Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes.

abstract：:Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, ...

journal_title：Blood

authors： Welner RS,Pelayo R,Nagai Y,Garrett KP,Wuest TR,Carr DJ,Borghesi LA,Farrar MA,Kincade PW

更新日期：2008-11-01 00:00:00

abstract：:Humans and grey collie dogs with cyclic neutropenia are known to suffer from an increased rate of bacterial infection. Because of the previously described microanatomic abnormalities of lysosome formation found in the polymorphonuclear leukocytes (PMNs) of dogs with canine cyclic neutropenia, studies of these cells we...

journal_title：Blood

authors： Chusid MJ,Bujak JS,Dale DC

更新日期：1975-12-01 00:00:00

abstract：:Activation of Janus tyrosine kinases (Jak) and Signal transducers and activators of transcription (Stat) after ligation of major histocompatibility complex class I (MHC-I) was explored in Jurkat T cells. Cross-linking of MHC-I mediated tyrosine phosphorylation of Tyk2, but not Jak1, Jak2, and Jak3. In addition, the tr...

journal_title：Blood

authors： Skov S,Nielsen M,Bregenholt S,Odum N,Claesson MH

更新日期：1998-05-15 00:00:00

abstract：:In 21 patients with lymphoproliferative disease of granular lymphocytes (LDGL), we investigated the expression and the function of molecules belonging to TNF-receptor and TNF-ligand superfamilies (CD30/CD30L; CD40/CD40L; CD27/CD70; Fas [CD95]/FasL[CD95L]). Fourteen patients were characterized by a proliferation of gra...

journal_title：Blood

authors： Zambello R,Trentin L,Facco M,Siviero M,Galvan S,Piazza F,Perin A,Agostini C,Semenzato G

更新日期：2000-07-15 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single in vivo treatment of se...

journal_title：Blood

authors： Ezekowitz RA,Sieff CA,Dinauer MC,Nathan DG,Orkin SH,Newburger PE

更新日期：1990-12-15 00:00:00

abstract：:We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin alphaIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable the storage of FIX in platelet alpha-granules and corrects the mur...

journal_title：Blood

authors： Zhang G,Shi Q,Fahs SA,Kuether EL,Walsh CE,Montgomery RR

更新日期：2010-08-26 00:00:00

abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

journal_title：Blood

authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

更新日期：2008-12-01 00:00:00

abstract：:ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative stat...

journal_title：Blood

authors： Neubauer A,Shannon K,Liu E

更新日期：1991-02-01 00:00:00

abstract：:Hematopoietic transplantation is the preferred treatment for many patients with hematologic malignancies. Some patients may develop invasive fungal diseases (IFDs) during initial chemotherapy, which need to be considered when assessing patients for transplantation and treatment posttransplantation. Given the associate...

journal_title：Blood

authors： Puerta-Alcalde P,Champlin RE,Kontoyiannis DP

更新日期：2020-12-10 00:00:00

abstract：:Considerable evidence indicates that activation of the contact system of intrinsic coagulation plays a role in the pathogenesis of septic shock. To monitor contact activation in patients with sepsis, we developed highly sensitive radioimmunoassays (RIAs) for factor XIIa-Cl(-)-inhibitor (Cl(-)-Inh) and kallikrein-Cl(-)...

journal_title：Blood

authors： Nuijens JH,Huijbregts CC,Eerenberg-Belmer AJ,Abbink JJ,Strack van Schijndel RJ,Felt-Bersma RJ,Thijs LG,Hack CE

更新日期：1988-12-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Rapamycin has been sh...

journal_title：Blood

authors： Teachey DT,Obzut DA,Axsom K,Choi JK,Goldsmith KC,Hall J,Hulitt J,Manno CS,Maris JM,Rhodin N,Sullivan KE,Brown VI,Grupp SA

更新日期：2006-09-15 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:We studied T-cell reconstitution in 31 primary T-cell-immunodeficient patients who had undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 patients, there was no evidence of myeloid chimerism because little or no myeloablation had been performed. Given this context, we sought facto...

journal_title：Blood

authors： Cavazzana-Calvo M,Carlier F,Le Deist F,Morillon E,Taupin P,Gautier D,Radford-Weiss I,Caillat-Zucman S,Neven B,Blanche S,Cheynier R,Fischer A,Hacein-Bey-Abina S

更新日期：2007-05-15 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00

abstract：:Although chemotherapy can induce complete responses in patients with chronic lymphocytic leukemia (CLL), it is not considered curative. Treated patients generally develop recurrent disease requiring additional therapy, which can cause worsening immune dysfunction, myelosuppression, and selection for chemotherapy-resis...

