Abstract：
:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for ∼20% of ALL cases. Intensive chemotherapy regimens result in cure rates >85% in children and <50% in adults, warranting a search of novel therapeutic strategies. Although immune-based therapies have tremendously improved the treatment of B-ALL and other B-cell malignancies, they are not yet available for T-ALL. We report here that humanized, non-Fcγ receptor (FcγR)-binding monoclonal antibodies (mAbs) to CD3 have antileukemic properties in xenograft (PDX) models of CD3+ T-ALL, resulting in prolonged host survival. We also report that these antibodies cooperate with chemotherapy to enhance antileukemic effects and host survival. Because these antibodies show only minor, manageable adverse effects in humans, they offer a new therapeutic option for the treatment of T-ALL. Our results also show that the antileukemic properties of anti-CD3 mAbs are largely independent of FcγR-mediated pathways in T-ALL PDXs.
journal_name
Bloodjournal_title
Bloodauthors
Tran Quang C,Zaniboni B,Humeau R,Lengliné E,Dourthe ME,Ganesan R,Singh S,Scheer JM,Asnafi V,Ghysdael Jdoi
10.1182/blood.2019003801subject
Has Abstractpub_date
2020-09-10 00:00:00pages
1298-1302issue
11eissn
0006-4971issn
1528-0020pii
460600journal_volume
136pub_type
杂志文章相关文献
BLOOD文献大全abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-01-15 00:00:00
abstract：:Current dendritic cell (DC)-based vaccines are based on ex vivo-generated autologous DCs loaded with antigen prior to readministration into patients. A more direct and less laborious strategy is to target antigens to DCs in vivo via specific surface receptors. Therefore, we developed a humanized antibody, hD1V1G2/G4 (...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-01-0318
更新日期：2005-08-15 00:00:00
abstract：:Karyotypes in multiple myeloma (MM) are complex and exhibit numerous structural and numerical aberrations. The largest subset of structural chromosome anomalies in clinical specimens and cell lines involves aberrations of chromosome 1. Unbalanced translocations and duplications involving all or part of the whole long ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:The molecular backgrounds of variants encountered in Afro-Caribbean black individuals and associated with the production of clinically significant antibodies against high-incidence antigens (anti-RH18, anti-RH34) and against Rhe epitopes were determined. We showed that RH:-18 phenotypes are produced by 3 distinct RHCE...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-01-0229
更新日期：2002-12-01 00:00:00
abstract：:Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2011-12-274019
更新日期：2012-08-09 00:00:00
abstract：:Identification of human hematopoietic stem cells and analysis of molecular mechanisms regulating their function require biological assays that permit differentiation in all hematopoietic lineages simultaneously. In this study, we established conditions that permit the joint expression of the B-lymphoid and myeloid pot...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-05-15 00:00:00
abstract：:The effects of human recombinant erythropoietin (rEpo) in the presence of other stimulators on the growth of clonogenic leukemic blast cells from ten Japanese patients with acute myeloblastic leukemia were studied with an in vitro leukemic blast colony assay in methylcellulose culture. With the addition of rEpo alone,...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：:Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles. Although blood-borne TF accumulates into the developing thrombus during thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation in vivo ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-03-0935
更新日期：2004-11-15 00:00:00
abstract：:Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length c...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-07-15 00:00:00
abstract：:Recent demonstration that Cromer-related human blood group antigens reside on decay-accelerating factor (DAF) has led to identification of an apparent null phenotype (Inab) for erythrocyte DAF. This study examined expression of other phosphatidylinositol (PI)-anchored proteins by Inab erythrocytes and showed that the ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Hematopoietic suppression is one of the serious problems induced by whole body irradiation. Granulocyte colony-stimulating factor (G-CSF) stimulates the progenitors of granulocytes and accelerates their recovery from bone marrow suppression induced by cytotoxic chemotherapy or radiation. On the other hand, G-CSF stimu...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in the pathology of heme...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.2019003986
更新日期：2020-08-06 00:00:00
abstract：:On the basis of the finding of alternatively spliced mRNAs, the alpha-subunit of the receptor for GM-CSF is thought to exist in both a membrane spanning (tmGMRalpha) and a soluble form (solGMRalpha). However, only limited data has been available to support that the solGMRalpha protein product exists in vivo. We hypoth...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-01-15 00:00:00
abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:In childhood acute lymphoblastic leukemia (ALL), early response to treatment is a powerful prognostic indicator. To identify genes associated with this response, we analyzed gene expression of diagnostic lymphoblasts from 189 children with ALL and compared the findings with minimal residual disease (MRD) levels on day...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-01-0322
更新日期：2006-08-01 00:00:00
abstract：:The TEL-JAK2 gene fusion, which has been identified in human leukemia, encodes a chimeric protein endowed with constitutive tyrosine kinase activity. TEL-JAK2 transgenic expression in the mouse lymphoid lineage results in fatal and rapid T-cell leukemia/lymphoma. In the present report we show that T-cell leukemic cell...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-09-048801
更新日期：2007-05-01 00:00:00
abstract：:A novel gene, jumonji was identified by a mouse gene trap strategy. The jumonji gene encodes a protein containing a putative DNA binding domain. The mice homozygous for jumonji gene with a BALB/cA genetic background show hypoplasia of the fetal liver and embryonic lethality, suggesting impaired hematopoiesis. In the p...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ~5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2012-10-462085
更新日期：2013-08-01 00:00:00
abstract：:The membrane-anchored CX3C chemokine fractalkine (FKN) is expressed on activated endothelium and is associated with the development of atherosclerosis. The potential of FKN in mediating platelet adhesion beyond platelet activation remains unexplored to date. A flow-based adhesion assay was used to study the adhesion o...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-02-335471
更新日期：2011-05-05 00:00:00
abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Pretreatment of endothelial cells with cytokines enhances the adherence of leukocytes, a process that is mediated by surface proteins expressed on both cell types. A three-dimensional model system for the simultaneous determination of leukocyte adherence and migration was used to study the contribution of CD11/CD18, e...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-11-15 00:00:00
abstract：:In chronic lymphocytic leukemia (CLL) patients with mutated IGHV, 3 recent studies have demonstrated prolonged progression-free survival (PFS) after treatment with fludarabine-cyclophosphamide-rituximab (FCR) chemoimmunotherapy. We performed a systematic review to assess the benefit of FCR for patients with CLL and id...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2017-07-731588
更新日期：2017-11-23 00:00:00
abstract：:Severe congenital neutropenia as well as primary myelofibrosis are rare in infancy. Elucidation of the underlying mechanism is important because it extends our understanding of the more common adult forms of these disorders. Using homozygosity mapping followed by exome sequencing, we identified a Thr224Asn mutation in...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-12-475566
更新日期：2013-06-20 00:00:00
abstract：:Concentrations of plasma fibrinopeptide A (FPA) were measured by radioimmunoassay in 50 patients with venous thromboembolism or disseminated intravascular coagulation or both. A consistent discrepancy was observed in values obtained with two anti-FPA antisera. Analysis of extracts from plasma of these patients by high...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:We report five patients who had greater than 30% peripheral blasts and less than 30% marrow blasts. By the current standards these cases would be classified as myelodysplastic syndrome. Four of five patients progressed to acute leukemia within approximately 1 1/2 months of developing greater than 30% peripheral blasts...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria. We studied five patients with advanced malignancy treated with IL-2. Eosinophilia was ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-09-15 00:00:00
abstract：:In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or immunosuppression. The primary limitation to the clinical application of IUHSCTx has been minimal donor cell engraftment, well below therapeutic levels...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-01-0016
更新日期：2002-08-01 00:00:00
abstract：:The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endot...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2007-02-069997
更新日期：2007-10-01 00:00:00
abstract：:In this issue of Blood, Pozzi et al demonstrate that removing an anionic cage promotes exposure of R169 thereby generating a protein C (PC) that is far more readily activated. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2012-05-427401
更新日期：2012-07-19 00:00:00
abstract：:The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at site...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
