Mapping of genes that control the antibody response to human factor IX in mice.

Abstract:

:We tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highest antibody response and 2 C57 mouse strains had the lowest response. We used the adenovirus vector to immunize 26 recombinant inbred mouse strains (AXB and BXA) derived from A/J and C57BL/6J mice and observed highly significant linkage (logarithmic odds [LOD] scores approximately 4.8) for the polymorphic D17Mit62 marker that is 1 centimorgan ( approximately 300 000 base pair [bp]) from the mouse major histocompatibility complex (MHC) locus (H-2). Experiments in mice with chimeric MHC genes indicated that class IaK or class II H-2 (or both) genes were critical, but other genes contributed to the antibody response. Polymorphic markers from chromosomes 1 and 10 that are near important immunoregulatory genes such as interleukin 10 and the interferon-gamma gene show suggestive linkage (LOD scores of approximately 2.3-2.6) to the factor IX antibody response. This study confirms the hypothesis that H-2 (and other) genes control factor IX antibody development in mice and suggests their potential importance for factor IX antibody development in humans with hemophilia B.

journal_name

Blood

journal_title

Blood

authors

Lozier JN,Tayebi N,Zhang P

doi

10.1182/blood-2004-03-1126

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

1029-35

issue

3

eissn

0006-4971

issn

1528-0020

pii

2004-03-1126

journal_volume

105

pub_type

杂志文章

相关文献

BLOOD文献大全
  • EBV-tissue positive primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity.

    abstract::Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020008520

    authors: Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

    更新日期:2020-11-17 00:00:00

  • Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro.

    abstract::To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healt...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Worm M,Krah JM,Manz RA,Henz BM

    更新日期:1998-09-01 00:00:00

  • A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.

    abstract::Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest "rolling" of leukocytes on the lumenal surface of endothelial cells at sites of inflammation. Previously, PSGL-1 has been shown to be the primary mediator of interactions between neutrophils and P-selectin, but studies o...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Snapp KR,Ding H,Atkins K,Warnke R,Luscinskas FW,Kansas GS

    更新日期:1998-01-01 00:00:00

  • Polarized fibronectin secretion and localized matrix assembly sites correlate with subendothelial matrix formation.

    abstract::Endothelial cells in vivo form the interface between the vascular and interstitial compartments and are strategically located to mediate vascular permeability and hemostasis. One mechanism endothelial cells use to maintain a nonthrombogenic surface is to polarize basement membrane constituents to the basolateral cell ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kowalczyk AP,Tulloh RH,McKeown-Longo PJ

    更新日期:1990-06-15 00:00:00

  • Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops.

    abstract::The biologic effects of endothelin-1 (ET-1) are not limited to its potent vasoconstricting activity. The endothelin receptors, ETA and ETB, have differential tissue and functional distributions. Here we showed that dendritic cells (DCs), the major antigen-presenting cells in the adaptive limb of the immune system, pro...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-10-3559

    authors: Guruli G,Pflug BR,Pecher S,Makarenkova V,Shurin MR,Nelson JB

    更新日期:2004-10-01 00:00:00

  • Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.

    abstract::The von Willebrand receptor complex, which is composed of the glycoproteins Ibα, Ibβ, GPV, and GPIX, plays an essential role in the earliest steps in hemostasis. During the last 4 decades, it has become apparent that loss of function of any 1 of 3 of the genes encoding these glycoproteins (namely, GP1BA, GP1BB, and GP...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2016-08-732248

    authors: Sivapalaratnam S,Westbury SK,Stephens JC,Greene D,Downes K,Kelly AM,Lentaigne C,Astle WJ,Huizinga EG,Nurden P,Papadia S,Peerlinck K,Penkett CJ,Perry DJ,Roughley C,Simeoni I,Stirrups K,Hart DP,Tait RC,Mumford AD,NI

    更新日期:2017-01-26 00:00:00

  • A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis.

    abstract::We report a novel chromosome translocation--t(2;5)(p23;q35) or its variant, t(2;5;13)(p23;q35;q12)--in 3 patients with peripheral T-cell lymphoma. All 3 were female children who had peripheral lymphadenopathy without organomegaly and underwent complete remission with or without chemotherapy. Their tumors were characte...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kaneko Y,Frizzera G,Edamura S,Maseki N,Sakurai M,Komada Y,Sakurai M,Tanaka H,Sasaki M,Suchi T

