Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo.

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we g...

journal_title：Blood

authors： Chapuy B,Cheng H,Watahiki A,Ducar MD,Tan Y,Chen L,Roemer MG,Ouyang J,Christie AL,Zhang L,Gusenleitner D,Abo RP,Farinha P,von Bonin F,Thorner AR,Sun HH,Gascoyne RD,Pinkus GS,van Hummelen P,Wulf GG,Aster JC,Weinst

更新日期：2016-05-05 00:00:00

abstract：:In a single institution, we have used recombinant interferon- (IFN-) to treat 116 newly diagnosed Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) patients and analyzed the predictive factors for response and survival. The patients whose median age was 50.3 years (range, 9 to 70) were administered IFN- (5 mi...

journal_title：Blood

authors： Mahon FX,Fabères C,Pueyo S,Cony-Makhoul P,Salmi R,Boiron JM,Marit G,Bilhou-Nabera C,Carrère A,Montastruc M,Pigneux A,Bernard P,Reiffers J

更新日期：1998-12-01 00:00:00

abstract：:We studied the respiration and glucose utilization of suspensions of cultured lymphocytes. Respiration was measured by a couloximetric method using closed systems without a gas-suspension interface. The sensitivity of the method allowed measurements during a time interval of less than 1 hr. We found that the respirati...

journal_title：Blood

authors： Sand T,Condie R,Rosenberg A

更新日期：1977-08-01 00:00:00

abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

journal_title：Blood

authors： Cobaleda C,Sánchez-García I

更新日期：2000-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a major unmet medical need. Most patients have poor long-term survival, and treatment has not significantly changed in 40 years. Recently, bispecific antibodies that redirect the cytotoxic activity of effector T cells by binding to CD3, the signaling component of the T-cell receptor, an...

journal_title：Blood

authors： Leong SR,Sukumaran S,Hristopoulos M,Totpal K,Stainton S,Lu E,Wong A,Tam L,Newman R,Vuillemenot BR,Ellerman D,Gu C,Mathieu M,Dennis MS,Nguyen A,Zheng B,Zhang C,Lee G,Chu YW,Prell RA,Lin K,Laing ST,Polson AG

更新日期：2017-02-02 00:00:00

abstract：:The interaction of thrombin with plasminogen activator inhibitor 1 (PAI-1) is shown to result in the simultaneous formation of both cleaved PAI-1 and a sodium dodecyl sulfate-stable thrombin-PAI-1 complex. The kinetics of this reaction can be described by a "suicide substrate" mechanism that includes a branched reacti...

journal_title：Blood

authors： van Meijer M,Smilde A,Tans G,Nesheim ME,Pannekoek H,Horrevoets AJ

更新日期：1997-09-01 00:00:00

abstract：:Epo-induced endocytosis of EpoR plays important roles in the down-regulation of EpoR signaling and is the primary means that regulates circulating Epo concentrations. Here we show that cell-surface EpoR is internalized via clathrin-mediated endocytosis. Both JAK2 kinase activity and EpoR cytoplasmic tyrosines are impo...

journal_title：Blood

authors： Sulahian R,Cleaver O,Huang LJ

更新日期：2009-05-21 00:00:00

abstract：:Escape from immune detection favors both tumor survival and progression, and new approaches to circumvent this are essential to combat cancers. Nonvirulent, tumor-tropic bacteria, such as Salmonella typhimurium, can unmask a tumor by transforming it into a site of inflammation; however, the nonspecific invasiveness of...

journal_title：Blood

authors： Massa PE,Paniccia A,Monegal A,de Marco A,Rescigno M

更新日期：2013-08-01 00:00:00

abstract：:Stromal cells are believed to regulate lympho-hematopoiesis through direct cell-cell interactions and the release of growth factors. Many questions remain, however, about their lineage derivation and functional heterogeneity. We previously prepared a panel of stromal cell lines from murine spleen and bone marrow and c...

journal_title：Blood

authors： Gimble JM,Pietrangeli C,Henley A,Dorheim MA,Silver J,Namen A,Takeichi M,Goridis C,Kincade PW

更新日期：1989-07-01 00:00:00

abstract：:Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens. Thirty of these patients also received an infusion of HLA-haploidentical marrow cells. Only those patients having evidence of hematologic recovery within 3 mo after ATG therapy were considered res...

