Angiostatic activity of the antitumor cytokine interleukin-21.

abstract：:The interleukin-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) pathway contributes to the pathogenesis of multiple myeloma (MM) and protects MM cells from apoptosis. However, MM cells survive the IL-6R blockade if they are cocultured with bone marrow stromal cells (BMSCs), suggesting tha...

journal_title：Blood

authors： Chatterjee M,Stühmer T,Herrmann P,Bommert K,Dörken B,Bargou RC

更新日期：2004-12-01 00:00:00

abstract：:Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects we investigated determinants of CLT. By comparison with 770 thrombosis patients, we assessed plasma levels of fibrinolytic prot...

journal_title：Blood

authors： Meltzer ME,Lisman T,de Groot PG,Meijers JC,le Cessie S,Doggen CJ,Rosendaal FR

更新日期：2010-07-08 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:Selective overexpression (50- to 100-fold) in adult erythroid cells of either G gamma or A gamma fetal globin gene is observed in hereditary conditions known as delta beta zero-thalassemia and hereditary persistence of fetal hemoglobin (HPFH). Recently, a C----T change at position -196 of an overexpressed A gamma glob...

journal_title：Blood

authors： Ottolenghi S,Giglioni B,Pulazzini A,Comi P,Camaschella C,Serra A,Guerrasio A,Saglio G

更新日期：1987-04-01 00:00:00

abstract：:The cytokine interleukin (IL)-7 exerts essential roles in lymph node (LN) organogenesis and lymphocyte development and homeostasis. Recent studies have identified lymphatic endothelial cells (LECs) as a major source of IL-7 in LNs. Here, we report that LECs not only produce IL-7, but also express the IL-7 receptor cha...

journal_title：Blood

authors： Iolyeva M,Aebischer D,Proulx ST,Willrodt AH,Ecoiffier T,Häner S,Bouchaud G,Krieg C,Onder L,Ludewig B,Santambrogio L,Boyman O,Chen L,Finke D,Halin C

更新日期：2013-09-26 00:00:00

abstract：:A new human leukemia cell line, designated as ME-1, was established from the peripheral blood leukemia cells of a patient with acute myelomonocytic leukemia with eosinophilia (M4E0). This cell line has the characteristic chromosome abnormality of M4E0, inv(16) (p13q22). When cultured in RPMI 1640 medium containing 10%...

journal_title：Blood

authors： Yanagisawa K,Horiuchi T,Fujita S

更新日期：1991-07-15 00:00:00

abstract：:Mature megakaryocytes form structures called proplatelets that serve as conduits for platelet packaging and release at vascular sinusoids. Since the megakaryocyte expresses abundant levels of integrin alpha IIb beta3, we have examined a role for fibrinogen in proplatelet development and platelet release alongside that...

journal_title：Blood

authors： Larson MK,Watson SP

更新日期：2006-09-01 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB (NF-kappaB). In this study, we evaluated the molecular basis of ...

journal_title：Blood

authors： Daniel S,Arvelo MB,Patel VI,Longo CR,Shrikhande G,Shukri T,Mahiou J,Sun DW,Mottley C,Grey ST,Ferran C

更新日期：2004-10-15 00:00:00

abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

journal_title：Blood

authors： Valent P,Akin C,Metcalfe DD

更新日期：2017-03-16 00:00:00

abstract：:Human fibrinogen 1 is homodimeric with respect to its gamma chains (gammaA-gammaA'), whereas fibrinogen 2 molecules each contain one gammaA (gammaA1-411V) and one gamma' chain, which differ by containing a unique C-terminal sequence from gamma'408 to 427L that binds thrombin and factor XIII. We investigated the struct...

journal_title：Blood

authors： Siebenlist KR,Mosesson MW,Hernandez I,Bush LA,Di Cera E,Shainoff JR,Di Orio JP,Stojanovic L

更新日期：2005-10-15 00:00:00

abstract：:Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or protein in lymphocytes in tissues. We present our experience with CAEBV during the last 28 years, including the first 8 cases treated with hematopoiet...

journal_title：Blood

authors： Cohen JI,Jaffe ES,Dale JK,Pittaluga S,Heslop HE,Rooney CM,Gottschalk S,Bollard CM,Rao VK,Marques A,Burbelo PD,Turk SP,Fulton R,Wayne AS,Little RF,Cairo MS,El-Mallawany NK,Fowler D,Sportes C,Bishop MR,Wilson W,St

更新日期：2011-06-02 00:00:00

abstract：:In this issue of Blood, Khorana and colleagues report a simple and practical model for the prediction of symptomatic venous thrombosis after the initiation of chemotherapy in cancer outpatients. ...

