AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.

abstract：:As B-cell chronic lymphocytic leukemia (B-CLL) progresses, malignant cells extravasate and infiltrate lymphoid tissues. Several molecules, including gelatinase B/MMP-9, contribute to these processes. Although mainly a secreted protease, some MMP-9 is present at the B-CLL cell surface and the function, mode of anchorin...

journal_title：Blood

authors： Redondo-Muñoz J,Ugarte-Berzal E,García-Marco JA,del Cerro MH,Van den Steen PE,Opdenakker G,Terol MJ,García-Pardo A

更新日期：2008-07-01 00:00:00

abstract：:To identify new cytogenetic abnormalities associated with leukemogenesis or disease outcome, T-cell acute lymphoblastic leukemia (T-ALL) patient samples were analyzed by means of the array-comparative genome hybridization technique (array-CGH). Here, we report the identification of a new recurrent and cryptic deletion...

journal_title：Blood

authors： Van Vlierberghe P,van Grotel M,Beverloo HB,Lee C,Helgason T,Buijs-Gladdines J,Passier M,van Wering ER,Veerman AJ,Kamps WA,Meijerink JP,Pieters R

更新日期：2006-11-15 00:00:00

abstract：:The evidence for a regulatory role of acidic isoferritins on hemopoiesis is not entirely consistent with our knowledge of ferritin biochemistry, and no clear picture of this phenomeonon has emerged. In the present study, we have been unable to confirm a consistent effect of purified heart (acidic), spleen (basic), or ...

journal_title：Blood

authors： Sala G,Worwood M,Jacobs A

更新日期：1986-02-01 00:00:00

abstract：:Neutrophils recruited from the blood are key players in the innate immune response. Selectins play critical roles in neutrophil recruitment by mediating their tethering and rolling in inflamed venules. While the roles of P- and E-selectin in this process are well established, the mechanisms of L-selectin-mediated neut...

journal_title：Blood

authors： Shigeta A,Matsumoto M,Tedder TF,Lowe JB,Miyasaka M,Hirata T

更新日期：2008-12-15 00:00:00

abstract：:Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer ...

journal_title：Blood

authors： Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR

更新日期：2008-03-01 00:00:00

abstract：:Hematopoietic stem cell (HSC)-based gene therapy holds promise for the cure of many diseases. The field is now moving toward the use of lentiviral vectors (LVs) as evidenced by 4 successful clinical trials. These trials used vesicular-stomatitis-virus-G protein (VSV-G)-LVs at high doses combined with strong cytokine-c...

journal_title：Blood

authors： Girard-Gagnepain A,Amirache F,Costa C,Lévy C,Frecha C,Fusil F,Nègre D,Lavillette D,Cosset FL,Verhoeyen E

更新日期：2014-08-21 00:00:00

abstract：:Bcl-2 protein expression has been associated with poor prognosis in patients with noncutaneous diffuse large B-cell lymphomas. In primary cutaneous large B-cell lymphomas, the location on the leg, the round-cell morphology defined as the predominance of centroblasts and immunoblasts over large centrocytes, and multipl...

journal_title：Blood

authors： Grange F,Petrella T,Beylot-Barry M,Joly P,D'Incan M,Delaunay M,Machet L,Avril MF,Dalac S,Bernard P,Carlotti A,Esteve E,Vergier B,Dechelotte P,Cassagnau E,Courville P,Saiag P,Laroche L,Bagot M,Wechsler J

更新日期：2004-05-15 00:00:00

abstract：:Maintenance of myeloid cell homeostasis requires continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence phagocyte longevity in the absence of inflammation remains unknown. Here, we show that the gut microbiota regulates the steady-state cellular lifespan of neutrophils and ...

journal_title：Blood

authors： Hergott CB,Roche AM,Tamashiro E,Clarke TB,Bailey AG,Laughlin A,Bushman FD,Weiser JN

更新日期：2016-05-19 00:00:00

abstract：:The ability of platelets to adsorb vinblastine has been used to treat patients with immune thrombocytopenia. It is hypothesized that the drug-platelet complex is coated with antibody, taken up by macrophages which are then destroyed by the drug. We gave 16 courses of vinblastine-platelets to six patients with immune t...

journal_title：Blood

authors： Kelton JG,McDonald JW,Barr RM,Walker I,Nicholson W,Neame PB,Hamid C,Wong TY,Hirsh J

