B-lymphocytic hairy cells contain no HTLV-II DNA sequences.

abstract：:Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ significantly in progenitor cell content and lymphocyte dose, the cl...

journal_title：Blood

authors： Glass B,Uharek L,Zeis M,Dreger P,Löffler H,Steinmann J,Schmitz N

更新日期：1997-08-15 00:00:00

abstract：:The cell-surface expression of the MIC2 antigen defined by the monoclonal antibody 12E7 was investigated on human leukocytes in bone marrow (BM), thymus, and peripheral blood (PB) using multiparameter flow cytometry and cell sorting. In contrast to preceding reports, we found that the MIC2 antigen is not restricted to...

journal_title：Blood

authors： Dworzak MN,Fritsch G,Buchinger P,Fleischer C,Printz D,Zellner A,Schöllhammer A,Steiner G,Ambros PF,Gadner H

更新日期：1994-01-15 00:00:00

abstract：:The belief is widely held, on the basis of indirect evidence, that a substantial, even brief elevation of red cell Ca content must result in a marked shortening of circulatory survival. To test this notion directly, we exposed rabbit red cells in vitro to the ionophore A23187 and Ca so as to produce sustained uniform ...

journal_title：Blood

authors： Bookchin RM,Roth EF Jr,Lew VL

更新日期：1985-07-01 00:00:00

abstract：:At inflammatory sites, proteoglycans are both secreted by activated mononuclear leukocytes and released as a consequence of extracellular matrix degradation. Chondroitin 4-sulfate proteoglycans constitute the predominant ones produced by activated human monocytes/macrophages. In this study, we show that two chondroiti...

journal_title：Blood

authors： Rachmilewitz J,Tykocinski ML

更新日期：1998-07-01 00:00:00

abstract：:The pathogenesis of corticosteroid-resistant immune thrombocytopenia (ITP), a clinically challenging condition in which patients exhibit either no response to corticosteroids or are corticosteroid-dependent, remains poorly understood. Murine studies suggest that bone marrow (BM) endothelial progenitor cells (EPCs) pla...

journal_title：Blood

authors： Kong Y,Cao XN,Zhang XH,Shi MM,Lai YY,Wang Y,Xu LP,Chang YJ,Huang XJ

更新日期：2018-03-15 00:00:00

abstract：:Recent studies have identified nonredundant roles for basophils in immune responses including allergy and protective immunity. It is well known that activated basophils release granule contents such as histamine and proteases as do mast cells. However, the functional significance of basophil-derived proteases remains ...

journal_title：Blood

authors： Iki M,Tanaka K,Deki H,Fujimaki M,Sato S,Yoshikawa S,Yamanishi Y,Karasuyama H

更新日期：2016-12-22 00:00:00

abstract：:Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...

journal_title：Blood

authors： Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

更新日期：2010-07-15 00:00:00

abstract：:Glucose is a major source of energy for living organisms, and its transport in vertebrates is a universally conserved property. Of all cell lineages, human erythrocytes express the highest level of the Glut1 glucose transporter with more than 200,000 molecules per cell. However, we recently reported that erythrocyte G...

journal_title：Blood

authors： Montel-Hagen A,Blanc L,Boyer-Clavel M,Jacquet C,Vidal M,Sitbon M,Taylor N

更新日期：2008-12-01 00:00:00

abstract：:Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have alre...

journal_title：Blood

authors： Holtan SG,Pasquini M,Weisdorf DJ

更新日期：2014-07-17 00:00:00

abstract：:Rituximab, a monoclonal antibody that targets CD20 on B cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success, a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 monoclonal antibodies (mAbs) are cont...

journal_title：Blood

authors： Beers SA,French RR,Chan HT,Lim SH,Jarrett TC,Vidal RM,Wijayaweera SS,Dixon SV,Kim H,Cox KL,Kerr JP,Johnston DA,Johnson PW,Verbeek JS,Glennie MJ,Cragg MS

更新日期：2010-06-24 00:00:00

abstract：:The functions of the alphaC domains of fibrinogen in clotting and fibrinolysis, which have long been enigmatic, were determined using recombinant fibrinogen truncated at Aalpha chain residue 251. Scanning electron microscopy and confocal microscopy revealed that the fibers of alpha251 clots were thinner and denser, wi...

journal_title：Blood

authors： Collet JP,Moen JL,Veklich YI,Gorkun OV,Lord ST,Montalescot G,Weisel JW

更新日期：2005-12-01 00:00:00

abstract：:Activated platelets release their granule content in a concentrated fashion at sites of injury. We examined whether ectopically expressed factor VIII in developing megakaryocytes would be stored in alpha-granules and whether its release from circulating platelets would effectively ameliorate bleeding in a factor VIIIn...

journal_title：Blood

authors： Yarovoi HV,Kufrin D,Eslin DE,Thornton MA,Haberichter SL,Shi Q,Zhu H,Camire R,Fakharzadeh SS,Kowalska MA,Wilcox DA,Sachais BS,Montgomery RR,Poncz M

更新日期：2003-12-01 00:00:00

abstract：:Cultured endothelial cells produce an extracellular matrix (ECM) to which platelets adhere and spread, ultimately resulting in platelet aggregation, thromboxane B2 production, and serotonin release. We have investigated the role of fibrinogen binding to the platelet GPIIb/IIIa complex in these reactions by comparing n...