journal_title：Blood

authors： Doggen CJ

更新日期：2008-05-15 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent linkage of drug to the...

journal_title：Blood

authors： Bougie DW,Birenbaum J,Rasmussen M,Poncz M,Aster RH

更新日期：2009-01-29 00:00:00

abstract：:Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC...

journal_title：Blood

authors： Hermand P,Mouro I,Huet M,Bloy C,Suyama K,Goldstein J,Cartron JP,Bailly P

更新日期：1993-07-15 00:00:00

abstract：:Adenosine diphosphate (ADP)-ribosyl-transferases (ARTs) transfer ADP-ribose from nicotinamide adenine dinucleotide (NAD) onto target proteins. T cells express ART2.2, a toxin-related, glycosylphosphatidylinositol (GPI)-anchored ecto-enzyme. After the release of NAD from cells, ART2.2 ADP-ribosylates the P2X7 purinocep...

journal_title：Blood

authors： Bannas P,Adriouch S,Kahl S,Braasch F,Haag F,Koch-Nolte F

更新日期：2005-05-01 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00

abstract：:The myeloid cell-surface glycoprotein CD13/aminopeptidase N (APN; EC 3.4.11.2) contains a pentapeptide (HExxH) in its extracellular domain that is characteristic of many zinc-dependent metalloproteinases. This region contains residues important for zinc binding and constitutes part of the catalytic domain of several m...

journal_title：Blood

authors： Ashmun RA,Shapiro LH,Look AT

更新日期：1992-06-15 00:00:00

abstract：:Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Convention...

journal_title：Blood

authors： Cervantes F

更新日期：2014-10-23 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00

abstract：:A rapid sensitive spectrophotometric assay for the measurement of methylmalonic and propionic acids in urine is described. The assay is based upon the quantitation of propionic acid using acetyl coenzyme A synthetase isolated from baker's yeast. This enzyme is highly specific for acetate and propionate, and acetate in...

journal_title：Blood

authors： Frenkel EP,Kitchens RL

更新日期：1977-01-01 00:00:00

abstract：:Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of ...

journal_title：Blood

authors： Feller AC,Griesser GH,Mak TW,Lennert K

更新日期：1986-09-01 00:00:00

abstract：:CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression. In the present study, we analy...

journal_title：Blood

authors： Tissino E,Pozzo F,Benedetti D,Caldana C,Bittolo T,Rossi FM,Bomben R,Nanni P,Chivilò H,Cattarossi I,Zaina E,Norris K,Polesel J,Gentile M,Tripepi G,Moia R,Santinelli E,Innocenti I,Olivieri J,D'Arena G,Laurenti L,Z

更新日期：2020-04-09 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia (ATL), a fatal T-cell leukemia resistant to chemotherapy, after more than 50 years of clinical latency from transmission through breast-feeding. Polyclonal expansion of virus-infected T cells predisposes them to transformation. Constitutive activ...

journal_title：Blood

authors： Watanabe M,Ohsugi T,Shoda M,Ishida T,Aizawa S,Maruyama-Nagai M,Utsunomiya A,Koga S,Yamada Y,Kamihira S,Okayama A,Kikuchi H,Uozumi K,Yamaguchi K,Higashihara M,Umezawa K,Watanabe T,Horie R

更新日期：2005-10-01 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:Beside its classical role in the coagulation cascade, coagulation factor X (FX) is involved in several major biological processes including inflammation and enhancement of virus-induced immune responses. We recently reported that the long circulatory half-life of FX is linked to its interaction with liver-resident mac...

journal_title：Blood

authors： Muczynski V,Bazaa A,Loubière C,Harel A,Cherel G,Denis CV,Lenting PJ,Christophe OD

更新日期：2016-02-11 00:00:00

abstract：:Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to expres...

journal_title：Blood

authors： McDonald PP,Russo MP,Ferrini S,Cassatella MA

更新日期：1998-12-15 00:00:00

abstract：:Current dendritic cell (DC)-based vaccines are based on ex vivo-generated autologous DCs loaded with antigen prior to readministration into patients. A more direct and less laborious strategy is to target antigens to DCs in vivo via specific surface receptors. Therefore, we developed a humanized antibody, hD1V1G2/G4 (...

journal_title：Blood

authors： Tacken PJ,de Vries IJ,Gijzen K,Joosten B,Wu D,Rother RP,Faas SJ,Punt CJ,Torensma R,Adema GJ,Figdor CG

更新日期：2005-08-15 00:00:00

abstract：:In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total p...

journal_title：Blood

authors： Pintao MC,Ribeiro DD,Bezemer ID,Garcia AA,de Visser MC,Doggen CJ,Lijfering WM,Reitsma PH,Rosendaal FR

更新日期：2013-10-31 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00