In vitro platelet abnormality in adenosine deaminase deficiency and severe combined immunodeficiency.

abstract：:Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

journal_title：Blood

authors： Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

更新日期：1995-05-15 00:00:00

abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

journal_title：Blood

authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

更新日期：1996-09-15 00:00:00

abstract：:Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secret...

journal_title：Blood

authors： Yee C,Biondi A,Wang XH,Iscove NN,de Sousa J,Aarden LA,Wong GG,Clark SC,Messner HA,Minden MD

更新日期：1989-08-01 00:00:00

abstract：:In a double-blind study, we compared the postoperative (post-op) blood loss in 161 children undergoing open heart surgery with cardiopulmonary bypass whose immediate post-op transfusion requirements were met with either very fresh whole blood (VFWB), 24- to 48-hour-old whole blood or reconstituted whole blood (packed ...

journal_title：Blood

authors： Manno CS,Hedberg KW,Kim HC,Bunin GR,Nicolson S,Jobes D,Schwartz E,Norwood WI

更新日期：1991-03-01 00:00:00

abstract：:We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 coul...

journal_title：Blood

authors： García A,Prabhakar S,Hughan S,Anderson TW,Brock CJ,Pearce AC,Dwek RA,Watson SP,Hebestreit HF,Zitzmann N

更新日期：2004-03-15 00:00:00

abstract：:Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response, many aspects of eosinophil accumulation remain unknown. This is particularly true with respect to tissue-specific mechanisms that may regulate the accumulation of ...

journal_title：Blood

authors： Larbi KY,Allen AR,Tam FW,Haskard DO,Lobb RR,Silva PM,Nourshargh S

更新日期：2000-11-15 00:00:00

abstract：:Nineteen noninfected adults receiving initial induction chemotherapy for acute nonlymphocytic leukemia (ANLL) were randomized to receive either prophylactic granulocyte transfusion or platelet transfusion alone on an alternate-day schedule. An average of 11 granulocyte transfusions (range 3--19) were administered/pati...

journal_title：Blood

authors： Schiffer CA,Aisner J,Daly PA,Schimpff SC,Wiernik PH

更新日期：1979-10-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00

abstract：:The biochemical basis for complement acting directly on antigen-presenting cells to enhance their function in T-cell stimulation has been unclear. Here we present evidence that engagement of C3a receptor (C3aR) on the surface of dendritic cells (DCs) leads to alterations in the level of intracellular cyclic adenosine ...

journal_title：Blood

authors： Li K,Anderson KJ,Peng Q,Noble A,Lu B,Kelly AP,Wang N,Sacks SH,Zhou W

更新日期：2008-12-15 00:00:00

abstract：:The extended (E) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (EC). A recombinant form of EC (rEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris...

journal_title：Blood

authors： Applegate D,Haraga L,Hertzberg KM,Steben LS,Zhang JZ,Redman CM,Grieninger G

更新日期：1998-11-15 00:00:00

abstract：:Hematopoiesis is tightly controlled by transcription regulatory networks, but how and when specific transcription factors control lineage commitment are still largely unknown. Within the hematopoietic stem cell (Lin(-)Sca-1(+)c-Kit(+)) compartment these lineage-specific transcription factors are expressed at low level...

journal_title：Blood

authors： Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP

更新日期：2010-11-18 00:00:00

abstract：:Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by thrombotic microangiopathy leading to end-organ damage. The standard of care (SOC) treatment is therapeutic plasma exchange (TPE) alongside immunomodulation with steroids, with increasing use of rituximab +/- other immuno...

journal_title：Blood

authors： Goshua G,Sinha P,Hendrickson JE,Tormey CA,Bendapudi P,Lee AI

更新日期：2020-12-06 00:00:00

abstract：:Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further define the role of rIFN-α, we investigated the outcomes of pegylated-rIFN-α2a (PEG) therapy in ET and PV patients previously treated with...

journal_title：Blood

authors： Yacoub A,Mascarenhas J,Kosiorek H,Prchal JT,Berenzon D,Baer MR,Ritchie E,Silver RT,Kessler C,Winton E,Finazzi MC,Rambaldi A,Vannucchi AM,Leibowitz D,Rondelli D,Arcasoy MO,Catchatourian R,Vadakara J,Rosti V,Hexner E

更新日期：2019-10-31 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we g...

journal_title：Blood

authors： Chapuy B,Cheng H,Watahiki A,Ducar MD,Tan Y,Chen L,Roemer MG,Ouyang J,Christie AL,Zhang L,Gusenleitner D,Abo RP,Farinha P,von Bonin F,Thorner AR,Sun HH,Gascoyne RD,Pinkus GS,van Hummelen P,Wulf GG,Aster JC,Weinst

更新日期：2016-05-05 00:00:00

abstract：:The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 ...

journal_title：Blood

authors： Badoux XC,Keating MJ,Wen S,Lee BN,Sivina M,Reuben J,Wierda WG,O'Brien SM,Faderl S,Kornblau SM,Burger JA,Ferrajoli A

更新日期：2011-09-29 00:00:00

abstract：:Two kinds of erythrocytes are released in the blood of irradiated adult hybrid mice grafted with parental fetal liver cells: fetal antigen-bearing erythrocytes (Ft+ cells) and adult-type Ft- erythrocytes. Both are of parental origin, as determined by immune lysis using histocompatibility alloantigens. The latter cells...

