T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics.

abstract：:Liver X receptors (LXRs) are nuclear receptors regulating lipid and cholesterol metabolism. Recent data revealed a cross talk between LXR and Toll-like receptor signaling in macrophages, indicating a role in immunity. Here, we show that LXRalpha is expressed in human myeloid dendritic cells (DCs) and induced during di...

journal_title：Blood

authors： Geyeregger R,Zeyda M,Bauer W,Kriehuber E,Säemann MD,Zlabinger GJ,Maurer D,Stulnig TM

更新日期：2007-05-15 00:00:00

abstract：:Bone disease is one of the most debilitating manifestations of multiple myeloma. A complex interdependence exists between myeloma bone disease and tumor growth, creating a vicious circle of extensive bone destruction and myeloma progression. Proteasome inhibitors have recently been shown to promote bone formation in v...

journal_title：Blood

authors： Terpos E,Sezer O,Croucher P,Dimopoulos MA

更新日期：2007-08-15 00:00:00

abstract：:The Scianna blood group encompasses the high-frequency antigens Sc1 and Sc3 and the low-frequency antigen Sc2. Another low-frequency antigen Rd (Radin) was suggested to belong to the Scianna blood group. The molecular basis of the Scianna blood group was unknown. The erythrocyte membrane-associated protein (ERMAP) sha...

journal_title：Blood

authors： Wagner FF,Poole J,Flegel WA

更新日期：2003-01-15 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:Adoptive transfer of allogeneic T cells has unmatched efficacy to eradicate leukemic cells. We therefore sought to evaluate in kinetic terms interactions between T cells and allogeneic leukemic cells. T cells primed against the model B6(dom1) minor histocompatibility antigen were adoptively transferred in irradiated B...

journal_title：Blood

authors： Meunier MC,Roy-Proulx G,Labrecque N,Perreault C

更新日期：2003-01-15 00:00:00

abstract：:Antithymocyte globulin (ATG) has recently been popularized as an effective treatment in myelodysplastic syndrome (MDS). We treated 8 anemic MDS patients (refractory anemia [RA] and refractory anemia with excess blasts [RAEB-1]) with ATG (40 mg/kg/d for 4 days) and prednisone in a phase 2 trial. The study was stopped e...

journal_title：Blood

authors： Steensma DP,Dispenzieri A,Moore SB,Schroeder G,Tefferi A

更新日期：2003-03-15 00:00:00

abstract：:Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA a...

journal_title：Blood

authors： Sekyere EO,Dunn LL,Suryo Rahmanto Y,Richardson DR

更新日期：2006-04-01 00:00:00

abstract：:The effectiveness of arabinosylcytosine (ara-C) for the treatment of acute myelogenous leukemia (AML) depends on the formation of its active metabolite, the triphosphate of ara-C (ara-CTP). Using biochemical modulation strategies to increase the accumulation of ara-CTP in leukemia blasts, a clinical protocol was desig...

journal_title：Blood

authors： Gandhi V,Estey E,Keating MJ,Chucrallah A,Plunkett W

更新日期：1996-01-01 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several groups studied the biological effects of MPs generated ex vivo. Here, we analyzed for the first time the impact of circulating MPs o...

journal_title：Blood

authors： Garnier Y,Ferdinand S,Garnier M,Cita KC,Hierso R,Claes A,Connes P,Hardy-Dessources MD,Lapouméroulie C,Lemonne N,Etienne-Julan M,El Nemer W,Romana M

更新日期：2020-07-09 00:00:00

abstract：:CD4(+), CD56(+) DC2 malignancies constitute a novel disease entity, which has recently been shown to arise from a transformed lymphoid-related plasmacytoid dendritic cell (DC2). Diagnosis is primarily based on a particular immunophenotype with tumor cells expressing CD4 and CD56 antigens in the absence of common lymph...

