Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases.

abstract：:Chronic granulomatous disease (CGD) is characterized by the absence of a respiratory burst in activated phagocytes. Defects in at least four different genes lead to CGD. Patients with the X-linked form of CGD have mutations in the gene for the beta-subunit of cytochrome b558 (gp91-phox). We studied the molecular defec...

journal_title：Blood

authors： de Boer M,Bolscher BG,Dinauer MC,Orkin SH,Smith CI,Ahlin A,Weening RS,Roos D

更新日期：1992-09-15 00:00:00

abstract：:In a patient with nonspherocytic hemolytic anemia, a hexokinase deficiency was detected in the red cells (residual activity about 25% of normal) and in blood platelets (20%-35% of normal activity). Although the total hexokinase activity in lymphocytes was normal, the amount of hexokinase type I was decreased to about ...

journal_title：Blood

authors： Rijksen G,Akkerman JW,van den Wall Bake AW,Hofstede DP,Staal GE

更新日期：1983-01-01 00:00:00

abstract：:The functions of the alphaC domains of fibrinogen in clotting and fibrinolysis, which have long been enigmatic, were determined using recombinant fibrinogen truncated at Aalpha chain residue 251. Scanning electron microscopy and confocal microscopy revealed that the fibers of alpha251 clots were thinner and denser, wi...

journal_title：Blood

authors： Collet JP,Moen JL,Veklich YI,Gorkun OV,Lord ST,Montalescot G,Weisel JW

更新日期：2005-12-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) is etiologically linked to Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease. Vascular endothelial growth factor-A (VEGF-A) is one of the essential factors required in KSHV pathogenesis, mainly due to its abil...

journal_title：Blood

authors： Akula SM,Ford PW,Whitman AG,Hamden KE,Bryan BA,Cook PP,McCubrey JA

更新日期：2005-06-01 00:00:00

abstract：:An inherited fibrinogen variant, fibrinogen Bern I, was isolated from plasma of an asymptomatic woman. Routine coagulation studies showed prolonged thrombin and reptilase clotting times. Fibrinogen concentration was diminished when determined by a functional assay, but was normal by the heat precipitation method. The ...

journal_title：Blood

authors： Steinmann C,Reber P,Jungo M,Lämmle B,Heinemann G,Wermuth B,Furlan M

更新日期：1993-10-01 00:00:00

abstract：:Mutations in the kinase domain (KD) of BCR-ABL are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations before and during therapy, and whether the ...

journal_title：Blood

authors： O'Hare T,Eide CA,Deininger MW

更新日期：2007-10-01 00:00:00

abstract：:BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are unknown. To test t...

journal_title：Blood

authors： Vasanthakumar A,Arnovitz S,Marquez R,Lepore J,Rafidi G,Asom A,Weatherly M,Davis EM,Neistadt B,Duszynski R,Vardiman JW,Le Beau MM,Godley LA,Churpek JE

更新日期：2016-01-21 00:00:00

abstract：:In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity...

journal_title：Blood

authors： Rajkumar SV,Gahrton G,Bergsagel PL

更新日期：2011-09-22 00:00:00

abstract：:Cervical internal carotid artery (cICA) occlusion is a recognized cause of acute ischemic stroke (AIS) in sickle cell disease (SCD), but the associated clinical and radiologic features are not well described. We reviewed data on cervical magnetic resonance angiography (cMRA) performed prospectively in 67 patients (55 ...

journal_title：Blood

authors： Telfer PT,Evanson J,Butler P,Hemmaway C,Abdulla C,Gadong N,Whitmarsh S,Kaya B,Kirkham FJ

更新日期：2011-12-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) was evaluated either alone or combined with cyclosporine (CSP) for preventing graft-versus-host disease (GVHD) in dogs given 9.2 Gy total body irradiation and DLA-nonidentical unrelated marrow grafts. Marrow autograft studies showed gut toxicity as limiting MMF side effects. Four groups wer...

journal_title：Blood

authors： Yu C,Seidel K,Nash RA,Deeg HJ,Sandmaier BM,Barsoukov A,Santos E,Storb R

更新日期：1998-04-01 00:00:00

abstract：:The bone and immune systems are closely related through cellular and molecular interactions. Because bone-resorbing osteoclasts (OCs) are derived from the monocyte/macrophage lineage, similar to dendritic cells (DCs), we hypothesized that OCs could serve as antigen-presenting cells (APCs) to activate T cells. In this ...

journal_title：Blood

authors： Li H,Hong S,Qian J,Zheng Y,Yang J,Yi Q

更新日期：2010-07-15 00:00:00

abstract：:Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...

journal_title：Blood

authors： Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

更新日期：1998-11-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin-1 (matrix metalloproteinase-3 [MMP-3]) induced in endothelial cells was critical for ICB induced b...

journal_title：Blood

authors： Suzuki Y,Nagai N,Yamakawa K,Kawakami J,Lijnen HR,Umemura K

更新日期：2009-10-08 00:00:00

abstract：:Low molecular weight heparin (LMWH) is being tested as an experimental drug for improving pregnancy outcome in women with inherited thrombophilia and placenta-mediated pregnancy complications, such as recurrent pregnancy loss. The role of thrombotic processes in these disorders remains unproven, and the issue of antit...

journal_title：Blood

authors： An J,Waitara MS,Bordas M,Arumugam V,Hoffmann RG,Petrich BG,Sinha U,North PE,Sood R

