Killer cell activity of human monoblastic leukemia cells as detected with a monocyte-specific target cell.

abstract：:Patients with the B-cell malignancy hairy cell leukemia (HCL) exhibit a skewed T-cell repertoire with oligoclonal expression or absence of many members of the T-cell receptor (TCR) BV gene families. To evaluate whether interferon-alpha (IFN-alpha) therapy would not only restore normal hematopoiesis, but also the abnor...

journal_title：Blood

authors： Kluin-Nelemans HC,Kester MG,van deCorput L,Boor PP,Landegent JE,van Dongen JJ,Willemze R,Falkenburg JH

更新日期：1998-06-01 00:00:00

abstract：:Donor lymphocyte infusions have been effective in patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation, but their use is associated with the risk of graft-versus-host disease. We investigated the effects of prophylactic infusion of in vitro-generated donor T cells reactive ...

journal_title：Blood

authors： Bornhäuser M,Thiede C,Platzbecker U,Kiani A,Oelschlaegel U,Babatz J,Lehmann D,Hölig K,Radke J,Tuve S,Wermke M,Wehner R,Jähnisch H,Bachmann MP,Rieber EP,Schetelig J,Ehninger G,Schmitz M

更新日期：2011-06-30 00:00:00

abstract：:A small quantity of extracellular calcium is required for the stimulation of lymphocytes by mitogens such as plant lectins. Lectin binding to the lymphocyte surface and early postbinding events that eventually lead to DNA synthesis are calcium dependent. Mitogenic lectins such as PHA and Con-A rapidly increase the siz...

journal_title：Blood

authors： Lichtman AH,Segel GB,Lichtman MA

更新日期：1983-03-01 00:00:00

abstract：:Current immunotherapeutic trials for patients with multiple myeloma (MM) focus on the idiotype (Id) as a tumor-specific antigen for active immunization. To bypass the need for the identification of shared MM-associated antigens and the characterization of possible immunogenic T-cell epitopes in a human leukocyte antig...

journal_title：Blood

authors： Milazzo C,Reichardt VL,Müller MR,Grünebach F,Brossart P

更新日期：2003-02-01 00:00:00

abstract：:A cohort of MDS patients was examined for mutations affecting 4 splice genes (SF3B1, SRSF2, ZRSR2, and U2AF35) and evaluated in the context of clinical and molecular markers. Splice gene mutations were detected in 95 of 221 patients. These mutations were mutually exclusive and less likely to occur in patients with com...

journal_title：Blood

authors： Damm F,Kosmider O,Gelsi-Boyer V,Renneville A,Carbuccia N,Hidalgo-Curtis C,Della Valle V,Couronné L,Scourzic L,Chesnais V,Guerci-Bresler A,Slama B,Beyne-Rauzy O,Schmidt-Tanguy A,Stamatoullas-Bastard A,Dreyfus F,Prébet T,

更新日期：2012-04-05 00:00:00

abstract：:Many current experimental results show the necessity of new conceptual approaches to understand hematopoietic stem cell organization. Recently, we proposed a novel theoretical concept and a corresponding quantitative model based on microenvironment-dependent stem cell plasticity. The objective of our present work is t...

journal_title：Blood

authors： Roeder I,Kamminga LM,Braesel K,Dontje B,de Haan G,Loeffler M

更新日期：2005-01-15 00:00:00

abstract：:The precise role of the endogenous immune system in modulating cancer development remains unclear. Tumor cells are generally thought to be nonimmunogenic because they are of 'self' origin. However, tumor-reactive lymphocytes can be isolated from patients with many types of cancer. It is unclear what role these lymphoc...

journal_title：Blood

authors： Lee PP,Zeng D,McCaulay AE,Chen YF,Geiler C,Umetsu DT,Chao NJ

更新日期：1997-08-15 00:00:00

abstract：:We have analyzed the binding of Sp1, a ubiquitously expressed transactivator, to the promoter region of the gamma genes. Low-affinity Sp1 sites were found at -50 and -200. A high-affinity site was detected at -140, over the CACCC sequence. To analyze the function of these sites, Drosophila SL-2 cells, which lack Sp1, ...

journal_title：Blood

authors： Gumucio DL,Rood KL,Blanchard-McQuate KL,Gray TA,Saulino A,Collins FS

更新日期：1991-10-01 00:00:00

abstract：:The last 2 years have seen much excitement in the field of genetics with the identification of a formerly unappreciated level of "structural variation" within the normal human genome. Genetic structural variants include deletions, duplications, and inversions in addition to the recently discovered, copy number variant...