journal_title：Blood

authors： Mouchiroud G,Blanchet JP

更新日期：1981-03-01 00:00:00

abstract：:Human cyclin A1 is a newly cloned, tissue-specific cyclin that is prominently expressed in normal testis. In this study, we showed that cyclin A1 was highly expressed in a subset of leukemia samples from patients. The highest frequency of cyclin A1 overexpression was observed in acute myelocytic leukemias, especially ...

journal_title：Blood

authors： Yang R,Nakamaki T,Lübbert M,Said J,Sakashita A,Freyaldenhoven BS,Spira S,Huynh V,Müller C,Koeffler HP

更新日期：1999-03-15 00:00:00

abstract：:The ex vivo expansion of hematopoietic progenitors is a promising approach for accelerating the engraftment of recipients, particularly when cord blood (CB) is used as a source of hematopoietic graft. With the aim of defining the in vivo repopulating properties of ex vivo-expanded CB cells, purified CD34(+) cells were...

journal_title：Blood

authors： Guenechea G,Segovia JC,Albella B,Lamana M,Ramírez M,Regidor C,Fernández MN,Bueren JA

更新日期：1999-02-01 00:00:00

abstract：:Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these pro...

journal_title：Blood

authors： Tripathi AK,Sha W,Shulaev V,Stins MF,Sullivan DJ Jr

更新日期：2009-11-05 00:00:00

abstract：:The response to intravenous challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity, or a surgically created omental pouch. There was a marked rise in heterophil antibody titer following intravenous challeng...

journal_title：Blood

authors： Schwartz AD,Dadash-Zadeh M,Goldstein R,Luck S,Conway JJ

更新日期：1977-05-01 00:00:00

abstract：:An unmet need in cell engineering is the availability of a single transgene encoded, functionally inert, human polypeptide that can serve multiple purposes, including ex vivo cell selection, in vivo cell tracking, and as a target for in vivo cell ablation. Here we describe a truncated human EGFR polypeptide (huEGFRt) ...

journal_title：Blood

authors： Wang X,Chang WC,Wong CW,Colcher D,Sherman M,Ostberg JR,Forman SJ,Riddell SR,Jensen MC

更新日期：2011-08-04 00:00:00

abstract：:This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....

journal_title：Blood

authors： Nakamura S,Yokoyama K,Shimizu E,Yusa N,Kondoh K,Ogawa M,Takei T,Kobayashi A,Ito M,Isobe M,Konuma T,Kato S,Kasajima R,Wada Y,Nagamura-Inoue T,Yamaguchi R,Takahashi S,Imoto S,Miyano S,Tojo A

更新日期：2019-06-20 00:00:00

abstract：:We previously reported that sphingosine 1-phosphate (S1P) regulates peritoneal B-cell trafficking and subsequent intestinal IgA production, but the underlying mechanisms remain obscure. We demonstrate here that nuclear factor kappaB-inducing kinase (NIK) is involved in the regulation of S1P-mediated trafficking of per...

journal_title：Blood

authors： Kunisawa J,Gohda M,Kurashima Y,Ishikawa I,Higuchi M,Kiyono H

更新日期：2008-05-01 00:00:00

abstract：:Although thrombin is a key enzyme in the coagulation cascade and is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its own negative feedback via activation of protein C, which downregulates thrombin generation by enzymatically inactivating factors Va and VIIIa. Our group and...

journal_title：Blood

authors： Tucker EI,Verbout NG,Markway BD,Wallisch M,Lorentz CU,Hinds MT,Shatzel JJ,Pelc LA,Wood DC,McCarty OJT,Di Cera E,Gruber A

更新日期：2020-02-27 00:00:00

abstract：:Microsatellite instability (MSI) and p53 mutations have been reported to occur in a significant proportion of patients with therapy-related acute myeloid leukemia (AML). MSH2 is one of the genes involved in DNA mismatch repair to maintain fidelity of genomic replication, and defects of MSH2 are directly involved in MS...

journal_title：Blood

authors： Zhu YM,Das-Gupta EP,Russell NH

更新日期：1999-07-15 00:00:00

abstract：:Growth of human B-cell precursors (BCP) was achieved by plating fetal CD10+ surface-mu (s mu)- cells in liquid medium onto bone marrow-derived fibroblastic stromal cell layers deprived of hematopoietic cells. Proliferation of the fetal BCP was strongly potentiated by the addition of interleukin-7 (IL-7) to the culture...

journal_title：Blood

authors： Moreau I,Duvert V,Banchereau J,Saeland S

更新日期：1993-03-01 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:Thrombopoietin (TPO, c-mpl ligand) has emerged as a major hematopoietic cytokine stimulating megakaryocyte proliferation, endomitosis, and platelet production. This study shows that a single administration of an adenovirus (Ad) vector encoding TPO (AdCMV.TPO) abrogates thrombocytopenia induced in mice by carboplatin a...

journal_title：Blood

authors： Ohwada A,Rafii S,Moore MA,Crystal RG

更新日期：1996-08-01 00:00:00

abstract：:Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited anemias that affect the normal differentiation-proliferation pathways of the erythroid lineage. They belong to the wide group of ineffective erythropoiesis conditions that mainly result in monolinear cytopenia. CDAs are classified into ...

journal_title：Blood

authors： Iolascon A,Andolfo I,Russo R

更新日期：2020-09-10 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00