Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.

abstract：:Similar to endothelial cells (ECs), vascular endothelial growth factor (VEGF) induces Bcl-2 expression on VEGF receptor-positive (VEGFR(+)) primary leukemias and cell lines, promoting survival. We investigated the molecular pathways activated by VEGF on such leukemias, by performing a gene expression analysis of VEGF-...

journal_title：Blood

authors： Dias S,Shmelkov SV,Lam G,Rafii S

更新日期：2002-04-01 00:00:00

abstract：:To examine the relationship between dietary iron exposure through the consumption of traditional beer and the presence of iron overload in black Africans not related by birth, we studied 28 husband and wife pairs from a rural Zimbabwean community. Lifetime traditional beer consumption was estimated by questioning subj...

journal_title：Blood

authors： Moyo VM,Gangaidzo IT,Gomo ZA,Khumalo H,Saungweme T,Kiire CF,Rouault T,Gordeuk VR

更新日期：1997-03-15 00:00:00

abstract：:We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of h...

journal_title：Blood

authors： van Dijken PJ,Wimperis J,Crawford JM,Ferrara JL

更新日期：1991-11-15 00:00:00

abstract：:3-Hydroxypropyl flufenamide (Flu-HPA) is one of a series of flufenamic acid derivatives that enhances blood clot lysis in vitro. Studies of possible mechanisms of action of Flu-HPA were undertaken. The profibrinolytic activity of Flu-HPA in clot lysis assays was found to be dependent on plasminogen. The influence of F...

journal_title：Blood

authors： Miles LA,Burnier JP,Verlander MS,Goodman M,Kleiss AJ,Griffin JH

更新日期：1981-06-01 00:00:00

abstract：:Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL...

journal_title：Blood

authors： Bueno C,Ayllón V,Montes R,Navarro-Montero O,Ramos-Mejia V,Real PJ,Romero-Moya D,Araúzo-Bravo MJ,Menendez P

更新日期：2013-05-09 00:00:00

abstract：:There is evidence from bone marrow transplantation that T cells may be involved in the immunologic control of leukemia. But many patients relapse despite a potent graft-versus-leukemia effect mediated by allogeneic T cells. The expression of the FasL protein has been suggested as a mechanism of tumor immune escape. We...

journal_title：Blood

authors： Buzyn A,Petit F,Ostankovitch M,Figueiredo S,Varet B,Guillet JG,Ameisen JC,Estaquier J

更新日期：1999-11-01 00:00:00

abstract：:Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because...

journal_title：Blood

authors： Asakura T,Shibutani Y,Reilly MP,DeMeio RH

更新日期：1984-07-01 00:00:00

abstract：:The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diag...

journal_title：Blood

authors： Yang JJ,Bhojwani D,Yang W,Cai X,Stocco G,Crews K,Wang J,Morrison D,Devidas M,Hunger SP,Willman CL,Raetz EA,Pui CH,Evans WE,Relling MV,Carroll WL

更新日期：2008-11-15 00:00:00

abstract：:The Philadelphia (Ph1) chromosome is present in greater than 90% of patients with chronic myelogenous leukemia (CML) and in 2% to 20% of those with acute leukemias, for which it is an important prognostic marker too. The chimeric BCR-ABL mRNAs resulting from the translocation encode either a 210-Kd or a 190-Kd protein...

journal_title：Blood

authors： Dhingra K,Talpaz M,Riggs MG,Eastman PS,Zipf T,Ku S,Kurzrock R

更新日期：1991-01-15 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:The large multimeric glyocoprotein von Willebrand factor (VWF) is a crucial component of both primary and secondary hemostasis. It is stored in secretory granules of vascular endothelial cells, the Weibel-Palade bodies (WPBs), and is released following stimulation by agonists that raise intracellular Ca(2+) or cyclic ...

journal_title：Blood

authors： Brandherm I,Disse J,Zeuschner D,Gerke V

更新日期：2013-08-08 00:00:00

abstract：:In eighty-three patients with confirmed deep vein thrombosis, the fibrinolytic system was studied before and after a 10-minute venous occlusion. Blood was collected at least 3 months after the last acute episode, and PAI-1 antigen and activity, as well as tissue-type plasminogen activator (t-PA) antigen, urokinase-typ...

journal_title：Blood

authors： Nguyen G,Horellou MH,Kruithof EK,Conard J,Samama MM

更新日期：1988-08-01 00:00:00

abstract：:During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monoc...

journal_title：Blood

authors： Fox JM,Letellier E,Oliphant CJ,Signoret N

更新日期：2011-02-10 00:00:00

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) remains an effective strategy for inducing durable remission in chronic myeloid leukemia (CML). Reduced-intensity conditioning (RIC) regimens extend HSCT to older patients and those with comorbidities who would otherwise not be suitable candidates for HSCT. The...

