Use of alpha interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation.

abstract：:Malignant cells from 52 children with acute lymphocytic leukemia (ALL) were investigated for inactivation of the p15ink4B and p16ink4 genes and other genetic alterations on chromosome 9p21. Homozygous deletions of the p15ink4B and/or the p16ink4 genes were detected in 16 cases and a further 9 cases showed evidence of ...

journal_title：Blood

authors： Rasool O,Heyman M,Brandter LB,Liu Y,Grandér D,Söderhäll S,Einhorn S

更新日期：1995-06-15 00:00:00

abstract：:A global phase 3 study evaluated the pharmacokinetics, efficacy, and safety of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in 63 previously treated male patients (12-61 years) with severe hemophilia B (factor IX [FIX] activity ≤2%). The study included 2 groups: group 1 patients recei...

journal_title：Blood

authors： Santagostino E,Martinowitz U,Lissitchkov T,Pan-Petesch B,Hanabusa H,Oldenburg J,Boggio L,Negrier C,Pabinger I,von Depka Prondzinski M,Altisent C,Castaman G,Yamamoto K,Álvarez-Roman MT,Voigt C,Blackman N,Jacobs I,PROLONG

更新日期：2016-04-07 00:00:00

abstract：:We have performed a retrospective analysis of the development of T- and B-cell functions after HLA-nonidentical T-cell-depleted bone marrow transplantation (BMT) performed in 193 patients with severe combined immunodeficiency (SCID) at 18 European centers between December 1982 and December 31, 1993. One hundred sixtee...

journal_title：Blood

authors： Haddad E,Landais P,Friedrich W,Gerritsen B,Cavazzana-Calvo M,Morgan G,Bertrand Y,Fasth A,Porta F,Cant A,Espanol T,Müller S,Veys P,Vossen J,Fischer A

更新日期：1998-05-15 00:00:00

abstract：:The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V(H)) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. We have now investigated activation...

journal_title：Blood

authors： Petlickovski A,Laurenti L,Li X,Marietti S,Chiusolo P,Sica S,Leone G,Efremov DG

更新日期：2005-06-15 00:00:00

abstract：:Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial. We developed a DNA-based deletion screen and investigated 339 chronic phase patie...

journal_title：Blood

authors： Kreil S,Pfirrmann M,Haferlach C,Waghorn K,Chase A,Hehlmann R,Reiter A,Hochhaus A,Cross NC,German Chronic Myelogenous Leukemia (CML) Study Group.

更新日期：2007-08-15 00:00:00

abstract：:In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their...

journal_title：Blood

authors： Prince HM

更新日期：2014-11-06 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether,...

journal_title：Blood

authors： van de Donk NWCJ,Richardson PG,Malavasi F

更新日期：2018-01-04 00:00:00

abstract：:Administration of cyclosporine A (CsA) after autologous stem cell transplantation elicits an autoimmune syndrome with pathology similar to graft-versus-host disease (GVHD). This syndrome, termed autologous GVHD, is associated with the appearance of autoreactive T cells directed at major histocompatibility class (MHC) ...

journal_title：Blood

authors： Miura Y,Thoburn CJ,Bright EC,Sommer M,Lefell S,Ueda M,Nakao S,Hess AD

更新日期：2001-08-01 00:00:00

abstract：:Containers constructed of polyvinylchloride (PVC) are used for the storage of platelet concentrates (PC) for transfusion, At 22 degrees C, pH often falls to such low levels (pH is less that 6.0) that viability is lost. Far lesser degrees of pH fall are observed in bags constructed of polyethylene (PE). In this study, ...

journal_title：Blood

authors： Murphy S,Gardner FH

更新日期：1975-08-01 00:00:00

abstract：:Unstained human eosinophils exhibit unusually bright autofluorescence, which allows them to be distinguished from other leukocytes using fluorescence microscopy. Eosinophil fluorescence is associated with the cytoplasmic granules of the cells. Eosinophil granule extracts, containing an as-yet-undefined eosinophil fluo...