journal_title：Blood

authors： Leroux D,Mugneret F,Callanan M,Radford-Weiss I,Dastugue N,Feuillard J,Le Mée F,Plessis G,Talmant P,Gachard N,Uettwiller F,Pages MP,Mozziconacci MJ,Eclache V,Sibille C,Avet-Loiseau H,Lafage-Pochitaloff M

更新日期：2002-06-01 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft-versus-host disease (GVHD) in murine models of allogeneic hematopoietic stem cell transplantation. W...

journal_title：Blood

authors： Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

更新日期：2016-12-15 00:00:00

abstract：:Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. This study investigated the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice and the extent to which levels of soluble PECAM-1 (sPECAM-1)...

journal_title：Blood

authors： Kellermair J,Redwan B,Alias S,Jabkowski J,Panzenboeck A,Kellermair L,Winter MP,Weltermann A,Lang IM

更新日期：2013-11-07 00:00:00

abstract：:It has been suggested that neutrophil tissue repopulation following bone marrow transplantation (BMT) serves as an earlier and more relevant marker of susceptibility to infection than circulating neutrophil counts. In a previous study using an oral rinse protocol, we found that oral neutrophil recovery always preceded...

journal_title：Blood

authors： Cheretakis C,Leung R,Sun CX,Dror Y,Glogauer M

更新日期：2006-10-15 00:00:00

abstract：:In this single-center, cross-sectional study, we evaluated 44 very long-term survivors with a median follow-up of 17.5 years (range, 11-26 years) after hematopoietic stem cell transplantation. We assessed the telomere length difference in human leukocyte antigen-identical donor and recipient sibling pairs and searched...

journal_title：Blood

authors： Baerlocher GM,Rovó A,Müller A,Matthey S,Stern M,Halter J,Heim D,Rischewski J,Gratwohl A,Tichelli A

更新日期：2009-07-02 00:00:00

abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

journal_title：Blood

authors： Sanders KE,Lo J,Sligar SG

更新日期：2002-07-01 00:00:00

abstract：:An understanding of the number and contribution of individual pluripotent hematopoietic stem cells (HSCs) to the formation of blood lineages has important clinical implications for gene therapy and stem cell transplantation. We have been able to efficiently mark rhesus macaque long-term repopulating stem and progenito...

journal_title：Blood

authors： Kuramoto K,Follman D,Hematti P,Sellers S,Laukkanen MO,Seggewiss R,Metzger ME,Krouse A,Donahue RE,von Kalle C,Dunbar CE

更新日期：2004-09-01 00:00:00

abstract：:Mechanisms underlying fetal hemoglobin (HbF) reactivation in stress erythropoiesis have not been fully elucidated. We suggested that a key role is played by kit ligand (KL). Because glucocorticoids (GCs) mediate stress erythropoiesis, we explored their capacity to potentiate the stimulatory effect of KL on HbF reactiv...

journal_title：Blood

authors： Gabbianelli M,Testa U,Massa A,Morsilli O,Saulle E,Sposi NM,Petrucci E,Mariani G,Peschle C

更新日期：2003-04-01 00:00:00

abstract：:The transmembrane 4 superfamily (TM4SF) has come into prominence for its association with a wide range of cell surface molecules, especially integrins. We report that TM4SF molecules CD9, CD63, and CD81 are physically associated with c-kit receptor tyrosine kinase in the human factor-dependent myeloid cell line, MO7e....

journal_title：Blood

authors： Anzai N,Lee Y,Youn BS,Fukuda S,Kim YJ,Mantel C,Akashi M,Broxmeyer HE

更新日期：2002-06-15 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a preneoplastic condition that frequently develops into overt acute myeloid leukemia (AML). The P39 MDS/AML cell line manifested constitutive NF-kappaB activation. In this cell line, NF-kappaB inhibition by small interfering RNAs specific for p65 or chemical inhibitors including borte...

journal_title：Blood

authors： Braun T,Carvalho G,Coquelle A,Vozenin MC,Lepelley P,Hirsch F,Kiladjian JJ,Ribrag V,Fenaux P,Kroemer G

