Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

abstract：:Severe congenital neutropenia (CN) is a rare bone marrow failure syndrome with a high incidence of acute leukemia. In previous studies, we could show that point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R are a highly predictive marker for leukemic development in CN patie...

journal_title：Blood

authors： Germeshausen M,Welte K,Ballmaier M

更新日期：2009-01-15 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:Despite the frequency of HIV-specific CD8 T cells, most HIV-infected patients do not control viral replication without antiviral drugs. Although CD8 T cells are important in containing acute HIV and simian immunodeficiency virus (SIV) infection, CD8 T-cell functions are compromised in chronic infection. To investigate...

journal_title：Blood

authors： Zhang D,Shankar P,Xu Z,Harnisch B,Chen G,Lange C,Lee SJ,Valdez H,Lederman MM,Lieberman J

更新日期：2003-01-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is marked by near 100% mutational frequency of BRAFV600E mutations. Recurrent cooperating genetic events that may contribute to HCL pathogenesis or affect the clinical course of HCL are currently not described. Therefore, we performed whole exome sequencing to explore the mutational landscape...

journal_title：Blood

authors： Dietrich S,Hüllein J,Lee SC,Hutter B,Gonzalez D,Jayne S,Dyer MJ,Oleś M,Else M,Liu X,Słabicki M,Wu B,Troussard X,Dürig J,Andrulis M,Dearden C,von Kalle C,Granzow M,Jauch A,Fröhling S,Huber W,Meggendorfer M,Hafe

更新日期：2015-08-20 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) pediatric patients exhibit a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich syndrome protein (WASP) regulates the differentiation and activation of memory B cells remains elusive. Here we examine the early activation events of memory B cells from the...

journal_title：Blood

authors： Bai X,Zhang Y,Huang L,Wang J,Li W,Niu L,Jiang H,Dai R,Zhou L,Zhang Z,Miller H,Song W,Zhao X,Liu C

更新日期：2016-09-29 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL) is a novel 25-kD protein of human neutrophils, that is in part covalently complexed with neutrophil gelatinase. However, both NGAL and gelatinase exist mainly in forms not associated with each other. An explanation for this phenomenon might be that the unassociated pro...

journal_title：Blood

authors： Kjeldsen L,Bainton DF,Sengeløv H,Borregaard N

更新日期：1994-02-01 00:00:00

abstract：:Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both enc...

journal_title：Blood

authors： Khamlichi AA,Rocca A,Touchard G,Aucouturier P,Preud'homme JL,Cogné M

更新日期：1995-11-15 00:00:00

abstract：:Lipid rafts are detergent-resistant, cholesterol- and sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Micros...

journal_title：Blood

authors： Mairhofer M,Steiner M,Mosgoeller W,Prohaska R,Salzer U

更新日期：2002-08-01 00:00:00

abstract：:The use of recombinant adeno-associated virus (rAAV) vectors provides a new strategy to investigate the role of specific regulatory elements and trans-acting factors in globin gene expression. We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma*) mutationally m...

journal_title：Blood

authors： Miller JL,Walsh CE,Ney PA,Samulski RJ,Nienhuis AW

更新日期：1993-09-15 00:00:00

abstract：:Cytoplasmic free calcium concentration (Ca2+)i was measured in neutrophils from patients with the classical X-linked form of chronic granulomatous disease (CGD) by trapping the fluorescent calcium indicator Quin 2 in intact cells. CGD neutrophils do not produce superoxide and are only slightly depolarized upon stimula...

journal_title：Blood

authors： Lew PD,Wollheim C,Seger RA,Pozzan T

更新日期：1984-01-01 00:00:00

abstract：:Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs). IREs are located in the 5'- or 3'-untranslated regions (UTRs) of specific mRNAs that encode proteins involved in iron homeostasis. The binding of IRPs to 5' IREs represses trans...

journal_title：Blood

authors： Phillips JD,Kinikini DV,Yu Y,Guo B,Leibold EA

更新日期：1996-04-01 00:00:00

abstract：:Studies were performed on 15 untreated and 14 treated patients with multiple myeloma. The monocyte content was normal in blood but elevated in mononuclear leukocytes (MNL) from treated but not untreated patients (p less than 0.001). This correlated with the severity of lymphopenia in blood (p less than 0.01). Three pa...

journal_title：Blood

authors： Twomey JJ,Laughter AH,Rice L,Ford RJ

更新日期：1982-08-01 00:00:00

abstract：:Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope speci...

journal_title：Blood

authors： Greinacher A,Krauel K,Jensch I

更新日期：2012-08-02 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

journal_title：Blood

authors： Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

更新日期：2020-11-17 00:00:00

abstract：:We have previously described the development of oncoretrovirus vectors for human gamma-globin using a truncated beta-globin promoter, modified gamma-globin cassette, and alpha-globin enhancer. However, one of these vectors is genetically unstable, and both vectors exhibit variable expression patterns in cultured cells...

journal_title：Blood

authors： Emery DW,Yannaki E,Tubb J,Nishino T,Li Q,Stamatoyannopoulos G

更新日期：2002-09-15 00:00:00

abstract：:The deregulated Bcr/Abl tyrosine kinase is responsible for the development of Philadelphia (Ph)-positive leukemia in humans. To investigate the significance of the C-terminal Abl actin-binding domain within Bcr/Abl p190 in the development of leukemia/lymphoma in vivo, mutant p190 DNA constructs were used to generate t...

journal_title：Blood

authors： Heisterkamp N,Voncken JW,Senadheera D,Gonzalez-Gomez I,Reichert A,Haataja L,Reinikainen A,Pattengale PK,Groffen J