journal_title：Blood

authors： Weil GJ,Chused TM

更新日期：1981-06-01 00:00:00

abstract：:Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock protein 70 (Hsp70) in the nucleus. Erythroid cell dysplasia observed in early myelodysplasti...

journal_title：Blood

authors： Frisan E,Vandekerckhove J,de Thonel A,Pierre-Eugène C,Sternberg A,Arlet JB,Floquet C,Gyan E,Kosmider O,Dreyfus F,Gabet AS,Courtois G,Vyas P,Ribeil JA,Zermati Y,Lacombe C,Mayeux P,Solary E,Garrido C,Hermine O,Fonte

更新日期：2012-02-09 00:00:00

abstract：:Among 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and i...

journal_title：Blood

authors： Au WY,Weisenburger DD,Intragumtornchai T,Nakamura S,Kim WS,Sng I,Vose J,Armitage JO,Liang R,International Peripheral T-Cell Lymphoma Project.

更新日期：2009-04-23 00:00:00

abstract：:A postulated role of the contact system in anaphylactic reactions to insect stings was investigated. During prospective, in-hospital sting challenge, we collected serial blood samples from five normal volunteers and 16 patients with a history of insect-sting anaphylaxis. Activation of the contact system was assessed b...

journal_title：Blood

authors： van der Linden PW,Hack CE,Eerenberg AJ,Struyvenberg A,van der Zwan JK

更新日期：1993-09-15 00:00:00

abstract：:Chronic graft-v-host disease (chronic GVHD) is a frequent cause of late morbidity and death after bone marrow transplantation (BMT). The actuarial survival after onset of chronic GVHD in 85 patients was 42% (95%Cl = 29%, 54%) at 10 years. Baseline characteristics present at the onset of chronic GVHD (before therapy) i...

journal_title：Blood

authors： Wingard JR,Piantadosi S,Vogelsang GB,Farmer ER,Jabs DA,Levin LS,Beschorner WE,Cahill RA,Miller DF,Harrison D

更新日期：1989-09-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors regulating lipid and cholesterol metabolism. Recent data revealed a cross talk between LXR and Toll-like receptor signaling in macrophages, indicating a role in immunity. Here, we show that LXRalpha is expressed in human myeloid dendritic cells (DCs) and induced during di...

journal_title：Blood

authors： Geyeregger R,Zeyda M,Bauer W,Kriehuber E,Säemann MD,Zlabinger GJ,Maurer D,Stulnig TM

更新日期：2007-05-15 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a prominent barrier to allogeneic hematopoietic stem cell transplantation (AHSCT). Definitive diagnosis of GVHD is invasive, and biopsies of involved tissues pose a high risk of bleeding and infection. T cells are central to GVHD pathogenesis, and our previous studies in a chronic G...

journal_title：Blood

authors： Assmann JC,Farthing DE,Saito K,Maglakelidze N,Oliver B,Warrick KA,Sourbier C,Ricketts CJ,Meyer TJ,Pavletic SZ,Linehan WM,Krishna MC,Gress RE,Buxbaum NP

更新日期：2021-01-07 00:00:00

abstract：:In this issue of Blood, in a first-rate example of collaboration between academia (University of California) and industry (Sangamo), Hoban et al show in situ gene correction of sickle cell anemia (SCA), a prototypical hemoglobinopathy. ...

journal_title：Blood

authors： Tolar J

更新日期：2015-04-23 00:00:00

abstract：:Crystallographic structures indicate that gamma-chain residue Asn308 participates in D:D interactions and indeed substitutions of gammaAsn308 with lysine or isoleucine have been identified in dysfibrinogens with impaired polymerization. To probe the role of Asn308 in polymerization, we synthesized 3 variant fibrinogen...

journal_title：Blood

authors： Okumura N,Gorkun OV,Terasawa F,Lord ST

更新日期：2004-06-01 00:00:00

abstract：:Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...

journal_title：Blood

authors： Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

更新日期：1998-11-01 00:00:00

abstract：:The Philadelphia (Ph1) chromosome is present in greater than 90% of patients with chronic myelogenous leukemia (CML) and in 2% to 20% of those with acute leukemias, for which it is an important prognostic marker too. The chimeric BCR-ABL mRNAs resulting from the translocation encode either a 210-Kd or a 190-Kd protein...

