Abstract:
:In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal residual disease.
journal_name
Bloodjournal_title
Bloodauthors
Fleischman AGdoi
10.1182/blood-2012-02-406751subject
Has Abstractpub_date
2012-04-12 00:00:00pages
3376-7issue
15eissn
0006-4971issn
1528-0020pii
119/15/3376journal_volume
119pub_type
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