Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection.

abstract：:In this issue of Blood, Rowley et al report that noncoding RNAs precisely regulate the messenger RNA (mRNA) profile in platelets. Interfering in this process using genetically engineered mice affects hemostatic and thrombotic functions of platelets. ...

journal_title：Blood

authors： Boilard E,Belleannée C

更新日期：2016-04-07 00:00:00

abstract：:Gene expression patterns of CD34(+)CD38(-) cells derived from human embryonic stem cells (ESCs) were compared with those of cells isolated from adult human bone marrow (BM) using microarrays; 1692 and 1494 genes were expressed at levels at least 3-fold above background in cells from BM and ESCs, respectively. Of these...

journal_title：Blood

authors： Lu SJ,Li F,Vida L,Honig GR

更新日期：2004-06-01 00:00:00

abstract：:Posttranscriptional modification of histones by methylation plays an important role in regulating Ag-driven T-cell responses. We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation. The functional relevance of ...

journal_title：Blood

authors： He S,Xie F,Liu Y,Tong Q,Mochizuki K,Lapinski PE,Mani RS,Reddy P,Mochizuki I,Chinnaiyan AM,Mineishi S,King PD,Zhang Y

更新日期：2013-12-12 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:Scurfy mice develop CD4 T-cell-mediated lymphoproliferative disease leading to death within 4 weeks of age. The scurfy mutation causes loss of function of the foxp3 gene (foxp3(sf)), which is essential for development and maintenance of naturally occurring regulatory CD4 T cells (nTregs). In humans, mutations of the f...

journal_title：Blood

authors： Singh N,Chandler PR,Seki Y,Baban B,Takezaki M,Kahler DJ,Munn DH,Larsen CP,Mellor AL,Iwashima M

更新日期：2007-08-15 00:00:00

abstract：:CD22 is an important immunotherapeutic target on B-cell malignancies, particularly hairy cell leukemia (HCL), but its soluble extracellular domain, sCD22, has not yet been reported in the blood. By immunoaffinity and enzyme-linked immunosorbent assay techniques using anti-CD22 monoclonal antibodies, we identified the ...

journal_title：Blood

authors： Matsushita K,Margulies I,Onda M,Nagata S,Stetler-Stevenson M,Kreitman RJ

更新日期：2008-09-15 00:00:00

abstract：:In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region. ...

journal_title：Blood

authors： Beà S

更新日期：2014-03-27 00:00:00

abstract：:An in vitro system has been developed that mimics the passage of erythrocytes from the bone marrow to the circulation. Bone marrow egress and its proper regulation are vital physiologic processes. However, because of the inaccessibility of the marrow, it is difficult to evaluate the various factors important in contro...

journal_title：Blood

authors： Waugh RE,Sassi M

更新日期：1986-07-01 00:00:00

abstract：:Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, perip...

journal_title：Blood

authors： Moir S,Buckner CM,Ho J,Wang W,Chen J,Waldner AJ,Posada JG,Kardava L,O'Shea MA,Kottilil S,Chun TW,Proschan MA,Fauci AS

更新日期：2010-12-16 00:00:00

abstract：:Intracellular oxidative stress in cells transformed by the BCR-ABL oncogene is associated with increased DNA double-strand breaks. Imprecise repair of these breaks can result in the accumulation of mutations, leading to therapy-related drug resistance and disease progression. Using several BCR-ABL model systems, we fo...

journal_title：Blood

authors： Fernandes MS,Reddy MM,Gonneville JR,DeRoo SC,Podar K,Griffin JD,Weinstock DM,Sattler M

更新日期：2009-08-27 00:00:00

abstract：:Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during mur...

journal_title：Blood

authors： Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

更新日期：2009-03-19 00:00:00

abstract：:Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we examine EZH2 protein tu...

journal_title：Blood

authors： Li B,Yan J,Phyu T,Fan S,Chung TH,Mustafa N,Lin B,Wang L,Eichhorn PJA,Goh BC,Ng SB,Kappei D,Chng WJ

更新日期：2019-12-05 00:00:00

abstract：:Low-grade follicular non-Hodgkin's lymphomas are characterized by the presence of a t(14;18) chromosomal translocation that results in deregulation of the B-cell lymphoma (Bcl-2) gene. Studies in cell lines and transgenic animal models have suggested that this results in the suppression of apoptotic cell death in germ...

journal_title：Blood

authors： Johnson PW,Watt SM,Betts DR,Davies D,Jordan S,Norton AJ,Lister TA

更新日期：1993-09-15 00:00:00

abstract：:Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we generated mice with disruption of MYH9 in megakaryocytes. MYH9Delta mice displayed macrothro...

journal_title：Blood

authors： Léon C,Eckly A,Hechler B,Aleil B,Freund M,Ravanat C,Jourdain M,Nonne C,Weber J,Tiedt R,Gratacap MP,Severin S,Cazenave JP,Lanza F,Skoda R,Gachet C

更新日期：2007-11-01 00:00:00

abstract：:Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and a...

journal_title：Blood

authors： To LB,Levesque JP,Herbert KE

更新日期：2011-10-27 00:00:00

abstract：:We report the results of unrelated cord blood transplantation (CBT) for 18 adult patients with de novo acute myeloid leukemia (AML). The median age was 43 years, the median weight was 55.2 kg, and the median number of cryopreserved nucleated cells was 2.51 x 107/kg. Seventeen patients had myeloid reconstitution and th...

