Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States.

abstract：:The fibrinogen structural variant, Marburg (A alpha 1-460B beta gamma)2, is comprised of normal B beta and gamma chains but contains severely truncated A alpha chains that are missing approximately one half of their factor XIIIa cross-linking domain. Immunochemical studies of fibrin(ogen) Marburg were conducted to cha...

journal_title：Blood

authors： Sobel JH,Trakht I,Wu HQ,Rudchenko S,Egbring R

更新日期：1995-08-01 00:00:00

abstract：:A noninferiority study was performed comparing low-dose and standard-dose prophylactic platelet transfusions. A double-blind randomized controlled trial (RCT) was performed in 6 sites in 3 countries. Thrombocytopenic adults requiring prophylactic platelet transfusion were randomly allocated to standard-dose (300-600 x...

journal_title：Blood

authors： Heddle NM,Cook RJ,Tinmouth A,Kouroukis CT,Hervig T,Klapper E,Brandwein JM,Szczepiorkowski ZM,AuBuchon JP,Barty RL,Lee KA,SToP Study Investigators of the BEST Collaborative.

更新日期：2009-02-12 00:00:00

abstract：:We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous leukemia (CML) in chronic, accelerated, or blastic phase and in 8 patients with myelofibrosis (MF) and 10 patients with multiple myeloma (MM). R115777 was administered at 600 mg orally twice dail...

journal_title：Blood

authors： Cortes J,Albitar M,Thomas D,Giles F,Kurzrock R,Thibault A,Rackoff W,Koller C,O'Brien S,Garcia-Manero G,Talpaz M,Kantarjian H

更新日期：2003-03-01 00:00:00

abstract：:Complete interleukin-12/interleukin-23 receptor beta1 (IL-12Rbeta1) deficiency is the most frequent known genetic etiology of the syndrome of Mendelian susceptibility to mycobacterial disease. The patients described to date lack IL-12Rbeta1 at the surface of their natural killer (NK) and T cells due to IL12RB1 mutatio...

journal_title：Blood

authors： Fieschi C,Bosticardo M,de Beaucoudrey L,Boisson-Dupuis S,Feinberg J,Santos OF,Bustamante J,Levy J,Candotti F,Casanova JL

更新日期：2004-10-01 00:00:00

abstract：:The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis of clinical, biologic, and early response data predictive of event-free survival (EFS) in acute lymphoblastic leukemia (ALL) to develop a new classification ...

journal_title：Blood

authors： Schultz KR,Pullen DJ,Sather HN,Shuster JJ,Devidas M,Borowitz MJ,Carroll AJ,Heerema NA,Rubnitz JE,Loh ML,Raetz EA,Winick NJ,Hunger SP,Carroll WL,Gaynon PS,Camitta BM

更新日期：2007-02-01 00:00:00

abstract：:Anticoagulation with vitamin K antagonists (VKAs) is problematic because of difficulties in safely managing dosing. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase genes (VKORC1) have been shown to affect VKA dosing in adults. The association of these polymorphisms on VKA dosing in childr...

journal_title：Blood

authors： Nowak-Göttl U,Dietrich K,Schaffranek D,Eldin NS,Yasui Y,Geisen C,Mitchell LG

更新日期：2010-12-23 00:00:00

abstract：:Human parvovirus B19 (B19V) infection shows a strong erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the disease outcomes associated with B19V infection. In this study, we systematically examined the 3 B19V nonstructural proteins, 7.5 kDa, 11 kDa, and NS1, for their funct...

journal_title：Blood

authors： Chen AY,Zhang EY,Guan W,Cheng F,Kleiboeker S,Yankee TM,Qiu J

更新日期：2010-02-04 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of inter...

journal_title：Blood

authors： Flynn R,Paz K,Du J,Reichenbach DK,Taylor PA,Panoskaltsis-Mortari A,Vulic A,Luznik L,MacDonald KK,Hill GR,Nyuydzefe MS,Weiss JM,Chen W,Trzeciak A,Serody JS,Aguilar EG,Murphy WJ,Maillard I,Munn D,Koreth J,Cutler CS

更新日期：2016-04-28 00:00:00

abstract：:Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expression compared wit...

