Early onset of immunoglobulin heavy chain gene rearrangements in normal human bone marrow CD34+ cells.

abstract：:Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phagocytosis in macrophages are unclear. We addressed the issue using bone marrow-derived macrophages from FcgammaR- or SHIP-deficient mice. Phagocytic activities of macrophages from FcgammaRII(b)(-/-)...

journal_title：Blood

authors： Nakamura K,Malykhin A,Coggeshall KM

更新日期：2002-11-01 00:00:00

abstract：:McCullough and colleagues show that problems with cord banking still exist. To improve the results of cord transplantations, more attention should be given to ensuring quality standards rather than just collecting more units. ...

journal_title：Blood

authors： Querol S

更新日期：2009-08-20 00:00:00

abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...

journal_title：Blood

authors： Greco NJ,Tenner TE Jr,Tandon NN,Jamieson GA

更新日期：1990-05-15 00:00:00

abstract：:The chemokine receptors (CCRs) CCR4 and CCR10, and the cutaneous lymphocyte antigen (CLA), have each been proposed as critical mediators of skin-specific TH lymphocyte homing in mice and humans. CLA initiates skin homing by mediating E-selectin-dependent tethering and rolling within cutaneous venules, but the specific...

journal_title：Blood

authors： Soler D,Humphreys TL,Spinola SM,Campbell JJ

更新日期：2003-03-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8-methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated pr...

journal_title：Blood

authors： Lin L,Londe H,Hanson CV,Wiesehahn G,Isaacs S,Cimino G,Corash L

更新日期：1993-07-01 00:00:00

abstract：:Cells derived from human cord blood were recently used instead of bone marrow (BM) for transplantation. However, several questions concerning the potential of these cells to reconstitute the hematopoietic and immunologic system of the recipient and to induce a graft-versus-host disease (GVHD) remain unanswered. Here w...

journal_title：Blood

authors： de La Selle V,Gluckman E,Bruley-Rosset M

更新日期：1996-05-01 00:00:00

abstract：:Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor,...

journal_title：Blood

authors： Gurer C,Strowig T,Brilot F,Pack M,Trumpfheller C,Arrey F,Park CG,Steinman RM,Münz C

更新日期：2008-08-15 00:00:00

abstract：:Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocati...

journal_title：Blood

authors： Guidez F,Ivins S,Zhu J,Söderström M,Waxman S,Zelent A

更新日期：1998-04-15 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker ...

journal_title：Blood

authors： Bhatt S,Ashlock BM,Natkunam Y,Sujoy V,Chapman JR,Ramos JC,Mesri EA,Lossos IS

更新日期：2013-08-15 00:00:00

abstract：:This study was designed to assess the presence of endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) within adherent layers of human Dexter-type cultures and to investigate the effect on granulomonopoiesis of adding exogenous GM-CSF to the culture medium. The presence of GM-CSF was demonstrated using...

journal_title：Blood

authors： Charbord P,Tamayo E,Saeland S,Duvert V,Poulet J,Gown AM,Herve P

更新日期：1991-09-01 00:00:00

abstract：:In this study, we analyzed tyrosine phosphorylation of guanosine triphosphatase (GTPase) activating protein in human B cells stimulated through surface IgG, using Western blot and immunoprecipitation. Stimulation through surface IgG induced the tyrosine phosphorylation of GTPase-activating protein (GAP) and two associ...

journal_title：Blood

authors： Yagura H,Oyaizu N,Pahwa S

更新日期：1993-03-15 00:00:00

abstract：:Erythroblastic synartesis is a rare form of acquired dyserythropoiesis, first described by Breton-Gorius et al in 1973. This syndrome is characterized by the presence of septate-like membrane junctions and "glove finger" invaginations between erythroblasts, which are very tightly linked together. This phenomenon, resp...

journal_title：Blood

authors： Cramer EM,Garcia I,Massé JM,Zini JM,Lambin P,Oksenhendler E,Souni F,Smith M,Flandrin G,Breton-Gorius J,Tobelem G,Casadevall N

更新日期：1999-12-01 00:00:00

abstract：:Gossypin, a flavone originally isolated from Hibiscus vitifolius, has been shown to suppress angiogenesis, inflammation, and carcinogenesis. The mechanisms of these activities, however, are unknown. Because nuclear factor-kappaB (NF-kappaB) is associated with inflammation, carcinogenesis, hyperproliferation, invasion,...

journal_title：Blood

authors： Kunnumakkara AB,Nair AS,Ahn KS,Pandey MK,Yi Z,Liu M,Aggarwal BB

更新日期：2007-06-15 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which th...

journal_title：Blood

authors： Sachs UJ,Hattar K,Weissmann N,Bohle RM,Weiss T,Sibelius U,Bux J

更新日期：2006-02-01 00:00:00

abstract：:DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display highly dysregulated DNA methylation profiles, characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG is...

journal_title：Blood

authors： Lio CJ,Yuita H,Rao A

更新日期：2019-10-31 00:00:00

abstract：:Unfractionated heparin (UFH) is a widely used anticoagulant that has long been known to potentiate platelet responses to subthreshold doses of platelet agonists. UFH has been reported to bind and induce modest conformational changes in the major platelet integrin, αIIbβ3, and induce minor changes in platelet morpholog...