    更新日期:1989-02-15 00:00:00

  • Stomatin is a major lipid-raft component of platelet alpha granules.

    abstract::Lipid rafts are detergent-resistant, cholesterol- and sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Micros...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v100.3.897

    authors: Mairhofer M,Steiner M,Mosgoeller W,Prohaska R,Salzer U

    更新日期:2002-08-01 00:00:00

  • Inactivation of the ATM gene in T-cell prolymphocytic leukemias.

    abstract::T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

    更新日期:1998-05-15 00:00:00

  • Malaria selectively targets pregnancy receptors.

    abstract::In this issue of Blood, Rieger et al show that malaria parasite infiltration in the human placenta requires a specific geometry and affinity of host receptors to facilitate strong adhesion. ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2014-11-610634

    authors: Chishti AH

    更新日期:2015-01-08 00:00:00

  • Platelet-associated complement C3 in immune thrombocytopenic purpura.

    abstract::Platelet-associated C3 (PA-C3) was measured with a quantitative immunofluorescence assay. With this assay, PA-C3 levels were determined for 78 normal volunteers, 30 patients with immune thrombocytopenic purpura (ITP), and 20 patients with nonimmune thrombocytopenias. Platelet-associated IgG (PA-IgG) levels were also m...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Myers TJ,Kim BK,Steiner M,Baldini MG

    更新日期:1982-05-01 00:00:00

  • CD34+CD38- hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern.

    abstract::Gene expression patterns of CD34(+)CD38(-) cells derived from human embryonic stem cells (ESCs) were compared with those of cells isolated from adult human bone marrow (BM) using microarrays; 1692 and 1494 genes were expressed at levels at least 3-fold above background in cells from BM and ESCs, respectively. Of these...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-10-3575

    authors: Lu SJ,Li F,Vida L,Honig GR

    更新日期:2004-06-01 00:00:00

  • Experimental transmission and pathogenesis of immunodeficiency syndrome in cats.

    abstract::We describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as FeLV-FAIDS) which induces fatal acquired immunodeficiency syndrome (AIDS) in 100% (25 of 25) of persistently viremic experimentally infe...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hoover EA,Mullins JI,Quackenbush SL,Gasper PW

    更新日期:1987-12-01 00:00:00

  • Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.

    abstract::Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Brodsky RA,Sensenbrenner LL,Jones RJ

    更新日期:1996-01-15 00:00:00

  • A common polymorphism in the annexin V Kozak sequence (-1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients.

    abstract::Annexin V has phospholipid-binding capacity and plays a potent antithrombotic role. Recently, a C to T transition has been described in the Kozak region of this gene, affecting the nucleotide preceding the initiation ATG codon. We have developed a simple method to detect this genetic change, showing by analysis of 580...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: González-Conejero R,Corral J,Roldán V,Martínez C,Marín F,Rivera J,Iniesta JA,Lozano ML,Marco P,Vicente V

    更新日期:2002-09-15 00:00:00

  • Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function.

    abstract::Hematopoiesis is a tightly regulated process resulting in the production of blood cells. Self-renewal and differentiation of hematopoietic stem cells (HSCs) are key processes in hematopoietic development. Disruption of these steps can lead to altered cell distribution and disease. To investigate the role of the nuclea...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-02-486142

    authors: Stein SJ,Baldwin AS

    更新日期:2013-06-20 00:00:00

  • Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation.

    abstract::There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in inflammatory processes. Here we report that neutrophils have to be simultaneously activated by integrin-mediated outside-in- and G-protein-coupled receptor (GPCR) signaling to induce NET formation in acute lung injury (ALI), ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-07-516484

    authors: Rossaint J,Herter JM,Van Aken H,Napirei M,Döring Y,Weber C,Soehnlein O,Zarbock A

    更新日期:2014-04-17 00:00:00

  • Human platelet cytoskeletons: specific content of glycolipids and phospholipids.

    abstract::The lipid composition of platelet cytoskeletons was analyzed. Triton X-100 (0.5%) was used to prepare cytoskeletons from thrombin-treated platelets. The lipid/protein ratio of platelet cytoskeletons was 0.260 and the phospholipid/protein ratio was 0.177, which were comparable to the ratios present in platelets. Howeve...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Schick PK,Tuszynski GP,Vander Voort PW

