Plasminogen activator inhibitor type 2: a regulator of monocyte proliferation and differentiation.

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00

abstract：:We tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highes...

journal_title：Blood

authors： Lozier JN,Tayebi N,Zhang P

更新日期：2005-02-01 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the Europe...

journal_title：Blood

authors： Soverini S,Hochhaus A,Nicolini FE,Gruber F,Lange T,Saglio G,Pane F,Müller MC,Ernst T,Rosti G,Porkka K,Baccarani M,Cross NC,Martinelli G

更新日期：2011-08-04 00:00:00

abstract：:Pregnancy represents a major challenge to immunologic tolerance. How the fetal "semiallograft" evades maternal immune attack is unknown. Pregnancy success may involve alteration of both central (thymic) and peripheral tolerance mechanisms. HIV infection is characterized by CD4(+) T-cell depletion, chronic immune activ...

journal_title：Blood

authors： Kolte L,Gaardbo JC,Karlsson I,Sørensen AL,Ryder LP,Skogstrand K,Ladelund S,Nielsen SD

更新日期：2011-02-10 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that human platelets expr...

journal_title：Blood

authors： Nagalla S,Shaw C,Kong X,Kondkar AA,Edelstein LC,Ma L,Chen J,McKnight GS,López JA,Yang L,Jin Y,Bray MS,Leal SM,Dong JF,Bray PF

更新日期：2011-05-12 00:00:00

abstract：:Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between k...

journal_title：Blood

authors： Preisler HD

更新日期：1980-09-01 00:00:00

abstract：:Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients....

journal_title：Blood

authors： Falanga A,Marchetti M,Evangelista V,Vignoli A,Licini M,Balicco M,Manarini S,Finazzi G,Cerletti C,Barbui T

更新日期：2000-12-15 00:00:00

abstract：:We designed a trial in which postremission therapy of young patients with de novo acute myeloid leukemia (AML) was decided combining cytogenetics/genetics and postconsolidation levels of minimal residual disease (MRD). After induction and consolidation, favorable-risk patients (FR) were to receive autologous stem cell...

journal_title：Blood

authors： Venditti A,Piciocchi A,Candoni A,Melillo L,Calafiore V,Cairoli R,de Fabritiis P,Storti G,Salutari P,Lanza F,Martinelli G,Luppi M,Mazza P,Martelli MP,Cuneo A,Albano F,Fabbiano F,Tafuri A,Chierichini A,Tieghi A,Frac

更新日期：2019-09-19 00:00:00

abstract：:The expression of Rhesus antigens on hematopoietic progenitor cells was studied using monoclonal antibodies. Because these antibodies are not capable of lysing mature red blood cells in a complement-dependent cytotoxicity assay, fluorescence-activated cell sorting was performed. Using the monoclonal anti-Rh 29 antibod...

journal_title：Blood

authors： Falkenburg JH,Fibbe WE,van der Vaart-Duinkerken N,Nichols ME,Rubinstein P,Jansen J

更新日期：1985-09-01 00:00:00

abstract：:The effects of colony-stimulating factor 1 (CSF-1), the primary regulator of mononuclear phagocyte production, are thought to be mediated by the CSF-1 receptor (CSF-1R), encoded by the c-fms proto-oncogene. To investigate the in vivo specificity of CSF-1 for the CSF-1R, the mouse Csf1r gene was inactivated. The phenot...

journal_title：Blood

authors： Dai XM,Ryan GR,Hapel AJ,Dominguez MG,Russell RG,Kapp S,Sylvestre V,Stanley ER

更新日期：2002-01-01 00:00:00

abstract：:An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...

journal_title：Blood

authors： Gertz MA,Dingli D

更新日期：2014-08-07 00:00:00

abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

journal_title：Blood

authors： Sanders KE,Lo J,Sligar SG

更新日期：2002-07-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of normal human hematopoiet...

journal_title：Blood

authors： Leary AG,Wong GG,Clark SC,Smith AG,Ogawa M

更新日期：1990-05-15 00:00:00

abstract：:Receptor tyrosine kinases are known to be important in growth and differentiation. We have recently found that c-kit, the tyrosine kinase receptor for steel factor, also regulates cell-matrix adhesion. Because Steel factor helps regulate cell migration and localization, this may be an important biologic function. Inte...