更新日期：2006-02-01 00:00:00

abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...

journal_title：Blood

authors： Colman RW,Jameson BA,Lin Y,Johnson D,Mousa SA

更新日期：2000-01-15 00:00:00

abstract：:Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of subunits of the receptor and the subsequent association with the receptor of the cytosolic protein tyrosine kinase Syk. The current experiments examined the functional importance of membrane association of Syk and the role of the SH2...

journal_title：Blood

authors： Sada K,Zhang J,Siraganian RP

更新日期：2001-03-01 00:00:00

abstract：:A pathogenic role for high-mobility group box 1 (HMGB1) protein has been postulated in severe sepsis. Activated protein C (APC) is the only drug approved by the Food and Drug Administration for severe sepsis; however, its effect on HMGB1 signaling has never been investigated. Here, we monitored the effect of APC on th...

journal_title：Blood

authors： Bae JS,Rezaie AR

更新日期：2011-10-06 00:00:00

abstract：:A recent clinical trial of gene therapy for X-linked severe combined immunodeficiency (XSCID) has shown that retroviral-mediated gene correction of bone marrow stem cells can lead to the development of normal immune function. These exciting results have been preceded by successful immune reconstitution in several XSCI...

journal_title：Blood

authors： Otsu M,Sugamura K,Candotti F

更新日期：2001-03-15 00:00:00

abstract：:Activation of intracellular signaling pathways is important for cellular transformation and tumorigenesis. The nonreceptor tyrosine kinases Jak1 and Jak3, which bind to the v-Abl oncoprotein, are constitutively activated in cells transformed with the Abelson murine leukemia virus. A mutant of p160 v-Abl lacking the Ja...

journal_title：Blood

authors： Oki S,Limnander A,Danial NN,Rothman PB

更新日期：2002-08-01 00:00:00

abstract：:Cytokine gene-modified tumor cells have increased immunogenicity and retain the antigenic repertoire of a particular neoplasia. However, practical concerns have led to an increased interest in allogeneic gene-transduced bystander cells as a broader source of cytokines for autologous tumor cell-based vaccines. Here, we...

journal_title：Blood

authors： Curti A,Parenza M,Colombo MP

更新日期：2003-01-15 00:00:00

abstract：:In 33 patients with thalassemia and idiopathic hemochromatosis, plasma ferritin protein levels ranged from 36 to 5,850 micrograms/L. The iron content of this ferritin as determined by immunoprecipitation ranged from undetectable amounts to 507 micrograms/L. The mean iron content of ferritin protein in those and other ...

journal_title：Blood

authors： Pootrakul P,Josephson B,Huebers HA,Finch CA

更新日期：1988-04-01 00:00:00

abstract：:Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the directional migration of DCs. Prostaglandin E2 (PGE2), present in inflam...

journal_title：Blood

authors： Yen JH,Khayrullina T,Ganea D

更新日期：2008-01-01 00:00:00

abstract：:Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in thrombosis. Both ligand-induced GPVI signaling through its coassociated Fc-receptor gamma-chain (FcRgamma) immunoreceptor tyrosine-activation motif (ITAM) and the calmodulin inhibitor, W7, dissociate calmodulin from GPVI and...

journal_title：Blood

authors： Gardiner EE,Karunakaran D,Arthur JF,Mu FT,Powell MS,Baker RI,Hogarth PM,Kahn ML,Andrews RK,Berndt MC

更新日期：2008-01-01 00:00:00

abstract：:It is known that at 37 degrees C plasmin may have two opposite effects on platelets: at high concentrations (greater than 1.5 caseinolytic units [CU]/mL), plasmin activates platelets; at lower concentrations (0.1 to 1.0 CU/mL) it inhibits platelet activation induced by thrombin, collagen, or calcium ionophore A23187. ...

journal_title：Blood

authors： Lu H,Soria C,Cramer EM,Soria J,Maclouf J,Perrot JY,Li H,Commin PL,Schumann F,Regnier O

更新日期：1991-03-01 00:00:00