MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.

abstract：:Regulated adherence of polymorphonuclear leukocytes (PMNs) to endothelium and subendothelial matrix is a critical event for PMN localization at and migration into inflammatory sites. We previously reported that human PMNs stimulated in vitro adhere to laminin, the major glycoprotein of mammalian basement membrane, by ...

journal_title：Blood

authors： Bohnsack JF

更新日期：1992-03-15 00:00:00

abstract：:Peripheral blood cells are increasingly used in place of bone marrow as a source of hematopoietic stem cells for allogeneic transplantation. The relative efficacy of these 2 approaches is unknown. This retrospective multivariate analysis compared results of 288 HLA-identical sibling blood stem cell transplantations wi...

journal_title：Blood

authors： Champlin RE,Schmitz N,Horowitz MM,Chapuis B,Chopra R,Cornelissen JJ,Gale RP,Goldman JM,Loberiza FR Jr,Hertenstein B,Klein JP,Montserrat E,Zhang MJ,Ringdén O,Tomany SC,Rowlings PA,Van Hoef ME,Gratwohl A

更新日期：2000-06-15 00:00:00

abstract：:A hamster antimouse CD3 monoclonal antibody (MoAb) opened the way to experimental studies on the suppression of allograft rejection and cytokine-related morbidity after treatment with antibodies modulating the CD3/T-cell receptor complex (CD3/TCR). Because earlier attempts to suppress graft-versus-host disease (GVHD) ...

journal_title：Blood

authors： Mysliwietz J,Thierfelder S

更新日期：1992-11-15 00:00:00

abstract：:The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differentiation. Little is known of possible variations in the levels of Pax5 expression and their influences on hematopoietic development. We have developed a retroviral transduction system that allows for the study of possible inte...

journal_title：Blood

authors： Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F

更新日期：2012-11-01 00:00:00

abstract：:Expression of the arterial marker molecule ephrinB2 in endothelial cells is a prerequisite for adequate remodeling processes of the developing or angiogenic vasculature. Although its role in these processes has been extensively studied, the impact of ephrinB2 on the remodeling of adult arteries is largely unknown. To ...

journal_title：Blood

authors： Korff T,Braun J,Pfaff D,Augustin HG,Hecker M

更新日期：2008-07-01 00:00:00

abstract：:Interleukin-3 (IL-3) has been shown to be a promising agent in the stimulation of bone marrow regeneration following myeloablative therapy. The biologic half-life of this agent is very short (5 to 15 minutes), which limits the effectiveness of low-dose therapy. Here we show that the biologic effects of low-dose IL-3 i...

journal_title：Blood

authors： Jones AT,Ziltener HJ

更新日期：1993-08-15 00:00:00

abstract：:The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA, saruplase), applied either as single intravenous bolus or as a continuous infusion over 60 minutes, was studied in 5 randomized blinded groups of 5 dogs with combined copper coil induced coro...

journal_title：Blood

authors： Rapold HJ,Wu ZM,Stassen T,Van de Werf F,Collen D

更新日期：1990-10-15 00:00:00

abstract：:The fact that the Xid mutation of Btk impairs the ability of pleckstrin homology domain of Btk to bind phosphatidylinositol-(3,4,5)-trisphosphate, a product of class IA phosphoinositide-3 kinases (PI3Ks), has been considered strong evidence for the hypothesis that Btk functions downstream of PI3Ks. We demonstrate here...

journal_title：Blood

authors： Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S

更新日期：2009-01-29 00:00:00

abstract：:Significant comorbidites and lethality complicate GVHD and its treatment. Targeting the cytokine milieu may improve GVHD control; and IL6 is an attractive candidate, given its role in dendritic cell activation and T-cell differentiation. Tocilizumab is a humanized mAb to IL6-receptor-α (IL6R-α), which is Food and Drug...

journal_title：Blood

authors： Betts BC,St Angelo ET,Kennedy M,Young JW

更新日期：2011-11-10 00:00:00

abstract：:MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...

