Chloroma (granulocytic sarcoma) without evidence of leukemia: facilitated light microscopic diagnosis.

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we g...

journal_title：Blood

authors： Chapuy B,Cheng H,Watahiki A,Ducar MD,Tan Y,Chen L,Roemer MG,Ouyang J,Christie AL,Zhang L,Gusenleitner D,Abo RP,Farinha P,von Bonin F,Thorner AR,Sun HH,Gascoyne RD,Pinkus GS,van Hummelen P,Wulf GG,Aster JC,Weinst

更新日期：2016-05-05 00:00:00

abstract：:Sickle red blood cells (RBC) become dehydrated as a consequence of potassium loss. This process depends at least partly on deoxygenation and may be influenced by the presence of oxygenation/deoxygenation cycles and the frequency of cycling. In this study, sickle RBC were subjected to approximately 180 oxygenation/deox...

journal_title：Blood

authors： McGoron AJ,Joiner CH,Palascak MB,Claussen WJ,Franco RS

更新日期：2000-03-15 00:00:00

abstract：:Cultured mononuclear phagocytes produce soluble factors that stimulate endothelial cells to release GM-colony-stimulating activity (GM-CSA). One such factor was recently identified as interleukin 1 (IL 1). Studies were designed to determine which types of granulopoietic factors are released by IL 1-stimulated endothel...

journal_title：Blood

authors： Zsebo KM,Yuschenkoff VN,Schiffer S,Chang D,McCall E,Dinarello CA,Brown MA,Altrock B,Bagby GC Jr

更新日期：1988-01-01 00:00:00

abstract：:Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...

journal_title：Blood

authors： Hokland P,Kerndrup G,Griffin JD,Ellegaard J

更新日期：1986-04-01 00:00:00

abstract：:Cytarabine (ara-C) requires activation into its triphosphorylated form, ara-CTP, to exert cytotoxic activity. Cytoplasmic 5'-nucleotidase (5NT) dephosphorylates ara-CMP, a key intermediate, preventing accumulation of ara-CTP and may reduce cellular sensitivity to the cytotoxic activity of ara-C. To determine whether t...

journal_title：Blood

authors： Galmarini CM,Graham K,Thomas X,Calvo F,Rousselot P,El Jafaari A,Cros E,Mackey JR,Dumontet C

更新日期：2001-09-15 00:00:00

abstract：:Healthy blood neutrophils are functionally quiescent in the bloodstream, have a short lifespan, and exit the circulation to carry out innate immune functions, or undergo rapid apoptosis and macrophage-mediated clearance to mitigate host tissue damage. Limitation of unnecessary intravascular neutrophil activation is al...

journal_title：Blood

authors： Lizcano A,Secundino I,Döhrmann S,Corriden R,Rohena C,Diaz S,Ghosh P,Deng L,Nizet V,Varki A

更新日期：2017-06-08 00:00:00

abstract：:In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the accuracy of these estimates is uncertain. We analyzed the dist...

journal_title：Blood

authors： McLaren CE,Gordeuk VR,Looker AC,Hasselblad V,Edwards CQ,Griffen LM,Kushner JP,Brittenham GM

更新日期：1995-09-01 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:Recurrent first trimester abortions led to evaluation of a 25-year-old woman. Studies revealed she had hypofibrinogenemia (68 mg/dL) without evidence of dysfibrinogenemia or increased fibrinogen turnover. She was also found to have a unique 46,XX, t(7;12) (p 15.2;q24.31) karyotype. Hypofibrinogenemia and identical chr...

journal_title：Blood

authors： Kitchens CS,Cruz AC,Kant JA

更新日期：1987-10-01 00:00:00

abstract：:It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive and BCR-ABL-positive [BCR-ABL+]) CD34+ cells. In the study described here, most such cells expressed a primitive phenotype (CD38-, CD...

journal_title：Blood

authors： Holyoake TL,Jiang X,Jorgensen HG,Graham S,Alcorn MJ,Laird C,Eaves AC,Eaves CJ

更新日期：2001-02-01 00:00:00

abstract：:The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cell lines (HMCLs) are highly sensitive to Gln depletion. In this study, we found that both HMCLs and primary bone marrow (BM) C...

journal_title：Blood

authors： Bolzoni M,Chiu M,Accardi F,Vescovini R,Airoldi I,Storti P,Todoerti K,Agnelli L,Missale G,Andreoli R,Bianchi MG,Allegri M,Barilli A,Nicolini F,Cavalli A,Costa F,Marchica V,Toscani D,Mancini C,Martella E,Dall'Asta V

更新日期：2016-08-04 00:00:00

abstract：:X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 tim...

journal_title：Blood

authors： Jain A,Kovacs JA,Nelson DL,Migueles SA,Pittaluga S,Fanslow W,Fan X,Wong DW,Massey J,Hornung R,Brown MR,Spinner JJ,Liu S,Davey V,Hill HA,Ochs H,Fleisher TA