journal_title：Blood

authors： Kater AP,van Oers MH,Kipps TJ

更新日期：2007-10-15 00:00:00

abstract：:From October 1987 to December 1990, 101 patients with acute myeloid leukemia (AML) were randomized to be transplanted in first complete remission (CR1). Preparative regimen including Cytoxan (120 mg/kg) with total body irradiation (CYTBI) (N = 50) or busulfan (16 mg/kg) (BUSCY) (N = 51) was followed by allogeneic bone...

journal_title：Blood

authors： Blaise D,Maraninchi D,Archimbaud E,Reiffers J,Devergie A,Jouet JP,Milpied N,Attal M,Michallet M,Ifrah N

更新日期：1992-05-15 00:00:00

abstract：:The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or wheth...

journal_title：Blood

authors： Taveirne S,Filtjens J,Van Ammel E,De Colvenaer V,Kerre T,Taghon T,Vandekerckhove B,Plum J,Held W,Leclercq G

更新日期：2011-07-14 00:00:00

abstract：:Before the contemporary development of rationally designed antineoplastic therapies, cladribine was identified as a lymphocyte-specific agent. Its profound impact on the natural history of hairy cell leukemia, with responses approaching 100% and a median duration of response of nearly a decade after only a single 7-da...

journal_title：Blood

authors： Sigal DS,Miller HJ,Schram ED,Saven A

更新日期：2010-10-21 00:00:00

abstract：:We show here that a human leukemic cell line, PER-117, bearing the markers of a T-cell precursor phenotype, can be induced to express receptors for interleukin-2 (IL-2). These IL-2 receptors could be demonstrated to mediate a physiologic response to the lymphokine for which the high-affinity form of the IL-2 receptor ...

journal_title：Blood

authors： Kees UR

更新日期：1988-11-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. The spectrum of its biologic and molecular activities in healthy individuals is coming into sha...

journal_title：Blood

authors： Anderlini P,Champlin RE

更新日期：2008-02-15 00:00:00

abstract：:To test the hypothesis that skeletal muscle myosins can directly influence blood coagulation and thrombosis, ex vivo studies of the effects of myosin on thrombogenesis in fresh human blood were conducted. Addition of myosin to blood augmented the thrombotic responses of human blood flowing over collagen-coated surface...

journal_title：Blood

authors： Deguchi H,Sinha RK,Marchese P,Ruggeri ZM,Zilberman-Rudenko J,McCarty OJT,Cohen MJ,Griffin JH

更新日期：2016-10-06 00:00:00

abstract：:We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb). Infusion of 0.6 mg/...

journal_title：Blood

authors： Greinix HT,Ladiges WC,Graham TC,Maslan S,Raff RF,Sandmaier BM,Appelbaum FR,Schuening FG,Deeg HJ,Storb R

更新日期：1991-10-15 00:00:00

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected in the Reed-Sternberg (RS) cells of mixed cellularity Hodgkin'...

journal_title：Blood

authors： Gulley ML,Eagan PA,Quintanilla-Martinez L,Picado AL,Smir BN,Childs C,Dunn CD,Craig FE,Williams JW Jr,Banks PM

更新日期：1994-03-15 00:00:00

abstract：:Significant comorbidites and lethality complicate GVHD and its treatment. Targeting the cytokine milieu may improve GVHD control; and IL6 is an attractive candidate, given its role in dendritic cell activation and T-cell differentiation. Tocilizumab is a humanized mAb to IL6-receptor-α (IL6R-α), which is Food and Drug...

journal_title：Blood

authors： Betts BC,St Angelo ET,Kennedy M,Young JW

更新日期：2011-11-10 00:00:00

abstract：:The reduction of nitroblue tetrazolium dye by human neutrophils was measured in the presence of serum in which the complement system had been activated through the alternate pathway by interaction with inulin. Neutrophils incubated with serum inulin supernatants reduced the dye and showed a general increase in oxidati...

journal_title：Blood

authors： Strauss RG,Mauer AM,Asbrock T,Spitzer RE,Stitzel AE

更新日期：1975-06-01 00:00:00

abstract：:The nature of cells present in the blood, marrow, and spleen of patients with hairy cell leukemia is largely debated. These cells have been tentatively categorized on the basis of either monocytic or lymphocytic markers, and the accumulating data points to the fact that they share some characteristics of both cell typ...

journal_title：Blood

authors： Reyes F,Gourdin MF,Farcet JP,Dreyfus B,Breton-Gorius J

更新日期：1978-09-01 00:00:00

abstract：:Oxygen deprivation (hypoxia) is a consistent component of ischemia that induces an inflammatory and prothrombotic response in the endothelium. In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-b...

journal_title：Blood

authors： Akman HO,Zhang H,Siddiqui MA,Solomon W,Smith EL,Batuman OA

更新日期：2001-12-01 00:00:00