Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.

abstract：:Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-beta superfamily and has been identified in different contexts as a hypoxia-inducible gene product and as a molecule involved in hepcidin regulation. The biology of iron and oxygen is closely related, and known regulatory ...

journal_title：Blood

authors： Lakhal S,Talbot NP,Crosby A,Stoepker C,Townsend AR,Robbins PA,Pugh CW,Ratcliffe PJ,Mole DR

更新日期：2009-02-12 00:00:00

abstract：:Perfluorocarbons have shown promise as clinical blood substitutes. Although early experience in Japan with one such product--Fluosol-DA--has been uncomplicated, we observed an adverse pulmonary reaction in the first American patient to receive it and know of similar reactions in two other Americans so treated. Postula...

journal_title：Blood

authors： Vercellotti GM,Hammerschmidt DE,Craddock PR,Jacob HS

更新日期：1982-06-01 00:00:00

abstract：:A hamster antimouse CD3 monoclonal antibody (MoAb) opened the way to experimental studies on the suppression of allograft rejection and cytokine-related morbidity after treatment with antibodies modulating the CD3/T-cell receptor complex (CD3/TCR). Because earlier attempts to suppress graft-versus-host disease (GVHD) ...

journal_title：Blood

authors： Mysliwietz J,Thierfelder S

更新日期：1992-11-15 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is characterized by the massive infiltration of secondary lymphoid organs with activated CD8(+) T lymphocytes. While converging data indicated that these cells were HIV-specific cytotoxic T lymphocytes (CTLs) responsible for HIV spread limitation, direct evidence was lackin...

journal_title：Blood

authors： Hosmalin A,Samri A,Dumaurier MJ,Dudoit Y,Oksenhendler E,Karmochkine M,Autran B,Wain-Hobson S,Cheynier R

更新日期：2001-05-01 00:00:00

abstract：:Anemia and neutropenia often develop in cats that are infected with the feline immunodeficiency virus (FIV), a lentivirus biologically similar to the human immunodeficiency virus (HIV). To assess the role of FIV in the pathogenesis of these abnormalities, marrow culture studies were performed on nine asymptomatic, hem...

journal_title：Blood

authors： Linenberger ML,Shelton GH,Persik MT,Abkowitz JL

更新日期：1991-10-15 00:00:00

abstract：:Juvenile chronic myelocytic leukemia (JCML) is a rare disorder of early childhood. Characteristic of JCML are the progressive appearance of high levels of fetal hemoglobin (HbF), reflecting a true reversion to a fetal type of erythropoiesis, and the presence of colony-forming cells able to grow in vitro spontaneously ...

journal_title：Blood

authors： Privitera E,Schirò R,Longoni D,Ronchi A,Rambaldi A,Bernasconi S,Ottolenghi S,Masera G,Biondi A

更新日期：1995-07-01 00:00:00

abstract：:Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF) to its receptor Kit. We observed that one of the major initial signaling events associated with Fc epsilon RI-mediated a...

journal_title：Blood

authors： Tkaczyk C,Horejsi V,Iwaki S,Draber P,Samelson LE,Satterthwaite AB,Nahm DH,Metcalfe DD,Gilfillan AM

更新日期：2004-07-01 00:00:00

abstract：:There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...

journal_title：Blood

authors： Walsby E,Buggins A,Devereux S,Jones C,Pratt G,Brennan P,Fegan C,Pepper C

更新日期：2014-06-05 00:00:00

abstract：:Polymorphonuclear neutrophils (PMN) contain multiple distinct secretory compartments that are sequentially mobilized during cell activation. Complement receptor type 1 (CR1) is a marker for a readily mobilizable secretory vesicle compartment, which can undergo exocytic fusion with the plasma membrane independently of ...

journal_title：Blood

authors： Jost C,Klickstein L,Wetzler E,Kumar A,Berger M

更新日期：1998-07-01 00:00:00

abstract：:Platelet membrane GPIIb is comprised of a disulfide-linked heavy chain (GPIIb(H)) and light chain (GPIIb(L)). We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function. Lysates of surface radioiodinated platelets were treated wi...

