Autologous bone marrow transplantation after a long first remission for children with recurrent acute lymphoblastic leukemia.

abstract：:The transmembrane 4 superfamily (TM4SF) has come into prominence for its association with a wide range of cell surface molecules, especially integrins. We report that TM4SF molecules CD9, CD63, and CD81 are physically associated with c-kit receptor tyrosine kinase in the human factor-dependent myeloid cell line, MO7e....

journal_title：Blood

authors： Anzai N,Lee Y,Youn BS,Fukuda S,Kim YJ,Mantel C,Akashi M,Broxmeyer HE

更新日期：2002-06-15 00:00:00

abstract：:Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma, which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL, but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report,...

journal_title：Blood

authors： Tobinai K,Minato K,Ohtsu T,Mukai K,Kagami Y,Miwa M,Watanabe S,Shimoyama M

更新日期：1988-09-01 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft-versus-host disease (GVHD) in murine models of allogeneic hematopoietic stem cell transplantation. W...

journal_title：Blood

authors： Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

更新日期：2016-12-15 00:00:00

abstract：:Varying doses of 5-azacytidine (5-aza) were given to four sickle cell individuals for 500, 200, 100, and 30 days. The percentage of fetal hemoglobin (HbF) containing reticulocytes (F reticulocytes) increased two- to five-fold within five days of 5-aza therapy in all patients, with a two- to three-fold rapid response (...

journal_title：Blood

authors： Dover GJ,Charache S,Boyer SH,Vogelsang G,Moyer M

更新日期：1985-09-01 00:00:00

abstract：:The relationship between platelet density and platelet age appears to vary between species with relatively few labeling studies in humans reported. In this study, irreversible monoamine oxidase (MAO) inhibitors were used to biochemically label the circulating platelet population in 15 humans. Platelet samples were the...

journal_title：Blood

authors： Chamberlain KG,Tong M,Chiu E,Penington DG

更新日期：1989-04-01 00:00:00

abstract：:Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To assess if the mammalian ...

journal_title：Blood

authors： Hoang B,Frost P,Shi Y,Belanger E,Benavides A,Pezeshkpour G,Cappia S,Guglielmelli T,Gera J,Lichtenstein A

更新日期：2010-11-25 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact...

journal_title：Blood

authors： Zhang X,Kimura Y,Fang C,Zhou L,Sfyroera G,Lambris JD,Wetsel RA,Miwa T,Song WC

更新日期：2007-07-01 00:00:00

abstract：:Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated lymphomas for whom standard therapies have failed, including high-dose chemotherapy followed by autologous stem-cell rescue. However, the ...

journal_title：Blood

authors： McLaughlin LP,Rouce R,Gottschalk S,Torrano V,Carrum G,Wu MF,Hoq F,Grilley B,Marcogliese AM,Hanley PJ,Gee AP,Brenner MK,Rooney CM,Heslop HE,Bollard CM

更新日期：2018-11-29 00:00:00

abstract：:We tested baseline positron emission tomography (PET)/computed tomography (CT) as a measure of total tumor burden to better identify high-risk patients with early-stage Hodgkin lymphoma (HL). Patients with stage I-II HL enrolled in the standard arm (combined modality treatment) of the H10 trial (NCT00433433) with avai...

journal_title：Blood

authors： Cottereau AS,Versari A,Loft A,Casasnovas O,Bellei M,Ricci R,Bardet S,Castagnoli A,Brice P,Raemaekers J,Deau B,Fortpied C,Raveloarivahy T,Van Zele E,Chartier L,Vander Borght T,Federico M,Hutchings M,Ricardi U,Andre M

更新日期：2018-03-29 00:00:00

abstract：:Eighteen patients with relapse of chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation (BMT) were treated with recombinant human alpha 2a interferon (IFN). Relapse was defined as greater than 90% metaphases containing the Philadelphia chromosome (Ph) and hematologic abnormalities consistent ...

journal_title：Blood

authors： Higano CS,Raskind WH,Singer JW

更新日期：1992-09-15 00:00:00

abstract：:Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections. We report here a new form of partial STAT1 deficiency in 2 siblings presenting mycobacterial and viral diseases. Both carried a homozygous missense muta...

journal_title：Blood

authors： Kong XF,Ciancanelli M,Al-Hajjar S,Alsina L,Zumwalt T,Bustamante J,Feinberg J,Audry M,Prando C,Bryant V,Kreins A,Bogunovic D,Halwani R,Zhang XX,Abel L,Chaussabel D,Al-Muhsen S,Casanova JL,Boisson-Dupuis S

更新日期：2010-12-23 00:00:00

abstract：:Regulated adherence of polymorphonuclear leukocytes (PMNs) to endothelium and subendothelial matrix is a critical event for PMN localization at and migration into inflammatory sites. We previously reported that human PMNs stimulated in vitro adhere to laminin, the major glycoprotein of mammalian basement membrane, by ...

