Abstract:
:In this study, we analyzed tyrosine phosphorylation of guanosine triphosphatase (GTPase) activating protein in human B cells stimulated through surface IgG, using Western blot and immunoprecipitation. Stimulation through surface IgG induced the tyrosine phosphorylation of GTPase-activating protein (GAP) and two associated proteins, a 190-Kd protein and a 62-Kd protein, within 1 minute and in a dose-dependent manner. This tyrosine phosphorylation was blocked by Genistein (Extrasynthese, Genay, France). These data suggest that GTPase-activating protein is involved in a signal transduction pathway initiated from surface IgG in human B cells.
journal_name
Bloodjournal_title
Bloodauthors
Yagura H,Oyaizu N,Pahwa Ssubject
Has Abstractpub_date
1993-03-15 00:00:00pages
1535-9issue
6eissn
0006-4971issn
1528-0020journal_volume
81pub_type
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