Abstract：
:The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minimal residual disease (MRD) is nowadays recognized as a potential critical tool to assess the quality of response after chemotherapy and to plan postremission strategies that are, therefore, driven by the individual risk of relapse. PCR and multiparametric flow cytometry have become the most popular methods to investigate MRD because they have been established as sensitive and specific enough to allow MRD to be studied serially. In the present review, we examine the evidence supporting the appropriateness of incorporating MRD detection into the AML risk assessment process. A comprehensive prognostic algorithm, generated by combining pretreatment cytogenetics/genetics and posttreatment MRD determination, should promote advances in development of personalized therapeutic approaches.
journal_name
Bloodjournal_title
Bloodauthors
Buccisano F,Maurillo L,Del Principe MI,Del Poeta G,Sconocchia G,Lo-Coco F,Arcese W,Amadori S,Venditti Adoi
10.1182/blood-2011-08-363291subject
Has Abstractpub_date
2012-01-12 00:00:00pages
332-41issue
2eissn
0006-4971issn
1528-0020pii
blood-2011-08-363291journal_volume
119pub_type
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