Abstract:
:Despite androgens and intensive supportive care, satisfactory survival in severe aplastic anemia remains at 20% or less. Histocompatible bone marrow transplantation can restore normal hematopoiesis in approximately 40% of similarly severe individuals. Delay of transplantation for 3 wk after diagnosis allows time for proper evaluation and for many spontaneous recoveries. Further delay increases risks of fatal complications and decreases chances for successful transplantation while the incidence of spontaneous remission declines. When available, early histocompatible bone marrow transplantation may be the treatment of choice for severe aplastic anemia.
journal_name
Bloodjournal_title
Bloodauthors
Camitta BM,Rappeport JM,Parkman R,Nathan DGsubject
Has Abstractpub_date
1975-03-01 00:00:00pages
355-63issue
3eissn
0006-4971issn
1528-0020journal_volume
45pub_type
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