Abstract:
:Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones typed as B. Whereas about 50% of colonies from normal subjects heterozygous as the G-6-PD locus show type-A G-6-PD and 50% type B, only two of the 1308 colonies from the CML patients had type-A G-6-PD. These data provide little evidence for persistence of normal committed stem cells in CML, a finding in contrast to that made previously in polycythemia vera, another clonal stem cell myeloproliferative disorder.
journal_name
Bloodjournal_title
Bloodauthors
Singer JW,Fialkow PJ,Steinmann L,Najfeld V,Stein SJ,Robinson WAsubject
Has Abstractpub_date
1979-02-01 00:00:00pages
264-8issue
2eissn
0006-4971issn
1528-0020journal_volume
53pub_type
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