journal_title：Blood

authors： Lam SC,Plow EF,Ginsberg MH

更新日期：1989-05-01 00:00:00

abstract：:Erythropoietin (Epo) and dimethyl sulfoxide (DMSO) are believed to induce the differentiation of transformed erythroid cells by different signal transduction pathways. We have now obtained evidence for the interaction of these pathways. We used a Rauscher murine erythroleukemia cell line with a relatively low (8% to 1...

journal_title：Blood

authors： Chern Y,Yonekura S,Sytkowski AJ

更新日期：1990-12-01 00:00:00

abstract：:Imatinib has revolutionized drug therapy of chronic myeloid leukemia (CML). Preclinical studies were promising but the results of clinical trials by far exceeded expectations. Responses in chronic phase are unprecedented, with rates of complete cytogenetic response (CCR) of more than 40% in patients after failure of i...

journal_title：Blood

authors： Deininger M,Buchdunger E,Druker BJ

更新日期：2005-04-01 00:00:00

abstract：:A polymorphic variant of the phosphatase PTPN22 has been associated with increased risk for multiple autoimmune diseases. The risk allele is thought to function by diminishing antigen-receptor signals responsible for negative selection of autoreactive lymphocytes. We now show that PTPN22 is markedly overexpressed in c...

journal_title：Blood

authors： Negro R,Gobessi S,Longo PG,He Y,Zhang ZY,Laurenti L,Efremov DG

更新日期：2012-06-28 00:00:00

abstract：:A new type of A alpha Glu-11 to Gly substitution has been identified in a congenitally abnormal fibrinogen, fibrinogen Mitaka II, derived from a 14-year-old female suffering from easy bruising since childhood. Plasma of the patient and fibrinogen purified therefrom were found to clot slowly by thrombin but in a normal...

journal_title：Blood

authors： Niwa K,Yaginuma A,Nakanishi M,Wada Y,Sugo T,Asakura S,Watanabe N,Matsuda M

更新日期：1993-12-15 00:00:00

abstract：:Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs)...

journal_title：Blood

authors： Jalkanen ST,Butcher EC

更新日期：1985-09-01 00:00:00

abstract：:Donor hematopoietic stem cells (HSCs) can correct T-cell deficiencies in patients with severe combined immunodeficiency by replacing resident thymus cells. However, as those progenitors that naturally migrate to the thymus are not capable of supporting long-term thymopoiesis, a successful transplant is thought to requ...

journal_title：Blood

authors： de Barros SC,Vicente R,Chebli K,Jacquet C,Zimmermann VS,Taylor N

更新日期：2013-03-14 00:00:00

abstract：:Pretreatment of endothelial cells with cytokines enhances the adherence of leukocytes, a process that is mediated by surface proteins expressed on both cell types. A three-dimensional model system for the simultaneous determination of leukocyte adherence and migration was used to study the contribution of CD11/CD18, e...

journal_title：Blood

authors： Hakkert BC,Kuijpers TW,Leeuwenberg JF,van Mourik JA,Roos D

更新日期：1991-11-15 00:00:00

abstract：:Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences...

journal_title：Blood

authors： Scheinberg P,Young NS

更新日期：2012-08-09 00:00:00

abstract：:Enzymes of the glycolytic pathway as well as some ancillary enzymes were studied in normal red cells parasitized with Plasmodium falciparum in culture at varying parasitemias as well as in isolated parasites. The levels of all enzymes except diphosphoglycerate mutase, glucose-6-phosphate dehydrogenase, and adenylate k...

journal_title：Blood

authors： Roth EF Jr,Calvin MC,Max-Audit I,Rosa J,Rosa R

更新日期：1988-12-01 00:00:00

abstract：:Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients. We analyzed results in 795 patients with FA who underwent first HSCT between May 1972...

