Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.

Abstract:

:Cyclophosphamide (CTX), a commonly used chemotherapeutic agent can enhance immune responses. The ability of CTX to promote the proliferation of effector T cells and abrogate the function of regulatory T cells (Tregs) has been described. In this study, we examined the effects of CTX treatment on dendritic cell (DC) subsets and the subsequent outcome on the effector and suppressive arms of adaptive immunity. In secondary lymphoid tissues, tissue-derived migratory DCs (migratory DCs), lymphoid tissue-resident DCs (resident DCs), and plasmacytoid DCs (pDCs) are well described. CTX has profound and selective cytotoxic effects on CD8(+) resident DCs, but not skin-derived migratory DCs or pDCs in lymph nodes (LNs) and spleen, causing an imbalance among these DC subsets. CTX treatment increases the potency of DCs in antigen presentation and cytokine secretion, and partially inhibits the suppressor activity of Tregs. Adoptive transfer of CD8(+) DCs can reconstitute this population in regional draining LNs and abrogate the immune-enhancing effects of CTX in vivo. These findings demonstrate that CTX may improve immune responses by preferentially depleting CD8(+) lymphoid-resident DCs, which leads to diminished Treg suppression and enhanced effector T-cell function in vivo.

journal_name

Blood

journal_title

Blood

authors

Nakahara T,Uchi H,Lesokhin AM,Avogadri F,Rizzuto GA,Hirschhorn-Cymerman D,Panageas KS,Merghoub T,Wolchok JD,Houghton AN

doi

10.1182/blood-2009-11-251231

subject

Has Abstract

pub_date

2010-06-03 00:00:00

pages

4384-92

issue

22

eissn

0006-4971

issn

1528-0020

pii

blood-2009-11-251231

journal_volume

115

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Expression and functional characterization of an abnormal platelet membrane glycoprotein Ib alpha (Met239 --> Val) reported in patients with platelet-type von Willebrand disease.

    abstract::Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF). Two distinct point mutations, Gly233 to Val ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Moriki T,Murata M,Kitaguchi T,Anbo H,Handa M,Watanabe K,Takahashi H,Ikeda Y

    更新日期:1997-07-15 00:00:00

  • Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.

    abstract::The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differentiation. Little is known of possible variations in the levels of Pax5 expression and their influences on hematopoietic development. We have developed a retroviral transduction system that allows for the study of possible inte...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-03-414821

    authors: Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F

    更新日期:2012-11-01 00:00:00

  • Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

    abstract::A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at t...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:

    authors: Reuter CW,Morgan MA,Bergmann L

    更新日期:2000-09-01 00:00:00

  • Heavy and light chain primary structures control IgG3 nephritogenicity in an experimental model for cryocrystalglobulinemia.

    abstract::Crystal formation by monoclonal immunoglobulins is a well-known but rare complication of B-cell neoplasia. We have designed an in vivo model of cryocrystalglobulinemia by grafting to mice hybridoma clones producing a pathogenic monoclonal immunogloblulin (Ig) G3kappa. One clone, 8A4, secreted a singular IgG3 that form...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Rengers JU,Touchard G,Decourt C,Deret S,Michel H,Cogné M

    更新日期:2000-06-01 00:00:00

  • Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features.

    abstract::Different biologic features have been associated with a more or less aggressive clinical course in chronic lymphocytic leukemia (CLL). In the present study, 20 patients with highly stable CLL observed at a single institution over a period of 10 to 23 years and who never required treatment were extensively characterize...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-12-3639

    authors: Guarini A,Gaidano G,Mauro FR,Capello D,Mancini F,De Propris MS,Mancini M,Orsini E,Gentile M,Breccia M,Cuneo A,Castoldi G,Foa R

    更新日期:2003-08-01 00:00:00

  • Identification of human juvenile chronic myelogenous leukemia stem cells capable of initiating the disease in primary and secondary SCID mice.

    abstract::Most juvenile chronic myelogenous leukemia (JCML) cells have limited long-term proliferative capacity, and only a minority of immature cells give rise to colonies in semisolid cultures. Clonogenic JCML progenitors cannot be maintained in culture because they differentiate, and within a few weeks the leukemic clone is ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Lapidot T,Grunberger T,Vormoor J,Estrov Z,Kollet O,Bunin N,Zaizov R,Williams DE,Freedman MH

    更新日期:1996-10-01 00:00:00

  • Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.

    abstract::We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cel...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-04-570879

    authors: Salem S,Langlais D,Lefebvre F,Bourque G,Bigley V,Haniffa M,Casanova JL,Burk D,Berghuis A,Butler KM,Leahy TR,Hambleton S,Gros P

    更新日期:2014-09-18 00:00:00

  • Thirty years of hemophilia treatment in the Netherlands, 1972-2001.