更新日期：1981-03-01 00:00:00

abstract：:TLRs expressed on dendritic cells (DCs) differentially activate DCs when activated alone or in combination, inducing distinct cytokines and costimulatory molecules that influence T-cell responses. Defining the requirements of DCs to program T cells during priming to become memory rather than effector cells could enhan...

journal_title：Blood

authors： Pufnock JS,Cigal M,Rolczynski LS,Andersen-Nissen E,Wolfl M,McElrath MJ,Greenberg PD

更新日期：2011-06-16 00:00:00

abstract：:Arsenic trioxide (As₂O₃) is a highly effective treatment for patients with refractory/relapsed acute promyelocytic leukemia (APL), but resistance to As₂O₃ has recently been seen. In the present study, we report the findings that 2 of 15 patients with refractory/relapsed APL treated with As₂O₃ were clinically As₂O₃ res...

journal_title：Blood

authors： Goto E,Tomita A,Hayakawa F,Atsumi A,Kiyoi H,Naoe T

更新日期：2011-08-11 00:00:00

abstract：:Electron microscopic (EM) studies were performed to clarify the interactions of membrane proteins in the red blood cell membrane structure in situ of a homozygous patient with total deficiency of protein 4.1 who carried a point mutation of the downstream translation initiation codon (AUG --> AGG) of the protein 4.1 ge...

journal_title：Blood

authors： Yawata A,Kanzaki A,Gilsanz F,Delaunay J,Yawata Y

更新日期：1997-09-15 00:00:00

abstract：:Human embryonic stem cells are a promising tool to study events associated with the earliest ontogenetic stages of hematopoiesis. We describe the generation of erythroid cells from hES (H1) by subsequent processing of cells present at early and late stages of embryoid body (EB) differentiation. Kinetics of hematopoiet...

journal_title：Blood

authors： Chang KH,Nelson AM,Cao H,Wang L,Nakamoto B,Ware CB,Papayannopoulou T

更新日期：2006-09-01 00:00:00

abstract：:Hematopoietic stem cells purified from mouse bone marrow are quiescent with less than 2% of Lin- Hoechst(low)/Rhodamine(low) (Lin- Ho(low)/Rho(low)) and 10% to 15% of Lin-/Sca+ cells in S phase. These cells enter proliferative cycle and progress through G1 and into S phase in the presence of cytokines and 5% heat-inac...

journal_title：Blood

authors： Reddy GP,Tiarks CY,Pang L,Wuu J,Hsieh CC,Quesenberry PJ

更新日期：1997-09-15 00:00:00

abstract：:A 27-year-old male patient with ataxia telangiectasia (AT) developed atypical chronic lymphocytic leukemia with increasing bone marrow infiltration in the absence of organomegaly. One-third of the leukemia cells expressed a mature suppressor/cytotoxic T cell phenotype (T3+ T4- T6- T8+ T10-), two-thirds demonstrated ad...

journal_title：Blood

authors： Dührsen U,Uppenkamp M,Uppenkamp I,Becher R,Engelhard M,König E,Meusers P,Meuer S,Brittinger G

更新日期：1986-08-01 00:00:00

abstract：:Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affy...

journal_title：Blood

authors： Merryweather-Clarke AT,Atzberger A,Soneji S,Gray N,Clark K,Waugh C,McGowan SJ,Taylor S,Nandi AK,Wood WG,Roberts DJ,Higgs DR,Buckle VJ,Robson KJ

更新日期：2011-03-31 00:00:00

abstract：:We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein, PIXY321, to ameliorate cumulative thrombocytopenia after multiple cycles of 5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide (FLAC) chemotherapy co...

journal_title：Blood

authors： O'Shaughnessy JA,Tolcher A,Riseberg D,Venzon D,Zujewski J,Noone M,Gossard M,Danforth D,Jacobson J,Chang V,Goldspiel B,Keegan P,Giusti R,Cowan KH

更新日期：1996-03-15 00:00:00

abstract：:Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene expression. HDAC inhibitors induce growth arrest, differentiation, and apoptosis of tumor cells and are used as anticancer agents. Here we des...

journal_title：Blood

authors： Roger T,Lugrin J,Le Roy D,Goy G,Mombelli M,Koessler T,Ding XC,Chanson AL,Reymond MK,Miconnet I,Schrenzel J,François P,Calandra T