    更新日期:1983-01-01 00:00:00

  • Integrin αIIbβ3 outside-in signaling.

    abstract::Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pathways increase the affinity of αIIbβ3 for fibrinogen and other ligands...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2017-03-773614

    authors: Durrant TN,van den Bosch MT,Hers I

    更新日期:2017-10-05 00:00:00

  • Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody.

    abstract::We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb). Infusion of 0.6 mg/...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Greinix HT,Ladiges WC,Graham TC,Maslan S,Raff RF,Sandmaier BM,Appelbaum FR,Schuening FG,Deeg HJ,Storb R

    更新日期:1991-10-15 00:00:00

  • Altered factor VII activity in hemophilia.

    abstract::Factor VII levels have been studied in hemophilia A and B plasmas and normal controls in a controlled, prospective study. Three assay methods were used: a standard clotting assay (FVIIc-A); a modified clotting assay (FVIIc-B) (Seligsohn et al, Blood 52:978-988, 1978); and a coupled amidolytic assay. By the FVIIc-B ass...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Miller BC,Hultin MB,Jesty J

    更新日期:1985-04-01 00:00:00

  • Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse.

    abstract::Prevention of erythrocyte dehydration is a potential therapeutic strategy for sickle cell disease. Increasing erythrocyte magnesium (Mg) could inhibit sickle cell dehydration by increasing chloride (CI) and water content and by inhibiting potassium chloride (K-CI) cotransport. In transgenic SAD 1 and (control) C57BL/6...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: De Franceschi L,Beuzard Y,Jouault H,Brugnara C

    更新日期:1996-10-01 00:00:00

  • Circulating peripheral blood plasma cells as a prognostic indicator in patients with primary systemic amyloidosis.

    abstract::This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-06-1698

    authors: Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

    更新日期:2003-02-01 00:00:00

  • Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation.

    abstract::Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-05-1707

    authors: Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

    更新日期:2004-01-15 00:00:00

  • Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages.

    abstract::The cells of hematopoietic and vascular endothelial cell lineages are believed to share a common precursor, termed hemangioblast. However, the existence of a growth factor acting relatively specifically on hemangioblasts remains unclear. Here we report the identification of hemangiopoietin (HAPO), a novel growth facto...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-06-1825

    authors: Liu YJ,Lu SH,Xu B,Yang RC,Ren Q,Liu B,Li B,Lu M,Yan FY,Han ZB,Han ZC

    更新日期:2004-06-15 00:00:00

  • Ultrastructural localization of nonspecific esterase activity in guinea pig and human monocytes, macrophages, and lymphocytes.

    abstract::Using either hexazotized pararosaniline or new fuchsin as coupling agents, we investigated the ultrastructural localization of alpha-naphthyl acetate esterase (ANAE) activity in guinea pig bone marrow and peritoneal exudates, and in human peripheral blood cells. DFP-inhibitable ANAE activity was present on the cell su...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Monahan RA,Dvorak HF,Dvorak AM

    更新日期:1981-12-01 00:00:00

  • Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands.

    abstract::Notch is a major factor mediating interaction between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However its contribution to dendritic cell (DC) differentiation is controversial. We found that main Notch ligands Delta-1 and Jagged-1 had the opposite effect on DC differentiation. Delta-1 promot...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-05-025601

    authors: Cheng P,Nefedova Y,Corzo CA,Gabrilovich DI

    更新日期:2007-01-15 00:00:00

  • Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.

    abstract::Hematopoietic stem cells differentiate in the thymus to T cells along precisely defined intermediates. This process is thymic epithelium dependent and involves cytokines and cell-cell interactions between thymic stroma and T-cell precursors. Here we report that highly purified human CD34++ fetal liver stem cells diffe...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Plum J,De Smedt M,Defresne MP,Leclercq G,Vandekerckhove B

    更新日期:1994-09-01 00:00:00

  • The inherited diseases of hemoglobin are an emerging global health burden.

    abstract::It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries. As these countries go through an epidemiologic transition, with a reduction in childhood and infant mortality due to ...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2010-01-251348

    authors: Weatherall DJ

    更新日期:2010-06-03 00:00:00

  • Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.

    abstract::The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-09-382390

    authors: Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

    更新日期:2012-05-03 00:00:00