    abstract::Since the introduction of replacement therapy in the early 1960s by the infusion of plasma-derived factor VIII and IX preparations, important changes have occurred for hemophilia patients. We studied the medical and social developments over 30 years of hemophilia treatment. Since 1972, 5 cross-sectional national posta...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-05-2008

    authors: Plug I,van der Bom JG,Peters M,Mauser-Bunschoten EP,de Goede-Bolder A,Heijnen L,Smit C,Zwart-van Rijkom JE,Willemse J,Rosendaal FR

    更新日期:2004-12-01 00:00:00

  • A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo.

    abstract::Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-gamma (IFN-gamma) and for their cytotoxic response. In patien...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2007-11-122259

    authors: Guia S,Cognet C,de Beaucoudrey L,Tessmer MS,Jouanguy E,Berger C,Filipe-Santos O,Feinberg J,Camcioglu Y,Levy J,Al Jumaah S,Al-Hajjar S,Stephan JL,Fieschi C,Abel L,Brossay L,Casanova JL,Vivier E

    更新日期:2008-05-15 00:00:00

  • Interleukin 7 worsens graft-versus-host disease.

    abstract::Impaired immune reconstitution has moved to the forefront of clinical problems limiting progress in allogeneic bone marrow transplantation (BMT). The identification of therapies that can enhance immune reconstitution by increasing thymopoiesis is critical to solving this problem. Interleukin 7 (IL-7) is the most poten...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-04-1082

    authors: Sinha ML,Fry TJ,Fowler DH,Miller G,Mackall CL

    更新日期:2002-10-01 00:00:00

  • Human FcγRIIA induces anaphylactic and allergic reactions.

    abstract::IgE and IgE receptors (FcεRI) are well-known inducers of allergy. We recently found in mice that active systemic anaphylaxis depends on IgG and IgG receptors (FcγRIIIA and FcγRIV) expressed by neutrophils, rather than on IgE and FcεRI expressed by mast cells and basophils. In humans, neutrophils, mast cells, basophils...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-07-367334

    authors: Jönsson F,Mancardi DA,Zhao W,Kita Y,Iannascoli B,Khun H,van Rooijen N,Shimizu T,Schwartz LB,Daëron M,Bruhns P

    更新日期:2012-03-15 00:00:00

  • Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.

    abstract::Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We s...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-07-515221

    authors: Poli M,Asperti M,Naggi A,Campostrini N,Girelli D,Corbella M,Benzi M,Besson-Fournier C,Coppin H,Maccarinelli F,Finazzi D,Arosio P

    更新日期:2014-03-06 00:00:00

  • New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls.

    abstract::Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-12-4884

    authors: Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

    更新日期:2006-07-01 00:00:00

  • Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation.

    abstract::Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase 2 trial assessed the effica...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2012-03-415307

    authors: Cortes J,Lipton JH,Rea D,Digumarti R,Chuah C,Nanda N,Benichou AC,Craig AR,Michallet M,Nicolini FE,Kantarjian H,Omacetaxine 202 Study Group.

    更新日期:2012-09-27 00:00:00

  • Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia.

    abstract::Approximately 40% of children with acute myeloid leukemia (AML) who respond to initial therapy subsequently relapse. Multidimensional flow cytometry employing a standardized panel of monoclonal antibodies enables the detection of small numbers of occult leukemic cells that persist during therapy using technology adapt...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-10-3064

    authors: Sievers EL,Lange BJ,Alonzo TA,Gerbing RB,Bernstein ID,Smith FO,Arceci RJ,Woods WG,Loken MR

    更新日期:2003-05-01 00:00:00

  • Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses.

    abstract::The nuclear receptors (NR) retinoid X receptors (RXRs) exert immunomodulatory functions to control inflammation and metabolism via homodimers and heterodimers with several other NRs including retinoic acid receptors. IRX4204 is a novel, highly specific RXR agonist in clinical trials that potently and selectively activ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020005628

    authors: Thangavelu G,Wang C,Loschi M,Saha A,Osborn M,Furlan SN,Aoyama K,McDonald-Hyman C,Aguilar EG,Janesick AS,Chandraratna RA,Refaeli Y,Panoskaltsis-Mortari A,MacDonald KP,Hill GR,Zeiser R,Maillard I,Serody J,Murphy WJ,Mu

    更新日期:2020-09-24 00:00:00

  • RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses.

    abstract::The receptor for hyaluronic acid-mediated motility (RHAMM) is an antigen eliciting both humoral and cellular immune responses in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and multiple myeloma (MM). We initiated a phase 1 clinical trial vaccinating 10 patients with R3 (ILSLELMKL), a hi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2007-07-099366

    authors: Schmitt M,Schmitt A,Rojewski MT,Chen J,Giannopoulos K,Fei F,Yu Y,Götz M,Heyduk M,Ritter G,Speiser DE,Gnjatic S,Guillaume P,Ringhoffer M,Schlenk RF,Liebisch P,Bunjes D,Shiku H,Dohner H,Greiner J

    更新日期:2008-02-01 00:00:00

  • Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma.