journal_title：Blood

authors： Doney K,Dahlberg SJ,Monroe D,Storb R,Buckner CD,Thomas ED

更新日期：1984-02-01 00:00:00

abstract：:A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive im...

journal_title：Blood

authors： Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PW

更新日期：2012-05-24 00:00:00

abstract：:Chronic graft-v-host disease (chronic GVHD) is a frequent cause of late morbidity and death after bone marrow transplantation (BMT). The actuarial survival after onset of chronic GVHD in 85 patients was 42% (95%Cl = 29%, 54%) at 10 years. Baseline characteristics present at the onset of chronic GVHD (before therapy) i...

journal_title：Blood

authors： Wingard JR,Piantadosi S,Vogelsang GB,Farmer ER,Jabs DA,Levin LS,Beschorner WE,Cahill RA,Miller DF,Harrison D

更新日期：1989-09-01 00:00:00

abstract：:On 1 September 2017, the US Food and Drug Administration (FDA) approved gemtuzumab ozogamicin (GO) for the treatment of adults with newly diagnosed CD33+ acute myeloid leukemia and for patients aged ≥2 years with CD33+ acute myeloid leukemia who have experienced a relapse or who have not responded to initial treatment...

journal_title：Blood

authors： Appelbaum FR,Bernstein ID

更新日期：2017-11-30 00:00:00

abstract：:Alas2 encodes the erythroid-specific delta-aminolevulinate synthase (ALAS2 or ALAS-E), the first enzyme in heme biosynthesis in erythroid cells. Mice with the Alas2-null phenotype showed massive cytoplasmic, but not mitochondrial, iron accumulation in their primitive erythroblasts. Because these animals died by day 11...

journal_title：Blood

authors： Harigae H,Nakajima O,Suwabe N,Yokoyama H,Furuyama K,Sasaki T,Kaku M,Yamamoto M,Sassa S

更新日期：2003-02-01 00:00:00

abstract：:Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies. However, its usefulness in adult acute lymphoblastic leukemia (ALL) is generally limited to the presence of the Philadelphia (Ph) chromosome because of the low incidence of other recurrent abnormalities. We present centrally reviewe...

journal_title：Blood

authors： Moorman AV,Harrison CJ,Buck GA,Richards SM,Secker-Walker LM,Martineau M,Vance GH,Cherry AM,Higgins RR,Fielding AK,Foroni L,Paietta E,Tallman MS,Litzow MR,Wiernik PH,Rowe JM,Goldstone AH,Dewald GW,Adult Leukaemia Worki

更新日期：2007-04-15 00:00:00

abstract：:Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version w...

journal_title：Blood

authors： Lee KN,Jackson KW,Christiansen VJ,Chung KH,McKee PA

更新日期：2004-05-15 00:00:00

abstract：:Human natural killer (NK) cells comprise 2 main subsets, CD56(bright) and CD56(dim) cells, that differ in function, phenotype, and tissue localization. To further dissect the heterogeneity of CD56(dim) cells, we have performed transcriptome analysis and functional ex vivo characterization of human NK-cell subsets acco...

journal_title：Blood

authors： Juelke K,Killig M,Luetke-Eversloh M,Parente E,Gruen J,Morandi B,Ferlazzo G,Thiel A,Schmitt-Knosalla I,Romagnani C

更新日期：2010-08-26 00:00:00

abstract：:Ruxolitinib is JAK1/JAK2 inhibitor with established clinical benefit in myelofibrosis (MF). We analyzed long-term outcomes of 107 patients with intermediate-2 or high-risk MF receiving ruxolitinib at MD Anderson Cancer Center (MDACC) on phase 1/2 trial. After a median of 32 months of follow-up, 58 patients (54%) were ...

journal_title：Blood

authors： Verstovsek S,Kantarjian HM,Estrov Z,Cortes JE,Thomas DA,Kadia T,Pierce S,Jabbour E,Borthakur G,Rumi E,Pungolino E,Morra E,Caramazza D,Cazzola M,Passamonti F

更新日期：2012-08-09 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are mostly found around the vasculature system of the adult bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, and support T-cell cytotoxicity. We hypothesize that these contradictory properties of MSCs are important for BM homeostasis and occur partly ...

