The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib.

abstract：:The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 ...

journal_title：Blood

authors： Badoux XC,Keating MJ,Wen S,Lee BN,Sivina M,Reuben J,Wierda WG,O'Brien SM,Faderl S,Kornblau SM,Burger JA,Ferrajoli A

更新日期：2011-09-29 00:00:00

abstract：:Although the rheologic behavior of sickle erythrocytes (SS cells) is highly dependent on oxygen tension (pO2) and temperature, very little data exist regarding the effects of deoxygenation and reoxygenation on the rheology of "individual" SS cells at body temperature. We have devised and assessed a new experiment syst...

journal_title：Blood

authors： Itoh T,Chien S,Usami S

更新日期：1992-04-15 00:00:00

abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

journal_title：Blood

authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

更新日期：1986-03-01 00:00:00

abstract：:CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positive ALL and has a poo...

journal_title：Blood

authors： Maude SL,Tasian SK,Vincent T,Hall JW,Sheen C,Roberts KG,Seif AE,Barrett DM,Chen IM,Collins JR,Mullighan CG,Hunger SP,Harvey RC,Willman CL,Fridman JS,Loh ML,Grupp SA,Teachey DT

更新日期：2012-10-25 00:00:00

abstract：:The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age. How 5mC deamination contributes to cancer risk in different tissues remains unclear. Genomic ...

journal_title：Blood

authors： Sanders MA,Chew E,Flensburg C,Zeilemaker A,Miller SE,Al Hinai AS,Bajel A,Luiken B,Rijken M,Mclennan T,Hoogenboezem RM,Kavelaars FG,Fröhling S,Blewitt ME,Bindels EM,Alexander WS,Löwenberg B,Roberts AW,Valk PJM,Majews

更新日期：2018-10-04 00:00:00

abstract：:Autologous membrane-bound IgG was isolated from a subpopulation of human red blood cells (RBC) with specific density greater than 1.110, by affinity chromatography of purified RBC membrane glycoprotein preparations using immobilized wheat germ agglutinin and immobilized anti-human immunoglobulin (Ig) as immunoabsorben...

journal_title：Blood

authors： Alderman EM,Fudenberg HH,Lovins RE

更新日期：1981-08-01 00:00:00

abstract：:Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mic...

journal_title：Blood

authors： Kraft AR,Krux F,Schimmer S,Ohlen C,Greenberg PD,Dittmer U

更新日期：2007-04-01 00:00:00

abstract：:The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V(H)) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. We have now investigated activation...

journal_title：Blood

authors： Petlickovski A,Laurenti L,Li X,Marietti S,Chiusolo P,Sica S,Leone G,Efremov DG

更新日期：2005-06-15 00:00:00

abstract：:IL-15 is an important cytokine for the function of the immune system, but the form(s) of IL-15 produced in the human body are not fully characterized. Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Rα) in the same cell allows for efficient production, surface display, and eventual cleavage a...

journal_title：Blood

authors： Bergamaschi C,Bear J,Rosati M,Beach RK,Alicea C,Sowder R,Chertova E,Rosenberg SA,Felber BK,Pavlakis GN

更新日期：2012-07-05 00:00:00

abstract：:Incubation of normal human plasma with dextran sulfate for 7 min at 4 degrees C generates kallikrein amidolytic activity. No kallikrein activity is generated in factor XII or prekallikrein-deficient plasma and only small amounts (8%) in high molecular weight (HMW) kininogen-deficient plasma. Addition of specific antis...

journal_title：Blood

authors： van der Graaf F,Keus FJ,Vlooswijk RA,Bouma BN

更新日期：1982-06-01 00:00:00

abstract：:NOTCH1 and SF3B1 mutations have been previously reported to have prognostic significance in chronic lymphocytic leukemia but to date they have not been validated in a prospective, controlled clinical trial. We have assessed the impact of these mutations in a cohort of 494 patients treated within the randomized phase 3...

journal_title：Blood

authors： Oscier DG,Rose-Zerilli MJ,Winkelmann N,Gonzalez de Castro D,Gomez B,Forster J,Parker H,Parker A,Gardiner A,Collins A,Else M,Cross NC,Catovsky D,Strefford JC

更新日期：2013-01-17 00:00:00

abstract：:Interleukin-1 (IL-1) has been shown to ameliorate the hematopoietic toxicities of antitumor chemotherapeutic agents in both mice and humans. However, IL-1 toxicity in humans is considerable and is similar to the systemic inflammatory toxicities induced by IL-3, IL-6, and other cytokines with pleiotropic biologic activ...

journal_title：Blood

authors： Rinehart J,Delamater EW,Keville L,Measel J

更新日期：1994-09-01 00:00:00

abstract：:Bacterial DNA and synthetic oligodeoxynucleotides containing the CpG motif (CpG ODN) can activate various immune cell subsets, including natural killer cells and macrophages. We evaluated whether the combination of CpG ODN and antitumor monoclonal antibody is effective at preventing tumor growth in an immunocompetent ...

journal_title：Blood

authors： Wooldridge JE,Ballas Z,Krieg AM,Weiner GJ

更新日期：1997-04-15 00:00:00

abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

journal_title：Blood

authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

更新日期：1996-04-01 00:00:00

abstract：:Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

journal_title：Blood

authors： McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

更新日期：1994-11-01 00:00:00

abstract：:In this study we investigated telomere restriction fragment (TRF) length in a panel of mature B-cell lymphoproliferative disorders (MBCLDs) and correlated this parameter with histology and histopathogenesis in relation to the germinal center (GC). We assessed 123 MBCLD samples containing 80% or more tumor cells. TRF l...

