T cells and/or natural killer (NK) cells in blood and skin lesions induced by sun exposure that are infiltrated with EBV-infected lymphocytes. HVLPD is very rare in the Unit...

journal_title：Blood

authors： Cohen JI,Manoli I,Dowdell K,Krogmann TA,Tamura D,Radecki P,Bu W,Turk SP,Liepshutz K,Hornung RL,Fassihi H,Sarkany RP,Bonnycastle LL,Chines PS,Swift AJ,Myers TG,Levoska MA,DiGiovanna JJ,Collins FS,Kraemer KH,Pittalu

更新日期：2019-06-27 00:00:00

abstract：:In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreove...

journal_title：Blood

authors： Fleischman AG

更新日期：2012-04-12 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) is a disease in which autoantibodies against red blood cells (RBCs) lead to their premature destruction. Most clinically significant autoantibodies are of the immunoglobulin G (IgG) type, which leads primarily to the uptake and destruction of RBCs by splenic and hepatic macrophages. ...

journal_title：Blood

authors： Jordan MB,van Rooijen N,Izui S,Kappler J,Marrack P

更新日期：2003-01-15 00:00:00

abstract：:One hundred fifty-one children with acute myelogenous leukemia (AML) entered the cooperative study BFM-78 between December 1978 and October 1982. The initial therapy consisted of an intensive induction and consolidation regimen over eight weeks with seven different drugs and cranial irradiation. It was followed by mai...

journal_title：Blood

authors： Creutzig U,Ritter J,Riehm H,Langermann HJ,Henze G,Kabisch H,Niethammer D,Jürgens H,Stollmann B,Lasson U

更新日期：1985-02-01 00:00:00

abstract：:Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying MK-restricted expr...

journal_title：Blood

authors： Macaulay IC,Thon JN,Tijssen MR,Steele BM,MacDonald BT,Meade G,Burns P,Rendon A,Salunkhe V,Murphy RP,Bennett C,Watkins NA,He X,Fitzgerald DJ,Italiano JE Jr,Maguire PB

更新日期：2013-01-03 00:00:00

abstract：:The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

journal_title：Blood

authors： Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

更新日期：1994-05-15 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced pr...

journal_title：Blood

authors： Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA

更新日期：2014-07-17 00:00:00

abstract：:Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) ...

journal_title：Blood

authors： Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J

更新日期：1991-05-15 00:00:00

abstract：:Gossypin, a flavone originally isolated from Hibiscus vitifolius, has been shown to suppress angiogenesis, inflammation, and carcinogenesis. The mechanisms of these activities, however, are unknown. Because nuclear factor-kappaB (NF-kappaB) is associated with inflammation, carcinogenesis, hyperproliferation, invasion,...

journal_title：Blood

authors： Kunnumakkara AB,Nair AS,Ahn KS,Pandey MK,Yi Z,Liu M,Aggarwal BB

更新日期：2007-06-15 00:00:00

abstract：:NF-kappaB is a transcription factor that controls the expression of a number of genes important for mediating immune and inflammatory responses. In this study, we examined whether bortezomib and PS-1145, each of which inhibits NF-kappaB, could protect mice from lethal graft-versus-host disease (GVHD), which is charact...

journal_title：Blood

authors： Vodanovic-Jankovic S,Hari P,Jacobs P,Komorowski R,Drobyski WR

更新日期：2006-01-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transc...

journal_title：Blood

authors： Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim N

更新日期：2006-04-01 00:00:00

abstract：:We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII < 1% of normal, a single tail vein administratio...

journal_title：Blood

authors： Binny C,McIntosh J,Della Peruta M,Kymalainen H,Tuddenham EG,Buckley SM,Waddington SN,McVey JH,Spence Y,Morton CL,Thrasher AJ,Gray JT,Castellino FJ,Tarantal AF,Davidoff AM,Nathwani AC

更新日期：2012-01-26 00:00:00

abstract：:T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by ...

journal_title：Blood

authors： Hainz U,Obexer P,Winkler C,Sedlmayr P,Takikawa O,Greinix H,Lawitschka A,Pötschger U,Fuchs D,Ladisch S,Heitger A

更新日期：2005-05-15 00:00:00

abstract：:In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity...

journal_title：Blood

authors： Rajkumar SV,Gahrton G,Bergsagel PL

更新日期：2011-09-22 00:00:00

abstract：:Immune deficiency viruses such as SIV in macaques or HIV-1 in human beings have evolved mechanisms to defeat host immunity that also impact the efficacy of vaccines. A key factor for vaccine protection is whether immune responses elicited by prior immunization remain at levels sufficient to limit disease progression o...