journal_title：Blood

authors： Lagasse E,Weissman IL

更新日期：1992-04-15 00:00:00

abstract：:Dendritic cells are the most potent antigen-presenting cells of the immune system. Although dendritic cells are likely to secrete selective cytokines that facilitate antigen presentation, the difficulty in isolating pure dendritic cells in sufficient numbers has made assessment of this function imprecise. In this stud...

journal_title：Blood

authors： Zhou LJ,Tedder TF

更新日期：1995-11-01 00:00:00

abstract：:There have been no studies on patient outcome after allogeneic hematopoietic cell transplantation (HCT) in patients with X-linked inhibitor of apoptosis (XIAP) deficiency. To estimate the success of HCT, we conducted an international survey of transplantation outcomes. Data were reported for 19 patients. Seven patient...

journal_title：Blood

authors： Marsh RA,Rao K,Satwani P,Lehmberg K,Müller I,Li D,Kim MO,Fischer A,Latour S,Sedlacek P,Barlogis V,Hamamoto K,Kanegane H,Milanovich S,Margolis DA,Dimmock D,Casper J,Douglas DN,Amrolia PJ,Veys P,Kumar AR,Jordan MB

更新日期：2013-02-07 00:00:00

abstract：:A Y-chromosome-specific in situ hybridization assay was used to assess the frequency with which host bone marrow cells are retained after marrow grafting. The majority of patients (74%) showed the presence of both host and donor marrow cells when assayed 14 days after transplant. By 84 days posttransplant only 4% of t...

journal_title：Blood

authors： Durnam DM,Anders KR,Fisher L,O'Quigley J,Bryant EM,Thomas ED

更新日期：1989-11-01 00:00:00

abstract：:The TEL-JAK2 gene fusion, which has been identified in human leukemia, encodes a chimeric protein endowed with constitutive tyrosine kinase activity. TEL-JAK2 transgenic expression in the mouse lymphoid lineage results in fatal and rapid T-cell leukemia/lymphoma. In the present report we show that T-cell leukemic cell...

journal_title：Blood

authors： dos Santos NR,Rickman DS,de Reynies A,Cormier F,Williame M,Blanchard C,Stern MH,Ghysdael J

更新日期：2007-05-01 00:00:00

abstract：:Two tumor necrosis factor receptors (TNFRs) with molecular weights of 55 kD (TNFR-p55) and 75 kD (TNFR-p75) have recently been identified and cloned. In previous studies, TNFR-p55 has been shown to exclusively mediate bidirectional effects of TNF-alpha on committed bone marrow granulocyte-macrophage progenitor cells, ...

journal_title：Blood

authors： Rusten LS,Jacobsen SE

更新日期：1995-02-15 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:We have re-evaluated the previously reported ability of TLCK-thrombin (N alpha-tosyl-L-lysine chloromethyl ketone-treated alpha-thrombin) and PPACK-thrombin (D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-treated alpha-thrombin) to inhibit alpha-thrombin-induced platelet activation (Harmon JT, Jamieson GA: J B...

journal_title：Blood

authors： Greco NJ,Tenner TE Jr,Tandon NN,Jamieson GA

更新日期：1990-05-15 00:00:00

abstract：:We analyzed the expression of plasma glutathione peroxidase (GSHPx-P) messenger RNA (mRNA) in mouse, rat, and human tissues, using a human GSHPx-P cDNA clone as the probe. Unlike the classical cellular glutathione peroxidase (GSHPx-1), GSHPx-P expression appears to be tissue-specific. In the mouse and rat, kidney expr...

journal_title：Blood

authors： Chu FF,Esworthy RS,Doroshow JH,Doan K,Liu XF

更新日期：1992-06-15 00:00:00

abstract：:The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance o...

journal_title：Blood

authors： Fonseca R,Blood EA,Oken MM,Kyle RA,Dewald GW,Bailey RJ,Van Wier SA,Henderson KJ,Hoyer JD,Harrington D,Kay NE,Van Ness B,Greipp PR

更新日期：2002-05-15 00:00:00

abstract：:Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the Europe...

journal_title：Blood

authors： Soverini S,Hochhaus A,Nicolini FE,Gruber F,Lange T,Saglio G,Pane F,Müller MC,Ernst T,Rosti G,Porkka K,Baccarani M,Cross NC,Martinelli G