更新日期：2011-10-06 00:00:00

abstract：:The acute myeloid leukemia (AML) treatment landscape has changed substantially since 2017. New targeted drugs have emerged, including venetoclax to target B-cell lymphoma 2, midostaurin and gilteritinib to target FLT3, and ivosidenib and enasidenib to target mutant isocitrate dehydrogenase 1 and 2, respectively. Other...

journal_title：Blood

authors： DiNardo CD,Wei AH

更新日期：2020-01-09 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:Analysis of molecular mechanisms associated with stem cell commitment and differentiation requires an in vitro assay that identifies the most primitive hematopoietic stem cells in human bone marrow. Such primitive stem cells usually do not form colonies in short-term semisolid assays and are best identified by their a...

journal_title：Blood

authors： Issaad C,Croisille L,Katz A,Vainchenker W,Coulombel L

更新日期：1993-06-01 00:00:00

abstract：:In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity...

journal_title：Blood

authors： Rajkumar SV,Gahrton G,Bergsagel PL

更新日期：2011-09-22 00:00:00

abstract：:Cytotoxic lymphocytes clear infected and transformed cells by releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has been documented previously. Although bidirectional trafficking of cytolytic machinery components along the endosomal pat...

journal_title：Blood

authors： Capuano C,Paolini R,Molfetta R,Frati L,Santoni A,Galandrini R

更新日期：2012-03-08 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：:We have previously shown that G-CSF-deficient (G-CSF(-/-)) mice are markedly protected from collagen-induced arthritis (CIA), which is the major murine model of rheumatoid arthritis, and now investigate the mechanisms by which G-CSF can promote inflammatory disease. Serum G-CSF levels were significantly elevated durin...

journal_title：Blood

authors： Eyles JL,Hickey MJ,Norman MU,Croker BA,Roberts AW,Drake SF,James WG,Metcalf D,Campbell IK,Wicks IP

更新日期：2008-12-15 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:Systemic inflammation perturbs the bone marrow environment by evicting resident B cells and favoring granulopoiesis over lymphopoiesis. Despite these conditions, a subset of marrow B cell remains to become activated and produce potent acute immunoglobulin M (IgM) responses. This discrepancy is currently unresolved and...

journal_title：Blood

authors： Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ

更新日期：2015-09-03 00:00:00

abstract：:Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring re...

journal_title：Blood

authors： Gardner R,Wu D,Cherian S,Fang M,Hanafi LA,Finney O,Smithers H,Jensen MC,Riddell SR,Maloney DG,Turtle CJ

更新日期：2016-05-19 00:00:00

abstract：:CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positive ALL and has a poo...

journal_title：Blood

authors： Maude SL,Tasian SK,Vincent T,Hall JW,Sheen C,Roberts KG,Seif AE,Barrett DM,Chen IM,Collins JR,Mullighan CG,Hunger SP,Harvey RC,Willman CL,Fridman JS,Loh ML,Grupp SA,Teachey DT

更新日期：2012-10-25 00:00:00

abstract：:Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (bet...

journal_title：Blood

authors： Santos M,Clevers H,de Sousa M,Marx JJ

更新日期：1998-04-15 00:00:00

abstract：:The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement therapy that affects up to 30% of previously untreated patients with severe hemophilia A. The development of inhibitors is a multifactorial complication i...

journal_title：Blood

authors： Gorski MM,Blighe K,Lotta LA,Pappalardo E,Garagiola I,Mancini I,Mancuso ME,Fasulo MR,Santagostino E,Peyvandi F

更新日期：2016-06-09 00:00:00

abstract：:Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cells leads to bone mar...

journal_title：Blood

authors： Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

更新日期：2011-04-21 00:00:00

abstract：:"Fetal" erythrocytes are present in older children and certain adults with hematologic disorders. To determine if regenerating bone marrow produces such cells, we examined the blood of seven allogeneic bone marrow transplant recipients. Six patients were engrafted with donor cells, while on e patients recovered autolo...

journal_title：Blood

authors： Alter BP,Rappeport JM,Huisman TH,Schroeder WA,Nathan DG

更新日期：1976-12-01 00:00:00

abstract：:ShcA is an important mediator of Ras/MAPK activation in PTK-regulated pathways triggered by surface receptors. This function is subserved by the constitutively expressed p52-kDa isoform. Besides activating Ras, p52Shc couples the TCR to Rho GTPases, and thereby participates in actin cytoskeleton remodeling in T cells....

journal_title：Blood

authors： Patrussi L,Ulivieri C,Lucherini OM,Paccani SR,Gamberucci A,Lanfrancone L,Pelicci PG,Baldari CT

更新日期：2007-09-15 00:00:00