journal_title：Blood

authors： Ooi J,Iseki T,Takahashi S,Tomonari A,Takasugi K,Shimohakamada Y,Yamada T,Ishii K,Ohno N,Nagamura F,Uchimaru K,Tojo A,Asano S

更新日期：2004-01-15 00:00:00

abstract：:The peripheral blood lymphocytes from 42 patients with multiple myeloma (MM) and 13 patients with monoclonal gammopathy of undetermined significance (MGUS) were studied by three-color immunofluorescence (IF) using antibodies directed to a broad range of B-cell markers (CD19, CD20, CD21, CD24), CALLA (CD10), PCA-1 (a p...

journal_title：Blood

authors： Jensen GS,Mant MJ,Belch AJ,Berenson JR,Ruether BA,Pilarski LM

更新日期：1991-08-01 00:00:00

abstract：:To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR). Increased AChE hydrolytic activity in the peripheral blood of TgR mice was associated with increased thrombopoietin levels and platelet counts...

journal_title：Blood

authors： Pick M,Perry C,Lapidot T,Guimaraes-Sternberg C,Naparstek E,Deutsch V,Soreq H

更新日期：2006-04-15 00:00:00

abstract：:Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in ...

journal_title：Blood

authors： Takahashi Y,Hori T,Cooper TK,Liao J,Desai N,Serfass JM,Young MM,Park S,Izu Y,Wang HG

更新日期：2013-02-28 00:00:00

abstract：:Murine bone marrow cells were fractionated by fluorescence-activated cell sorting into Rh123lo Lin- c-kit+ Ly6A+, Rh123hi Lin-c-kit+ Ly6A+, and Lin- c-kit+ Ly6A- populations within which most, if not all, of the hematopoietic activities of the marrow resided. The Rh123lo Lin- c-kit+Ly6A+ cells, which consist exclusive...

journal_title：Blood

authors： Li CL,Johnson GR

更新日期：1995-03-15 00:00:00

abstract：:From October 1987 to December 1990, 101 patients with acute myeloid leukemia (AML) were randomized to be transplanted in first complete remission (CR1). Preparative regimen including Cytoxan (120 mg/kg) with total body irradiation (CYTBI) (N = 50) or busulfan (16 mg/kg) (BUSCY) (N = 51) was followed by allogeneic bone...

journal_title：Blood

authors： Blaise D,Maraninchi D,Archimbaud E,Reiffers J,Devergie A,Jouet JP,Milpied N,Attal M,Michallet M,Ifrah N

更新日期：1992-05-15 00:00:00

abstract：:The addition of a T-cell growth-promoting medium (PHA-TCM) to culture conditions that support growth of multi-lineage hemopoietic colonies enhances the proliferation of cells with lymphoid morphology within these colonies. These cells were identified as T lymphocytes by their ability to form rosettes with SRBC and the...

journal_title：Blood

authors： Messner HA,Izaquirre CA,Jamal N

更新日期：1981-08-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which th...

journal_title：Blood

authors： Sachs UJ,Hattar K,Weissmann N,Bohle RM,Weiss T,Sibelius U,Bux J

更新日期：2006-02-01 00:00:00

abstract：:Reticular dysgenesis is a rare inherited immunodeficiency characterized by the lack of blood monocytes and neutrophils and low lymphocyte counts, contrasting with normal red blood cell counts and normal or decreased platelet counts. Whether dendritic cells or macrophages, both of which derive primarily from blood mono...

journal_title：Blood

authors： Emile JF,Geissmann F,Martin OC,Radford-Weiss I,Lepelletier Y,Heymer B,Espanol T,de Santes KB,Bertrand Y,Brousse N,Casanova JL,Fischer A

更新日期：2000-07-01 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to...

journal_title：Blood

authors： Lentz SR

更新日期：2016-11-17 00:00:00

abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

journal_title：Blood

authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

更新日期：1998-06-15 00:00:00

abstract：:Treatment outcomes for older patients with acute myeloid leukemia (AML) have remained dismal. This randomized, phase 2 trial in AML patients not considered suitable for intensive induction therapy compared low-dose cytarabine (LDAC) with or without volasertib, a highly potent and selective inhibitor of polo-like kinas...

journal_title：Blood

authors： Döhner H,Lübbert M,Fiedler W,Fouillard L,Haaland A,Brandwein JM,Lepretre S,Reman O,Turlure P,Ottmann OG,Müller-Tidow C,Krämer A,Raffoux E,Döhner K,Schlenk RF,Voss F,Taube T,Fritsch H,Maertens J

更新日期：2014-08-28 00:00:00

abstract：:Human monocytes generate the procoagulant tissue factor (MTF) following exposure to a variety of immune stimuli in vitro. The generation of MTF is modified by T cells, lymphokines, and immunoregulatory lipoproteins, and recent studies have shown that MTF can be activated in an immune-specific manner following exposure...

journal_title：Blood

authors： Edwards RL,Perla D

更新日期：1984-09-01 00:00:00

abstract：:Impaired immune reconstitution has moved to the forefront of clinical problems limiting progress in allogeneic bone marrow transplantation (BMT). The identification of therapies that can enhance immune reconstitution by increasing thymopoiesis is critical to solving this problem. Interleukin 7 (IL-7) is the most poten...

journal_title：Blood

authors： Sinha ML,Fry TJ,Fowler DH,Miller G,Mackall CL

更新日期：2002-10-01 00:00:00