journal_title：Blood

authors： Dhingra K,Talpaz M,Riggs MG,Eastman PS,Zipf T,Ku S,Kurzrock R

更新日期：1991-01-15 00:00:00

abstract：:Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...

journal_title：Blood

authors： Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

更新日期：2015-01-22 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide with biologic effects that include regulation of hematopoietic stem cell development, extracellular matrix remodeling, and inflammatory cytokine generation. To delineate the potential role of VEGF in patients with myelodysplastic syndrome (MDS), ...

journal_title：Blood

authors： Bellamy WT,Richter L,Sirjani D,Roxas C,Glinsmann-Gibson B,Frutiger Y,Grogan TM,List AF

更新日期：2001-03-01 00:00:00

abstract：:Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often unavailable. Many specialized tests are usually required to reach a put...

journal_title：Blood

authors： Simeoni I,Stephens JC,Hu F,Deevi SV,Megy K,Bariana TK,Lentaigne C,Schulman S,Sivapalaratnam S,Vries MJ,Westbury SK,Greene D,Papadia S,Alessi MC,Attwood AP,Ballmaier M,Baynam G,Bermejo E,Bertoli M,Bray PF,Bury L,

更新日期：2016-06-09 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:Uniformly adopted response criteria are essential for assessment of therapies incorporating conventional chemotherapy and chemoimmunotherapy regimens. Recently, immunomodulatory agents, such as immune checkpoint inhibitors, have demonstrated impressive activity in a broad range of lymphoma histologies. However, these ...

journal_title：Blood

authors： Cheson BD,Ansell S,Schwartz L,Gordon LI,Advani R,Jacene HA,Hoos A,Barrington SF,Armand P

更新日期：2016-11-24 00:00:00

abstract：:We analyzed the incidence of posttransplant chronic myelogenous leukemia (CML) relapse in 283 consecutive related-donor (n = 177) and unrelated-donor (n = 106) allogeneic transplant recipients. Twenty-two of 165 related-donor recipients with stable or advanced disease at the time of transplant had hematologic relapse ...

journal_title：Blood

authors： Enright H,Davies SM,DeFor T,Shu X,Weisdorf D,Miller W,Ramsay NK,Arthur D,Verfaillie C,Miller J,Kersey J,McGlave P

更新日期：1996-07-15 00:00:00

abstract：:Norovirus (NV) infections are a frequent cause of gastroenteritis (GE), but data on this disease in immunocompromised patients are limited. We analyzed an NV outbreak, which affected immunosuppressed patients in the context of chemotherapy or HSCT. On recognition, 7 days after admission of the index patient, preventiv...

journal_title：Blood

authors： Schwartz S,Vergoulidou M,Schreier E,Loddenkemper C,Reinwald M,Schmidt-Hieber M,Flegel WA,Thiel E,Schneider T

更新日期：2011-06-02 00:00:00

abstract：:To characterize genetic contributions toward aberrant splicing of the hyaluronan synthase 1 (HAS1) gene in multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), we sequenced 3616 bp in HAS1 exons and introns involved in aberrant splicing, from 17 patients. We identified a total of 197 HAS1 genetic variations (...

journal_title：Blood

authors： Adamia S,Reichert AA,Kuppusamy H,Kriangkum J,Ghosh A,Hodges JJ,Pilarski PM,Treon SP,Mant MJ,Reiman T,Belch AR,Pilarski LM

更新日期：2008-12-15 00:00:00

abstract：:The lymphocytosis manifested in infectious mononucleosis (IM) during acute phase is ascribed to a reactive expansion of CD8+ T lymphocytes caused by Epstein-Barr virus (EBV)-infected B lymphocytes. Expression of HLA-DR antigen on IM lymphocytes suggests that these T lymphocytes are somehow activated in vivo. In the pr...

journal_title：Blood

authors： Kamio M,Uchiyama T,Hori T,Kodaka T,Ishikawa T,Onishi R,Uchino H,Yoneda N,Tatsumi E,Yamaguchi N

更新日期：1990-01-15 00:00:00