A clinical study of the lupus anticoagulant.

abstract：:We prospectively studied 98 chronic myeloid leukemia (CML) patients after bone marrow transplantation by competitive polymerase chain reaction to detect and quantify leukemia-specific BCR-ABL mRNA. Of 69 patients who had persistently undetectable, decreasing, or low BCR-ABL levels ( < 50 transcripts/microgram RNA) on ...

journal_title：Blood

authors： Lin F,van Rhee F,Goldman JM,Cross NC

更新日期：1996-05-15 00:00:00

abstract：:The costimulatory effects of CD27 on T lymphocyte effector function and memory formation has been confined to evaluations in mouse models, in vitro human cell culture systems, and clinical observations. Here, we tested whether CD27 costimulation actively enhances human T-cell function, expansion, and survival in vitro...

journal_title：Blood

authors： Song DG,Ye Q,Poussin M,Harms GM,Figini M,Powell DJ Jr

更新日期：2012-01-19 00:00:00

abstract：:The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cell lines (HMCLs) are highly sensitive to Gln depletion. In this study, we found that both HMCLs and primary bone marrow (BM) C...

journal_title：Blood

authors： Bolzoni M,Chiu M,Accardi F,Vescovini R,Airoldi I,Storti P,Todoerti K,Agnelli L,Missale G,Andreoli R,Bianchi MG,Allegri M,Barilli A,Nicolini F,Cavalli A,Costa F,Marchica V,Toscani D,Mancini C,Martella E,Dall'Asta V

更新日期：2016-08-04 00:00:00

abstract：:Proapoptotic Bax and Bak are the key B-cell lymphoma-2 family members mediating apoptosis through the intrinsic pathway. Cells doubly deficient for Bax and Bak are profoundly resistant to apoptotic stimuli originating from multiple stimuli. Here we describe mice in which Bax and Bak have been deleted specifically in T...

journal_title：Blood

authors： Biswas S,Shi Q,Matise L,Cleveland S,Dave U,Zinkel S

更新日期：2010-12-09 00:00:00

abstract：UNLABELLED:Several studies have demonstrated that hematopoietic cells originate from endotheliumin early development; however, the phenotypic progression of progenitor cells during human embryonic hemogenesis is not well described. Here, we define the developmental hierarchy among intermediate populations of hematopoie...

journal_title：Blood

authors： Rafii S,Kloss CC,Butler JM,Ginsberg M,Gars E,Lis R,Zhan Q,Josipovic P,Ding BS,Xiang J,Elemento O,Zaninovic N,Rosenwaks Z,Sadelain M,Rafii JA,James D

更新日期：2013-01-31 00:00:00

abstract：:Survivin has been described as an important regulator of late mitosis and as antiapoptotic in various cells. In this issue of Blood, Wen and colleagues describe a megakaryocyte-specific knockout of survivin, with no influence on megakaryocyte survival, and a stimulating effect on polyploidy. ...

journal_title：Blood

authors： Ravid K

更新日期：2009-07-02 00:00:00

abstract：:Cytogenetic and histopathologic data were correlated with clinical parameters from 423 patients with non-Hodgkin's lymphoma (NHL). Clinical correlations were performed on subgroups of 149 patients with low-grade lymphoma (LG) and 205 patients with diffuse lymphoma with a large cell component (DLLC). Correlations were ...

journal_title：Blood

authors： Offit K,Wong G,Filippa DA,Tao Y,Chaganti RS

更新日期：1991-04-01 00:00:00

abstract：:The incidence of neutralizing isoantibody formation to infused factor VIII in a cohort of 67 hemophilia A patients, born between January 1, 1971 and April 30, 1990, who had been treated exclusively with lyophilized cryoprecipitate, was 6% (5.3 per 1,000 patient years of observation). The age-dependent cumulative risk ...

journal_title：Blood

authors： Peerlinck K,Rosendaal FR,Vermylen J

更新日期：1993-06-15 00:00:00

abstract：:In this issue of Blood, Usmani et al provide important information on second primary malignancies in patients treated with thalidomide and lenalidomide in the Arkansas total therapy trials. ...

journal_title：Blood

authors： Rajkumar SV

更新日期：2012-08-23 00:00:00

abstract：:CD20 is a nonglycosylated 33 to 37 kD phosphoprotein involved in B-cell signaling that subserves important functions in the regulation of B-cell proliferation and differentiation. In addition, this B-cell surface antigen has been shown recently to be an effective target for immunotherapy of B-cell malignancies using c...

journal_title：Blood

authors： Shan D,Ledbetter JA,Press OW

更新日期：1998-03-01 00:00:00

abstract：:Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subs...

journal_title：Blood

authors： Beckman DL,Lin LL,Quinones ME,Longmore GD

更新日期：1999-10-15 00:00:00

abstract：:Aberrant activation of the Wnt pathway plays a pathogenetic role in various tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). LEF1, a key mediator of Wnt signaling, has been linked to leukemic transformation, and recurrent mutations of LEF1 have been identified in pediatric T-A...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Kaiser M,Schlee C,Stroux A,Burmeister T,Mochmann LH,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2011-12-08 00:00:00

abstract：:Platelet membrane GPIIb is comprised of a disulfide-linked heavy chain (GPIIb(H)) and light chain (GPIIb(L)). We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function. Lysates of surface radioiodinated platelets were treated wi...

journal_title：Blood

authors： Lam SC,Plow EF,Ginsberg MH

更新日期：1989-05-01 00:00:00

abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...