journal_title：Blood

authors： Kebriaei P,Detry MA,Giralt S,Carrasco-Yalan A,Anagnostopoulos A,Couriel D,Khouri IF,Anderlini P,Hosing C,Alousi A,Champlin RE,de Lima M

更新日期：2007-11-01 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgj/bgj, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-...

journal_title：Blood

authors： Kitamura Y,Hatanaka K,Murakami M,Shibata H

更新日期：1979-06-01 00:00:00

abstract：:Radioiodinated L-cell-derived colony-stimulating factor (CSF) was used to characterize the binding reaction to murine bone marrow cells. The major increment in cell-associated radioactivity occurred over 24 hr incubation at 37 degrees C, but virtually no binding was observed at 4 degrees C. The reaction was saturable ...

journal_title：Blood

authors： Pigoli G,Waheed A,Shadduck RK

更新日期：1982-02-01 00:00:00

abstract：:The effect of donor/recipient histocompatibility on relapse in patients receiving T-cell-depleted (TCD) grafts for chronic myelogenous leukemia (CML) was evaluated. Specifically, we sought to determine whether TCD results in an attenuation of the graft-versus-leukemia (GVL) effect on recipients of unrelated marrow gra...

journal_title：Blood

authors： Hessner MJ,Endean DJ,Casper JT,Horowitz MM,Keever-Taylor CA,Roth M,Flomenberg N,Drobyski WR

更新日期：1995-11-15 00:00:00

abstract：:Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...

journal_title：Blood

authors： Merkenschlager J,Eksmond U,Danelli L,Attig J,Young GR,Nowosad C,Tolar P,Kassiotis G

更新日期：2019-03-07 00:00:00

abstract：:Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of normal human hematopoiet...

journal_title：Blood

authors： Leary AG,Wong GG,Clark SC,Smith AG,Ogawa M

更新日期：1990-05-15 00:00:00

abstract：:The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. Although the mechanisms controlling memory T-cell migration to peripheral tissues are poorly understood, the current paradigm includes the localized secretion of "imprinting" signal...

journal_title：Blood

authors： McCully ML,Ladell K,Hakobyan S,Mansel RE,Price DA,Moser B

更新日期：2012-11-29 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemother...

journal_title：Blood

authors： Munneke JM,Björklund AT,Mjösberg JM,Garming-Legert K,Bernink JH,Blom B,Huisman C,van Oers MH,Spits H,Malmberg KJ,Hazenberg MD

更新日期：2014-07-31 00:00:00

abstract：:Eighteen patients with agnogenic myeloid metaplasia with myelofibrosis were studied for clinical and laboratory evidence of immunologic dysfunction. Clinical findings included the presence of arthritis, vasculitis, and erythema nodosum. Laboratory abnormalities included the presence of circulating immune complexes, an...

journal_title：Blood

authors： Gordon BR,Coleman M,Kohen P,Day NK

更新日期：1981-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is characterized by the massive infiltration of secondary lymphoid organs with activated CD8(+) T lymphocytes. While converging data indicated that these cells were HIV-specific cytotoxic T lymphocytes (CTLs) responsible for HIV spread limitation, direct evidence was lackin...

journal_title：Blood

authors： Hosmalin A,Samri A,Dumaurier MJ,Dudoit Y,Oksenhendler E,Karmochkine M,Autran B,Wain-Hobson S,Cheynier R

更新日期：2001-05-01 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:Bone marrow CD34(+) cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia secondary to MDS (MDS-AML) and in 30 normal donors (NBM). Apoptosis was significantly increased in r...

journal_title：Blood

authors： Parker JE,Mufti GJ,Rasool F,Mijovic A,Devereux S,Pagliuca A

更新日期：2000-12-01 00:00:00

abstract：:Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differentia...

journal_title：Blood

authors： Vickers MA,McLeod E,Spector TD,Wilson IJ

更新日期：2001-03-01 00:00:00

abstract：:Immune reconstitution of autologous hematopoietic stem-cell transplant recipients with the progeny of mature T cells in the graft leads to profound changes in the emerging functional T-cell repertoire. In the steady state, the host is frequently tolerant to tumor antigens, reflecting dominant suppression of naive and ...

journal_title：Blood

authors： Mirmonsef P,Tan G,Zhou G,Morino T,Noonan K,Borrello I,Levitsky HI

更新日期：2008-02-15 00:00:00

abstract：:Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

journal_title：Blood

authors： Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

更新日期：1995-05-15 00:00:00