journal_title：Blood

authors： Liyanage SU,Hurren R,Voisin V,Bridon G,Wang X,Xu C,MacLean N,Siriwardena TP,Gronda M,Yehudai D,Sriskanthadevan S,Avizonis D,Shamas-Din A,Minden MD,Bader GD,Laposa R,Schimmer AD

更新日期：2017-05-11 00:00:00

abstract：:Donor-matched transplantation of hematopoietic stem cells (HSCs) is widely used to treat hematologic malignancies but is associated with high mortality. The expansion of HSC numbers and their mobilization into the bloodstream could significantly improve therapy. We report here that adult mice conditionally deficient f...

journal_title：Blood

authors： Khandanpour C,Sharif-Askari E,Vassen L,Gaudreau MC,Zhu J,Paul WE,Okayama T,Kosan C,Möröy T

更新日期：2010-12-09 00:00:00

abstract：:Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobese diabetic-severe combined immunodeficient (NOD/SCID) mic...

journal_title：Blood

authors： Bair S,Spaulding E,Parkkinen J,Shulman HM,Lesnikov V,Beauchamp M,Canonne-Hergaux F,Kowdley KV,Deeg HJ

更新日期：2009-02-19 00:00:00

abstract：:Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells. Although the overall survival of FL patients has recently improved with the introduction of novel therapies, there is significant heterogeneity in patient outcome and a need for rationally designed therapeutic strategies that target disease...

journal_title：Blood

authors： Green MR

更新日期：2018-02-08 00:00:00

abstract：:Hematopoiesis is a tightly regulated process resulting in the production of blood cells. Self-renewal and differentiation of hematopoietic stem cells (HSCs) are key processes in hematopoietic development. Disruption of these steps can lead to altered cell distribution and disease. To investigate the role of the nuclea...

journal_title：Blood

authors： Stein SJ,Baldwin AS

更新日期：2013-06-20 00:00:00

abstract：:Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...

journal_title：Blood

authors： Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

更新日期：2013-04-18 00:00:00

abstract：:Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fluda...

journal_title：Blood

authors： Stelljes M,Bornhauser M,Kroger M,Beyer J,Sauerland MC,Heinecke A,Berning B,Scheffold C,Silling G,Buchner T,Neubauer A,Fauser AA,Ehninger G,Berdel WE,Kienast J,Cooperative German Transplant Study Group.

更新日期：2005-11-01 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders in which recurrent mutations define clonal hematopoiesis. The origin of the phenotypic diversity of non-del(5q) MDS remains unclear. Here, we investigated the clonal architecture of the CD34+CD38- hematopoietic stem/progenitor cell (HSPC) compartme...

journal_title：Blood

authors： Chesnais V,Arcangeli ML,Delette C,Rousseau A,Guermouche H,Lefevre C,Bondu S,Diop M,Cheok M,Chapuis N,Legros L,Raynaud S,Willems L,Bouscary D,Lauret E,Bernard OA,Kosmider O,Pflumio F,Fontenay M

更新日期：2017-01-26 00:00:00

abstract：:Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients. To determine the impact of pretransplantation hyperferritinemia on the risk of SOS after HSC transplantation, we retrospectively studied 427 HSCT recipients (179 autologous and 248 allogenei...

journal_title：Blood

authors： Maradei SC,Maiolino A,de Azevedo AM,Colares M,Bouzas LF,Nucci M

更新日期：2009-08-06 00:00:00

abstract：:Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosphorylated form of St...

journal_title：Blood

authors： Bessette K,Lang ML,Fava RA,Grundy M,Heinen J,Horne L,Spolski R,Al-Shami A,Morse HC 3rd,Leonard WJ,Kelly JA

更新日期：2008-01-01 00:00:00

abstract：:The administration of interleukin-2 (IL-2) may induce complete remissions in acute myelogenous leukemia (AML) patients with a low proportion of residual bone marrow (BM) blasts. To confirm this preliminary observation, we treated 14 AML patients with advanced disease and with a residual BM blastosis that ranged betwee...

journal_title：Blood

authors： Meloni G,Foa R,Vignetti M,Guarini A,Fenu S,Tosti S,Tos AG,Mandelli F

更新日期：1994-10-01 00:00:00

abstract：:To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell-depleted bone marrow, we measured the appearance of CD4(+)CD45RA(+)RO(-) naive T cells (thymic rebound), restoration of the diversity of the T-cell-receptor (TCR) repertoire and the response to vaccinations with tetan...