journal_title：Blood

authors： White JG,Krumwiede M

更新日期：1985-04-01 00:00:00

abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...

journal_title：Blood

authors： Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

更新日期：2015-04-16 00:00:00

abstract：:One hundred thirty-eight patients with hairy cell leukemia were randomized to receive either a dose of 2.0 megaunits (MU)/m2 or a 10-fold lower dose of 0.2 MU/m2 of a highly purified natural alpha-interferon, administered daily for 28 days followed by a three times a week schedule. Ninety-seven of these patients had p...

journal_title：Blood

authors： Smalley RV,Anderson SA,Tuttle RL,Connors J,Thurmond LM,Huang A,Castle K,Magers C,Whisnant JK

更新日期：1991-12-15 00:00:00

abstract：:Current approaches for treatment of late-stage breast cancer rarely result in a long-term cure. In part this is due to tumor stroma that prevents access of systemically or intratumorally applied therapeutics. We propose a stem cell gene therapy approach for controlled tumor stroma degradation that uses the pathophysio...

journal_title：Blood

authors： Li Z,Liu Y,Tuve S,Xun Y,Fan X,Min L,Feng Q,Kiviat N,Kiem HP,Disis ML,Lieber A

更新日期：2009-05-28 00:00:00

abstract：:Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels control mitochondri...

journal_title：Blood

authors： Jacque N,Ronchetti AM,Larrue C,Meunier G,Birsen R,Willems L,Saland E,Decroocq J,Maciel TT,Lambert M,Poulain L,Hospital MA,Sujobert P,Joseph L,Chapuis N,Lacombe C,Moura IC,Demo S,Sarry JE,Recher C,Mayeux P,Tambur

更新日期：2015-09-10 00:00:00

abstract：:Human band 3 Walton is an AE1 mutation that results in the deletion of the 11 COOH-terminal amino acids of the protein and is associated with dominant distal renal tubular acidosis. The properties of band 3 Walton expressed with normal band 3 in the heterozygous mutant erythrocytes and the kidney isoform expressed in ...

journal_title：Blood

authors： Toye AM,Bruce LJ,Unwin RJ,Wrong O,Tanner MJ

更新日期：2002-01-01 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:Platelets stored as concentrates (PC) for 72 h at 22 degrees C develop a functional defect. Alterations in adenine nucleotides of platelets have been shown to affect platelet function. Adenine nucleotide content of platelets was measured before and after storage and a decrease of 27.1 /+- 1.7% (mean /+- SE) in ATP and...

journal_title：Blood

authors： Rao AK,Niewiarowski S,Murphy S

更新日期：1981-02-01 00:00:00

abstract：:Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation-induced cytidine deaminase (AID). Resulting uracil-guanine mismatches are processed by uracil DNA glycosylase (UNG)-media...

journal_title：Blood

authors： Gu X,Booth CJ,Liu Z,Strout MP

更新日期：2016-01-07 00:00:00

abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...

journal_title：Blood

authors： Dick JE,Kamel-Reid S,Murdoch B,Doedens M

更新日期：1991-08-01 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:The presence of a serum factor in chronic renal failure (CRF) which inhibits erythropoietin-stimulated erythropoiesis was studied, using a technique in which dog marrow cells were stimulated to produce heme in the presence of human serum. In the total series comparing 27 normal sera with 52 CRF sera, less heme was syn...

journal_title：Blood

authors： Wallner SF,Kurnick JE,Ward HP,Vautrin R,Alfrey AC

更新日期：1976-04-01 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:The model of erythroleukemia caused by Spi-1/PU.1 transgenesis in mice is a multistage disease. A preleukemic step is characterized by an acute proliferation of proerythroblasts due to the arrest of differentiation provoked by Spi-1/PU.1. Later on, a blastic crisis occurs associated with somatic oncogenic mutations in...

journal_title：Blood

authors： Monni R,Haddaoui L,Naba A,Gallais I,Arpin M,Mayeux P,Moreau-Gachelin F

更新日期：2008-03-15 00:00:00

abstract：:Donor hematopoietic stem cells (HSCs) can correct T-cell deficiencies in patients with severe combined immunodeficiency by replacing resident thymus cells. However, as those progenitors that naturally migrate to the thymus are not capable of supporting long-term thymopoiesis, a successful transplant is thought to requ...

journal_title：Blood

authors： de Barros SC,Vicente R,Chebli K,Jacquet C,Zimmermann VS,Taylor N

更新日期：2013-03-14 00:00:00

abstract：:Controversy exists as to whether hematopoietic progenitor cells are infected by human immunodeficiency virus-1 (HIV-1) in vivo. Most studies have focused on patients with acquired immunodeficiency syndrome (AIDS)/AIDS-related complex, and little data are available on asymptomatic patients with well preserved CD4+ T-ce...

journal_title：Blood

authors： Neal TF,Holland HK,Baum CM,Villinger F,Ansari AA,Saral R,Wingard JR,Fleming WH

更新日期：1995-09-01 00:00:00

abstract：:To gain further insights in the pathogenesis of herpesvirus pneumonia in allogeneic bone marrow transplant recipients, transplanted mice (B10.BR --> CBA) with graft-versus-host disease (GVHD) and control mice (transplanted mice without GVHD and normal CBA mice) were infected intranasally with herpes simplex virus type...

journal_title：Blood

authors： Adler H,Beland JL,Kozlow W,Del-Pan NC,Kobzik L,Rimm IJ

更新日期：1998-10-01 00:00:00