journal_title：Blood

authors： Bohnsack JF

更新日期：1992-03-15 00:00:00

abstract：:Many current experimental results show the necessity of new conceptual approaches to understand hematopoietic stem cell organization. Recently, we proposed a novel theoretical concept and a corresponding quantitative model based on microenvironment-dependent stem cell plasticity. The objective of our present work is t...

journal_title：Blood

authors： Roeder I,Kamminga LM,Braesel K,Dontje B,de Haan G,Loeffler M

更新日期：2005-01-15 00:00:00

abstract：:Endothelial cells play an important role in the regulation of fibrinolysis by the production of several key regulatory proteins. The cytokines tumor necrosis factor (TNF), lymphotoxin, and interleukin-1 (IL-1), but not interleukin-6, increase the production of plasminogen activator inhibitor-1 (PAI-1) by endothelial c...

journal_title：Blood

authors： van Hinsbergh VW,van den Berg EA,Fiers W,Dooijewaard G

更新日期：1990-05-15 00:00:00

abstract：:Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of ...

journal_title：Blood

authors： Wootla B,Christophe OD,Mahendra A,Dimitrov JD,Repessé Y,Ollivier V,Friboulet A,Borel-Derlon A,Levesque H,Borg JY,Andre S,Bayry J,Calvez T,Kaveri SV,Lacroix-Desmazes S

更新日期：2011-02-17 00:00:00

abstract：:Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the ...

journal_title：Blood

authors： Petzer V,Tymoszuk P,Asshoff M,Carvalho J,Papworth J,Deantonio C,Bayliss L,Wake MS,Seifert M,Brigo N,Valente de Souza L,Hilbe R,Grubwieser P,Demetz E,Dichtl S,Volani C,Berger S,Böhm F,Hoffmann A,Pfeifhofer-Obermair C

更新日期：2020-08-27 00:00:00

abstract：:A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibl...

journal_title：Blood

authors： Ramsay NK,Kim T,Nesbit ME,Krivit W,Coccia PF,Levitt SH,Woods WG,Kersey JH

更新日期：1980-02-01 00:00:00

abstract：:Fetal hemoglobin (HbF) is a potent genetic modifier of the severity of beta-thalassemia and sickle cell anemia. We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+) hematopoietic cells to evaluate HbF production. This system recapitulates e...

journal_title：Blood

authors： Wilber A,Tschulena U,Hargrove PW,Kim YS,Persons DA,Barbas CF 3rd,Nienhuis AW

更新日期：2010-04-15 00:00:00

abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...

journal_title：Blood

authors： Dubrac A,Quemener C,Lacazette E,Lopez F,Zanibellato C,Wu WG,Bikfalvi A,Prats H

更新日期：2010-11-25 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:We have previously demonstrated a significant inverse correlation between circulating thrombopoietin (TPO) levels and peripheral platelet (PLT) counts in patients with thrombocytopenia secondary to megakaryocytic hypoplasia but not in patients with immune thrombocytopenic purpura (ITP; Chang et al, Blood 88:3354, 1996...

journal_title：Blood

authors： Chang M,Qian JX,Lee SM,Joubran J,Fernandez G,Nichols J,Knoppel A,Buzby JS

更新日期：1999-04-15 00:00:00

abstract：:We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficac...

journal_title：Blood

authors： Inagaki K,Oda T,Naka Y,Shinkai H,Komatsu N,Iwamura H

更新日期：2004-07-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:We document findings on c-kit (CD117) expression in 1,937 pediatric and adult de novo acute leukemia cases, diagnosed in five single European centers. All cases were well characterized as to the morphologic, cytochemical, and immunologic features, according to the European Group for the Immunological Classification of...

journal_title：Blood

authors： Bene MC,Bernier M,Casasnovas RO,Castoldi G,Knapp W,Lanza F,Ludwig WD,Matutes E,Orfao A,Sperling C,van't Veer MB

更新日期：1998-07-15 00:00:00

abstract：:Thymosin beta 4 (T beta 4) was originally isolated as a thymic hormone. Its functional properties remain obscure; however, the N-terminal peptidic sequence could have a regulatory function on hematopoietic stem cell proliferation. To investigate the mechanism of T beta 4 expression, we studied T beta 4 gene expression...

journal_title：Blood

authors： Shimamura R,Kudo J,Kondo H,Dohmen K,Gondo H,Okamura S,Ishibashi H,Niho Y

更新日期：1990-09-01 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:The number of bone marrow fibroblast colony formations decreases in most cases of acute leukemia before the initiation of chemotherapy. This study was undertaken to clarify the mechanism of suppression of fibroblast colony formation in leukemic patients. Titration of the number of bone marrow cells did not indicate a ...

journal_title：Blood

authors： Nagao T,Yamauchi K,Komatsuda M,Noguchi K,Shimizu M,Yonekura S,Nozaki H

更新日期：1983-12-01 00:00:00