更新日期：2000-09-15 00:00:00

abstract：:Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA a...

journal_title：Blood

authors： Sekyere EO,Dunn LL,Suryo Rahmanto Y,Richardson DR

更新日期：2006-04-01 00:00:00

abstract：:Most juvenile chronic myelogenous leukemia (JCML) cells have limited long-term proliferative capacity, and only a minority of immature cells give rise to colonies in semisolid cultures. Clonogenic JCML progenitors cannot be maintained in culture because they differentiate, and within a few weeks the leukemic clone is ...

journal_title：Blood

authors： Lapidot T,Grunberger T,Vormoor J,Estrov Z,Kollet O,Bunin N,Zaizov R,Williams DE,Freedman MH

更新日期：1996-10-01 00:00:00

abstract：:Using a cohort of C57BL/6 (B6) x (NZB x B6)F1 backcross male mice bearing the Yaa (Y-linked autoimmune acceleration) mutation, we mapped and characterized the NZB-derived susceptibility loci predisposing to the development of autoimmune hemolytic anemia (AHA). Our analysis identified 2 major loci on NZB chromosome 7 a...

journal_title：Blood

authors： Kikuchi S,Amano H,Amano E,Fossati-Jimack L,Santiago-Raber ML,Moll T,Ida A,Kotzin BL,Izui S

更新日期：2005-08-15 00:00:00

abstract：:The translocation t(8;14)(q24;q32) is the characteristic chromosomal aberration of Burkitt's-type lymphomas and leukemias (BLs). On the molecular level, the t(8;14) juxtaposes the c-myc gene in 8q24 next to the IgH locus in 14q32, resulting in overexpression of the transcription factor c-Myc. The detection of a t(8;14...

journal_title：Blood

authors： Siebert R,Matthiesen P,Harder S,Zhang Y,Borowski A,Zühlke-Jenisch R,Metzke S,Joos S,Weber-Matthiesen K,Grote W,Schlegelberger B

更新日期：1998-02-01 00:00:00

abstract：:About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Nor...

journal_title：Blood

authors： Abu-Issa R,Eichele G,Youssoufian H

更新日期：1999-07-15 00:00:00

abstract：:Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HP...

journal_title：Blood

authors： Cramer DE,Allendorf DJ,Baran JT,Hansen R,Marroquin J,Li B,Ratajczak J,Ratajczak MZ,Yan J

更新日期：2006-01-15 00:00:00

abstract：:We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment t...

journal_title：Blood

authors： Kaufmann H,Raderer M,Wöhrer S,Püspök A,Bankier A,Zielinski C,Chott A,Drach J

更新日期：2004-10-15 00:00:00

abstract：:Using Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) as a model, our aim has been to develop a molecular cytogenetic method of high resolution analysis for monitoring the frequency of cells with nonrandom chromosome rearrangements in the bone marrow of patients receiving treatment for hemato...

journal_title：Blood

authors： Seong DC,Kantarjian HM,Ro JY,Talpaz M,Xu J,Robinson JR,Deisseroth AB,Champlin RE,Siciliano MJ

更新日期：1995-09-15 00:00:00

abstract：:We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. The cum...

journal_title：Blood

authors： Curtis RE,Travis LB,Rowlings PA,Socié G,Kingma DW,Banks PM,Jaffe ES,Sale GE,Horowitz MM,Witherspoon RP,Shriner DA,Weisdorf DJ,Kolb HJ,Sullivan KM,Sobocinski KA,Gale RP,Hoover RN,Fraumeni JF Jr,Deeg HJ

更新日期：1999-10-01 00:00:00

abstract：:Gene therapy holds a major promise. However, until now, this promise was fulfilled only in few cases, in rare genetic diseases. One very common clinical condition is anemia. Patients with anemia of chronic renal failure are treated with erythropoietin. The objective of this study was to develop a therapeutic platform ...

journal_title：Blood

authors： Lippin Y,Dranitzki-Elhalel M,Brill-Almon E,Mei-Zahav C,Mizrachi S,Liberman Y,Iaina A,Kaplan E,Podjarny E,Zeira E,Harati M,Casadevall N,Shani N,Galun E

更新日期：2005-10-01 00:00:00

abstract：:We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)-induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycy...

journal_title：Blood

authors： Mizutani A,Okajima K,Uchiba M,Noguchi T

更新日期：2000-06-15 00:00:00

abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...

journal_title：Blood

authors： Liu C,Iqbal J,Teruya-Feldstein J,Shen Y,Dabrowska MJ,Dybkaer K,Lim MS,Piva R,Barreca A,Pellegrino E,Spaccarotella E,Lachel CM,Kucuk C,Jiang CS,Hu X,Bhagavathi S,Greiner TC,Weisenburger DD,Aoun P,Perkins SL,McKeith

更新日期：2013-09-19 00:00:00

abstract：:To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by t...

journal_title：Blood

authors： Zhou S,Mody D,DeRavin SS,Hauer J,Lu T,Ma Z,Hacein-Bey Abina S,Gray JT,Greene MR,Cavazzana-Calvo M,Malech HL,Sorrentino BP

更新日期：2010-08-12 00:00:00

abstract：:Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad spectrum proteolytic activity of plasmin. In addition to its role in thrombolysis, cell surface plasmin facilitates a wide array of physiologi...

journal_title：Blood

authors： Andronicos NM,Chen EI,Baik N,Bai H,Parmer CM,Kiosses WB,Kamps MP,Yates JR 3rd,Parmer RJ,Miles LA

更新日期：2010-02-18 00:00:00