journal_title：Blood

authors： Peffault de Latour R,Porcher R,Dalle JH,Aljurf M,Korthof ET,Svahn J,Willemze R,Barrenetxea C,Mialou V,Soulier J,Ayas M,Oneto R,Bacigalupo A,Marsh JC,Peters C,Socie G,Dufour C,FA Committee of the Severe Aplastic Anemia W

更新日期：2013-12-19 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) consists of at least 2 phenotypic subtypes; that is, the germinal center B-cell-like (GCB-DLBCL) and the activated B-cell-like (ABC-DLBCL) groups. It has been shown that GCB-DLBCL responds favorably to chemotherapy and expresses high levels of BCL6, a transcription repressor known...

journal_title：Blood

authors： Ding BB,Yu JJ,Yu RY,Mendez LM,Shaknovich R,Zhang Y,Cattoretti G,Ye BH

更新日期：2008-02-01 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the differentiation of human monocytes into two phenotypically distinct types of macrophages. However, in vivo, not only CSF but also many other cytokines are produced under va...

journal_title：Blood

authors： Akagawa KS,Takasuka N,Nozaki Y,Komuro I,Azuma M,Ueda M,Naito M,Takahashi K

更新日期：1996-11-15 00:00:00

abstract：:Despite the success of human leukocyte antigen (HLA) typing in allogeneic stem cell transplantation (SCT) it is rare to find an unrelated donor that is perfectly matched, making identification of "permissive" mismatches of paramount importance. Here, we describe novel associations between donor T-cell cytokine product...

journal_title：Blood

authors： Jordan WJ,Brookes PA,Szydlo RM,Goldman JM,Lechler RI,Ritter MA

更新日期：2004-01-15 00:00:00

abstract：:Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs). IREs are located in the 5'- or 3'-untranslated regions (UTRs) of specific mRNAs that encode proteins involved in iron homeostasis. The binding of IRPs to 5' IREs represses trans...

journal_title：Blood

authors： Phillips JD,Kinikini DV,Yu Y,Guo B,Leibold EA

更新日期：1996-04-01 00:00:00

abstract：:Despite androgens and intensive supportive care, satisfactory survival in severe aplastic anemia remains at 20% or less. Histocompatible bone marrow transplantation can restore normal hematopoiesis in approximately 40% of similarly severe individuals. Delay of transplantation for 3 wk after diagnosis allows time for p...

journal_title：Blood

authors： Camitta BM,Rappeport JM,Parkman R,Nathan DG

更新日期：1975-03-01 00:00:00

abstract：:The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD34(+) progenitor cells are treated with granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor necrosis factor (TNF) +/- stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokin...

journal_title：Blood

authors： Santiago-Schwarz F,McCarthy M,Tucci J,Carsons SE

更新日期：1998-08-01 00:00:00

abstract：:Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...

journal_title：Blood

authors： Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

更新日期：2012-05-31 00:00:00

abstract：:Endothelial cells play an important role in the regulation of fibrinolysis by the production of several key regulatory proteins. The cytokines tumor necrosis factor (TNF), lymphotoxin, and interleukin-1 (IL-1), but not interleukin-6, increase the production of plasminogen activator inhibitor-1 (PAI-1) by endothelial c...

journal_title：Blood

authors： van Hinsbergh VW,van den Berg EA,Fiers W,Dooijewaard G

更新日期：1990-05-15 00:00:00

abstract：:A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB (NF-kappaB). In this study, we evaluated the molecular basis of ...

journal_title：Blood

authors： Daniel S,Arvelo MB,Patel VI,Longo CR,Shrikhande G,Shukri T,Mahiou J,Sun DW,Mottley C,Grey ST,Ferran C

更新日期：2004-10-15 00:00:00

abstract：:Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mu...

journal_title：Blood

authors： Zhang X,Shang X,Guo F,Murphy K,Kirby M,Kelly P,Reeves L,Smith FO,Williams DA,Zheng Y,Pang Q

更新日期：2008-09-01 00:00:00