更新日期：2011-01-27 00:00:00

abstract：:Timed sequencing of cycles of induction chemotherapy in acute myeloid leukemia (AML) has been proposed as a way to achieve maximal leukemic cell kill through recruitment and synchronization of residual neoplastic cells. Furthermore, whether intensive induction therapy should be continued in the presence of profound my...

journal_title：Blood

authors： Woods WG,Kobrinsky N,Buckley JD,Lee JW,Sanders J,Neudorf S,Gold S,Barnard DR,DeSwarte J,Dusenbery K,Kalousek D,Arthur DC,Lange BJ

更新日期：1996-06-15 00:00:00

abstract：:Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of ...

journal_title：Blood

authors： Wootla B,Christophe OD,Mahendra A,Dimitrov JD,Repessé Y,Ollivier V,Friboulet A,Borel-Derlon A,Levesque H,Borg JY,Andre S,Bayry J,Calvez T,Kaveri SV,Lacroix-Desmazes S

更新日期：2011-02-17 00:00:00

abstract：:The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy, but is largely unexplored in hematologic malignancies. In the present study, we show that the extra domain B (EDB) of fibronectin, a marker of angiogenesis, is expressed in B-cell non-Hodgkin...

journal_title：Blood

authors： Schliemann C,Palumbo A,Zuberbühler K,Villa A,Kaspar M,Trachsel E,Klapper W,Menssen HD,Neri D

更新日期：2009-03-05 00:00:00

abstract：:BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate-resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutants emerging in the p...

journal_title：Blood

authors： Bradeen HA,Eide CA,O'Hare T,Johnson KJ,Willis SG,Lee FY,Druker BJ,Deininger MW

更新日期：2006-10-01 00:00:00

abstract：:In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this a...

journal_title：Blood

authors： Fernandez-Viña MA,Wang T,Lee SJ,Haagenson M,Aljurf M,Askar M,Battiwalla M,Baxter-Lowe LA,Gajewski J,Jakubowski AA,Marino S,Oudshoorn M,Marsh SG,Petersdorf EW,Schultz K,Turner EV,Waller EK,Woolfrey A,Umejiego J,Spell

更新日期：2014-02-20 00:00:00

abstract：:In common variable immunodeficiency (CVID) defects in early stages of B-cell development, bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically. Here we report the first morphologic and flow cytometric study of B- and T-cell populations in CVID BM biopsies and aspirates. Whereas the hema...

journal_title：Blood

authors： Ochtrop ML,Goldacker S,May AM,Rizzi M,Draeger R,Hauschke D,Stehfest C,Warnatz K,Goebel H,Technau-Ihling K,Werner M,Salzer U,Eibel H,Schlesier M,Peter HH

更新日期：2011-07-14 00:00:00

abstract：:Erythroid progenitor cells isolated from patients with polycythemia vera (PV) proliferate and differentiate in methylcellulose in the absence of exogenous erythropoietin (EPO). To investigate the potential role of the erythropoietin receptor (EPO-R) in the pathogenesis of PV, we cultured bone marrow-derived or periphe...

journal_title：Blood

authors： Fisher MJ,Prchal JF,Prchal JT,D'Andrea AD

更新日期：1994-09-15 00:00:00

abstract：:Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to which in vitro programming can qualitatively substitute for an in vivo antigen stimulation remains unknown. We show that self-/tumor-reactive effector memory CD8(+) T cells...

journal_title：Blood

authors： Klebanoff CA,Yu Z,Hwang LN,Palmer DC,Gattinoni L,Restifo NP

更新日期：2009-08-27 00:00:00

abstract：:This study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononu...

journal_title：Blood

authors： Srivastava G,Wong KY,Chiang AK,Lam KY,Tao Q

更新日期：2000-04-01 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:HGAL is a newly identified germinal center (GC)-specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas. The function of HGAL is unknown. Previous studies demonstrated that HGAL is dispensable for GC formation, immuno...

journal_title：Blood

authors： Lu X,Chen J,Malumbres R,Cubedo Gil E,Helfman DM,Lossos IS

更新日期：2007-12-15 00:00:00

abstract：:Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs...

journal_title：Blood

authors： Creusot RJ,Yaghoubi SS,Chang P,Chia J,Contag CH,Gambhir SS,Fathman CG

更新日期：2009-06-25 00:00:00