更新日期：2011-08-04 00:00:00

abstract：:Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H(2)O(2), as dimerization was observed after exposure of ...

journal_title：Blood

authors： Low FM,Hampton MB,Peskin AV,Winterbourn CC

更新日期：2007-03-15 00:00:00

abstract：:Survivin has been described as an important regulator of late mitosis and as antiapoptotic in various cells. In this issue of Blood, Wen and colleagues describe a megakaryocyte-specific knockout of survivin, with no influence on megakaryocyte survival, and a stimulating effect on polyploidy. ...

journal_title：Blood

authors： Ravid K

更新日期：2009-07-02 00:00:00

abstract：:CTLA-4 is an inhibitory molecule that down-regulates T-cell activation. Although polymorphisms at CTLA-4 have been correlated with autoimmune diseases their association with clinical outcome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has yet to be explored. A total of 5 CTLA-4 single-nucleoti...

journal_title：Blood

authors： Pérez-García A,De la Cámara R,Román-Gómez J,Jiménez-Velasco A,Encuentra M,Nieto JB,de la Rubia J,Urbano-Ispizúa A,Brunet S,Iriondo A,González M,Serrano D,Espigado I,Solano C,Ribera JM,Pujal JM,Hoyos M,Gallardo D,GVHD\

更新日期：2007-07-01 00:00:00

abstract：:Cryopreservation of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) is crucial for cord blood (CB) banking and transplantation. We evaluated recovery of functional HPC cryopreserved as mononuclear or unseparated cells for up to 23.5 years compared with prefreeze values of the same CB units. H...

journal_title：Blood

authors： Broxmeyer HE,Lee MR,Hangoc G,Cooper S,Prasain N,Kim YJ,Mallett C,Ye Z,Witting S,Cornetta K,Cheng L,Yoder MC

更新日期：2011-05-05 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:Human natural killer (NK) cells comprise 2 main subsets, CD56(bright) and CD56(dim) cells, that differ in function, phenotype, and tissue localization. To further dissect the heterogeneity of CD56(dim) cells, we have performed transcriptome analysis and functional ex vivo characterization of human NK-cell subsets acco...

journal_title：Blood

authors： Juelke K,Killig M,Luetke-Eversloh M,Parente E,Gruen J,Morandi B,Ferlazzo G,Thiel A,Schmitt-Knosalla I,Romagnani C

更新日期：2010-08-26 00:00:00

abstract：:The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML...

journal_title：Blood

authors： Metzeler KH,Herold T,Rothenberg-Thurley M,Amler S,Sauerland MC,Görlich D,Schneider S,Konstandin NP,Dufour A,Bräundl K,Ksienzyk B,Zellmeier E,Hartmann L,Greif PA,Fiegl M,Subklewe M,Bohlander SK,Krug U,Faldum A,Berdel

更新日期：2016-08-04 00:00:00

abstract：:Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional knockin (ASXL1-MT-KI) mice suggested that ASXL1-MT alone is insufficient for myeloid transformation. In our previous study, we used retrovirus-mediated insertional mutag...

journal_title：Blood

authors： Takeda R,Asada S,Park SJ,Yokoyama A,Becker HJ,Kanai A,Visconte V,Hershberger C,Hayashi Y,Yonezawa T,Tamura M,Fukushima T,Tanaka Y,Fukuyama T,Matsumoto A,Yamasaki S,Nakai K,Yamazaki S,Inaba T,Shibata T,Inoue D,Ho

更新日期：2020-10-01 00:00:00

abstract：:Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II and III clinical trials of DCLHb. Two very sensitive immunoassays, an e...

journal_title：Blood

authors： Patel MJ,Webb EJ,Shelbourn TE,Mattia-Goldberg C,George AJ,Zhang F,Moore EG,Nelson DJ

更新日期：1998-01-15 00:00:00

abstract：:Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Platelet packaging and release concludes at the tips of each proplatelet. Essential in this process is the distribution of organelles and platelet-specific granules i...

journal_title：Blood

authors： Richardson JL,Shivdasani RA,Boers C,Hartwig JH,Italiano JE Jr

更新日期：2005-12-15 00:00:00