journal_title：Blood

authors： Gao C,Boylan B,Fang J,Wilcox DA,Newman DK,Newman PJ

更新日期：2011-05-05 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial dysfunction and vascular remodeling. Recently, bone marrow progenitor cells have been localized to PAH lungs, raising the question of their role in disease progression. Independently, serotonin (5-HT) and its receptors hav...

journal_title：Blood

authors： Launay JM,Hervé P,Callebert J,Mallat Z,Collet C,Doly S,Belmer A,Diaz SL,Hatia S,Côté F,Humbert M,Maroteaux L

更新日期：2012-02-16 00:00:00

abstract：:Primary infection with the human herpesvirus, Epstein-Barr virus (EBV), may result in subclinical seroconversion or may appear as infectious mononucleosis (IM), a lymphoproliferative disease of variable severity. Why primary infection manifests differently between patients is unknown, and, given the difficulties in id...

journal_title：Blood

authors： Silins SL,Sherritt MA,Silleri JM,Cross SM,Elliott SL,Bharadwaj M,Le TT,Morrison LE,Khanna R,Moss DJ,Suhrbier A,Misko IS

更新日期：2001-12-15 00:00:00

abstract：:Fcgamma receptors (FcgammaRs) on mononuclear phagocytes trigger autoantibody and immune complex-induced diseases through coupling the self-reactive immunoglobulin G (IgG) response to innate effector pathways, such as phagocytosis, and the recruitment of inflammatory cells. FcRgamma-based activation is critical in the ...

journal_title：Blood

authors： Braun A,Gessner JE,Varga-Szabo D,Syed SN,Konrad S,Stegner D,Vögtle T,Schmidt RE,Nieswandt B

更新日期：2009-01-29 00:00:00

abstract：:The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller...

journal_title：Blood

authors： Davies SM,Bhatia S,Ross JA,Kiffmeyer WR,Gaynon PS,Radloff GA,Robison LL,Perentesis JP

更新日期：2002-07-01 00:00:00

abstract：:Cytokine gene-modified tumor cells have increased immunogenicity and retain the antigenic repertoire of a particular neoplasia. However, practical concerns have led to an increased interest in allogeneic gene-transduced bystander cells as a broader source of cytokines for autologous tumor cell-based vaccines. Here, we...

journal_title：Blood

authors： Curti A,Parenza M,Colombo MP

更新日期：2003-01-15 00:00:00

abstract：:We have studied the antileukemic effects of cyclosporin-A (CyA) on the cells of a number of human hematopoietic biopsies and established cell lines in vitro. Cya killed the tumor cells but not the nonmalignant control cells from three of four patients with T-lymphocytic leukemia/lymphoma at concentrations comparable t...

journal_title：Blood

authors： Tötterman TH,Danersund A,Nilsson K,Killander A

更新日期：1982-05-01 00:00:00

abstract：:We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34;q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single...

journal_title：Blood

authors： Carroll AJ,Crist WM,Link MP,Amylon MD,Pullen DJ,Ragab AH,Buchanan GR,Wimmer RS,Vietti TJ

更新日期：1990-09-15 00:00:00

abstract：:The cellular isoform of the prion protein (PrPC) is a small glycoprotein attached to the outer leaflet of the plasma membrane by a glycosylphosphatidylinositol anchor. This molecule is involved in the pathogenesis of prion diseases in both humans and animals. We have characterized the expression patterns of PrPC durin...

journal_title：Blood

authors： Dodelet VC,Cashman NR

更新日期：1998-03-01 00:00:00

abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

journal_title：Blood

authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

更新日期：1996-04-01 00:00:00

abstract：:The anti-CD20 antibody rituximab depletes human B cells from peripheral blood, but it remains controversial to what extent tissue-resident B cells are affected. In representative patients with rheumatoid arthritis, we here demonstrate that recently activated presumably short-lived plasmablasts expressing HLA-DR(high) ...

journal_title：Blood

authors： Mei HE,Frölich D,Giesecke C,Loddenkemper C,Reiter K,Schmidt S,Feist E,Daridon C,Tony HP,Radbruch A,Dörner T

更新日期：2010-12-09 00:00:00

abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

journal_title：Blood

authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

更新日期：2010-12-16 00:00:00

abstract：:The combination of imatinib with chemotherapy has been recently reported as very promising in patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). During 2004 and 2005, 45 patients with newly diagnosed Ph+ ALL were treated in the Group for Research on Adult Acute Lymphoblastic Leuke...

journal_title：Blood

authors： de Labarthe A,Rousselot P,Huguet-Rigal F,Delabesse E,Witz F,Maury S,Réa D,Cayuela JM,Vekemans MC,Reman O,Buzyn A,Pigneux A,Escoffre M,Chalandon Y,MacIntyre E,Lhéritier V,Vernant JP,Thomas X,Ifrah N,Dombret H,Group

更新日期：2007-02-15 00:00:00

abstract：:We infused six human immunodeficiency virus (HIV)-seropositive subjects with autologous CD8+ cytotoxic T cells (CTLs) enriched for HIV-specific cytotoxicity targeted against a diversity of HIV epitopes in gp120, gag p17 and p24, and nef. There was no toxicity and no subject deteriorated clinically. In the first 2 week...

journal_title：Blood

authors： Lieberman J,Skolnik PR,Parkerson GR 3rd,Fabry JA,Landry B,Bethel J,Kagan J

更新日期：1997-09-15 00:00:00