更新日期：2013-03-14 00:00:00

abstract：:The hereditary stomatocytoses are a series of dominantly inherited hemolytic anemias in which the permeability of the erythrocyte membrane to monovalent cations is pathologically increased. The causative mutations for some forms of hereditary stomatocytosis have been found in the transporter protein genes, RHAG and SL...

journal_title：Blood

authors： Flatt JF,Guizouarn H,Burton NM,Borgese F,Tomlinson RJ,Forsyth RJ,Baldwin SA,Levinson BE,Quittet P,Aguilar-Martinez P,Delaunay J,Stewart GW,Bruce LJ

更新日期：2011-11-10 00:00:00

abstract：:An increasing number of reports document instances in which individual leukemic cells coexpress markers normally believed to be restricted to a single lineage. This has been interpreted by McCulloch and colleagues as aberrant programming or lineage infidelity and contrasts with earlier suggestions that lineage fidelit...

journal_title：Blood

authors： Greaves MF,Chan LC,Furley AJ,Watt SM,Molgaard HV

更新日期：1986-01-01 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:Factor XIII is the fibrin-stabilizing factor that covalently cross-links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consist...

journal_title：Blood

authors： Weisberg LJ,Shiu DT,Conkling PR,Shuman MA

更新日期：1987-08-01 00:00:00

abstract：:Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that Δ(12)-PGJ(3), a n...

journal_title：Blood

authors： Hegde S,Kaushal N,Ravindra KC,Chiaro C,Hafer KT,Gandhi UH,Thompson JT,van den Heuvel JP,Kennett MJ,Hankey P,Paulson RF,Prabhu KS

更新日期：2011-12-22 00:00:00

abstract：:Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

journal_title：Blood

authors： Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

更新日期：2006-07-01 00:00:00

abstract：:Serum from 398 myeloma patients at diagnosis and serial samples from 29 patients were analysed for hepatocyte growth factor (HGF). HGF was elevated at diagnosis in 43% of myeloma patients compared with healthy controls (median 1.00 ng/mL and 0.44 ng/mL, respectively; P < .00001). In the group with elevated HGF levels ...

journal_title：Blood

authors： Seidel C,Børset M,Turesson I,Abildgaard N,Sundan A,Waage A

更新日期：1998-02-01 00:00:00

abstract：:We have explored the role of plasminogen activator inhibitor type 2 (PAI-2) in THP-1 monocyte-like cells. These cells possess a mutation in the PAI-2 gene and do not produce an active PAI-2 protein. Transfection of THP-1 cells with plasmids expressing active PAI-2 reduced the cells' inherent adhesive properties and de...

journal_title：Blood

authors： Yu H,Maurer F,Medcalf RL

更新日期：2002-04-15 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

journal_title：Blood

authors： Bahler DW,Miklos JA,Swerdlow SH

更新日期：1997-05-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) with thrombosis is a serious complication of heparin use. HIT sera can generate platelet-derived microparticles, which are produced in a heparin-dependent manner and are hypothesized to be important initial pathological participants because they promote vascular occlusion. To dat...

journal_title：Blood

authors： Hughes M,Hayward CP,Warkentin TE,Horsewood P,Chorneyko KA,Kelton JG

更新日期：2000-07-01 00:00:00

abstract：:The continuous generation of mature blood cells from primitive multipotent progenitor cells requires a highly complex series of cellular events that are still largely unknown. To examine the molecular events associated with the commitment of these hematopoietic progenitor cells to the megakaryocytic lineage, the alpha...

journal_title：Blood

authors： Tropel P,Roullot V,Vernet M,Poujol C,Pointu H,Nurden P,Marguerie G,Tronik-Le Roux D

更新日期：1997-10-15 00:00:00

abstract：:By stimulating the expression of murine IP-10 and Mig, CXC chemokines that inhibit neovascularization and cause damage to established tumor vasculature, human B cells immortalized with Epstein-Barr virus (EBV) can promote an effective antitumor response in athymic mice. In the present study, we examined the potential ...

journal_title：Blood

authors： Cherney BW,Sgadari C,Kanegane C,Wang F,Tosato G

更新日期：1998-04-01 00:00:00

abstract：:The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell product...

journal_title：Blood

authors： Chen X,Barfield R,Benaim E,Leung W,Knowles J,Lawrence D,Otto M,Shurtleff SA,Neale GA,Behm FG,Turner V,Handgretinger R

更新日期：2005-01-15 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), a new anticancer agent currently in clinical trials, has been demonstrated to inhibit superoxide dismutase (SOD) and to induce apoptosis in leukemia cells through a free radical-mediated mechanism. Because the accumulation of superoxide (O(2)-) by inhibition of SOD depends on the cellular ge...

journal_title：Blood

authors： Zhou Y,Hileman EO,Plunkett W,Keating MJ,Huang P

更新日期：2003-05-15 00:00:00

abstract：:Although the graft-versus-leukemia effect of allogeneic bone marrow transplantation (BMT) is of paramount importance in the maintenance of disease remission, the role played by the autologous T-cell response in antitumor immune surveillance is less defined. We evaluated the emergence of antileukemia cytotoxic T-lympho...

journal_title：Blood

authors： Montagna D,Maccario R,Locatelli F,Montini E,Pagani S,Bonetti F,Daudt L,Turin I,Lisini D,Garavaglia C,Dellabona P,Casorati G

更新日期：2006-12-01 00:00:00