In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia.

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00

abstract：:The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human ...

journal_title：Blood

authors： Bentfeld-Barker ME,Bainton DF

更新日期：1982-03-01 00:00:00

abstract：:All-trans retinoic acid (tRA) and arsenic trioxide (As(2)O(3)) induce non-cross-resistant complete clinical remission in patients with acute promyelocytic leukemia with t(15;17) translocation and target PML-RARalpha, the leukemogenic protein, by different pathways suggesting a possible therapeutic synergism. To evalua...

journal_title：Blood

authors： Jing Y,Wang L,Xia L,Chen GQ,Chen Z,Miller WH,Waxman S

更新日期：2001-01-01 00:00:00

abstract：:Neurexin I α (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. NRXN1α was expressed in primitive populations in human CB (huCB) and murine BM (muBM). DAG1 is ubiquitously expressed in hematopoietic tissue; however, osteobla...

journal_title：Blood

authors： Kinzfogl J,Hangoc G,Broxmeyer HE

更新日期：2011-07-21 00:00:00

abstract：:Fibronectin is a major component of the extracellular matrix of adherent layers of human long-term marrow cultures where it may stabilize the extracellular matrix network and provide adhesion sites for primitive hemopoietic cells. This study was devised to analyze the role of adherent cell populations in fibronectin s...

journal_title：Blood

authors： Lerat H,Lissitzky JC,Singer JW,Keating A,Herve P,Charbord P

更新日期：1993-09-01 00:00:00

abstract：:Multinucleated giant cells (MGC) are a common feature of granulomas that develop during various inflammatory reactions. MGC originate from fusion of monocytes or macrophages, but the exact mechanism of their generation is still unclear. In the present study, we investigated the influence of monocyte to macrophage matu...

journal_title：Blood

authors： Möst J,Spötl L,Mayr G,Gasser A,Sarti A,Dierich MP

更新日期：1997-01-15 00:00:00

abstract：:A cone and plate viscometer and Coulter Counter were used to study platelet modulation of polymorphonuclear leukocyte (PMNL) aggregation caused by controlled shear stress. As an index of aggregation, the large-particle percentage (LPP) was calculated. This represents the ratio of aggregated cell count to total cell co...

journal_title：Blood

authors： Rhee BG,Hall ER,McIntire LV

更新日期：1986-01-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:Adoptive transfer of patient-derived T cells modified to express chimeric antigen receptors (CARTs) has demonstrated dramatic success in relapsed/refractory pre-B-cell acute lymphoblastic leukemia (ALL), but response and durability of remission requires exponential CART expansion and persistence. Tumors are known to a...

journal_title：Blood

authors： Qin H,Ishii K,Nguyen S,Su PP,Burk CR,Kim BH,Duncan BB,Tarun S,Shah NN,Kohler ME,Fry TJ

更新日期：2018-11-01 00:00:00

abstract：:K-562 human leukemia cells grown in the presence of specific goat anti-K-562 gamma globulin, F(ab)'2, Fab', or Fab showed a decrease in DNA and protein syntheses and a loss of cell viability within several hours. Eventually all cells died and lysed within 2-5 days. These events occurred in the absence of added effecto...

journal_title：Blood

authors： Wust CJ,Green M,Lozzio CB,Lozzio BB

更新日期：1982-01-01 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several established or novel anti-multiple myeloma (anti-MM) agents, such as dexamethasone, thalidomide, and proteasome inhibitors (PS-341), inhibit NF-kappaB activity as part of their diverse acti...

journal_title：Blood

authors： Mitsiades N,Mitsiades CS,Poulaki V,Chauhan D,Richardson PG,Hideshima T,Munshi N,Treon SP,Anderson KC

更新日期：2002-06-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for ∼20% of ALL cases. Intensive chemotherapy regimens result in cure rates >85% in children and <50% in adults, warranting a search of novel therapeutic strategies. Although immune-based therapies have tremendously improved the trea...

journal_title：Blood

authors： Tran Quang C,Zaniboni B,Humeau R,Lengliné E,Dourthe ME,Ganesan R,Singh S,Scheer JM,Asnafi V,Ghysdael J

更新日期：2020-09-10 00:00:00

abstract：:Several strategies can be used to manage fetal or neonatal alloimmune thrombocytopenia (FNAIT) in subsequent pregnancies. Serial fetal blood sampling (FBS) and intrauterine platelet transfusions (IUPT), as well as weekly maternal IV immunoglobulin infusion (IVIG), with or without additional corticosteroid therapy, are...

journal_title：Blood

authors： Winkelhorst D,Murphy MF,Greinacher A,Shehata N,Bakchoul T,Massey E,Baker J,Lieberman L,Tanael S,Hume H,Arnold DM,Baidya S,Bertrand G,Bussel J,Kjaer M,Kaplan C,Kjeldsen-Kragh J,Oepkes D,Ryan G

更新日期：2017-03-16 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are mostly found around the vasculature system of the adult bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, and support T-cell cytotoxicity. We hypothesize that these contradictory properties of MSCs are important for BM homeostasis and occur partly ...

