How I treat myelofibrosis.

abstract：:We infused six human immunodeficiency virus (HIV)-seropositive subjects with autologous CD8+ cytotoxic T cells (CTLs) enriched for HIV-specific cytotoxicity targeted against a diversity of HIV epitopes in gp120, gag p17 and p24, and nef. There was no toxicity and no subject deteriorated clinically. In the first 2 week...

journal_title：Blood

authors： Lieberman J,Skolnik PR,Parkerson GR 3rd,Fabry JA,Landry B,Bethel J,Kagan J

更新日期：1997-09-15 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an inherited immunodeficiency resulting from the inability of an individual's phagocytes to produce superoxide anions because of defective NADPH oxidase. The disease may be treated by bone marrow transplantation and as such is a candidate for somatic gene therapy. Two thirds of p...

journal_title：Blood

authors： Porter CD,Parkar MH,Levinsky RJ,Collins MK,Kinnon C

更新日期：1993-10-01 00:00:00

abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

journal_title：Blood

authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

更新日期：1996-04-01 00:00:00

abstract：:In this issue of Blood, Whyte et al describe how under flow conditions, phosphatidylserine-expressing platelets modulate the lysis of whole blood clots by providing direct and indirect binding sites for plasminogen. ...

journal_title：Blood

authors： Kim PY

更新日期：2015-04-16 00:00:00

abstract：:After the discovery of NPM1-mutated acute myeloid leukemia (AML) in 2005 and its subsequent inclusion as a provisional entity in the 2008 World Health Organization classification of myeloid neoplasms, several controversial issues remained to be clarified. It was unclear whether the NPM1 mutation was a primary genetic ...

journal_title：Blood

authors： Falini B,Martelli MP,Bolli N,Sportoletti P,Liso A,Tiacci E,Haferlach T

更新日期：2011-01-27 00:00:00

abstract：:CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positive ALL and has a poo...

journal_title：Blood

authors： Maude SL,Tasian SK,Vincent T,Hall JW,Sheen C,Roberts KG,Seif AE,Barrett DM,Chen IM,Collins JR,Mullighan CG,Hunger SP,Harvey RC,Willman CL,Fridman JS,Loh ML,Grupp SA,Teachey DT

更新日期：2012-10-25 00:00:00

abstract：:Increasingly, allogeneic and even more often autologous bone marrow transplants are being done to correct a wide variety of diseases. In addition, autologous marrow transplants potentially provide an opportune means of delivering genes in transfected, engrafting stem cells. However, despite its widespread clinical use...

journal_title：Blood

authors： Nilsson SK,Dooner MS,Tiarks CY,Weier HU,Quesenberry PJ

更新日期：1997-06-01 00:00:00

abstract：:Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying MK-restricted expr...

journal_title：Blood

authors： Macaulay IC,Thon JN,Tijssen MR,Steele BM,MacDonald BT,Meade G,Burns P,Rendon A,Salunkhe V,Murphy RP,Bennett C,Watkins NA,He X,Fitzgerald DJ,Italiano JE Jr,Maguire PB

更新日期：2013-01-03 00:00:00

abstract：:CXC ligand 12 (CXCL12; also known as stromal cell-derived factor 1alpha/SDF-1alpha) chemoattracts hematopoietic stem and progenitor cells (HSCs/HPCs) and is thought to play a crucial role in the mobilization of HSCs/HPCs from the bone marrow. CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular pept...

journal_title：Blood

authors： Christopherson KW 2nd,Cooper S,Broxmeyer HE

更新日期：2003-06-15 00:00:00

abstract：:Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...

journal_title：Blood

authors： Rowley M,Liu P,Van Ness B

更新日期：2000-11-01 00:00:00

abstract：:The Bernard-Soulier syndrome is an inherited bleeding disorder that is due to a deficiency in platelet glycoprotein Ib. Bernard-Soulier platelets fail to agglutinate in response to ristocetin despite normal levels of factor VIII:von Willebrand factor. We report a patient who developed severe refractory thrombocytopeni...

journal_title：Blood

authors： Devine DV,Currie MS,Rosse WF,Greenberg CS

更新日期：1987-08-01 00:00:00

abstract：:Current immunotherapeutic trials for patients with multiple myeloma (MM) focus on the idiotype (Id) as a tumor-specific antigen for active immunization. To bypass the need for the identification of shared MM-associated antigens and the characterization of possible immunogenic T-cell epitopes in a human leukocyte antig...

journal_title：Blood

authors： Milazzo C,Reichardt VL,Müller MR,Grünebach F,Brossart P

更新日期：2003-02-01 00:00:00

abstract：:Production of tumor necrosis factor-alpha (TNFalpha) by the neutrophil (PMN) is a pivotal event in innate immunity, but the signals regulating TNFalpha induction in this primary cell are poorly understood. Herein, we use protein transduction to identify novel, opposing anti- and pro-cytokine-inducing roles for RhoA in...