journal_title：Blood

authors： Ladetto M,Compagno M,Ricca I,Pagano M,Rocci A,Astolfi M,Drandi D,di Celle PF,Dell'Aquila M,Mantoan B,Vallet S,Pagliano G,De Marco F,Francese R,Santo L,Cuttica A,Marinone C,Boccadoro M,Tarella C

更新日期：2004-06-15 00:00:00

abstract：:Members of the 14-3-3 family of proteins function as adapters/modulators that recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular proteins and play fundamental roles in signal transduction pathways of eukaryotic cells. In platelets, 14-3-3 plays a wide range of regulatory roles in phosp...

journal_title：Blood

authors： Chen Y,Ruggeri ZM,Du X

更新日期：2018-05-31 00:00:00

abstract：:Multiple mechanisms operate to ensure T-cell tolerance toward self-antigens. Three main processes have been described: clonal deletion, anergy, and deviation to CD4(+) regulatory T cells (Tregs) that suppress autoreactive T cells that have escaped the first 2 mechanisms. Although it is accepted that dendritic cells (D...

journal_title：Blood

authors： Morlacchi S,Soldani C,Viola A,Sarukhan A

更新日期：2011-07-28 00:00:00

abstract：:Hypereosinophilic syndromes (HESs) are a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end organ manifestations attributable to the eosinophilia or unexplained in the clinical setting. Whereas corticosteroids remain the mainstay of treatment for most patients, recent dia...

journal_title：Blood

authors： Klion AD

更新日期：2009-10-29 00:00:00

abstract：:Human granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances numerous functions of mature neutrophils (PMN) including phagocytosis, superoxide responses to chemotaxins, antibody-dependent cellular cytotoxicity, and expression of complement receptors. A central question concerns whether the mechanism of enh...

journal_title：Blood

authors： Fletcher MP,Gasson JC

更新日期：1988-03-01 00:00:00

abstract：:Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

journal_title：Blood

authors： Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

更新日期：2009-11-26 00:00:00

abstract：:Hepatitis B virus (HBV)-infected individuals are occasionally used as donors for bone marrow transplantation (BMT). We studied the rate of HBV infection and the clinical expression of the associated liver disease in patients receiving marrow from HBsAg+ donors. We performed a retrospective survey in 14 BMT units in It...

journal_title：Blood

authors： Locasciulli A,Alberti A,Bandini G,Polchi P,Arcese W,Alessandrino P,Bosi A,Testa M,Bacigalupo A

更新日期：1995-10-15 00:00:00

abstract：:The transcription factor TAL1 has major functions during embryonic hematopoiesis and in adult erythropoiesis and megakaryocytopoiesis. These functions rely on different TAL1 structural domains that are responsible for dimerization, transactivation, and DNA binding. Previous work, most often done in mice, has shown tha...

journal_title：Blood

authors： Ravet E,Reynaud D,Titeux M,Izac B,Fichelson S,Roméo PH,Dubart-Kupperschmitt A,Pflumio F

更新日期：2004-05-01 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by...

journal_title：Blood

authors： Casper C,Nichols WG,Huang ML,Corey L,Wald A

更新日期：2004-03-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal antibody directed at CD20 with significant activity in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of tumor cytotoxicity different from cytotoxic chemotherapy have been proposed for this therapeutic antibody including antibody-dependent ce...

journal_title：Blood

authors： Byrd JC,Kitada S,Flinn IW,Aron JL,Pearson M,Lucas D,Reed JC

更新日期：2002-02-01 00:00:00

abstract：:LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecule...

journal_title：Blood

authors： Borges L,Kubin M,Kuhlman T

更新日期：2003-02-15 00:00:00

abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...

journal_title：Blood

authors： Greco NJ,Tenner TE Jr,Tandon NN,Jamieson GA

更新日期：1990-05-15 00:00:00

abstract：:Recent studies performed in mice knocked out for the tumor necrosis factor (TNF ), the lymphotoxin-alpha, or the type I TNF receptor (R), genes have shown that these animals display gross defects in germinal center (GC) formation, suggesting that members of the TNF and TNFR superfamilies are involved in the control of...

journal_title：Blood

authors： Corcione A,Ottonello L,Tortolina G,Tasso P,Ghiotto F,Airoldi I,Taborelli G,Malavasi F,Dallegri F,Pistoia V

更新日期：1997-12-01 00:00:00

abstract：:Normal human B cell proliferation is controlled by various immunoregulatory signals including the T cell-derived lymphokine B cell growth factor (BCGF). The role of BCGF in the regulation of malignant B cell proliferation is unclear. Therefore, we studied the proliferative response of purified chronic lymphocytic leuk...

journal_title：Blood

authors： Perri RT

更新日期：1986-04-01 00:00:00

abstract：:This study examines the role of neutrophils (PMN) in the pathogenesis of endotoxin-induced microclot formation. It is intended to clarify whether granulocytes are involved in endotoxin-induced activation of intravascular coagulation (generation of soluble fibrin) and/or in endotoxin-induced precipitation of soluble fi...

journal_title：Blood

authors： Müller-Berghaus G,Eckhardt T

更新日期：1975-05-01 00:00:00