    abstract::Multiple myeloma is characterized by genomic alterations frequently involving gains and losses of chromosomes. Single nucleotide polymorphism (SNP)-based mapping arrays allow the identification of copy number changes at the sub-megabase level and the identification of loss of heterozygosity (LOH) due to monosomy and u...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-02-005496

    authors: Walker BA,Leone PE,Jenner MW,Li C,Gonzalez D,Johnson DC,Ross FM,Davies FE,Morgan GJ

    更新日期:2006-09-01 00:00:00

  • C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function.

    abstract::We describe a novel localization of C7 as a membrane-bound molecule on endothelial cells (ECs). Data obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Western blot analysis, Northern blot analysis, and mass spectrometry revealed that membrane-associated C7 (mC7) was indistinguishable fr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-03-146472

    authors: Bossi F,Rizzi L,Bulla R,Debeus A,Tripodo C,Picotti P,Betto E,Macor P,Pucillo C,Würzner R,Tedesco F

    更新日期:2009-04-09 00:00:00

  • P-selectin glycoprotein ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines.

    abstract::P-selectin (CD62P) is a member of the selectin family of adhesion molecules involved in the regulation of leukocyte traffic. P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-like molecule that is thought to be a primary ligand for P-selectin. The interaction of P-selectin with PSGL-1 results in leukocyte rolling a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Snapp KR,Wagers AJ,Craig R,Stoolman LM,Kansas GS

    更新日期:1997-02-01 00:00:00

  • Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation.

    abstract::Macrophages as inflammatory cells are involved in the pathogenesis of atherosclerosis that today is recognized as an inflammatory disease. Activation of coagulation leads to the late complication of atherosclerosis, namely atherothrombosis with its clinical manifestations stroke, unstable angina, myocardial infarction...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-01-200915

    authors: Kastl SP,Speidl WS,Katsaros KM,Kaun C,Rega G,Assadian A,Hagmueller GW,Hoeth M,de Martin R,Ma Y,Maurer G,Huber K,Wojta J

    更新日期:2009-09-24 00:00:00

  • The quantity and duration of FcRgamma signals determine mast cell degranulation and survival.

    abstract::Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcepsilonRI, the molecular mechanism gen...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-08-2944

    authors: Yamasaki S,Ishikawa E,Kohno M,Saito T

    更新日期:2004-04-15 00:00:00

  • Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency--possible immunologic and clinical consequences.

    abstract::In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Aukrust P,Lien E,Kristoffersen AK,Müller F,Haug CJ,Espevik T,Frøland SS

    更新日期:1996-01-15 00:00:00

  • The future of anti-CD20 monoclonal antibodies: are we making progress?

    abstract::The anti-CD20 monoclonal antibody (mAb) rituximab has revolutionized the treatment of B-cell malignancies. This unprecedented success has not only substantially changed the mindset of the clinical community about the ability of mAb to improve outcomes but has catalyzed the interest in the pharmaceutical industry to de...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-07-298356

    authors: Alduaij W,Illidge TM

    更新日期:2011-03-17 00:00:00

  • Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion.

    abstract::The present studies were undertaken to determine whether factor VIII/von Willebrand factor (vWF) present in the vessel wall (in addition to that in plasma) may mediate the attachment of platelets to subendothelium. Subendothelium from everted rabbit aorta was exposed to human citrated blood flowing through an annular ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Turitto VT,Weiss HJ,Zimmerman TS,Sussman II

    更新日期:1985-04-01 00:00:00

  • Hematopoietic stem cell transplantation for multiple myeloma beyond 2010.

    abstract::Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventional chemotherapy. The greatest benefit from ASCT is obtained in patients...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2009-08-238196

    authors: Bladé J,Rosiñol L,Cibeira MT,Rovira M,Carreras E

    更新日期:2010-05-06 00:00:00

  • A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis.

    abstract::The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, val...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-04-570010

    authors: Palladini G,Hegenbart U,Milani P,Kimmich C,Foli A,Ho AD,Vidus Rosin M,Albertini R,Moratti R,Merlini G,Schönland S

    更新日期:2014-10-09 00:00:00

  • Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study.

    abstract::In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total p...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-04-499335

    authors: Pintao MC,Ribeiro DD,Bezemer ID,Garcia AA,de Visser MC,Doggen CJ,Lijfering WM,Reitsma PH,Rosendaal FR

    更新日期:2013-10-31 00:00:00

  • The missense mutation Arg593 --> Cys is related to antibody formation in a patient with mild hemophilia A.

    abstract::The development of inhibitory antibodies to factor VIII in patients affected by a mild form of hemophilia A (factor VIII > 0.05 IU/mL) is considered a rare event. In this study, we evaluated the relationship between genotype and anti-factor VIII antibody formation in a patient with mild hemophilia A. Mutation analysis...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Fijnvandraat K,Turenhout EA,van den Brink EN,ten Cate JW,van Mourik JA,Peters M,Voorberg J

    更新日期:1997-06-15 00:00:00

  • Circulating peripheral blood plasma cells as a prognostic indicator in patients with primary systemic amyloidosis.

    abstract::This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-06-1698

    authors: Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

    更新日期:2003-02-01 00:00:00