CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date.

abstract：:The most common forms of hereditary persistence of fetal hemoglobin (HPFH) involve large deletions that remove the adult delta and beta genes but leave the paired fetal genes (G gamma and A gamma) intact. The size of these deletions has previously eluded exact definition. Using pulsed-field gel electrophoresis and the...

journal_title：Blood

authors： Collins FS,Cole JL,Lockwood WK,Iannuzzi MC

更新日期：1987-12-01 00:00:00

abstract：:In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squ...

journal_title：Blood

authors： Janin A,Murata H,Leboeuf C,Cayuela JM,Gluckman E,Legrès L,Desveaux A,Varna M,Ratajczak P,Soulier J,de Thé H,Bertheau P,Socié G

更新日期：2009-02-19 00:00:00

abstract：:Clinical results after T-cell-depleted allografts might be improved by modifying the graft content of progenitor and accessory cells. Although the association of the number of donor T cells with the clinical outcome has been studied extensively, the optimum number of progenitor cells that should be administered to pat...

journal_title：Blood

authors： Urbano-Ispizua A,Carreras E,Marín P,Rovira M,Martínez C,Fernández-Avilés F,Xicoy B,Hernández-Boluda JC,Montserrat E

更新日期：2001-10-15 00:00:00

abstract：:We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment t...

journal_title：Blood

authors： Kaufmann H,Raderer M,Wöhrer S,Püspök A,Bankier A,Zielinski C,Chott A,Drach J

更新日期：2004-10-15 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence o...

journal_title：Blood

authors： Ljungman P,Brand R,Einsele H,Frassoni F,Niederwieser D,Cordonnier C

更新日期：2003-12-15 00:00:00

abstract：:Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical m...

journal_title：Blood

authors： Weiss SJ,Turk J,Needleman P

更新日期：1979-06-01 00:00:00

abstract：:Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(...

journal_title：Blood

authors： Pui CH,Carroll AJ,Raimondi SC,Schell MJ,Head DR,Shuster JJ,Crist WM,Borowitz MJ,Link MP,Behm FG

更新日期：1992-05-01 00:00:00

abstract：:The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus-driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and...

journal_title：Blood

authors： Rigaud S,Lopez-Granados E,Sibéril S,Gloire G,Lambert N,Lenoir C,Synaeve C,Stacey M,Fugger L,Stephan JL,Fischer A,Picard C,Durandy A,Chapel H,Latour S

更新日期：2011-07-14 00:00:00

abstract：:Multiple myeloma is characterized by genomic alterations frequently involving gains and losses of chromosomes. Single nucleotide polymorphism (SNP)-based mapping arrays allow the identification of copy number changes at the sub-megabase level and the identification of loss of heterozygosity (LOH) due to monosomy and u...

journal_title：Blood

authors： Walker BA,Leone PE,Jenner MW,Li C,Gonzalez D,Johnson DC,Ross FM,Davies FE,Morgan GJ

更新日期：2006-09-01 00:00:00

abstract：:To characterize early B-cell precursors in humans, we correlated immunoglobulin heavy chain (IgH) gene rearrangement status with the CD34, CD19, and CD10 cell surface markers. Highly purified adult bone marrow (BM) cell fractions were obtained by two successive rounds of flow cytometric cell sorting, and IgH rearrange...

journal_title：Blood

authors： Davi F,Faili A,Gritti C,Blanc C,Laurent C,Sutton L,Schmitt C,Merle-Béral H

更新日期：1997-11-15 00:00:00

abstract：:In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL. ...

journal_title：Blood

authors： Moreno C

更新日期：2015-05-28 00:00:00

abstract：:Macrophage colony-stimulating factor (M-CSF or CSF-1) and granulocyte-macrophage CSF (GM-CSF) have been shown to increase human monocyte urokinase-type plasminogen-activator (u-PA) activity with possible consequences for cell migration and tissue remodeling; because monocyte u-PA activity is likely to be controlled in...

journal_title：Blood

authors： Hamilton JA,Whitty GA,Stanton H,Wojta J,Gallichio M,McGrath K,Ianches G

更新日期：1993-12-15 00:00:00

abstract：:In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the accuracy of these estimates is uncertain. We analyzed the dist...

journal_title：Blood

authors： McLaren CE,Gordeuk VR,Looker AC,Hasselblad V,Edwards CQ,Griffen LM,Kushner JP,Brittenham GM

更新日期：1995-09-01 00:00:00

abstract：:Ad.CMV-CD is a replication incompetent adenoviral vector carrying a cytomegalovirus (CMV)-driven transcription unit of the cytosine deaminase (CD) gene. The CD transcription unit in this vector catalyzes the deamination of the nontoxic pro-drug, 5-fluorocytosine (5-FC), thus converting it to the cytotoxic drug 5-fluor...

journal_title：Blood

authors： Garcia-Sanchez F,Pizzorno G,Fu SQ,Nanakorn T,Krause DS,Liang J,Adams E,Leffert JJ,Yin LH,Cooperberg MR,Hanania E,Wang WL,Won JH,Peng XY,Cote R,Brown R,Burtness B,Giles R,Crystal R,Deisseroth AB

更新日期：1998-07-15 00:00:00

abstract：:In 2017, 4 drugs received US Food and Drug Administration marketing approval for acute myeloid leukemia (AML) treatment: targeted therapies for mutant FLT3 and IDH2, a liposomal cytarabine-daunorubicin formulation for therapy-related AML and AML with myelodysplasia-related changes, and resurgence of an antibody-drug c...