journal_title：Blood

authors： Mullally A,Ritz J

更新日期：2007-02-15 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, cytopenia, and in some cases hemophagocytosis. Here, we describe the mutation analysis, clinical presentation, and functional analysis of natural killer (NK) cells in patients with mutation...

journal_title：Blood

authors： Meeths M,Entesarian M,Al-Herz W,Chiang SC,Wood SM,Al-Ateeqi W,Almazan F,Boelens JJ,Hasle H,Ifversen M,Lund B,van den Berg JM,Gustafsson B,Hjelmqvist H,Nordenskjöld M,Bryceson YT,Henter JI

更新日期：2010-10-14 00:00:00

abstract：:Hematopoietic reconstitution following syngeneic bone marrow transplantation with graded doses of untreated and drug-treated bone marrow was studied in B6D2F1 mice. Granulocyte-macrophage colony-forming units (CFU-GM) and spleen colony-forming units (CFU-S) showed similar in vitro drug sensitivities. Both the speed of...

journal_title：Blood

authors： Jones RJ,Sharkis SJ,Celano P,Colvin OM,Rowley SD,Sensenbrenner LL

更新日期：1987-10-01 00:00:00

abstract：:Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, muri...

journal_title：Blood

authors： Sgadari C,Farber JM,Angiolillo AL,Liao F,Teruya-Feldstein J,Burd PR,Yao L,Gupta G,Kanegane C,Tosato G

更新日期：1997-04-15 00:00:00

abstract：:Peripheral lymphocytes from normal individuals and from patients with chronic lymphocytic leukemia (CLL) were cultured in vitro for 1-7 days. The growth response to phytohemagglutinin (PHA) was quantitated by the incorporation of tritiated uridine into RNA nucleotide during a 2-hr pulse with the radioisotope. While th...

journal_title：Blood

authors： Schultz EF,Davis S,Rubin AD

更新日期：1976-08-01 00:00:00

abstract：:To define the role of the alpha2beta1 integrin in pathologic angiogenesis, we investigated tumor-associated growth and angiogenesis in wild-type and alpha2-null mice. Our findings reveal that the alpha2beta1 integrin plays an important role in angiogenesis via regulation of VEGFR1 expression. When challenged with B16F...

journal_title：Blood

authors： Zhang Z,Ramirez NE,Yankeelov TE,Li Z,Ford LE,Qi Y,Pozzi A,Zutter MM

更新日期：2008-02-15 00:00:00

abstract：:Peripheral blood cell (PBC) rescue has become the mainstay for autologous transplantation in patients with lymphoma, multiple myeloma, and solid tumors. Different methods of hematopoietic progenitor cell (HPC) mobilization are in use without an established standard. Forty-seven patients with relapsed or refractory lym...

journal_title：Blood

authors： Narayanasami U,Kanteti R,Morelli J,Klekar A,Al-Olama A,Keating C,O'Connor C,Berkman E,Erban JK,Sprague KA,Miller KB,Schenkein DP

更新日期：2001-10-01 00:00:00

abstract：:Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, wh...

journal_title：Blood

authors： Begonja AJ,Gambaryan S,Geiger J,Aktas B,Pozgajova M,Nieswandt B,Walter U

更新日期：2005-10-15 00:00:00

abstract：:The International Lymphoma Radiation Oncology Group (ILROG) guidelines for using radiation therapy (RT) in hematological malignancies are widely used in many countries. The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. Furthermore, in recognition of the need to ...

journal_title：Blood

authors： Yahalom J,Dabaja BS,Ricardi U,Ng A,Mikhaeel NG,Vogelius IR,Illidge T,Qi S,Wirth A,Specht L

更新日期：2020-05-21 00:00:00

abstract：:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 ...

journal_title：Blood

authors： Bergerson RJ,Collier LS,Sarver AL,Been RA,Lugthart S,Diers MD,Zuber J,Rappaport AR,Nixon MJ,Silverstein KA,Fan D,Lamblin AF,Wolff L,Kersey JH,Delwel R,Lowe SW,O'Sullivan MG,Kogan SC,Adams DJ,Largaespada DA

更新日期：2012-05-10 00:00:00

abstract：:Male (NZW x BXSB)F1 (W/BF1) mice develop systemic autoimmunity involving autoantibodies, thrombocytopenia, lupus nephritis, and coronary vascular disease with myocardial infarction (CVD). To determine whether this murine lupus-associated CVD could be transferred to otherwise autoimmune-resistant (C57BL/6 x C3H/He)F1 (...