journal_title：Blood

authors： Kinashi T,Escobedo JA,Williams LT,Takatsu K,Springer TA

更新日期：1995-09-15 00:00:00

abstract：:BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are unknown. To test t...

journal_title：Blood

authors： Vasanthakumar A,Arnovitz S,Marquez R,Lepore J,Rafidi G,Asom A,Weatherly M,Davis EM,Neistadt B,Duszynski R,Vardiman JW,Le Beau MM,Godley LA,Churpek JE

更新日期：2016-01-21 00:00:00

abstract：:Activation of Fas antigen, a cell surface receptor molecule, by its ligand results in transduction of a signal for cell death. The Fas system has been implicated in target cell recognition, clonal development of immune effector cells, and termination of the cellular immune response. Fas antigen expression on lymphocyt...

journal_title：Blood

authors： Maciejewski J,Selleri C,Anderson S,Young NS

更新日期：1995-06-01 00:00:00

abstract：:Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum ...

journal_title：Blood

authors： Tiedemann K,Waters KD,Tauro GP,Tucker D,Ekert H

更新日期：1993-12-15 00:00:00

abstract：:Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis re...

journal_title：Blood

authors： Hope C,Foulcer S,Jagodinsky J,Chen SX,Jensen JL,Patel S,Leith C,Maroulakou I,Callander N,Miyamoto S,Hematti P,Apte SS,Asimakopoulos F

更新日期：2016-08-04 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) have previously been reported to mediate phagocytosis of anti-CD20-opsonized B cells from patients with chronic lymphocytic leukemia (CLL). However, recent data have suggested that PMNs, like macrophages, can also mediate trogocytosis. We have performed experiments to more precisel...

journal_title：Blood

authors： Valgardsdottir R,Cattaneo I,Klein C,Introna M,Figliuzzi M,Golay J

更新日期：2017-05-11 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig et al, Science 276:1851, 1997). We sought to confirm these observation...

journal_title：Blood

authors： Tisdale JF,Stewart AK,Dickstein B,Little RF,Dubé I,Cappe D,Dunbar CE,Brown KE

更新日期：1998-10-15 00:00:00

abstract：:The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differentiation. Little is known of possible variations in the levels of Pax5 expression and their influences on hematopoietic development. We have developed a retroviral transduction system that allows for the study of possible inte...

journal_title：Blood

authors： Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F

更新日期：2012-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:We describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as FeLV-FAIDS) which induces fatal acquired immunodeficiency syndrome (AIDS) in 100% (25 of 25) of persistently viremic experimentally infe...

journal_title：Blood

authors： Hoover EA,Mullins JI,Quackenbush SL,Gasper PW

更新日期：1987-12-01 00:00:00

abstract：:Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells. The disease is driven by somatic mutations in exon 9 of CALR or exon 10 of MPL or JAK2-V617F in >90% of the cases, whereas the rem...

journal_title：Blood

authors： Milosevic Feenstra JD,Nivarthi H,Gisslinger H,Leroy E,Rumi E,Chachoua I,Bagienski K,Kubesova B,Pietra D,Gisslinger B,Milanesi C,Jäger R,Chen D,Berg T,Schalling M,Schuster M,Bock C,Constantinescu SN,Cazzola M,Kralovi

更新日期：2016-01-21 00:00:00

abstract：:Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligandbound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contact region between th...

journal_title：Blood

authors： Gupta V,Gylling A,Alonso JL,Sugimori T,Ianakiev P,Xiong JP,Arnaout MA

更新日期：2007-04-15 00:00:00

abstract：:Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD). The pathologic mechanisms leading to the perception of pain during acute RBC sickling episodes and development of chronic pain remain poorly understood and ineffectively treate...

journal_title：Blood

authors： Hillery CA,Kerstein PC,Vilceanu D,Barabas ME,Retherford D,Brandow AM,Wandersee NJ,Stucky CL

更新日期：2011-09-22 00:00:00

abstract：:Erythropoiesis is regulated at multiple levels to ensure the proper generation of mature red cells under multiple physiological conditions. To probe the contribution of long noncoding RNAs (lncRNAs) to this process, we examined >1 billion RNA-seq reads of polyadenylated and nonpolyadenylated RNA from differentiating m...

journal_title：Blood

authors： Alvarez-Dominguez JR,Hu W,Yuan B,Shi J,Park SS,Gromatzky AA,van Oudenaarden A,Lodish HF

更新日期：2014-01-23 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00