journal_title：Blood

authors： Roux E,Dumont-Girard F,Starobinski M,Siegrist CA,Helg C,Chapuis B,Roosnek E

更新日期：2000-09-15 00:00:00

abstract：:We have used monoclonal antibodies (M Abs) and proteolytic fragmentation to localize structurally the functional sites of human von Willebrand factor (vWF) responsible for interaction with membrane glycoproteins GPIb, GPIIb/IIIa, and with collagen. SpII (215 kd) and SpIII (320 kd), the S aureus V-8 protease homodimeri...

journal_title：Blood

authors： Girma JP,Kalafatis M,Piétu G,Lavergne JM,Chopek MW,Edgington TS,Meyer D

更新日期：1986-05-01 00:00:00

abstract：:Glutathione-S-transferase (GST)-Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA. Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of...

journal_title：Blood

authors： Robinson A,Gibbins J,Rodríguez-Liñares B,Finan PM,Wilson L,Kellie S,Findell P,Watson SP

更新日期：1996-07-15 00:00:00

abstract：:Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections. We report here a new form of partial STAT1 deficiency in 2 siblings presenting mycobacterial and viral diseases. Both carried a homozygous missense muta...

journal_title：Blood

authors： Kong XF,Ciancanelli M,Al-Hajjar S,Alsina L,Zumwalt T,Bustamante J,Feinberg J,Audry M,Prando C,Bryant V,Kreins A,Bogunovic D,Halwani R,Zhang XX,Abel L,Chaussabel D,Al-Muhsen S,Casanova JL,Boisson-Dupuis S

更新日期：2010-12-23 00:00:00

abstract：:Recently (J Pharmacol Exp Ther 261:580, 1992), we have shown that K562 leukemia cells express a calcium-signaling purinoceptor with characteristics of the P2T receptor subtype for adenosine diphosphate (ADP) previously found only in platelets. Because these results suggested that the P2T receptor may be an early marke...

journal_title：Blood

authors： Murgo AJ,Contrera JG,Sistare FD

更新日期：1994-03-01 00:00:00

abstract：:Glycosaminoglycans (GAG) are a group of negatively charged molecules that have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, transforming growth factor-beta, IL-7, and interferon-gamma. The ability of GAG to interact with human IL-10 (h...

journal_title：Blood

authors： Salek-Ardakani S,Arrand JR,Shaw D,Mackett M

更新日期：2000-09-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) transplanted in utero are in competition with endogenous HSC; thus, ultimately the graft constitutes a relatively small fraction of total HSC pool. To enhance the engraftment of donor cells in sheep fetuses, we preincubated these cells, ex vivo, for 16 hours at 37 degrees C with the cond...

journal_title：Blood

authors： Zanjani ED,Ascensao JL,Harrison MR,Tavassoli M

更新日期：1992-06-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

journal_title：Blood

authors： Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

更新日期：2012-01-12 00:00:00

abstract：:The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular injury. Unexpectedly, we observed platelets translocating over A1A2A3 domains protein slower than on A1 domain at high shear stress. This observ...

journal_title：Blood

authors： Da Q,Behymer M,Correa JI,Vijayan KV,Cruz MA

更新日期：2014-04-24 00:00:00

abstract：:An autoantibody, developed by a patient with severe and recurrent arterial thrombosis, was characterized to be directed against the anion-binding exosite of thrombin, and inhibited all thrombin interactions requiring this secondary binding site without interfering with the catalytic site. The effect of the antibody wa...

journal_title：Blood

authors： Arnaud E,Lafay M,Gaussem P,Picard V,Jandrot-Perrus M,Aiach M,Rendu F

更新日期：1994-09-15 00:00:00

abstract：:Circulating endothelial progenitor cells (EPCs) are thought to contribute to angiogenesis following vascular injury, stimulating interest in their ability to mediate therapeutic angiogenesis. However, the number of EPCs in the blood is low, limiting endogenous repair, and a method to rapidly mobilize EPCs has not been...

journal_title：Blood

authors： Shepherd RM,Capoccia BJ,Devine SM,Dipersio J,Trinkaus KM,Ingram D,Link DC

更新日期：2006-12-01 00:00:00