journal_title：Blood

authors： Poonia B,Salvato MS,Yagita H,Maeda T,Okumura K,Pauza CD

更新日期：2009-08-06 00:00:00

abstract：:Measurement of plasma levels of two secreted platelet proteins (beta-thromboglobulin and platelet factor 4) has been suggested as a means for detecting increased platelet activation in vivo. A crucial question in the measurement is the distinction between in vivo and in vitro secretion of the proteins. One approach to...

journal_title：Blood

authors： Kaplan KL,Owen J

更新日期：1981-02-01 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin (IL)-3/IL-5 receptor family regulates the production and function of myeloid cells. These cytokines signal through receptor complexes that consist of unique ligand-binding alpha-chains and common signaling beta-chains. IL-5 is distinct from IL-3...

journal_title：Blood

authors： Beekman JM,Verhagen LP,Geijsen N,Coffer PJ

更新日期：2009-10-29 00:00:00

abstract：:Translocations in myeloma are thought to occur solely in mature B cells in the germinal center through class switch recombination (CSR). We used a targeted captured technique followed by massively parallel sequencing to determine the exact breakpoints in both the immunoglobulin heavy chain (IGH) locus and the partner ...

journal_title：Blood

authors： Walker BA,Wardell CP,Johnson DC,Kaiser MF,Begum DB,Dahir NB,Ross FM,Davies FE,Gonzalez D,Morgan GJ

更新日期：2013-04-25 00:00:00

abstract：:Stem cells of highly regenerative organs including blood are susceptible to endogenous DNA damage caused by both intrinsic and extrinsic stress. Response mechanisms to such stress equipped in hematopoietic stem cells (HSCs) are crucial in sustaining hematopoietic homeostasis but remain largely unknown. In this study, ...

journal_title：Blood

authors： Yahata T,Takanashi T,Muguruma Y,Ibrahim AA,Matsuzawa H,Uno T,Sheng Y,Onizuka M,Ito M,Kato S,Ando K

更新日期：2011-09-15 00:00:00

abstract：:At present, one of the most sensitive assays for human erythropoietin (Ep) is a bioassay that measures the Ep-dependent proliferation of spleen cells from phenylhydrazine-treated mice after 24 hours in culture. We describe how this assay can be used as the basis of a very sensitive method for detecting mouse antibodie...

journal_title：Blood

authors： Wognum AW,Lansdorp PM,Eaves CJ,Krystal G

更新日期：1988-06-01 00:00:00

abstract：:Histone deacetylase 6 (HDAC6) is a heat shock protein 90 (hsp90) deacetylase. Treatment with pan-HDAC inhibitors or depletion of HDAC6 by siRNA induces hyperacetylation and inhibits ATP binding and chaperone function of hsp90. Treatment with 17-allylamino-demothoxy geldanamycin (17-AAG) also inhibits ATP binding and c...

journal_title：Blood

authors： Rao R,Fiskus W,Yang Y,Lee P,Joshi R,Fernandez P,Mandawat A,Atadja P,Bradner JE,Bhalla K

更新日期：2008-09-01 00:00:00

abstract：:Coated vesicles bearing the transferrin-transferrin receptor complex were isolated from rabbit reticulocytes by freeze-thaw cell lysis, followed by differential centrifugation with pelleting of vesicles at 100,000 g. Electronmicroscopy demonstrated the vesicles to have the characteristic morphology of coated vesicles,...

journal_title：Blood

authors： Choe HR,Moseley ST,Glass J,Nunez MT

更新日期：1987-10-01 00:00:00

abstract：:Techniques for the quantitation of virus-specific and alloantigen-reactive T cells vary in their measurement of clinically relevant T-cell effector populations, their sensitivity and quantitative accuracy, and the time required to obtain measurable results. We compared frequencies of Epstein-Barr virus (EBV)-specific ...

journal_title：Blood

authors： Koehne G,Smith KM,Ferguson TL,Williams RY,Heller G,Pamer EG,Dupont B,O'Reilly RJ

更新日期：2002-03-01 00:00:00

abstract：:In this investigation, we studied the importance of cellular glutathione (GSH) in the hexose monophosphate shunt (HMPS) activity of unstimulated human erythrocytes and the mechanism by which pyruvate stimulates the HMPS. The rate of HMPS activity was measured by the production of radioactive CO2 from 14C-1-glucose or ...

journal_title：Blood

authors： Sagone AL Jr,Balcerzak SP,Metz EN

更新日期：1975-01-01 00:00:00

abstract：:Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients....

journal_title：Blood

authors： Falanga A,Marchetti M,Evangelista V,Vignoli A,Licini M,Balicco M,Manarini S,Finazzi G,Cerletti C,Barbui T

更新日期：2000-12-15 00:00:00

abstract：:The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral gen...

journal_title：Blood

authors： Srinivasan A,York D,Ranganathan P,Ferguson R,Butler D Jr,Feorino P,Kalyanaraman V,Jaffe H,Curran J,Anand R

更新日期：1987-06-01 00:00:00