Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults.

abstract：:Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-dependent and Toll/interleukin (IL)-1R domain-containing adapter, inducing interferon (IFN)-beta-dependent signaling, leading to production of proinflammatory mediators and type I interferon (IFN) to eliminate pathogens. However, unco...

journal_title：Blood

authors： Wang Y,Chen T,Han C,He D,Liu H,An H,Cai Z,Cao X

更新日期：2007-08-01 00:00:00

abstract：:The platelets of an infant with severe combined immune deficiency and adenosine deaminase deficiency showed markedly diminished responses to ADP-induced aggregation in vitro. This abnormality was corrected by the addition of purified adenosine deaminase in vitro. Exogenous adenosine added to platelet-rich plasma cause...

journal_title：Blood

authors： Lee CH,Evans SP,Rozenberg MC,Bagnara AS,Ziegler JB,Van der Weyden MB

更新日期：1979-03-01 00:00:00

abstract：:We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous leukemia (CML) in chronic, accelerated, or blastic phase and in 8 patients with myelofibrosis (MF) and 10 patients with multiple myeloma (MM). R115777 was administered at 600 mg orally twice dail...

journal_title：Blood

authors： Cortes J,Albitar M,Thomas D,Giles F,Kurzrock R,Thibault A,Rackoff W,Koller C,O'Brien S,Garcia-Manero G,Talpaz M,Kantarjian H

更新日期：2003-03-01 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00

abstract：:De novo erythroleukemia (EL) is a rare disease. Reported median survival are poor and vary from 4 to 14 months. The value of hematopoietic stem cell transplantation (HSCT) for EL is unknown. This EBMT registry study reports on the largest series of patients with EL treated with HSCT in first complete remission-103 aut...

journal_title：Blood

authors： Fouillard L,Labopin M,Gorin NC,Polge E,Prentice HG,Meloni G,Reiffers J,Pigneux A,Willemze R,Schattenberg A,Sica S,Lagrange M,Fenneteau O,Perot C,Frassoni F,Acute Leukemia Working Party of the EBMT.

更新日期：2002-11-01 00:00:00

abstract：:To test the efficacy of poststorage bedside leucodepletion of blood products in the prevention of primary HLA alloimmunization and its clinical sequelae, 172 patients with hematologic malignancy requiring intensive red blood cell and platelet support were randomized to receive either standard or filtered red blood cel...

journal_title：Blood

authors： Williamson LM,Wimperis JZ,Williamson P,Copplestone JA,Gooi HC,Morgenstern GR,Norfolk DR

更新日期：1994-05-15 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:In 21 patients with lymphoproliferative disease of granular lymphocytes (LDGL), we investigated the expression and the function of molecules belonging to TNF-receptor and TNF-ligand superfamilies (CD30/CD30L; CD40/CD40L; CD27/CD70; Fas [CD95]/FasL[CD95L]). Fourteen patients were characterized by a proliferation of gra...

journal_title：Blood

authors： Zambello R,Trentin L,Facco M,Siviero M,Galvan S,Piazza F,Perin A,Agostini C,Semenzato G

更新日期：2000-07-15 00:00:00

abstract：:Clonality studies of hematopoietic reconstitution after remission were performed in 24 female patients (pts) with leukemias characterized by specific molecular markers. At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philad...

journal_title：Blood

authors： Lo Coco F,Pelicci PG,D'Adamo F,Diverio D,Alimena G,Montefusco E,Arcese W,Avvisati G,De Felice L,Meloni G

更新日期：1993-07-15 00:00:00

abstract：:Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-m...

journal_title：Blood

authors： Barbano G,Saleh MN,Mori PG,LoBuglio AF,Shaw DR

更新日期：1989-02-15 00:00:00

abstract：:Pretreatment of endothelial cells with cytokines enhances the adherence of leukocytes, a process that is mediated by surface proteins expressed on both cell types. A three-dimensional model system for the simultaneous determination of leukocyte adherence and migration was used to study the contribution of CD11/CD18, e...

journal_title：Blood

authors： Hakkert BC,Kuijpers TW,Leeuwenberg JF,van Mourik JA,Roos D

更新日期：1991-11-15 00:00:00

abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

journal_title：Blood

authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

更新日期：1986-03-01 00:00:00

abstract：:Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates Lyn, the predominan...

journal_title：Blood

authors： Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ

更新日期：2011-07-28 00:00:00

abstract：:Cholesterol, in addition to providing rigidity to the fluid membrane, plays a critical role in receptor function, endocytosis, recycling, and signal transduction. In the present study, we examined the effect of membrane cholesterol on functional expression of tissue factor (TF), a cellular receptor for clotting factor...

journal_title：Blood

authors： Mandal SK,Iakhiaev A,Pendurthi UR,Rao LV

更新日期：2005-01-01 00:00:00

abstract：:High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectin...