journal_title：Blood

authors： Chan JL,Tang KC,Patel AP,Bonilla LM,Pierobon N,Ponzio NM,Rameshwar P

更新日期：2006-06-15 00:00:00

abstract：:Serial erythrocyte volume distribution curves were used to characterize changes in erythrocyte subpopulations following the induction of Heinz body hemolytic anemia in cats. Macrocytes produced in response to hemolysis were observed after loss of reticulum. After recovery from hemolysis, a gradual reduction in mean ce...

journal_title：Blood

authors： Weiser MG,Kociba GJ

更新日期：1982-08-01 00:00:00

abstract：:We have conducted a pilot study to investigate the role of high-dose therapy and autologous bone marrow/stem cell transplantation (ASCT) during first complete or partial remission in 52 patients with poor-risk aggressive lymphoma. There were 42 patients with intermediate-grade or immunoblastic lymphoma who were consid...

journal_title：Blood

authors： Nademanee A,Molina A,O'Donnell MR,Dagis A,Snyder DS,Parker P,Stein A,Smith E,Planás I,Kashyap A,Spielberger R,Fung H,Wong KK,Somlo G,Margolin K,Chow W,Sniecinski I,Vora N,Blume KG,Niland J,Forman SJ

更新日期：1997-11-15 00:00:00

abstract：:The non-Hodgkin's lymphomas (NHL) are a diverse group of human lymphoid neoplasms that have long presented pathologists with formidable diagnostic challenges. These tumors of the immune system are thought to represent neoplastic transformations of most of the recognized stages in T and B lymphocyte ontogeny. Lymphoma ...

journal_title：Blood

authors： Ford RJ,Cramer M,Davis FM

更新日期：1984-03-01 00:00:00

abstract：:Clonality studies of hematopoietic reconstitution after remission were performed in 24 female patients (pts) with leukemias characterized by specific molecular markers. At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philad...

journal_title：Blood

authors： Lo Coco F,Pelicci PG,D'Adamo F,Diverio D,Alimena G,Montefusco E,Arcese W,Avvisati G,De Felice L,Meloni G

更新日期：1993-07-15 00:00:00

abstract：:Children with Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) have a poorer prognosis than do most pediatric patients with ALL. Because of this poor prognosis and the presence of the Ph chromosome, we have asked whether or not Ph + ALL involves a multipotential stem cell. We cultured hematopoietic pro...

journal_title：Blood

authors： Tachibana N,Raimondi SC,Lauer SJ,Sartain P,Dow LW

更新日期：1987-11-01 00:00:00

abstract：:Aneuploidy and lg light chain restriction were used as separate, independent tumor specific markers to study 26 patients with multiple myeloma to determine whether bone marrow B cells, as defined by CD19 expression, are clonally related to myeloma plasma cells. Specimens were characterized using multidimensional flow ...

journal_title：Blood

authors： McSweeney PA,Wells DA,Shults KE,Nash RA,Bensinger WI,Buckner CD,Loken MR

更新日期：1996-07-15 00:00:00

abstract：:Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated with favorable overall...

journal_title：Blood

authors： Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Del

更新日期：2012-03-08 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes (LGLs) that contain distinct lysosomal granules. The present study was undertaken to determine if these lysosomes contain glycosaminoglycans (GAGs) similar to those previously described in myeloid cells. Mononuclear cells from human blood were stained with HNK-1...

journal_title：Blood

authors： Parmley RT,Rahemtulla F,Cooper MD,Rodén L

更新日期：1985-07-01 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

journal_title：Blood

authors： Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

更新日期：2005-03-01 00:00:00

abstract：:Graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation, is caused by alloreactive donor T cells that trigger host tissue damage. The inflammatory environment inside recipients is critical for GVHD pathogenesis, but the underpinning mechanisms remain e...

journal_title：Blood

authors： Zhao F,Zhang Y,Wang H,Jin M,He S,Shi Y,Guo Y,Zhang Y

更新日期：2011-02-03 00:00:00

abstract：:Isokinetic-gradient sedimentation employing a shallow linear gradient of Ficoll in tissue culture medium was used to isolate erythroid progenitor cells (CFU-e) from mouse bone marrow. Following gradient sedimentation, 34% of the total nucleated cells and 48% of the CFU-e applied to the gradient were recovered, and thr...

journal_title：Blood

authors： Misiti J,Spivak JL

更新日期：1979-07-01 00:00:00

abstract：:A critical role for the endothelium of yolk sac and dorsal aorta has been shown in embryonic hematopoiesis. A stromal cell line derived from yolk sac, YSCL-72, has been chosen to search for a novel molecule associated with embryonic hematopoiesis. Analysis between YSCL-72 and an adult aorta-derived endothelial cell li...

journal_title：Blood

authors： Ohneda O,Ohneda K,Arai F,Lee J,Miyamoto T,Fukushima Y,Dowbenko D,Lasky LA,Suda T

更新日期：2001-10-01 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00