Abstract:
:Uniformly adopted response criteria are essential for assessment of therapies incorporating conventional chemotherapy and chemoimmunotherapy regimens. Recently, immunomodulatory agents, such as immune checkpoint inhibitors, have demonstrated impressive activity in a broad range of lymphoma histologies. However, these agents may be associated with clinical and imaging findings during treatment suggestive of progressive disease (PD) despite evidence of clinical benefit (eg, tumor flare or pseudo-progression). Considering this finding as PD could lead to patients being prematurely removed from a treatment from which they actually stand to benefit. This phenomenon has been well described with checkpoint blockade therapy in solid tumors and anecdotally seen in lymphoma as well. To address this issue in the context of lymphoma immunomodulatory therapy, a workshop was convened to provide provisional recommendations to modify current response criteria in patients receiving these and future agents in clinical trials. The term "indeterminate response" was introduced to identify such lesions until confirmed as flare/pseudo-progression or true PD by either biopsy or subsequent imaging.
journal_name
Bloodjournal_title
Bloodauthors
Cheson BD,Ansell S,Schwartz L,Gordon LI,Advani R,Jacene HA,Hoos A,Barrington SF,Armand Pdoi
10.1182/blood-2016-05-718528subject
Has Abstractpub_date
2016-11-24 00:00:00pages
2489-2496issue
21eissn
0006-4971issn
1528-0020pii
blood-2016-05-718528journal_volume
128pub_type
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