journal_title：Blood

authors： Kirby EP,Mills DC,Holmsen H,Russo M

更新日期：1982-12-01 00:00:00

abstract：:The active form of vitamin D3 [1 alpha, 25-dihydroxyvitamin-D3 (1 alpha, 25(OH)2D3)] modulates the proliferation and differentiation of hematopoietic cells. Analogs of 1 alpha, 25(OH)2D3 that have greater potency may have the potential as adjuvant therapy for high-risk patients in remission for acute myelogenous leuke...

journal_title：Blood

authors： Munker R,Kobayashi T,Elstner E,Norman AW,Uskokovic M,Zhang W,Andreeff M,Koeffler HP

更新日期：1996-09-15 00:00:00

abstract：:Retrovirus-mediated gene transfer into long-lived human pluripotent hematopoietic stem cells (HSCs) is a widely sought but elusive goal. A major problem is the quiescent nature of most HSCs, with the perceived requirement for ex vivo prestimulation in cytokines to induce stem cell cycling and allow stable gene integra...

journal_title：Blood

authors： Rebel VI,Tanaka M,Lee JS,Hartnett S,Pulsipher M,Nathan DG,Mulligan RC,Sieff CA

更新日期：1999-04-01 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

journal_title：Blood

authors： Moulding DA,Quayle JA,Hart CA,Edwards SW

更新日期：1998-10-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

journal_title：Blood

authors： Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

更新日期：2005-03-01 00:00:00

abstract：:CCAAT/enhancer binding proteins (C/EBPs) are a family of factors that regulate cell growth and differentiation. These factors, particularly C/EBPalpha and C/EBPepsilon, have important roles in normal myelopoiesis. In addition, loss of C/EBP activity appears to have a role in the pathogenesis of myeloid disorders inclu...

journal_title：Blood

authors： Truong BT,Lee YJ,Lodie TA,Park DJ,Perrotti D,Watanabe N,Koeffler HP,Nakajima H,Tenen DG,Kogan SC

更新日期：2003-02-01 00:00:00

abstract：:Glycosaminoglycans (GAG) are a group of negatively charged molecules that have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, transforming growth factor-beta, IL-7, and interferon-gamma. The ability of GAG to interact with human IL-10 (h...

journal_title：Blood

authors： Salek-Ardakani S,Arrand JR,Shaw D,Mackett M

更新日期：2000-09-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) introduced in association with the luciferase reporter gene into Jurkat T cells was strongly activated by a combination of human neutrophils and phorbol myristate acetate (PMA). Activation was not observed when normal neutrophils were replaced ...

journal_title：Blood

authors： Klebanoff SJ,Headley CM

更新日期：1999-01-01 00:00:00

abstract：:Adoptive transfer of T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 has produced impressive results in treating patients with B-cell malignancies. Although these CAR-modified T cells target the same antigen, the designs of CARs vary as well as several key aspects of the clinic...

journal_title：Blood

authors： Park JH,Geyer MB,Brentjens RJ

更新日期：2016-06-30 00:00:00

abstract：:Human hematopoietic progenitor cells express L-selectin and also express PSGL-1, a ligand for all selectins. Using a shear-based adhesion assay, a hematopoietic cell L-selectin ligand (HCLL) that is expressed on the hematopoietic cell line KG1a and on normal human hematopoietic progenitors was previously identified. T...

journal_title：Blood

authors： Sackstein R,Dimitroff CJ

更新日期：2000-10-15 00:00:00

abstract：:It has recently been shown that the Naka antigen, which is absent in 3% to 11% of Japanese blood donors, is expressed on platelet glycoprotein IV (GPIV; CD36) (Tomiyama et al, BLOOD, 75:684, 1990). In the present studies, flow cytometry was used to distinguish differences in the reactivity of Naka+ and Naka- platelets...

journal_title：Blood

authors： Yamamoto N,Ikeda H,Tandon NN,Herman J,Tomiyama Y,Mitani T,Sekiguchi S,Lipsky R,Kralisz U,Jamieson GA

更新日期：1990-11-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for ∼20% of ALL cases. Intensive chemotherapy regimens result in cure rates >85% in children and <50% in adults, warranting a search of novel therapeutic strategies. Although immune-based therapies have tremendously improved the trea...

journal_title：Blood

authors： Tran Quang C,Zaniboni B,Humeau R,Lengliné E,Dourthe ME,Ganesan R,Singh S,Scheer JM,Asnafi V,Ghysdael J

更新日期：2020-09-10 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...

journal_title：Blood

authors： White JG,Krumwiede M

更新日期：1985-04-01 00:00:00

abstract：:Signaling through the receptor tyrosine kinase kit controls proliferation and differentiation of hematopoietic precursor cells and mast cells. Somatic point mutations of the receptor that constitutively activate kit signaling are associated with mastocytosis and various hematopoietic malignancies. We generated a Cre/l...

journal_title：Blood

authors： Gerbaulet A,Wickenhauser C,Scholten J,Peschke K,Drube S,Horny HP,Kamradt T,Naumann R,Müller W,Krieg T,Waskow C,Hartmann K,Roers A

更新日期：2011-02-10 00:00:00