journal_title：Blood

authors： Wei AH,Tiong IS

更新日期：2017-12-07 00:00:00

abstract：:Scott syndrome is an hereditary bleeding disorder characterized by a deficiency in platelet procoagulant activity. Unlike normal blood cells, Scott platelets, as well as erythrocytes and lymphocytes, are strongly impaired in their ability to scramble their membrane phospholipids when challenged with Ca2+. In normal ce...

journal_title：Blood

authors： Dekkers DW,Comfurius P,Vuist WM,Billheimer JT,Dicker I,Weiss HJ,Zwaal RF,Bevers EM

更新日期：1998-03-15 00:00:00

abstract：:A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at t...

journal_title：Blood

authors： Reuter CW,Morgan MA,Bergmann L

更新日期：2000-09-01 00:00:00

abstract：:The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minim...

journal_title：Blood

authors： Buccisano F,Maurillo L,Del Principe MI,Del Poeta G,Sconocchia G,Lo-Coco F,Arcese W,Amadori S,Venditti A

更新日期：2012-01-12 00:00:00

abstract：:Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, f...

journal_title：Blood

authors： Chen Y,Ma X,Zhang M,Wang X,Wang C,Wang H,Guo P,Yuan W,Rudolph KL,Zhan Q,Ju Z

更新日期：2014-02-06 00:00:00

abstract：:Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...

journal_title：Blood

authors： Shi X,He BL,Ma AC,Guo Y,Chi Y,Man CH,Zhang W,Zhang Y,Wen Z,Cheng T,Leung AY

更新日期：2015-05-07 00:00:00

abstract：:Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cel...

journal_title：Blood

authors： von Hoff L,Kärgel E,Franke V,McShane E,Schulz-Beiss KW,Patone G,Schleussner N,Kolesnichenko M,Hübner N,Daumke O,Selbach M,Akalin A,Mathas S,Scheidereit C

更新日期：2019-03-28 00:00:00

abstract：:Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation through a complex signaling network. To elucidate the ALK pathways s...

journal_title：Blood

authors： Boccalatte FE,Voena C,Riganti C,Bosia A,D'Amico L,Riera L,Cheng M,Ruggeri B,Jensen ON,Goss VL,Lee K,Nardone J,Rush J,Polakiewicz RD,Comb MJ,Chiarle R,Inghirami G

更新日期：2009-03-19 00:00:00

abstract：:Myeloma plasma cells constitute 10% to 90% of the total bone marrow cell count in patients with multiple myeloma (MM). These cells express a variety of cell surface markers, such as HLA-ABC and HLA-DR, and surface antigens that are necessary for professional antigen-presenting cells, including adhesion and costimulato...

journal_title：Blood

authors： Yi Q,Dabadghao S,Osterborg A,Bergenbrant S,Holm G

更新日期：1997-09-01 00:00:00

abstract：:In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in Thelper (TH) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specific, coactivator role of...

journal_title：Blood

authors： Sarkar K,Sadhukhan S,Han SS,Vyas YM

更新日期：2015-10-01 00:00:00

abstract：:Tumor-infiltrating T lymphocytes (TIL-T) are always present in B-cell-derived non-Hodgkin's lymphoma (NHL). In this investigation, we explored the possibility that collaboration might exist between these cells. TIL-T were isolated from 39 lymph nodes of patients with NHL. In most of the cases, few of them (less than 1...

journal_title：Blood

authors： Jacob MC,Piccinni MP,Bonnefoix T,Sotto MF,Couderc P,Bensa JC,Sotto JJ

更新日期：1990-03-01 00:00:00

abstract：:Pruritus is a common symptom in patients with Philadelphia chromosome-negative myeloproliferative disorders (MPDs). The pathophysiology of MPD-associated pruritus is unclear. We have demonstrated that MPD mast cells (MCs) are involved by the malignant process. In the present study, we explored the hypothesis that MCs ...

journal_title：Blood

authors： Ishii T,Wang J,Zhang W,Mascarenhas J,Hoffman R,Dai Y,Wisch N,Xu M

更新日期：2009-06-04 00:00:00

abstract：:In this issue of Blood, Vérollet et al show that expression of the HIV-1–derived protein Nef alters the migratory mode adopted by macrophages, enhancing macrophage tissue infiltration and explaining the observed accumulation of tissue-resident macrophages in some HIV-infected patients. ...

journal_title：Blood

authors： Morley SC

更新日期：2015-03-05 00:00:00

abstract：:With the aim of establishing whether the HR2 haplotype in factor V affects the risk of venous thromboembolism, a retrospective multicenter cohort study was performed in 810 family members identified through 174 probands who suffered from at least 1 episode of deep vein thrombosis and/or pulmonary embolism and had an i...

journal_title：Blood

authors： Faioni EM,Franchi F,Bucciarelli P,Margaglione M,De Stefano V,Castaman G,Finazzi G,Mannucci PM

更新日期：1999-11-01 00:00:00

abstract：:The molecular basis of different outcomes in pediatric acute lymphoblastic leukemia (ALL) remains poorly understood. We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionizing radiation (IR)-induced DNA double-strand breaks in 74 pediatric patients with ALL. We found an apopto...

journal_title：Blood

authors： Marston E,Weston V,Jesson J,Maina E,McConville C,Agathanggelou A,Skowronska A,Mapp K,Sameith K,Powell JE,Lawson S,Kearns P,Falciani F,Taylor M,Stankovic T

更新日期：2009-01-01 00:00:00