journal_title：Blood

authors： Chan JL,Tang KC,Patel AP,Bonilla LM,Pierobon N,Ponzio NM,Rameshwar P

更新日期：2006-06-15 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:Thirty-two patients treated on consecutive Southwest Oncology Group (SWOG) protocols for malignant lymphoma were subsequently diagnosed as having lymphoblastic lymphoma. Combination chemistry, usually adriamycin-based, produced complete responses (CR) in 17 patients (53%). Median survival was 15 mo. Patients achieving...

journal_title：Blood

authors： Voakes JB,Jones SE,McKelvey EM

更新日期：1981-01-01 00:00:00

abstract：:We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cel...

journal_title：Blood

authors： Salem S,Langlais D,Lefebvre F,Bourque G,Bigley V,Haniffa M,Casanova JL,Burk D,Berghuis A,Butler KM,Leahy TR,Hambleton S,Gros P

更新日期：2014-09-18 00:00:00

abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

journal_title：Blood

authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

更新日期：2008-12-01 00:00:00

abstract：:The experience at a single institution in harvesting marrow for allogeneic transplantation on 1,270 occasions from 1,160 normal donors is presented in detail, together with an analysis of all the donor complications. Four donors were less than 2 years old, and the youngest was 6 1/2 months. No special difficulties wer...

journal_title：Blood

authors： Buckner CD,Clift RA,Sanders JE,Stewart P,Bensinger WI,Doney KC,Sullivan KM,Witherspoon RP,Deeg HJ,Appelbaum FR

更新日期：1984-09-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis of TRALI, particularly with respect to recipient factors are unknown. We used a murine model of ...

journal_title：Blood

authors： Fung YL,Kim M,Tabuchi A,Aslam R,Speck ER,Chow L,Kuebler WM,Freedman J,Semple JW

更新日期：2010-10-21 00:00:00

abstract：:We evaluated phagocytic and lytic activities of peripheral blood monocytes (PBMo) from patients with thalassemia major (ThP) using C pseudotropicalis as the target. PBMo from ThP showed decreased lytic activity (P less than .001), whereas the phagocytic activity did not differ from that of the controls. Significant in...

journal_title：Blood

authors： Ballart IJ,Estevez ME,Sen L,Diez RA,Giuntoli J,de Miani SA,Peñalver J

更新日期：1986-01-01 00:00:00

abstract：:Hemophiliac patients with chronic hepatitis C might be exposed to and become infected with multiple hepatitis C virus (HCV) strains by means of frequent use of blood products, even if they are infected with a single subtype of HCV. To test this hypothesis, we analyzed the genetic diversity of hypervariable region 1 (H...

journal_title：Blood

authors： Toyoda H,Fukuda Y,Koyama Y,Nakano I,Kinoshita M,Hadama T,Takamatsu J,Hayakawa T

更新日期：1996-08-15 00:00:00

abstract：:Erythropoiesis-inhibiting factors (EIF) have been demonstrated in plasma from hypertransfused animals and from polycythemic individuals during periods of hyperoxia, but there is a decided discrepancy in the data published. In the present paper methodologic variations of a bioassay for demonstrating the erythropoiesis-...

journal_title：Blood

authors： Lindemann R

更新日期：1976-01-01 00:00:00

abstract：:We report 2 new mutations identified in 3 patients and characterized by the markedly decreased affinity of von Willebrand factor (vWF) for factor VIII (FVIII). Patients 2 and 3, who have a typical type 2N phenotype, were found to be compound heterozygous for Arg91Gln and Cys25Tyr or Cys95Phe, respectively. Patient 1, ...

journal_title：Blood

authors： Jorieux S,Fressinaud E,Goudemand J,Gaucher C,Meyer D,Mazurier C

更新日期：2000-05-15 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, or 5-HT), released from activated platelets, not only accelerates aggregation of platelets but also is known to promote mitosis, migration, and contraction of vascular smooth muscle cells (VSMCs). These effects are considered to contribute to thrombus formation and atherosclerosis. The ...

journal_title：Blood

authors： Kawano H,Tsuji H,Nishimura H,Kimura S,Yano S,Ukimura N,Kunieda Y,Yoshizumi M,Sugano T,Nakagawa K,Masuda H,Sawada S,Nakagawa M

更新日期：2001-03-15 00:00:00