journal_title：Blood

authors： Eldor A,Vlodavsky I,Martinowicz U,Fuks Z,Coller BS

更新日期：1985-06-01 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on endothelial cells is a key component of the inflammatory response seen in Gram-negative sepsis. LPS does not cause death of cultured human endothelial cells. However, when the expression of new proteins is inhibited by cycloheximide, microvascular endothelial cells in culture ...

journal_title：Blood

authors： Hu X,Yee E,Harlan JM,Wong F,Karsan A

更新日期：1998-10-15 00:00:00

abstract：:B7-H2, which is expressed constitutively on B cells and binds the inducible costimulator (ICOS) on antigen-activated T cells, is a member of the B7 family of costimulatory ligands. We have inactivated B7-H2 in the mouse. B7-H2-/- mice generate normal populations of B and T cells in their various lymphoid organs but ha...

journal_title：Blood

authors： Wong SC,Oh E,Ng CH,Lam KP

更新日期：2003-08-15 00:00:00

abstract：:Pregnancy can precipitate thrombotic thrombocytopenic purpura (TTP). We present a prospective study of TTP cases from the United Kingdom Thrombotic Thrombocytopenic Purpura (UK TTP) Registry with clinical and laboratory data from the largest cohort of pregnancy-associated TTP and describe management through pregnancy,...

journal_title：Blood

authors： Scully M,Thomas M,Underwood M,Watson H,Langley K,Camilleri RS,Clark A,Creagh D,Rayment R,Mcdonald V,Roy A,Evans G,McGuckin S,Ni Ainle F,Maclean R,Lester W,Nash M,Scott R,O Brien P,collaborators of the UK TTP Registr

更新日期：2014-07-10 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:The composition of the erythrocyte plasma membrane is extensively modified during the intracellular growth of the malaria parasite Plasmodium falciparum. It has been previously shown that an 80-kD phosphoprotein is associated with the plasma membrane of human red blood cells (RBCs) infected with trophozoite/schizont s...

journal_title：Blood

authors： Chishti AH,Maalouf GJ,Marfatia S,Palek J,Wang W,Fisher D,Liu SC

更新日期：1994-06-01 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T-cell progenitors. OP9 stromal cells ex...

journal_title：Blood

authors： Lehar SM,Dooley J,Farr AG,Bevan MJ

更新日期：2005-02-15 00:00:00

abstract：:In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...

journal_title：Blood

authors： Sweetenham JW

更新日期：2015-06-11 00:00:00

abstract：:CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with fol...

journal_title：Blood

authors： Karube K,Guo Y,Suzumiya J,Sugita Y,Nomura Y,Yamamoto K,Shimizu K,Yoshida S,Komatani H,Takeshita M,Kikuchi M,Nakamura N,Takasu O,Arakawa F,Tagawa H,Seto M,Ohshima K

更新日期：2007-04-01 00:00:00

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:Beginning in 1985, patients in British Columbia with Hodgkin lymphoma (HL) that was not controlled by conventional chemotherapy routinely underwent high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT). Long-term complications of HD-ASCT have become apparent as more patients survive without recurre...

journal_title：Blood

authors： Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

更新日期：2005-08-15 00:00:00

abstract：:Delivery of biologically active peptides into human polymorphonuclear neutrophils (PMNs) has implications for studying cellular functions and may be therapeutically relevant. The transcription factor nuclear factor-kappaB (NF-kappaB) regulates the expression of multiple genes controlling inflammation, proliferation, a...

journal_title：Blood

authors： Choi M,Rolle S,Wellner M,Cardoso MC,Scheidereit C,Luft FC,Kettritz R

更新日期：2003-09-15 00:00:00

abstract：:In this study human mononuclear phagocytes from the bone marrow (promonocytes and monocytes), peripheral blood monocytes, and tissue macrophages from the skin and the peritoneal cavity were studied with respect to their morphological, cytochemical, and functional characteristics, cell surface receptors, and 3H-thymidi...

journal_title：Blood

authors： van Furth R,Raeburn JA,van Zwet TL

更新日期：1979-08-01 00:00:00

abstract：:A method is described that allows for the routine long-term (greater than 3 mo) growth of normal, immature human myeloid cells in liquid suspension culture. The techniques employ cell separation, utilization of special growth conditions (RPMI with hydrocortisone and vitamin D), and cord blood as the source of leukocyt...

journal_title：Blood

authors： Salahuddin SZ,Markham PD,Ruscetti FW,Gallo RC

更新日期：1981-11-01 00:00:00

abstract：:Analysis of fresh human tumors have indicated that patients with B type lymphoproliferative diseases and the majority of patients with acute lymphoblastic leukemia (ALL) express elevated levels of p53 production. It is suggested that in these human malignancies, p53 may provide a novel tool for monitoring cancer activ...

journal_title：Blood

authors： Prokocimer M,Shaklai M,Bassat HB,Wolf D,Goldfinger N,Rotter V

更新日期：1986-07-01 00:00:00

abstract：:The presence of multiple VHDJH joinings in upwards of 30% of acute lymphoblastic leukemias (ALL) suggests a relative instability of the rearranged immunoglobulin heavy chain (IgH) gene, but the mechanisms involved are not completely understood. An investigation of the structure of the VHDJH joinings using complementar...

journal_title：Blood

authors： Wasserman R,Yamada M,Ito Y,Finger LR,Reichard BA,Shane S,Lange B,Rovera G

更新日期：1992-01-01 00:00:00

abstract：:Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 const...

journal_title：Blood

authors： Jakob SM,Pick R,Brechtefeld D,Nussbaum C,Kiefer F,Sperandio M,Walzog B

更新日期：2013-05-16 00:00:00