journal_title：Blood

authors： Fessler MB,Arndt PG,Just I,Nick JA,Malcolm KC,Worthen GS

更新日期：2007-02-01 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

journal_title：Blood

authors： Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

更新日期：1993-07-01 00:00:00

abstract：:The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone developmen...

journal_title：Blood

authors： Talebian L,Li Z,Guo Y,Gaudet J,Speck ME,Sugiyama D,Kaur P,Pear WS,Maillard I,Speck NA

更新日期：2007-01-01 00:00:00

abstract：:Cutaneous T-cell lymphoma (CTCL) constitutes a malignant proliferative disease involving mostly CD4(+) T cells arising in the skin. Because of the lack of curative treatment options, interferons (IFN) have been introduced into the therapy of CTCL. Although effective even in advanced disease, response rates were about ...

journal_title：Blood

authors： Stadler R,Otte HG,Luger T,Henz BM,Kühl P,Zwingers T,Sterry W

更新日期：1998-11-15 00:00:00

abstract：:This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Posttransplantation CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pretransplantation CMV serology (P ...

journal_title：Blood

authors： Albano MS,Taylor P,Pass RF,Scaradavou A,Ciubotariu R,Carrier C,Dobrila L,Rubinstein P,Stevens CE

更新日期：2006-12-15 00:00:00

abstract：:Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation through a complex signaling network. To elucidate the ALK pathways s...

journal_title：Blood

authors： Boccalatte FE,Voena C,Riganti C,Bosia A,D'Amico L,Riera L,Cheng M,Ruggeri B,Jensen ON,Goss VL,Lee K,Nardone J,Rush J,Polakiewicz RD,Comb MJ,Chiarle R,Inghirami G

更新日期：2009-03-19 00:00:00

abstract：:Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen receptors, and expo...

journal_title：Blood

authors： Kelly RM,Highfill SL,Panoskaltsis-Mortari A,Taylor PA,Boyd RL,Holländer GA,Blazar BR

更新日期：2008-06-15 00:00:00

abstract：:Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin. ...

journal_title：Blood

authors： Hsu LL

更新日期：2012-02-23 00:00:00

abstract：:It has been shown previously that multilineage human hematopoiesis is maintained within human fetal bone marrow (BM) fragments implanted into severe combined immunodeficient (SCID) mice. We describe here an application of this animal model, the SCID-hu mouse, to the study of human myeloid leukemias. BM cells from 8 pa...

journal_title：Blood

authors： Namikawa R,Ueda R,Kyoizumi S

更新日期：1993-10-15 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary ly...

journal_title：Blood

authors： Christopherson KW 2nd,Hood AF,Travers JB,Ramsey H,Hromas RA

更新日期：2003-02-01 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:Hematopoietic stem cell (HSC)-based gene therapy holds promise for the cure of many diseases. The field is now moving toward the use of lentiviral vectors (LVs) as evidenced by 4 successful clinical trials. These trials used vesicular-stomatitis-virus-G protein (VSV-G)-LVs at high doses combined with strong cytokine-c...

journal_title：Blood

authors： Girard-Gagnepain A,Amirache F,Costa C,Lévy C,Frecha C,Fusil F,Nègre D,Lavillette D,Cosset FL,Verhoeyen E

更新日期：2014-08-21 00:00:00

abstract：:Chromosomal translocation involving the BCL6 gene affects not only immunoglobulin (Ig) genes but also a number of non-Ig genes as partners. The molecular anatomy of the BCL6 gene rearrangements in 39 cases with diffuse large B-cell lymphoma (DLBCL) by long-distance polymerase chain reaction-based assays was determined...

journal_title：Blood

authors： Akasaka T,Ueda C,Kurata M,Akasaka H,Yamabe H,Uchiyama T,Ohno H

更新日期：2000-10-15 00:00:00

abstract：:Using a recently described serum-free culture system of purified human CD34+ progenitor cells, we show here a critical cooperation of flt3 ligand (FL) with transforming growth factor-beta1 (TGF-beta1) in the induction of in vitro dendritic cell/Langerhans cell (DC/LC) development. The addition of FL to serum-free cult...

journal_title：Blood

authors： Strobl H,Bello-Fernandez C,Riedl E,Pickl WF,Majdic O,Lyman SD,Knapp W

更新日期：1997-08-15 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) is an important growth and survival factor in multiple myeloma (MM). Here, we demonstrate that IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in MM cells. Reduced Bim levels by RNA interference (RNAi) protected cells from drug-induced cell death....

journal_title：Blood

authors： De Bruyne E,Bos TJ,Schuit F,Van Valckenborgh E,Menu E,Thorrez L,Atadja P,Jernberg-Wiklund H,Vanderkerken K

更新日期：2010-03-25 00:00:00