journal_title：Blood

authors： Mizutani H,Engelman RW,Kinjoh K,Kurata Y,Ikehara S,Good RA

更新日期：1993-11-15 00:00:00

abstract：:Posttranslational protein modifications (PTMs) are necessary for cells to function properly. The role of PTMs in regulating immune responses, specifically those mediated by dendritic cells (DCs), which are critical for both innate and adaptive immunity, is not well understood. Utilizing multiple but complementary appr...

journal_title：Blood

authors： Mathewson N,Toubai T,Kapeles S,Sun Y,Oravecz-Wilson K,Tamaki H,Wang Y,Hou G,Sun Y,Reddy P

更新日期：2013-09-19 00:00:00

abstract：:We studied eight patients with intermittent bleeding episodes usually following trauma and associated with the ingestion of medicine known to interfere with platelet function. All patients had a normal or minimally prolonged baseline bleeding time. All had a normal platelet count, glass bead retention test, and platel...

journal_title：Blood

authors： Czapek EE,Deykin D,Salzman E,Lian EC,Hellerstein LJ,Rosoff CB

更新日期：1978-07-01 00:00:00

abstract：:Cyclophosphamide (CTX), a commonly used chemotherapeutic agent can enhance immune responses. The ability of CTX to promote the proliferation of effector T cells and abrogate the function of regulatory T cells (Tregs) has been described. In this study, we examined the effects of CTX treatment on dendritic cell (DC) sub...

journal_title：Blood

authors： Nakahara T,Uchi H,Lesokhin AM,Avogadri F,Rizzuto GA,Hirschhorn-Cymerman D,Panageas KS,Merghoub T,Wolchok JD,Houghton AN

更新日期：2010-06-03 00:00:00

abstract：:To investigate the natural history of stage A chronic lymphocytic leukemia (CLL) we reviewed 84 such patients. Among 74 cases evaluable for disease progression, 22 (29.6%) progressed to more advanced clinical stages (9 to stage B, 13 to stage C); the actuarial estimation of such an event at 4 years was 30% (95% CI: 26...

journal_title：Blood

authors： Molica S

更新日期：1991-08-15 00:00:00

abstract：:Ectopic expression of the erythropoietin receptor (EpoR) in the interleukin-3 (IL-3)-dependent cell line Ba/F3 results in growth and partial erythroid differentiation in Epo. In contrast, introduction and activation of the interleukin-5 receptor (IL-5R) or of the granulocyte-macrophage colony-stimulating factor recept...

journal_title：Blood

authors： Pless M,Norga K,Carroll M,Heim MH,D'Andrea AD,Mathey-Prevot B

更新日期：1997-05-01 00:00:00

abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...

journal_title：Blood

authors： White JG,Krumwiede M

更新日期：1985-04-01 00:00:00

abstract：:Recent studies with long-term mouse marrow cultures have indicated the importance of the adherent layer as a primary reservoir of the most primitive stem cells, from which derivative stem cells and more differentiated progenitors are continuously generated. We have now examined the role of the adherent cell layer in l...

journal_title：Blood

authors： Coulombel L,Eaves AC,Eaves CJ

更新日期：1983-08-01 00:00:00

abstract：:Ribosomal protein S19 (RPS19) is frequently mutated in Diamond-Blackfan anemia (DBA), a rare congenital hypoplastic anemia. Recent studies have shown that RPS19 expression decreases during terminal erythroid differentiation. Currently no information is available on the subcellular localization of normal RPS19 and the ...

journal_title：Blood

authors： Da Costa L,Tchernia G,Gascard P,Lo A,Meerpohl J,Niemeyer C,Chasis JA,Fixler J,Mohandas N

更新日期：2003-06-15 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer types in animal models, and clinical studies are ongoing. IL-21 belongs to the type I cytokine family of which other members, ie, IL-2, IL-15, and IL-4, have been ...

journal_title：Blood

authors： Castermans K,Tabruyn SP,Zeng R,van Beijnum JR,Eppolito C,Leonard WJ,Shrikant PA,Griffioen AW

更新日期：2008-12-15 00:00:00

abstract：:Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the addic...

journal_title：Blood

authors： Cramer-Morales K,Nieborowska-Skorska M,Scheibner K,Padget M,Irvine DA,Sliwinski T,Haas K,Lee J,Geng H,Roy D,Slupianek A,Rassool FV,Wasik MA,Childers W,Copland M,Müschen M,Civin CI,Skorski T

更新日期：2013-08-15 00:00:00